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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3A 203
Other AURKA 133
Other AURKB 77
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
CMGC CDK5 4
CAMK CHEK1 9
CAMK CHEK2 220
TK EPHB3 633
CMGC GSK3B 56
TK ITK 363
TK JAK2 849
TK JAK3 822
TK LCK 245
CMGC MAPK1 13
CAMK PIM1 38
CAMK PIM3 40
AGC PRKCA 339
TK SRC 270
--YTDIKVIGNGSFGVVYQARLA----ETRELVAIKKVLQDK-RFK---NR--------------ELQIMRKL-D----HCN--IVRLRYFFY--SSG-EKKDELYLNLVLEYVPETVYRVARHFT---KAKL---TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVL---KLCDFGSAKQ-------LVRGEPNVS---YICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF--------------
--FEIGRPLGKGKFGNVYLAREK----QSKFILALKVLFKAQLEKA---GV--EHQLRR------EVEIQSHL-R----HPN--ILRLYGYFH--D-----ATRVY--LILEYAPLG--TVYRELQ----KLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL---KIADFGWSV--------HAPSSRRTT---LCGTLDYLPPEMIE---GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETYKRISRVEFTFPDFVT----------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--------------
--FEIGRPLGKGKFGNVYLAREK----KSHFIVALKVLFKSQ-IEK---EG--VEHQLR-----REIEIQAHL-H----HPN--ILRLYNYFY--D-----RRRIY--LILEYAPRG--ELYKELQ----KSC---TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGEL---KIADFGWSV--------HAPSLRRKT---MCGTLDYLPPEMIE---GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FESA----SHNETYRRIVKVDLKFPASVP----------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV--------------
--YTKIEKIGEGTYGVVYKGRHK----TTGQVVAMKKIRLES-EEE---GV--PSTAIR------EISLLKEL-R----HPN--IVSLQDVLM--Q-----DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---KLADFGLARAF------GIPIRVYTH---EVVTLWYRSPEVLL--GSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--------------
--FQKVEKIGEGTYGVVYKARNK----LTGEVVALKKIRLDT-ETE---GV--PSTAIR------EISLLKEL-N----HPN--IVKLLDVIH--T-----ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF------GVPVRTYTH---EVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--------------
-Y-EPVAEIGVGAYGTVYKARDP----HSGHFVALKSVRVPN-GGGGGGGL--PISTVR------EVALLRRL-EA-FEHPN--VVRLMDVCA--TSRTDREIKVT--LVFEHVDQ---DLRTYLDK--APPP---GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTV---KLADFGLARI-------YSYQMALTP---VVVTLWYRAPEVLL---QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FCGN-SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR----PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL--------------
--YEKLEKIGEGTYGTVFKAKNR----ETHEIVALKRVRLDD-DDE---GV--PSSALR------EICLLKEL-K----HKN--IVRLHDVLH--S-----DKKLT--LVFEFCDQ---DLKKYFD---SCNG---DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL---KLADFGLARAF------GIPVRCYSA---EVVTLWYRPPDVLF--GAKLYSTSIDMWSAGCIFAELANAGRPL---------------FPGN-DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT--TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF--------------
-W-DLVQTLGEGAYGEVQLAVNR----VTEEAVAVKIVDMKR-AVD---CP--ENI-KK------EICINKML-N----HEN--VVKFYGHRR--E-----GNIQY--LFLEYCSGG--ELFDRIE----PDI---GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---KISDFGLATVFR----YNNRERLLNK---MCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLA-GELP---------------WDQP---SDSCQEYSDWKEKKTYLNPWKKI--D------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y-------------
YI--MSKTLGSGACGEVKLAFER----KTCKKVAIKIISKRK-FAI---GS--AREADPALNVETEIEILKKL-N----HPC--IIKIKNFF---D-----AEDYY--IVLELMEGG--ELFDKVV----GNK---RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDCLIKITDFGHSKI-------LGETSLMRT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPP---------------FSEH---RTQVSLKDQITSGKYNFIPEVWAEVS------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL--------------
-V-KIEEVIGAGEFGEVCRGRLK-QPGRREVFVAIKTLK-VG-YT----ERQRRDFL-S------EASIMGQF-D----HPN--IIRLEGVVT--K-----SRPVM--ILTEFMENC--ALDSFLR-----LN-DGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVN-SNLVC---KVSDFGLSRFLEDDP--S--DPTYTSSLGGKIPIRWTAPEAIA---YRKFTSASDVWSYGIVMWEVMSYGERP---------------YWDM-SNQDVINAVEQDYRLPPPMDCP------------------------------TALHQLMLDCWVRDRNLRPKFSQIVNTL----------------
--YTDTKVIGNGSFGVVYQAKLC----DSGELVAIKKVLQDK-RFK---NR--------------ELQIMRKL-D----HCN--IVRLRYFFY--SSG-EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ-------LVRGEPNVS---YICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF--------------
--LTFVQEIGSGQFGLVHLGYWL-----NKDKVAIKTIR-EG-AM----SE--EDFI-E------EAEVMMKL-S----HPK--LVQLYGVCL--E-----QAPIC--LVFEFMEHG--CLSDYLR-----TQ-RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVG-ENQVI---KVSDFGMTRFV------L--DDQYTSSTGTKFPVKWASPEVFS---FSRYSSKSDVWSFGVLMWEVFSEGKIP---------------YENR-SNSEVVEDISTGFRLYKPRLAS------------------------------THVYQIMNHCWKERPEDRPAFSRLLRQL----------------
--LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ-HS-TE-----EHLRDFE-R------EIEILKSL-Q----HDN--IVKYKGVCYSAG-----RRNLK--LIMEYLPYG--SLRDYLQ-----KH-KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-NENRV---KIGDFGLTKVL--PQ--D--KEYYKVKEPGESPIFWYAPESLT---ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV------------
-L-KYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQ-HS-GP----DQ-QRDFQ-R------EIQILKAL-H----SDF--IVKYRGVSYGPG-----RQSLR--LVMEYLPSG--CLRDFLQ-----RH-RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVE-SEAHV---KIADFGLAKLL--PL--D--KDYYVVREPGQSPIFWYAPESLS---DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACP------------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL-------------
--LKLVERLGAGQFGEVWMGYYN-----GHTKVAVKSLK-QG-SM----SP--DAFL-A------EANLMKQL-Q----HQR--LVRLYAVVT--------QEPIY--IITEYMENG--SLVDFLK-----TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSC---KIADFGLARLI------E--DNEYTAREGAKFPIKWTAPEAIN---YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNLERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--------------
--YTNLSYIGEGAYGMVCSAYDN----VNKVRVAIKKISPFE-HQT---YC--QRT-LR------EIKILLRF-R----HEN--IIGINDIIR--APTIEQMKDVY--IVQDLMET---DLYKLLK-----TQ---HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDL---KICDFGLARVAD---PDHDHTGFLTE---YVATRWYRAPEIML--NSKGYTKSIDIWSVGCILAEMLS-NRPI---------------FPGK-HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL--------------
--YQVGPLLGSGGFGSVYSGIRV----SDNLPVAIKHVEKDR-ISD---WG--ELPNGTRV--PMEVVLLKKV-S----SGFSGVIRLLDWFE--R-----PDSFV--LILERPEPV-QDLFDFIT----ERG---ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL---KLIDFGSGA--------LLKDTVYTD---FDGTRVYSPPEWIR--YHRYHGRSAAVWSLGILLYDMVC-GDIP---------------FEHD----------EEIIRGQVFFRQRVS----------------------------SECQHLIRWCLALRPSDRPTFEEIQNHPWM--------------
--YQVGAVLGSGGFGTVYAGSRI----ADGLPVAVKHVVKER-VTE---WG--SLGGATV---PLEVVLLRKV-GAAGGARG--VIRLLDWFE--R-----PDGFL--LVLERPEPA-QDLFDFIT----ERG---ALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGEL---KLIDFGSGA--------LLKDTVYTD---FDGTRVYSPPEWIR--YHRYHGRSATVWSLGVLLYDMVC-GDIP---------------FEQD----------EEILRGRLLFRRRVS----------------------------PECQQLIRWCLSLRPSERPSLDQIAAHPWM--------------
-F-NFLMVLGKGSFGKVMLADRK----GTEELYAIKILKKDV-VIQ---DD--DVECTM-----VEKRVLALLDK----PPF--LTQLHSCFQ--T-----VDRLY--FVMEYVNGG--DLMYHIQ----QVG---KFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLD-SEGHI---KIADFGMCKEH------MMDGVTTRT---FCGTPDYIAPEIIA---YQPYGKSVDWWAYGVLLYEMLA-GQPP---------------FDGE----DEDELFQSIMEHNVSYPKSLS----------------------------KEAVSVCKGLMTKHPAKRLGC---------GPEGERDVREHAFF
-L-RLEVKLGQGCFGEVWMGTWN-----GTTRVAIKTLK-PG-TM----SP--EAFL-Q------EAQVMKKL-R----HEK--LVQLYAVVS--------EEPIY--IVTEYMSKG--SLLDFLK-----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVC---KVADFGLARLI------E--DNEYTARQGAKFPIKWTAPEAAL---YGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQVERGYRMPCPPECP------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L--------------
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