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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3A 203
Other AURKA 133
Other CAMKK2 165
CAMK CASK 12
CMGC CDC2 4
CMGC CDC2L5 705
CMGC CDC2L6 20
CMGC CDK11A 438
CMGC CDK15 103
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK4 6
CMGC CDK5 4
CMGC CDK9 2.7.11.23
CMGC CDKL2 4
CMGC CDKL5 13
CMGC CLK1 161
CMGC CLK2 163
CMGC CLK3 156
CMGC CLK4 159
CMGC DYRK1A 150
CMGC DYRK1B 111
CMGC DYRK2 222
TK EPHB3 633
CMGC GSK3B 56
CMGC ICK 4
CMGC MAK 4
STE MAP2K1 68
Other NEK2 8
CMGC PCTK1 165
CMGC PCTK2 192
CMGC PCTK3 172
CMGC PFTK1 117
AGC PRKCQ 380
STE SLK 34
---YTDIKVIGNGSFGVVYQARLA---E-T-RE--LVAIKKVLQDK-RFK---NR---------------------------------ELQIMRKL-D------HCN-----IVRLRYFFYSSG------EKKDELYLNLVLEYVPETVYRVA-RHFT------KAKL--TI---PILYVKVYMYQLFRSLAYIHS--Q-----GVCHRDIKPQNLLVD---PDTAVL--------------------KLCDFGSAKQ--------LVRGEPNVS---YICSRYYRAPELIF----GATD--YTSSIDVWSAGCVLAELLL-GQPIFPGD---------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPL-EACAHSFF-
---FEIGRPLGKGKFGNVYLAREK---Q-S-KF--ILALKVLFKAQLEKA---GV--EHQLRR-------------------------EVEIQSHL-R------HPN-----ILRLYGYFHD----------ATRVY--LILEYAPLG--TVY-RELQ-------KLS--KF---DEQRTATYITELANALSYCHS--K-----RVIHRDIKPENLLLG----SAGEL--------------------KIADFGWSV---------HAPSSRRTT---LCGTLDYLPPEMIE-----GRM--HDEKVDLWSLGVLCYEFLV-GKPPFEAN------------TYQETYKRISRVEFTFPDFVT-------------------------------------------------------------EGARDLISRLLKHNPSQRPMLR-EVLEHPWI-
---YTLKDEIGKGSYGVVKLAYNE---N-D-NT--YYAMKVLSKKK-LIR---QA--GFPR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL-D------HPN-----VVKLVEVLDDP--------NEDHLY--MVFELVNQG--PVM-EVPT--------LK--PL---SEDQARFYFQDLIKGIEYLHY--Q-----KIIHRDIKPSNLLVG----EDGHI--------------------KIADFGVSNEF-------KGSDALLSN---TVGTPAFMAPESLS----ETRKIFSGKALDVWAMGVTLYCFVF-GQCPFMDE------------RIMCLHSKIKSQALEFPDQPDIA-----------------------------------------------------------EDLKDLITRMLDKNPESRIVVP-EIKLHPWV-
---YELCEVIGKGPFSVVRRCINR---E-T-GQ--QFAVKIVDVAK-FTS---SP--GLSTEDL----------------------KREASICHML-K------HPH-----IVELLETYSS----------DGMLY--MVFEFMDGA--DLCFEIVKR----ADAGF--VY---SEAVASHYMRQILEALRYCHD--N-----NIIHRDVKPHCVLLA----SKENSA-----------------PVKLGGFGVAIQL-------GESGLVAGG---RVGTPHFMAPEVVK-----REP--YGKPVDVWGCGVILFILLS-GCLPFYGT-------------KERLFEGIIKGKYKMNPRQWSHIS---------------------------------------------------------ESAKDLVRRMLMLDPAERITVY-EALNHPWL-
---YTKIEKIGEGTYGVVYKGRHK---T-T-GQ--VVAMKKIRLES-EEE---GV--PSTAIR-------------------------EISLLKEL-R------HPN-----IVSLQDVLMQ----------DSRLY--LIFEFLSM---DLK-KYLDS----IPPGQ--YM---DSSLVKSYLYQILQGIVFCHS--R-----RVLHRDLKPQNLLID----DKGTI--------------------KLADFGLARAF-------GIPIRVYTH---EVVTLWYRSPEVLL----GSAR--YSTPVDIWSIGTIFAELAT-KKPLFHGD---------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-----------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGK-MALNHPYF-
--F-DIIGIIGEGTYGQVYKARDK---D-T-GE--MVALKKVRLDN-EKE---GF--PITAIR-------------------------EIKILRQL-T------HQS-----IINMKEIVTDKEDALDFKKDKGAFY--LVFEYMDH---DLM-GLLE------SGLV--HF---NENHIKSFMRQLMEGLDYCHK--K-----NFLHRDIKCSNILLN----NRGQI--------------------KLADFGLARLY------SSEESRPYTN---KVITLWYRPPELLL----GEER--YTPAIDVWSCGCILGELFT-KKPIFQAN---------QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQY----------------------------------RRKLREEFVFIPAAALDLFDYMLALDPSKRCTAE-QALQCEF-L
EGC-----KVGRGTYGHVYKARRK---D-G-KDEKEYALKQIEGTG-ISM---SA--C----R-------------------------EIALLREL-K------HPN-----VIALQKVFLSH--------SDRKVW--LLFDYAEH---DLW-HIIKFHRASKANKK--PMQ-LPRSMVKSLLYQILDGIHYLHA--N-----WVLHRDLKPANILVMGEGPERGRV--------------------KIADMGFARLFN----SPLKPLADLDP---VVVTFWYRAPELLL----GARH--YTKAIDIWAIGCIFAELLT-SEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYA--------------------------NSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSE-QALQDPYF-
---FQCLNRIEEGTYGVVYRAKDK---K-T-DE--IVALKRLKMEK-EKE---GF--PITSLR-------------------------EINTILKA-Q------HPN-----IVTVREIVVGS--------NMDKIY--IVMNYVEH---DLK-SLME------TMKQ--PF---LPGEVKTLMIQLLRGVKHLHD--N-----WILHRDLKTSNLLLS----HAGIL--------------------KVGDFGLAREY-------GSPLKAYTP---VVVTLWYRAPELLL----GAKE--YSTAVDMWSVGCIFGELLT-QKPLFPGK---------SEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPY---------------------------------NNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAE-DGLKHEYF-
-YL--NLEKLGEGSYATVYKGISR---I-N-GQ--LVALKVISMNA-EEG---VP---FTAIR-------------------------EASLLKGL-K------HAN-----IVLLHDIIHT----------KETLT--FVFEYMHT---DLA-QYMS------QHPG--GL---HPHNVRLFMFQLLRGLAYIHH--Q-----HVLHRDLKPQNLLIS----HLGEL--------------------KLADFGLARAK-------SIPSQTYSS---EVVTLWYRPPDALL----GATE--YSSELDIWGAGCIFIEMFQ-GQPLFPGV--------SNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEWFPLPTP--------------------------------RSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQ-EALVHDYF-
---FQKVEKIGEGTYGVVYKARNK---L-T-GE--VVALKKIRLDT-ETE---GV--PSTAIR-------------------------EISLLKEL-N------HPN-----IVKLLDVIHT----------ENKLY--LVFEFLHQ---DLK-KFMDA-----SALT--GI---PLPLIKSYLFQLLQGLAFCHS--H-----RVLHRDLKPQNLLIN----TEGAI--------------------KLADFGLARAF-------GVPVRTYTH---EVVTLWYRAPEILL----GCKY--YSTAVDIWSLGCIFAEMVT-RRALFPGD---------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAK-AALAHPFF-
---FQKVEKIGEGTYGVVYKAKNR---E-T-GQ--LVALKKIRLDL-EME---GV--PSTAIR-------------------------EISLLKEL-K------HPN-----IVRLLDVVHN----------ERKLY--LVFEFLSQ---DLK-KYMDS-----TPGS--EL---PLHLIKSYLFQLLQGVSFCHS--H-----RVIHRDLKPQNLLIN----ELGAI--------------------KLADFGLARAF-------GVPLRTYTH---EVVTLWYRAPEILL----GSKF--YTTAVDIWSIGCIFAEMVT-RKALFPGD---------SEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-----------------------------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAK-TALAHPYF-
--Y-EPVAEIGVGAYGTVYKARDP---H-S-GH--FVALKSVRVPN-GGGGGGGL--PISTVR-------------------------EVALLRRL-EA---FEHPN-----VVRLMDVCATSR-----TDREIKVT--LVFEHVDQ---DLR-TYLDK-----APPP--GL---PAETIKDLMRQFLRGLDFLHA--N-----CIVHRDLKPENILVT----SGGTV--------------------KLADFGLARI--------YSYQMALTP---VVVTLWYRAPEVLL-----QST--YATPVDMWSVGCIFAEMFR-RKPLFCGN---------SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR-------------------------------------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAF-RALQHSYL-
---YEKLEKIGEGTYGTVFKAKNR---E-T-HE--IVALKRVRLDD-DDE---GV--PSSALR-------------------------EICLLKEL-K------HKN-----IVRLHDVLHS----------DKKLT--LVFEFCDQ---DLK-KYFD------SCNG--DL---DPEIVKSFLFQLLKGLGFCHS--R-----NVLHRDLKPQNLLIN----RNGEL--------------------KLADFGLARAF-------GIPVRCYSA---EVVTLWYRPPDVLF----GAKL--YSTSIDMWSAGCIFAELANAGRPLFPGN---------DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-----------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAE-EALQHPYF-
---YEKLAKIGQGTFGEVFKARHR---K-T-GQ--KVALKKVLMEN-EKE---GF--PITALR-------------------------EIKILQLL-K------HEN-----VVNLIEICRTKASP--YNRCKGSIY--LVFDFCEH---DLA-GLLS------NVLV--KF---TLSEIKRVMQMLLNGLYYIHR--N-----KILHRDMKAANVLIT----RDGVL--------------------KLADFGLARAFSL---AKNSQPNRYTN---RVVTLWYRPPELLL----GERD--YGPPIDLWGAGCIMAEMWT-RSPIMQGN---------TEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK--------------------------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSD-DALNHDFF-
---YENLGLVGEGSYGMVMKCRNK---D-T-GR--IVAIKKFLESD-DDK---MV--KKIAMR-------------------------EIKLLKQL-R------HEN-----LVNLLEVCKK----------KKRWY--LVFEFVDHT--ILD-DLEL-------FPN--GL---DYQVVQKYLFQIINGIGFCHS--H-----NIIHRDIKPENILVS----QSGVV--------------------KLCDFGFARTL-------AAPGEVYTD---YVATRWYRAPELLV----GDVK--YGKAVDVWAIGCLVTEMFM-GEPLFPGD---------SDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKE---------------------------------REPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCA-ELLHHDFF-
---FEILGVVGEGAYGVVLKCRHK---E-T-HE--IVAIKKFKDSE-ENE---EV--KETTLR-------------------------ELKMLRTL-K------QEN-----IVELKEAFRR----------RGKLY--LVFEYVEK---NML-ELLE------EMPN--GV---PPEKVKSYIYQLIKAIHWCHK--N-----DIVHRDIKPENLLIS----HNDVL--------------------KLCDFGFARNL------SEGNNANYTE---YVATRWYRSPELLL-----GAP--YGKSVDMWSVGCILGELSD-GQPLFPGE---------SEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNH--------------------------------PQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTE-QCLNHPTF-
---YEIVDTLGEGAFGKVVECIDH---K-AGGR--HVAVKIVKNVD-RYC---EA--ARS----------------------------EIQVLEHL-NT----TDPNST-FRCVQMLEWFEH----------HGHIC--IVFELLGL---STY-DFIK-------ENG--FLP-FRLDHIRKMAYQICKSVNFLHS--N-----KLTHTDLKPENILFV----QSDYTEAYNPKIKR-DERTLINPDIKVVDFGSA----------TYDDEHHST---LVSTRHYRAPEVIL-----ALG--WSQPCDVWSIGCILIEYYL-GFTVFPTH---------DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRY--------------------VSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLR-EALKHPFF-
---YEIVSTLGEGTFGRVVQCVDH---R-R-GG-ARVALKIIKNVE-KYK---EA--AR---L-------------------------EINVLEKI-NEK-DPDNKN----LCVQMFDWFDY----------HGHMC--ISFELLGL---STF-DFLK-------DNN--YLP-YPIHQVRHMAFQLCQAVKFLHD--N-----KLTHTDLKPENILFV----NSDYELTYNLEKKR-DERSVKSTAVRVVDFGSAT----------FDHEHHST---IVSTRHYRAPEVIL-----ELG--WSQPCDVWSIGCIIFEYYV-GFTLFQTH---------DNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY--------------------VRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLG-EALQHPFF-
---YEIVGNLGEGTFGKVVECLDH---A-R-GK-SQVALKIIRNVG-KYR---EA--AR---L-------------------------EINVLKKI-KE---KDKENK--FLCVLMSDWFNF----------HGHMC--IAFELLGK---NTF-EFLK--------EN--NFQPYPLPHVRHMAYQLCHALRFLHE--N-----QLTHTDLKPENILFV----NSE-FETLYNEHKSCEEKSVKNTSIRVADFGSAT----------FDHEHHTT---IVATRHYRPPEVIL-----ELG--WAQPCDVWSIGCILFEYYR-GFTLFQTH---------ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRY--------------------VKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLA-EALLHPFF-
---YEIVDTLGEGAFGKVVECIDH---GMD-GM--HVAVKIVKNVG-RYR---EA--ARS----------------------------EIQVLEHL-NS----TDPNSV-FRCVQMLEWFDH----------HGHVC--IVFELLGL---STY-DFIK-------ENS--FLP-FQIDHIRQMAYQICQSINFLHH--N-----KLTHTDLKPENILFV----KSDYVVKYNSKMKR-DERTLKNTDIKVVDFGSA----------TYDDEHHST---LVSTRHYRAPEVIL-----ALG--WSQPCDVWSIGCILIEYYL-GFTVFQTH---------DSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRY--------------------VRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLD-EALQHPFF-
---YEIDSLIGKGSFGQVVKAYDR---V-E-QE--WVAIKIIKNKK-AFL---NQ--AQI----------------------------EVRLLELMNK------HDTEMKYYIVHLKRHFMF----------RNHLC--LVFEMLSY---NLY-DLLR--------NT--NFRGVSLNLTRKFAQQMCTALLFLATPEL-----SIIHCDLKPENILLCN--PKRSAI--------------------KIVDFGSSCQ----------LGQRIYQ---YIQSRFYRSPEVLL-----GMP--YDLAIDMWSLGCILVEMHT-GEPLFSGA---------NEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPY-YALQHSFF-
---YEIDSLIGKGSFGQVVKAYDH---Q-T-QE--LVAIKIIKNKK-AFL---NQ--AQI----------------------------ELRLLELMNQ------HDTEMKYYIVHLKRHFMF----------RNHLC--LVFELLSY---NLY-DLLR--------NT--HFRGVSLNLTRKLAQQLCTALLFLATPEL-----SIIHCDLKPENILLCN--PKRSAI--------------------KIVDFGSSCQ----------LGQRIYQ---YIQSRFYRSPEVLL-----GTP--YDLAIDMWSLGCILVEMHT-GEPLFSGS---------NEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPL-GALQHGFF-
---YEVLKVIGKGSFGQVVKAYDH---K-V-HQ--HVALKMVRNEK-RFH---RQ--AAE----------------------------EIRILEHL-RKQDKDNTMN-----VIHMLENFTF----------RNHIC--MTFELLSM---NLY-ELIKK-----NKFQ--GF---SLPLVRKFAHSILQCLDALHK--N-----RIIHCDLKPENILLK----QQGRSG------------------IKVIDFGSSC----------YEHQRVYT---YIQSRFYRAPEVIL-----GAR--YGMPIDMWSLGCILAELLT-GYPLLPGE---------DEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNG-----GRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPG-QALRHPWL-
--V-KIEEVIGAGEFGEVCRGRLKQPGR-R-EV--FVAIKTLK-VG-YT----ERQRRDFL-S-------------------------EASIMGQF-D------HPN-----IIRLEGVVTK----------SRPVM--ILTEFMENC--ALD-SFLR--------LNDGQF---TVIQLVGMLRGIAAGMKYLSE--M-----NYVHRDLAARNILVN----SNLVC--------------------KVSDFGLSRFLE-DDP--S--DPTYTSSLGGKIPIRWTAPEAIA-----YRK--FTSASDVWSYGIVMWEVMSYGERPYWDM---------SNQDVINAVEQDYRLPPPMDCP---------------------------------------------------------------TALHQLMLDCWVRDRNLRPKFS-QIVNTL---
---YTDTKVIGNGSFGVVYQAKLC---D-S-GE--LVAIKKVLQDK-RFK---NR---------------------------------ELQIMRKL-D------HCN-----IVRLRYFFYSSG------EKKDEVYLNLVLDYVPETVYRVA----RHY---SRAKQ--TL---PVIYVKLYMYQLFRSLAYIHS--F-----GICHRDIKPQNLLLD---PDTAVL--------------------KLCDFGSAKQ--------LVRGEPNVS---YICSRYYRAPELIF----GATD--YTSSIDVWSAGCVLAELLL-GQPIFPGD---------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPL-EACAHSFF-
---YTTIRQLGDGTYGSVLLGRSI---E-S-GE--LIAIKKMKRKF-YSW---EE--C-MNLR-------------------------EVKSLKKL-N------HAN-----VVKLKEVIRE----------NDHLY--FIFEYMKE---NLY-QLIK------ERNK--LF---PESAIRNIMYQILQGLAFIHK--H-----GFFHRDLKPENLLCM----GPELV--------------------KIADFGLARE--------IRSKPPYTD---YVSTRWYRAPEVLL----RSTN--YSSPIDVWAVGCIMAEVYT-LRPLFPGA---------SEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFRWPQCV----------------------------------PNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTAS-QALRYPYF-
---YTTMRQLGDGTYGSVLMGKSN---E-S-GE--LVAIKRMKRKF-YSW---DE--CM-NLR-------------------------EVKSLKKL-N------HAN-----VIKLKEVIRE----------NDHLY--FIFEYMKE---NLY-QLMK------DRNK--LF---PESVIRNIMYQILQGLAFIHK--H-----GFFHRDMKPENLLCM----GPELV--------------------KIADFGLARE--------LRSQPPYTD---YVSTRWYRAPEVLL----RSSV--YSSPIDVWAVGSIMAELYM-LRPLFPGT---------SEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCV----------------------------------PINLKTLIPNASNEAIQLMTEMLNWDPKKRPTAS-QALKHPYF-
---FEKISELGAGNGGVVFKVSHK---P-S-GL---VMARKLIHLE-IKP---AI--RNQIIR-------------------------ELQVLHEC-N------SPY-----IVGFYGAFYS----------DGEIS--ICMEHMDGG--SLD-QVLK-------KAG--RI---PEQILGKVSIAVIKGLTYLRE-KH-----KIMHRDVKPSNILVN----SRGEI--------------------KLCDFGVSG---------QLIDSMANS---FVGTRSYMSPERLQ-----GTH--YSVQSDIWSMGLSLVEMAV-GRYPIPPP---------DAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFE--------------------LLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLK-QLMVHAFI-
---YEVLYTIGTGSYGRCQKIRRK---S-D-GK--ILVWKELDYGS-MTE---AE--KQMLVS-------------------------EVNLLREL-K------HPN-----IVRYYDRIIDR--------TNTTLY--IVMEYCEGG--DLA-SVITKG---TKERQ--YL---DEEFVLRVMTQLTLALKECHR--RSDGGHTVLHRDLKPANVFLD----GKQNV--------------------KLGDFGLARIL-------NHDTSFAKT---FVGTPYYMSPEQMN-----RMS--YNEKSDIWSLGCLLYELCA-LMPPFTAF------------SQKELAGKIREGKFRRIPYRY---S---------------------------------------------------------DELNEIITRMLNLKDYHRPSVE-EILENPL-I
--Y-IKLDKLGEGTYATVYKGKSK---L-T-DN--LVALKEIRLEH-EEG---AP--C-TAIR-------------------------EVSLLKDL-K------HAN-----IVTLHDIIHT----------EKSLT--LVFEYLDK---DLK-QYLD------DCGN--II---NMHNVKLFLFQLLRGLAYCHR--Q-----KVLHRDLKPQNLLIN----ERGEL--------------------KLADFGLARAK-------SIPTKTYSN---EVVTLWYRPPDILL----GSTD--YSTQIDMWGVGCIFYEMAT-GRPLFPGS---------TVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYR----------------------------------AEALLSHAPRLDSDGADLLTKLLQFEGRNRISAE-DAMKHPFF-
--Y-IKLEKLGEGTYATVYKGRSK---L-T-EN--LVALKEIRLEH-EEG---AP--C-TAIR-------------------------EVSLLKDL-K------HAN-----IVTLHDIVHT----------DKSLT--LVFEYLDK---DLK-QYMD------DCGN--IM---SMHNVKLFLYQILRGLAYCHR--R-----KVLHRDLKPQNLLIN----EKGEL--------------------KLADFGLARAK-------SVPTKTYSN---EVVTLWYRPPDVLL----GSSE--YSTQIDMWGVGCIFFEMAS-GRPLFPGS---------TVEDELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYK----------------------------------PQPLINHAPRLDSEGIELITKFLQYESKKRVSAE-EAMKHVYF-
---YVKLDKLGEGTYATVFKGRSK---L-T-EN--LVALKEIRLEH-EEG---AP--C-TAIR-------------------------EVSLLKNL-K------HAN-----IVTLHDLIHT----------DRSLT--LVFEYLDS---DLK-QYLD-------HCG--NL--MSMHNVKIFMFQLLRGLAYCHH--R-----KILHRDLKPQNLLIN----ERGEL--------------------KLADFGLARAK-------SVPTKTYSN---EVVTLWYRPPDVLL----GSTE--YSTPIDMWGVGCIHYEMAT-GRPLFPGS---------TVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYL----------------------------------PQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAE-AALSHSYF-
---YEKLEKLGEGSYATVYKGKSK---V-N-GK--LVALKVIRLQE-EEG---TP--F-TAIR-------------------------EASLLKGL-K------HAN-----IVLLHDIIHT----------KETLT--LVFEYVHT---DLC-QYMD------KHPG--GL---HPDNVKLFLFQLLRGLSYIHQ--R-----YILHRDLKPQNLLIS----DTGEL--------------------KLADFGLARAK-------SVPSHTYSN---EVVTLWYRPPDVLL----GSTE--YSTCLDMWGVGCIFVEMIQ-GVAAFPGM--------KDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSS--------------------------------KNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQ-AALSHEYF-
-FI--LHKMLGKGSFGKVFLAEFK---K-T-NQ--FFAIKALKKDV-VLM---DD--DVECTM------------------------VEKRVLSLAWE------HPF-----LTHMFCTFQT----------KENLF--FVMEYLNGG--DLM-YHIQ-------SCH--KF---DLSRATFYAAEIILGLQFLHS--K-----GIVYRDLKLDNILLD----KDGHI--------------------KIADFGMCKEN-------MLGDAKTNT---FCGTPDYIAPEILL-----GQK--YNHSVDWWSFGVLLYEMLI-GQSPFHGQ------------DEEELFHSIRMDNPFYPRWLE-------------------------------------------------------------KEAKDLLVKLFVREPEKRLGVRGDIRQHPLF-
---WEIIGELGDGAFGKVYKAQNK---E-T-SV--LAAAKVIDTKS-EEE---LE--DYM--V-------------------------EIDILASC-D------HPN-----IVKLLDAFYY----------ENNLW--ILIEFCAGG--AVD-AVML------ELER--PL---TESQIQVVCKQTLDALNYLHD--N-----KIIHRDLKAGNILFT----LDGDI--------------------KLADFGVSAKN-------TRTIQRRDS---FIGTPYWMAPEVVMCETSKDRP--YDYKADVWSLGITLIEMAE-IEPPHHEL---------NPMRVLLKIAKSEPPTLAQPSRWS-------------------------------------------------------------SNFKDFLKKCLEKNVDARWTTS-QLLQHPFV-
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