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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3A 203
Other AURKA 133
CAMK BRSK1 50
CAMK BRSK2 19
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK5 4
CMGC CDK6 13
CMGC CDK9 2.7.11.23
CAMK CHEK1 9
CAMK CHEK2 220
CMGC DYRK2 222
CMGC GSK3B 56
CAMK NUAK1 55
STE PAK1 270
STE PAK2 249
AGC PDPK1 82
CAMK PHKG1 20
CAMK PIM3 40
AGC RPS6KA2 59
AGC RPS6KA3 68
AGC RPS6KA6 73
CAMK SIK2 20
--YTDIKVIGNGSFGVVYQARLAETRE---LVAIKKVLQDK-RFKNR--------------ELQIMRKL-D------HCNIVRLRYFFYSSG----EKKDELYLNLVLEYVPETVYRVARHFT---KAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVL---KLCDFGSAKQ-----LVRGEPNVSYICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS-----PLEACAHSFF-----------
--FEIGRPLGKGKFGNVYLAREKQSKF---ILALKVLFKAQLEKAGVEH-QLRR-------EVEIQSHL-R------HPNILRLYGYFHD--------ATRVY--LILEYAPLG--TVYRELQ----KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL---KIADFGWSV------HAPSSRRTTLCGTLDYLPPEMIE------GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT--------------------------------------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI-----------
--YRLEKTLGKGQTGLVKLGVHCITGQ---KVAIKIVNREK-LSESVLM-KVER-------EIAILKLI-E------HPHVLKLHDVYEN--------KKYLY--LVLEHVSGG--ELFDYLV----KKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLD-EKNNI---RIADFGMASL-----QVGDSLLETSCGSPHYACPEVIK-----GEKYDGRRADMWSCGVILFALLV-GALPFDDD---NLRQLLEKVKRGVFHMPHFIP--------------------------------------------------------PDCQSLLRGMIEVEPEKRLS-----LEQIQKHPW-Y----------
--YRLEKTLGKGQTGLVKLGVHCVTCQ---KVAIKIVNREK-LSESVLM-KVER-------EIAILKLI-E------HPHVLKLHDVYEN--------KKYLY--LVLEHVSGG--ELFDYLV----KKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLD-EKNNI---RIADFGMASL-----QVGDSLLETSCGSPHYACPEVIR-----GEKYDGRKADVWSCGVILFALLV-GALPFDDD---NLRQLLEKVKRGVFHMPHFIP--------------------------------------------------------PDCQSLLRGMIEVDAARRLT-----LEHIQKHIW-Y----------
--YTKIEKIGEGTYGVVYKGRHKTTGQ---VVAMKKIRLES-EEEGVPS-TAIR-------EISLLKEL-R------HPNIVSLQDVLMQ--------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---KLADFGLARAF----GIPIRVYTHEVVTLWYRSPEVLL-----GSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF-----------
--FQKVEKIGEGTYGVVYKARNKLTGE---VVALKKIRLDT-ETEGVPS-TAIR-------EISLLKEL-N------HPNIVKLLDVIHT--------ENKLY--LVFEFLHQ---DLKKFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF----GVPVRTYTHEVVTLWYRAPEILL-----GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF-----------
--FQKVEKIGEGTYGVVYKAKNRETGQ---LVALKKIRLDL-EMEGVPS-TAIR-------EISLLKEL-K------HPNIVRLLDVVHN--------ERKLY--LVFEFLSQ---DLKKYMDS--TPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLIN-ELGAI---KLADFGLARAF----GVPLRTYTHEVVTLWYRAPEILL-----GSKFYTTAVDIWSIGCIFAEMVT-RKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR------------------------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRIT-----AKTALAHPYF-----------
--YEKLEKIGEGTYGTVFKAKNRETHE---IVALKRVRLDD-DDEGVPS-SALR-------EICLLKEL-K------HKNIVRLHDVLHS--------DKKLT--LVFEFCDQ---DLKKYFD---SCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL---KLADFGLARAF----GIPVRCYSAEVVTLWYRPPDVLF-----GAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF-----------
--YECVAEIGEGAYGKVFKARDLKNGG--RFVALKRVRVQT-GEEGMPL-STIR-------EVAVLRHL-ET---FEHPNVVRLFDVCTVSR---TDRETKLT--LVFEHVDQ---DLTTYLDK--VPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SSGQI---KLADFGLARI-----YSFQMALTSVVVTLWYRAPEVLL------QSSYATPVDLWSVGCIFAEMFR-RKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQ--------------------------------PIEKFVTDIDELGKDLLLKCLTFNPAKRIS-----AYSALSHPYF-----------
--YEKLAKIGQGTFGEVFKARHRKTGQ---KVALKKVLMEN-EKEGFPI-TALR-------EIKILQLL-K------HENVVNLIEICRTKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVL---KLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLL-----GERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK---------------------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SDDALNHDFF-----------
-W-DLVQTLGEGAYGEVQLAVNRVTEE---AVAVKIVDMKR-AVDCPEN-I-KK-------EICINKML-N------HENVVKFYGHRRE--------GNIQY--LFLEYCSGG--ELFDRIE----PDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---KISDFGLATVFR--YNNRERLLNKMCGTLPYVAPELLK-----RREFHAEPVDVWSCGIVLTAMLA-GELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D----------------------------------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y----------
YI--MSKTLGSGACGEVKLAFERKTCK---KVAIKIISKRK-FAIGSAR-EADPALN-VETEIEILKKL-N------HPCIIKIKNFF-D--------AEDYY--IVLELMEGG--ELFDKVV----GNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDCLIKITDFGHSKI-----LGETSLMRTLCGTPTYLAPEVLVS---VGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--RTQVSLKDQITSGKYNFIPEVWAEVS----------------------------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL-----------
--YEVLKVIGKGSFGQVVKAYDHKVHQ---HVALKMVRNEK-RFHRQAA-E----------EIRILEHL-RKQDKDNTMNVIHMLENFTF--------RNHIC--MTFELLSM---NLYELIKK--NKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLK-QQGRSG-IKVIDFGSSC-------YEHQRVYTYIQSRFYRAPEVIL------GARYGMPIDMWSLGCILAELLT-GYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMT-----PGQALRHPWL-----------
--YTDTKVIGNGSFGVVYQAKLCDSGE---LVAIKKVLQDK-RFKNR--------------ELQIMRKL-D------HCNIVRLRYFFYSSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ-----LVRGEPNVSYICSRYYRAPELIF-----GATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF-----------
--YELQETLGKGTYGKVKRATERFSGR---VVAIKSIRKDK-IKDEQDM-VHIR------REIEIMSSL-N------HPHIISIYEVFEN--------KDKIV--IIMEYASKG--ELYDYIS----ERRRLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLD-DNCNI---KIADFGLSNL-----YQKDKFLQTFCGSPLYASPEIVN-----GRPYRGPEVDSWALGVLLYTLVY-GTMPFDGF---DHKNLIRQISSGEYREPTQP---------------------------------------------------------SDARGLIRWMLMVNPDRRAT-----IEDIANHWW-V----------
--YTRFEKIGQGASGTVYTAMDVATGQ---EVAIKQMNLQQ-QPKKELI-I--N-------EILVMREN-K------NPNIVNYLDSYLV--------GDELW--VVMEYLAGG--SLTDVVT-----ETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLG-MDGSV---KLTDFGFCAQI----TPEQSKRSTMVGTPYWMAPEVVT------RKAYGPKVDIWSLGIMAIEMIE-GEPPYLNENPLRALYLIATNGTPELQNPEKLS--------------------------------------------------------AIFRDFLNRCLEMDVEKRGS-----AKELLQHQFL-----------
--YTRYEKIGQGASGTVFTATDVALGQ---EVAIKQINLQK-QPKKELI-I--N-------EILVMKEL-K------NPNIVNFLDSYLV--------GDELF--VVMEYLAGG--SLTDVVT-----ETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLG-MEGSV---KLTDFGFCAQI----TPEQSKRSTMVGTPYWMAPEVVT------RKAYGPKVDIWSLGIMAIEMVE-GEPPYLNENPLRALYLIATNGTPELQNPEKLS--------------------------------------------------------PIFRDFLNRCLEMDVEKRGS-----AKELLQHPFL-----------
-F-KFGKILGEGSFSTVVLARELATSR---EYAIKILEKRH-IIKENKVPYVTR-------ERDVMSRL-D------HPFFVKLYFTFQD--------DEKLY--FGLSYAKNG--ELLKYIR----KIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI---QITDFGTAKVLS--PESKQARANSFVGTAQYVSPELLT------EKSACKSSDLWALGCIIYQLVA-GLPPFRAG---NEYLIFQKIIKLEYDFPEKFF--------------------------------------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
--YEPKEILGRGVSSVVRRCIHKPTSQ---EYAVKVIDVTG-GGSFSPE-EVRELREATLKEVDILRKVSG------HPNIIQLKDTYET--------NTFFF--LVFDLMKRG--ELFDYLT----EKVTLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLD-DNMNI---KLTDFGFSCQ-----LEPGERLREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLA-GSPPFWHR---KQMLMLRMIMSGNYQFGSPEWDDYS----------------------------------------------------DTVKDLVSRFLVVQPQNRYT-----AEEALAHPFF-----------
--YQVGAVLGSGGFGTVYAGSRIADGL---PVAVKHVVKER-VTEWGSL-GGATV----PLEVVLLRKV-GAA--GGARGVIRLLDWFER--------PDGFL--LVLERPEPA-QDLFDFIT----ERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGEL---KLIDFGSGA------LLKDTVYTDFDGTRVYSPPEWIR-----YHRYHGRSATVWSLGVLLYDMVC-GDIPFEQD---------EEILRGRLLFRRRVS--------------------------------------------------------PECQQLIRWCLSLRPSERPS-----LDQIAAHPWM-----------
--FELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKAT-LKVRDRV-RSKM-------ERDILAEV-N------HPFIVKLHYAFQT--------EGKLY--LILDFLRGG--DLFTRLS----KEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD-EEGHI---KITDFGLSKEA----IDHDKRAYSFCGTIEYMAPEVVN------RRGHTQSADWWSFGVLMFEMLT-GSLPFQGK---DRKETMALILKAKLGMPQFLS--------------------------------------------------------GEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF-----------
--FELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKAT-LKVRDRV-RTKM-------ERDILVEV-N------HPFIVKLHYAFQT--------EGKLY--LILDFLRGG--DLFTRLS----KEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD-EEGHI---KLTDFGLSKES----IDHEKKAYSFCGTVEYMAPEVVN------RRGHTQSADWWSFGVLMFEMLT-GTLPFQGK---DRKETMTMILKAKLGMPQFLS--------------------------------------------------------PEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF-----------
--FELLKVLGQGSFGKVFLVRKKTGPDAGQLYAMKVLKKAS-LKVRDRV-RTKM-------ERDILVEV-N------HPFIVKLHYAFQT--------EGKLY--LILDFLRGG--DVFTRLS----KEVLFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLD-EIGHI---KLTDFGLSKES----VDQEKKAYSFCGTVEYMAPEVVN------RRGHSQSADWWSYGVLMFEMLT-GTLPFQGK---DRNETMNMILKAKLGMPQFLS--------------------------------------------------------AEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFF-----------
--YDIEGTLGKGNFAVVKLGRHRITKT---EVAIKIIDKSQ-LDAVNLE-KIYR-------EVQIMKML-D------HPHIIKLYQVMET--------KSMLY--LVTEYAKNG--EIFDYLA----NHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLD-NNMNI---KIADFGFGNF-----FKSGELLATWCGSPPYAAPEVFE-----GQQYEGPQLDIWSMGVVLYVLVC-GALPFDGP---TLPILRQRVLEGRFRIPYFMS--------------------------------------------------------EDCEHLIRRMLVLDPSKRLT-----IAQIKEHKWM-----------
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