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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3A 203
Other AURKA 133
Other AURKB 77
CMGC CDK2 4
CMGC CDK4 6
CMGC CDK5 4
CAMK CHEK1 9
TK FYN 271
CMGC GSK3B 56
TK ITK 363
CMGC MAPK1 13
CMGC MAPK10 64
CMGC MAPK8 26
CMGC MAPK9 26
-YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDK-RFK---NR-------ELQIMRKLD---HCNIVRLRYFFYSSG--EKKDELYLNLVLEYVPETVYRVARHFT---KAKL---TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQ----LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF-
-FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKA---GVEHQLRR-EVEIQSHLR---HPNILRLYGYFHD------ATRVY--LILEYAPLG--TVYRELQ----KLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGELKIADFGWSV-----HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI-
-FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ-IEK---EGVEHQLRREIEIQAHLH---HPNILRLYNYFYD------RRRIY--LILEYAPRG--ELYKELQ----KSC---TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGELKIADFGWSV-----HAPSLRRKT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPPFESA---SHNETYRRIVKVDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV-
-FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETE---GVPSTAIR-EISLLKELN---HPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF---GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-
Y-EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPN-GGGGGGGLPISTVR-EVALLRRLEAFEHPNVVRLMDVCATSR-TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP---GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARI----YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL-
-YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDE---GVPSSALR-EICLLKELK---HKNIVRLHDVLHS------DKKLT--LVFEFCDQ---DLKKYFD---SCNG---DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGELKLADFGLARAF---GIPVRCYSA---EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF-
W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKR-AVD---CPENI-KK-EICINKMLN---HENVVKFYGHRRE------GNIQY--LFLEYCSGG--ELFDRIE----PDI---GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNLKISDFGLATVFR-YNNRERLLNK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y
-LQLIKRLGNGQFGEVWMGTWN-GNTKVAIKTLK-PG-TM----SPESFL-E-EAQIMKKLK---HDKLVQLYAVVS-------EEPIY--IVTEYMNKG--SLLDFLK-----DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVG-NGLICKIADFGLARLI---E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCP-----------------------------------------ISLHELMIHCWKKDPEERPTFEYLQSFL---
-YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-RFK---NR-------ELQIMRKLD---HCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ----LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF-
-LTFVQEIGSGQFGLVHLGYWL-NKDKVAIKTIR-EG-AM----SEEDFI-E-EAEVMMKLS---HPKLVQLYGVCLE------QAPIC--LVFEFMEHG--CLSDYLR-----TQ-RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVG-ENQVIKVSDFGMTRFV---L--DDQYTSSTGTKFPVKWASPEVFS-FSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLAS-----------------------------------------THVYQIMNHCWKERPEDRPAFSRLLRQL---
-YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE-HQT---YCQRT-LR-EIKILLRFR---HENIIGINDIIRAPT-IEQMKDVY--IVQDLMET---DLYKLLK-----TQ---HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICDFGLARVADPDHDHTGFLTE---YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-----------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL-
-YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF-QNQ---THAKRAYR-ELVLMKCVN---HKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART----AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI-
-YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPF-QNQ---THAKRAYR-ELVLMKCVN---HKNIIGLLNVFTPQKSLEEFQDVY--IVMELMDA---NLCQVIQ------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART----AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVC-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI-
-YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPF-QNQ---THAKRAYR-ELVLLKCVN---HKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIH------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART----ACTNFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGELVK-GCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI-
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