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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3A 203
Other AURKA 133
Other AURKB 77
CMGC CDK2 4
CMGC GSK3B 56
TK HCK 241
TK INSR 1023
CMGC MAPK14 24
CAMK MAPKAPK2 64
Other PLK1 53
---YTDIKVIGNGSFGVVYQARLA-----ETRELVAIKKVLQDK-RFKNR---------ELQIMRKL-DHCNIVRLRYFFYSSG--EKKDELYLNLVLEYVPETVYRVARHFT---KAKL-----------TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVL---KLCDFGSAKQ--LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF
---FEIGRPLGKGKFGNVYLAREK-----QSKFILALKVLFKAQLEKAGV--EHQLRR-EVEIQSHL-RHPNILRLYGYFHD------ATRVY--LILEYAPLG--TVYRELQ----KLS-----------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL---KIADFGWSV---HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN----TYQETYKRISRVEFTFPDFVT----------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI
---FEIGRPLGKGKFGNVYLAREK-----KSHFIVALKVLFKSQ-IEKEG--VEHQLRREIEIQAHL-HHPNILRLYNYFYD------RRRIY--LILEYAPRG--ELYKELQ----KSC-----------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGEL---KIADFGWSV---HAPSLRRKT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPPFESA----SHNETYRRIVKVDLKFPASVP----------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV
---FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDT-ETEGV--PSTAIR-EISLLKEL-NHPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-----------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF-GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
---YTDTKVIGNGSFGVVYQAKLC-----DSGELVAIKKVLQDK-RFKNR---------ELQIMRKL-DHCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-----------TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ--LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF
---LKLEKKLGAGQFGEVWMATYN------KHTKVAVKTMK-PG-SM-SV--EAFL-A-EANVMKTL-QHDKLVKLHAVVT-------KEPIY--IITEFMAKG--SLLDFLK-----SD--------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVS-ASLVC---KIADFGLARVI-E--DNEYTAREGAKFPIKWTAPEAIN-FGSFTIKSDVWSFGILLMEIVTYGRIPYPGM-SNPEVIRALERGYRMPRPENCP------------------------------EELYNIMMRCWKNRPEERPTFEYIQSV--L
---ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN-ES-AS-LRERIEFL-N-EASVMKGF-TCHHVVRLLGVVSK------GQPTL--VVMELMAHG--DLKSYLR-----SLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVA-HDFTV---KIGDFGMTRDIYE--TDYYRKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEITSLAEQPYQGL-SNEQVLKFVMDGGYLDQPDNCP------------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL--
---YQNLSPVGSGAYGSVCAAFDT-----KTGLRVAVKKLSRPF-QSIIH--AKRTYR-ELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ-----------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL---KILDFGLAR----HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT-DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
KVT---SQVLGLGINGKVLQIFNK-----RTQEKFALKMLQDCP-KAR---------R-EVELHWRASQCPHIVRIVDVYENLY--AGRKCLL--IVMECLDGG--ELFSRIQD--RGDQ-----------AFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT-SKRPNAILKLTDFGFAKE--TTSHNSLTT---PCYTPYYVAPEVLG-PEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS------------------------EEVKMLIRNLLKTEPTQRMTITEFMNHPWI
-YV--RGRFLGKGGFAKCFEISDA-----DTKEVFAGKIVPKSL-LLKPH--QREKMSMEISIHRSL-AHQHVVGFHGFFED------NDFVF--VVLELCRRR--SLLELHK----RRK-----------ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEV---KIGDFGLATKV-EYDGERKKT---LCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS----CLKETYLRIKKNEYSIPKHIN----------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF
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