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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3A 203
TK ABL1 261
TK ABL2 288
TK ALK 1116
Other AURKA 133
Other AURKB 77
TK BMX 422
CAMK BRSK1 50
CAMK BRSK2 19
TK BTK 402
CAMK CAMK2A 13
CAMK CAMK2G 14
Other CAMKK1 128
Other CAMKK2 165
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CMGC CDK4 6
CMGC CDK5 4
CMGC CDK6 13
CMGC CDK9 2.7.11.23
CAMK CHEK1 9
CAMK CHEK2 220
CMGC DYRK2 222
TK FER 563
TK FES 561
AGC GRK6 186
AGC GRK7 191
CMGC GSK3B 56
TK ITK 363
TK JAK1 875
TK JAK2 849
TK JAK3 822
TKL LIMK1 339
STE MAP4K2 16
CMGC MAPK10 64
CMGC MAPK8 26
CMGC MAPK9 26
CAMK MAPKAPK2 64
CAMK MARK2 53
CAMK MARK4 59
CAMK MELK 11
CAMK MYLK 1464
Other NEK4 6
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
CAMK NUAK2 97
STE PAK4 321
AGC PDPK1 82
CAMK PHKG1 20
CAMK PHKG2 24
CAMK PIM1 38
CAMK PIM3 40
Other PLK4 12
AGC PRKCD 349
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
AGC PRKG2 453
TK PTK2B 425
TKL RAF1 349
TK RET 724
AGC RPS6KB1 91
AGC RPS6KB2 67
CAMK SIK2 20
STE SLK 34
STE STK10 36
CAMK STK17A 61
STE STK3 27
STE STK4 30
TK SYK 371
STE TAOK1 28
STE TAOK2 28
TK TEK 824
TK TNK2 150
CAMK TSSK1B 12
TK TXK 271
-----YTDIKVIGNGSFGVVYQARL---A-----ETRE---LVAIKKVLQD--K-RFK---NR-----------------------------------ELQIMRKL--D------HCN--IVRLRYFFY--SSG----EKKDE--LYLNLVLEYVPETVYRVARHFT---KAKL-------------------------TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPD---TAVL---KLCDFGSAKQ-------LVRGEPN--------------VS---YICSRYYRAPEL--IF-----GATD----YTSSIDVWSAGCVLAELLL-GQPI---------------FPGD--SGVDQLVEI-IKVLG----TPTREQIREMNPNYTEFKFPQIKAH------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS-----PLEACAHSFF-----------
-----ITMKHKLGGGQYGEVYEGVW---K-----KYSL---TVAVKTLK-E--D-TM----EV---EE-FL-K-------------------------EAAVMKEI--K------HPN--LVQLLGVCT--R--------EPP--FY--IITEFMTYG--NLLDYLR-----EC----------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-E---NHLV---KVADFGLSRLM------T--GDTY--------------TAHAGAKFPIKWTAPES--LA------YNK----FSIKSDVWAFGVLLWEIATYGMSP---------------YPGI--DLSQVYELL-EKDYR----MERPEGCP----------------------------------------------------------EKVYELMRACWQWNPSDRPS-----FAEIHQA--F-----------
-----ITMKHKLGGGQYGEVYVGVW---K-----KYSL---TVAVKTLK-E--D-TM----EV---EE-FL-K-------------------------EAAVMKEI--K------HPN--LVQLLGVCT--L--------EPP--FY--IVTEYMPYG--NLLDYLR-----EC----------------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-E---NHVV---KVADFGLSRLM------T--GDTY--------------TAHAGAKFPIKWTAPES--LA------YNT----FSIKSDVWAFGVLLWEIATYGMSP---------------YPGI--DLSQVYDLL-EKGYR----MEQPEGCP----------------------------------------------------------PKVYELMRACWKWSPADRPS-----FAETHQA--F-----------
----I-TLIRGLGHGAFGEVYEGQV---SGMPNDPSPL---QVAVKTLP-E--V-CS----EQD-ELD-FL-M-------------------------EALIISKF--N------HQN--IVRCIGVSL--Q--------SLP--RF--ILLELMAGG--DLKSFLR-----ETRP-----------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLT-CPGPGRVA---KIGDFGMARDI---Y--R--ASYY--------------RKGGCAMLPVKWMPPEA--FM------EGI----FTSKTDTWSFGVLLWEIFSLGYMP---------------YPSK--SNQEVLEFV-TSGGR----MDPPKNCP----------------------------------------------------------GPVYRIMTQCWQHQPEDRPN-----FAIILER--I-----------
-----FEIGRPLGKGKFGNVYLARE---K-----QSKF---ILALKVLFKA--QLEKA---GV---EH-QLRR-------------------------EVEIQSHL--R------HPN--ILRLYGYFH--D--------ATR--VY--LILEYAPLG--TVYRELQ----KLS-------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-S---AGEL---KIADFGWSV--------HAPSSRR--------------TT---LCGTLDYLPPEM--IE------GRM----HDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN-----TYQETY-KRISR----VEFTFPDFVT--------------------------------------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI-----------
-----FEIGRPLGKGKFGNVYLARE---K-----KSHF---IVALKVLFKS--Q-IEK---EG---VE-HQLR------------------------REIEIQAHL--H------HPN--ILRLYNYFY--D--------RRR--IY--LILEYAPRG--ELYKELQ----KSC-------------------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-L---KGEL---KIADFGWSV--------HAPSLRR--------------KT---MCGTLDYLPPEM--IE------GRM----HNEKVDLWCIGVLCYELLV-GNPP---------------FESA-----SHNETY-RRIVK----VDLKFPASVP--------------------------------------------------------MGAQDLISKLLRHNPSERLP-----LAQVSAHPWV-----------
-----ITLLKELGSGQFGVVQLGKW---K------GQY---DVAVKMIK-E--G-SM----SE---DE-FF-Q-------------------------EAQTMMKL--S------HPK--LVKFYGVCS--K--------EYP--IY--IVTEYISNG--CLLNYLR-----SH-----------------------GKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVD-R---DLCV---KVSDFGMTRYV------L--DDQY--------------VSSVGTKFPVKWSAPEV--FH------YFK----YSSKSDVWAFGILMWEVFSLGKQP---------------YDLY--DNSQVVLKV-SQGHR----LYRPHLAS----------------------------------------------------------DTIYQIMYSCWHELPEKRPT-----FQQLLSS--I-----------
-----YRLEKTLGKGQTGLVKLGVH---C-----ITGQ---KVAIKIVNRE--K-LSE---SV---LM-KVER-------------------------EIAILKLI--E------HPH--VLKLHDVYE--N--------KKY--LY--LVLEHVSGG--ELFDYLV----KKG-------------------------RLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLD-E---KNNI---RIADFGMASL-------QVGDSLL--------------ET---SCGSPHYACPEV--IK-----GEKY----DGRRADMWSCGVILFALLV-GALP---------------FDDD-----NLRQLL-EKVKR----GVFHMPHFIP--------------------------------------------------------PDCQSLLRGMIEVEPEKRLS-----LEQIQKHPW-Y----------
-----YRLEKTLGKGQTGLVKLGVH---C-----VTCQ---KVAIKIVNRE--K-LSE---SV---LM-KVER-------------------------EIAILKLI--E------HPH--VLKLHDVYE--N--------KKY--LY--LVLEHVSGG--ELFDYLV----KKG-------------------------RLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLD-E---KNNI---RIADFGMASL-------QVGDSLL--------------ET---SCGSPHYACPEV--IR-----GEKY----DGRKADVWSCGVILFALLV-GALP---------------FDDD-----NLRQLL-EKVKR----GVFHMPHFIP--------------------------------------------------------PDCQSLLRGMIEVDAARRLT-----LEHIQKHIW-Y----------
-----LTFLKELGTGQFGVVKYGKW---R------GQY---DVAIKMIK-E--G-SM----SE---DE-FI-E-------------------------EAKVMMNL--S------HEK--LVQLYGVCT--K--------QRP--IF--IITEYMANG--CLLNYLR-----EM-----------------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVN-D---QGVV---KVSDFGLSRYV------L--DDEY--------------TSSVGSKFPVRWSPPEV--LM------YSK----FSSKSDIWAFGVLMWEIYSLGKMP---------------YERF--TNSETAEHI-AQGLR----LYRPHLAS----------------------------------------------------------EKVYTIMYSCWHEKADERPT-----FKILLSN--I-----------
-----YQLFEELGKGAFSVVRRCVK---V-----LAGQ---EYAAKIINTK--K-LSA---RD---HQ-KLER-------------------------EARICRLL--K------HPN--IVRLHDSIS--E--------EGH--HY--LIFDLVTGG--ELFEDIV----ARE-------------------------YYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLA-S---KLKGAAVKLADFGLAIEV------EGEQQAW--------------FG---FAGTPGYLSPEV--LR------KDP----YGKPVDLWACGVILYILLV-GYPP---------------FWDE-----DQHRLY-QQIKA----GAYDFPSPEWDTVT----------------------------------------------------PEAKDLINKMLTINPSKRIT-----AAEALKHPWI-----------
-----YQLFEELGKGAFSVVRRCVK---K-----TSTQ---EYAAKIINTK--K-LSA---RD---HQ-KLER-------------------------EARICRLL--K------HPN--IVRLHDSIS--E--------EGF--HY--LVFDLVTGG--ELFEDIV----ARE-------------------------YYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLA-S---KCKGAAVKLADFGLAIEV------QGEQQAW--------------FG---FAGTPGYLSPEV--LR------KDP----YGKPVDIWACGVILYILLV-GYPP---------------FWDE-----DQHKLY-QQIKA----GAYDFPSPEWDTVT----------------------------------------------------PEAKNLINQMLTINPAKRIT-----ADQALKHPWV-----------
-----YKLQSEIGKGAYGVVRLAYN---E-----SEDR---HYAMKVLSKK--K-LLK---QY---GF-PR-RPPPRGSQAAQGGPAKQLLPLERVYQEIAILKKL--D------HVN--VVKLIEVLD--DP------AEDN--LY--LVFDLLRKG--PVMEVPC-----DK-------------------------PFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLG-D---DGHV---KIADFGVSNQF------EGNDAQL--------------SS---TAGTPAFMAPEA--ISD---SGQSF----SGKALDVWATGVTLYCFVY-GKCP---------------FIDD-----FILALH-RKIKN----EPVVFPEEPEIS------------------------------------------------------EELKDLILKMLDKNPETRIG-----VPDIKLHPWV-----------
-----YTLKDEIGKGSYGVVKLAYN---E-----NDNT---YYAMKVLSKK--K-LIR---QA---GF-PR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL--D------HPN--VVKLVEVLD--DP------NEDH--LY--MVFELVNQG--PVMEVPT-----LK-------------------------PLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG-E---DGHI---KIADFGVSNEF------KGSDALL--------------SN---TVGTPAFMAPES--LS-----ETRKIF--SGKALDVWAMGVTLYCFVF-GQCP---------------FMDE-----RIMCLH-SKIKS----QALEFPDQPDIA------------------------------------------------------EDLKDLITRMLDKNPESRIV-----VPEIKLHPWV-----------
-----YTKIEKIGEGTYGVVYKGRH---K-----TTGQ---VVAMKKIRLE--S-EEE---GV---PS-TAIR-------------------------EISLLKEL--R------HPN--IVSLQDVLM--Q--------DSR--LY--LIFEFLSM---DLKKYLDS-IPPGQ-------------------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-D---KGTI---KLADFGLARAF------GIPIRVY--------------TH---EVVTLWYRSPEV--LL-----GSAR----YSTPVDIWSIGTIFAELAT-KKPL---------------FHGD--SEIDQLFRI-FRALG----TPNNEVWPEVESLQDYKNTFPKWKP------------------------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-----GKMALNHPYF-----------
-----FQKVEKIGEGTYGVVYKARN---K-----LTGE---VVALKKIRLD--T-ETE---GV---PS-TAIR-------------------------EISLLKEL--N------HPN--IVKLLDVIH--T--------ENK--LY--LVFEFLHQ---DLKKFMDA--SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-T---EGAI---KLADFGLARAF------GVPVRTY--------------TH---EVVTLWYRAPEI--LL-----GCKY----YSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD--SEIDQLFRI-FRTLG----TPDEVVWPGVTSMPDYKPSFPKWAR------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF-----------
-----FQKVEKIGEGTYGVVYKAKN---R-----ETGQ---LVALKKIRLD--L-EME---GV---PS-TAIR-------------------------EISLLKEL--K------HPN--IVRLLDVVH--N--------ERK--LY--LVFEFLSQ---DLKKYMDS--TPGS-------------------------ELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLIN-E---LGAI---KLADFGLARAF------GVPLRTY--------------TH---EVVTLWYRAPEI--LL-----GSKF----YTTAVDIWSIGCIFAEMVT-RKAL---------------FPGD--SEIDQLFRI-FRMLG----TPSEDTWPGVTQLPDYKGSFPKWTR------------------------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQRIT-----AKTALAHPYF-----------
----Y-EPVAEIGVGAYGTVYKARD---P-----HSGH---FVALKSVRVP--N-GGGGGGGL---PI-STVR-------------------------EVALLRRL--EA---FEHPN--VVRLMDVCA--TSR---TDREIK--VT--LVFEHVDQ---DLRTYLDK--APPP-------------------------GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-S---GGTV---KLADFGLARI-------YSYQMAL--------------TP---VVVTLWYRAPEV--LL------QST----YATPVDMWSVGCIFAEMFR-RKPL---------------FCGN--SEADQLGKI-FDLIG----LPPEDDWPRDVSLPRGAFPPRGPR--------------------------------PVQSVVPEMEESGAQLLLEMLTFNPHKRIS-----AFRALQHSYL-----------
-----YEKLEKIGEGTYGTVFKAKN---R-----ETHE---IVALKRVRLD--D-DDE---GV---PS-SALR-------------------------EICLLKEL--K------HKN--IVRLHDVLH--S--------DKK--LT--LVFEFCDQ---DLKKYFD---SCNG-------------------------DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-R---NGEL---KLADFGLARAF------GIPVRCY--------------SA---EVVTLWYRPPDV--LF-----GAKL----YSTSIDMWSAGCIFAELANAGRPL---------------FPGN--DVDDQLKRI-FRLLG----TPTEEQWPSMTKLPDYKPYPMYPAT------------------------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRIS-----AEEALQHPYF-----------
-----YECVAEIGEGAYGKVFKARD---L-----KNGG--RFVALKRVRVQ--T-GEE---GM---PL-STIR-------------------------EVAVLRHL--ET---FEHPN--VVRLFDVCT--VSR---TDRETK--LT--LVFEHVDQ---DLTTYLDK--VPEP-------------------------GVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-S---SGQI---KLADFGLARI-------YSFQMAL--------------TS---VVVTLWYRAPEV--LL------QSS----YATPVDLWSVGCIFAEMFR-RKPL---------------FRGS--SDVDQLGKI-LDVIG----LPGEEDWPRDVALPRQAFHSKSAQ--------------------------------PIEKFVTDIDELGKDLLLKCLTFNPAKRIS-----AYSALSHPYF-----------
-----YEKLAKIGQGTFGEVFKARH---R-----KTGQ---KVALKKVLME--N-EKE---GF---PI-TALR-------------------------EIKILQLL--K------HEN--VVNLIEICR--TKASPYNRCKGS--IY--LVFDFCEH---DLAGLLS---NVLV-------------------------KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-R---DGVL---KLADFGLARAFSL--AKNSQPNRY--------------TN---RVVTLWYRPPEL--LL-----GERD----YGPPIDLWGAGCIMAEMWT-RSPI---------------MQGN--TEQHQLALI-SQLCG----SITPEVWPNVDNYELYEKLELVKGQK---------------------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SDDALNHDFF-----------
----W-DLVQTLGEGAYGEVQLAVN---R-----VTEE---AVAVKIVDMK--R-AVD---CP---EN-I-KK-------------------------EICINKML--N------HEN--VVKFYGHRR--E--------GNI--QY--LFLEYCSGG--ELFDRIE----PDI-------------------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-E---RDNL---KISDFGLATVFR----YNNRERLL--------------NK---MCGTLPYVAPEL--LK-----RREF----HAEPVDVWSCGIVLTAMLA-GELP---------------WDQP----SDSCQEY-SDWKE----KKTYLNPWKKI--D----------------------------------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y----------
---YI--MSKTLGSGACGEVKLAFE---R-----KTCK---KVAIKIISKR--K-FAI---GS---AR-EADPALN-------------------VETEIEILKKL--N------HPC--IIKIKNFF---D--------AED--YY--IVLELMEGG--ELFDKVV----GNK-------------------------RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-S---QEEDCLIKITDFGHSKI-------LGETSLM--------------RT---LCGTPTYLAPEV--LVS---VGTAG----YNRAVDCWSLGVILFICLS-GYPP---------------FSEH----RTQVSLK-DQITS----GKYNFIPEVWAEVS----------------------------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL-----------
-----YEVLKVIGKGSFGQVVKAYD---H-----KVHQ---HVALKMVRNE--K-RFH---RQ---AA-E----------------------------EIRILEHL--RKQDKDNTMN--VIHMLENFT--F--------RNH--IC--MTFELLSM---NLYELIKK--NKFQ-------------------------GFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLK-Q---QGRSG-IKVIDFGSSC---------YEHQRV--------------YT---YIQSRFYRAPEV--IL------GAR----YGMPIDMWSLGCILAELLT-GYPL---------------LPGE--DEGDQLACM-IELLG----MPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMT-----PGQALRHPWL-----------
---VI--LGELLGKGNFGEVYKGTL---K------DKT---SVAVKTCK-E--D-LP----QEL-KIK-FL-Q-------------------------EAKILKQY--D------HPN--IVKLIGVCT--Q--------RQP--VY--IIMELVSGG--DFLTFLR-----RK-----------------------KDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVG-E---NNVL---KISDFGMSRQE------D--GGVY--------------SSSGLKQIPIKWTAPEA--LN------YGR----YSSESDVWSFGILLWETFSLGVCP---------------YPGM--TNQQAREQV-ERGYR----MSAPQHCP----------------------------------------------------------EDISKIMMKCWDYKPENRPK-----FSELQKEL-------------
----L-VLGEQIGRGNFGEVFSGRL---R-----ADNT---LVAVKSCR-E--T-LP----PDL-KAK-FL-Q-------------------------EARILKQY--S------HPN--IVRLIGVCT--Q--------KQP--IY--IVMELVQGG--DFLTFLR-----TE-----------------------GARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVT-E---KNVL---KISDFGMSREE---A--D--GVYA--------------ASGGLRQVPVKWTAPEA--LN------YGR----YSSESDVWSFGILLWETFSLGASP---------------YPNL--SNQQTREFV-EKGGR----LPCPELCP----------------------------------------------------------DAVFRLMEQCWAYEPGQRPS-----FSTIYQEL-------------
----F-RQYRVLGKGGFGEVCACQV---R-----ATGK---MYACKKLEKK--R-IKK---RK---GE-AMAL------------------------NEKQILEKV--N------SRF--VVSLAYAYE--T--------KDA--LC--LVLTLMNGG--DLKFHIYH--MGQA-------------------------GFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD-D---HGHI---RISDLGLAVH-------VPEGQTI--------------KG---RVGTVGYMAPEV--VK------NER----YTFSPDWWALGCLLYEMIA-GQSP---------------FQQR--KKKIKREEV-ERLVK-----EVPEEYSER--FS----------------------------------------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF-----------
----F-TEFRVLGKGGFGEVCAVQV---K-----NTGK---MYACKKLDKK--R-LKK---KG---GE-KMAL------------------------LEKEILEKV--S------SPF--IVSLAYAFE--S--------KTH--LC--LVMSLMNGG--DLKFHIYN--VGTR-------------------------GLDMSRVIFYSAQIACGMLHLHELGIVYRDMKPENVLLD-D---LGNC---RLSDLGLAVE-------MKGGKPI--------------TQ---RAGTNGYMAPEI--LM-----EKVS----YSYPVDWFAMGCSIYEMVA-GRTP---------------FKDY-KEKVSKEDLK-QRTLQ----DEVKFQHDNF---T----------------------------------------------------EEAKDICRLFLAKKPEQRLG-----SRE-------KSDDPR-----
-----YTDTKVIGNGSFGVVYQAKL---C-----DSGE---LVAIKKVLQD--K-RFK---NR-----------------------------------ELQIMRKL--D------HCN--IVRLRYFFY--SSG----EKKDE--VYLNLVLDYVPETVYRVA---RHYSRAKQ-------------------------TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPD---TAVL---KLCDFGSAKQ-------LVRGEPN--------------VS---YICSRYYRAPEL--IF-----GATD----YTSSIDVWSAGCVLAELLL-GQPI---------------FPGD--SGVDQLVEI-IKVLG----TPTREQIREMNPNYTEFKFPQIKAH------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF-----------
-----LTFVQEIGSGQFGLVHLGYW---L------NKD---KVAIKTIR-E--G-AM----SE---ED-FI-E-------------------------EAEVMMKL--S------HPK--LVQLYGVCL--E--------QAP--IC--LVFEFMEHG--CLSDYLR-----TQ-----------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVG-E---NQVI---KVSDFGMTRFV------L--DDQY--------------TSSTGTKFPVKWASPEV--FS------FSR----YSSKSDVWSFGVLMWEVFSEGKIP---------------YENR--SNSEVVEDI-STGFR----LYKPRLAS----------------------------------------------------------THVYQIMNHCWKERPEDRPA-----FSRLLRQL-------------
----L-KRIRDLGEGHFGKVELCRY---DP-EGDNTGE---QVAVKSLK-P--E-SG----GNH-IAD-LK-K-------------------------EIEILRNL--Y------HEN--IVKYKGICT-ED---------GGNGIK--LIMEFLPSG--SLKEYLP-----KN-----------------------KNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVE-S---EHQV---KIGDFGLTKAI--ET--D--KEYY--------------TVKDDRDSPVFWYAPEC--LM------QSK----FYIASDVWSFGVTLHELLTYCDSDSSPMALF-LKMIGPTHGQM--TVTRLVNTL-KEGKR----LPCPPNCP----------------------------------------------------------DEVYQLMRKCWEFQPSNRTS-----FQNLIE---GF----------
-----LKFLQQLGKGNFGSVEMCRY---DP-LQDNTGE---VVAVKKLQ-H--S-TE-----EH-LRD-FE-R-------------------------EIEILKSL--Q------HDN--IVKYKGVCYSAG--------RRN--LK--LIMEYLPYG--SLRDYLQ-----KH-----------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-N---ENRV---KIGDFGLTKVL--PQ--D--KEYY--------------KVKEPGESPIFWYAPES--LT------ESK----FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM--IVFHLIELL-KNNGR----LPRPDGCP----------------------------------------------------------DEIYMIMTECWNNNVNQRPS-----FRDLA----LRV---------
----L-KYISQLGKGNFGSVELCRY---DP-LGDNTGA---LVAVKQLQ-H--S-GP----DQ--QRD-FQ-R-------------------------EIQILKAL--H------SDF--IVKYRGVSYGPG--------RQS--LR--LVMEYLPSG--CLRDFLQ-----RH-----------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVE-S---EAHV---KIADFGLAKLL--PL--D--KDYY--------------VVREPGQSPIFWYAPES--LS------DNI----FSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVP-ALCRLLELL-EEGQR----LPAPPACP----------------------------------------------------------AEVHELMKLCWAPSPQDRPS-----FSALGP---QL----------
---LI--HGEVLGKGCFGQAIKVTH---R-----ETGE---VMVMKELI----R-FD----EET-QRT-FL-K-------------------------EVKVMRCL--E------HPN--VLKFIGVLY--K--------DKR--LN--FITEYIKGG--TLRGIIK-----SM-----------------------DSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVR-E---NKNV---VVADFGLARLM---V--D--EKTQPEGLRS--LKKPDRKKRYTVVGNPYWMAPEM--IN------GRS----YDEKVDVFSFGIVLCEIIGRVNAD---------------PDYLP-RTMDFGLNV-RGFLD----RYCPPNCP----------------------------------------------------------PSFFPITVRCCDLDPEKRPS-----FVKLEH---WL----------
-----FELLQRVGAGTYGDVYKARD---T-----VTSE---LAAVKIVKLD--P-GDD---IS---SL---QQ-------------------------EITILREC--R------HPN--VVAYIGSYL--R--------NDR--LW--ICMEFCGGG--SLQEIYH----ATG-------------------------PLEERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLT-L---QGDV---KLADFGVSGEL------TASVAKR--------------RS---FIGTPYWMAPEVAAVE-----RKGG----YNELCDVWALGITAIELGE-LQPP---------------LFHL--HPMRALMLM-SKSSF----QPPKLRDKTR--WT----------------------------------------------------QNFHHFLKLALTKNPKKRPT-----AEKLLQHPF-T----------
-----YQNLKPIGSGAQGIVCAAYD---A-----VLDR---NVAIKKLSRP--F-QNQ---TH---AK-RAYR-------------------------ELVLMKCV--N------HKN--IISLLNVFT--PQKT--LEEFQD--VY--LVMELMDA---NLCQVIQ------M-------------------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-S---DCTL---KILDFGLART-------AGTSFMM--------------TP---YVVTRYYRAPEV--IL------GMG----YKENVDIWSVGCIMGEMVR-HKIL---------------FPGR--DYIDQWNKV-IEQLG----TPCPEFMKKLQPTVRNYVENRPKYAGLTFPK-----------------LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI-----------
-----YQNLKPIGSGAQGIVCAAYD---A-----ILER---NVAIKKLSRP--F-QNQ---TH---AK-RAYR-------------------------ELVLMKCV--N------HKN--IIGLLNVFT--PQKS--LEEFQD--VY--IVMELMDA---NLCQVIQ------M-------------------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-S---DCTL---KILDFGLART-------AGTSFMM--------------TP---YVVTRYYRAPEV--IL------GMG----YKENVDLWSVGCIMGEMVC-HKIL---------------FPGR--DYIDQWNKV-IEQLG----TPCPEFMKKLQPTVRTYVENRPKYAGYSFEK-----------------LFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-----VDEALQHPYI-----------
-----YQQLKPIGSGAQGIVCAAFD---T-----VLGI---NVAVKKLSRP--F-QNQ---TH---AK-RAYR-------------------------ELVLLKCV--N------HKN--IISLLNVFT--PQKT--LEEFQD--VY--LVMELMDA---NLCQVIH------M-------------------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-S---DCTL---KILDFGLART-------ACTNFMM--------------TP---YVVTRYYRAPEV--IL------GMG----YKENVDIWSVGCIMGELVK-GCVI---------------FQGT--DHIDQWNKV-IEQLG----TPSAEFMKKLQPTVRNYVENRPKYPGIKFEE-----------------LFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS-----VDEALRHPYI-----------
--KVT---SQVLGLGINGKVLQIFN---K-----RTQE---KFALKMLQDC--P-KAR--------------R-------------------------EVELHWRA-SQ------CPH--IVRIVDVYE--NLY----AGRKC--LL--IVMECLDGG--ELFSRIQD--RGDQ-------------------------AFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYT-S---KRPNAILKLTDFGFAKE-------TTSHNSL--------------TT---PCYTPYYVAPEV--LG------PEK----YDKSCDMWSLGVIMYILLC-GYPP---------------FYSN-HGLAISPGMK-TRIRM----GQYEFPNPEWSEVS----------------------------------------------------EEVKMLIRNLLKTEPTQRMT-----ITEFMNHPWI-----------
-----YRLLKTIGKGNFAKVKLARH---I-----LTGK---EVAVKIIDKT--Q-LNS---SS---LQ-KLFR-------------------------EVRIMKVL--N------HPN--IVKLFEVIE--T--------EKT--LY--LVMEYASGG--EVFDYLV----AHG-------------------------RMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLD-A---DMNI---KIADFGFSNE-------FTFGNKL--------------DT---FCGSPPYAAPEL--FQ-----GKKY----DGPEVDVWSLGVILYTLVS-GSLP---------------FDGQ-----NLKELR-ERVLR----GKYRIPFYMS--------------------------------------------------------TDCENLLKKFLILNPSKRGT-----LEQIMKDRWM-----------
-----YRLLRTIGKGNFAKVKLARH---I-----LTGR---EVAIKIIDKT--Q-LNP---SS---LQ-KLFR-------------------------EVRIMKGL--N------HPN--IVKLFEVIE--T--------EKT--LY--LVMEYASAG--EVFDYLV----SHG-------------------------RMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLD-A---EANI---KIADFGFSNE-------FTLGSKL--------------DT---FCGSPPYAAPEL--FQ-----GKKY----DGPEVDIWSLGVILYTLVS-GSLP---------------FDGH-----NLKELR-ERVLR----GKYRVPFYMS--------------------------------------------------------TDCESILRRFLVLNPAKRCT-----LEQIMKDKWI-----------
-----YELHETIGTGGFAKVKLACH---I-----LTGE---MVAIKIMDKN--T-LGS---DL---PR-IKT--------------------------EIEALKNL--R------HQH--ICQLYHVLE--T--------ANK--IF--MVLEYCPGG--ELFDYII----SQD-------------------------RLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFD-E---YHKL---KLIDFGLCAKP-----KGNKDYHL--------------QT---CCGSLAYAAPEL--IQ-----GKSY----LGSEADVWSMGILLYVLMC-GFLP---------------FDDD-----NVMALY-KKIMR----GKYDVPKWLS--------------------------------------------------------PSSILLLQQMLQVDPKKRIS-----MKNLLNHPWI-----------
-----YDIEERLGSGKFGQVFRLVE---K-----KTRK---VWAGKFFKAY--S-AKE---KE---NI-R--Q-------------------------EISIMNCL--H------HPK--LVQCVDAFE--E--------KAN--IV--MVLEIVSGG--ELFERII---DEDF-------------------------ELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCV-N---KTGTR-IKLIDFGLARR-------LENAGSL--------------KV---LFGTPEFVAPEV--IN------YEP----IGYATDMWSIGVICYILVS-GLSP---------------FMGD-----NDNETL-ANVTS----ATWDFDDEAFDEIS----------------------------------------------------DDAKDFISNLLKKDMKNRLD-----CTQCLQHPWL-----------
----Y-CYLRVVGKGSYGEVTLVKH---R-----RDGK---QYVIKKLNLR--N-ASS---RE---RR-AAEQ-------------------------EAQLLSQL--K------HPN--IVTYKESWE--G-------GDGL--LY--IVMGFCEGG--DLYRKLKE--QKGQ-------------------------LLPENQVVEWFVQIAMALQYLHEKHILHRDLKTQNVFLT-R---TNII---KVGDLGIARVL------ENHCDMA--------------ST---LIGTPYYMSPEL--FS------NKP----YNYKSDVWALGCCVYEMAT-LKHA---------------FNAK-----DMNSLV-YRIIE----GKLPPMPRDY---S----------------------------------------------------PELAELIRTMLSKRPEERPS-----VRSILRQPYI-----------
---IV--LKWELGEGAFGKVFLAEC---HNLLPEQDKM---LVAVKALK-E--A-SE----SA--RQD-FQ-R-------------------------EAELLTML--Q------HQH--IVRFFGVCT--E--------GRP--LL--MVFEYMRHG--DLNRFLR-----SHGPDAKL---------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVG-Q---GLVV---KIGDFGMSRDI---Y--S--TDYY--------------RVGGRTMLPIRWMPPES--IL------YRK----FTTESDVWSFGVVLWEIFTYGKQP---------------WYQL--SNTEAIDCI-TQGRE----LERPRACP----------------------------------------------------------PEVYAIMRGCWQREPQQRHS-----IKDVHARL-------------
----I-VLKRELGEGAFGKVFLAEC---YNLCPEQDKI---LVAVKTLK-D--A-SD----NA--RKD-FH-R-------------------------EAELLTNL--Q------HEH--IVKFYGVCV--E--------GDP--LI--MVFEYMKHG--DLNKFLR-----AHGPDAV-----------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVG-E---NLLV---KIGDFGMSRDV---Y--S--TDYY--------------RVGGHTMLPIRWMPPES--IM------YRK----FTTESDVWSLGVVLWEIFTYGKQP---------------WYQL--SNNEVIECI-TQGRV----LQRPRTCP----------------------------------------------------------QEVYELMLGCWQREPHMRKN-----IKGIHTL--L-----------
----I-VLKRELGEGAFGKVFLAEC---YNLSPTKDKM---LVAVKALK-D--P-TL----AA--RKD-FQ-R-------------------------EAELLTNL--Q------HEH--IVKFYGVCG--D--------GDP--LI--MVFEYMKHG--DLNKFLR-----AHGPDAMIL--------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVG-A---NLLV---KIGDFGMSRDV---Y--S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPES--IM------YRK----FTTESDVWSFGVILWEIFTYGKQP---------------WFQL--SNTEVIECI-TQGRV----LERPRVCP----------------------------------------------------------KEVYDVMLGCWQREPQQRLN-----IKEIYKIL-------------
-----YELQETLGKGTYGKVKRATE---R-----FSGR---VVAIKSIRKD--K-IKD---EQ---DM-VHIR------------------------REIEIMSSL--N------HPH--IISIYEVFE--N--------KDK--IV--IIMEYASKG--ELYDYIS----ERR-------------------------RLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLD-D---NCNI---KIADFGLSNL-------YQKDKFL--------------QT---FCGSPLYASPEI--VN-----GRPY----RGPEVDSWALGVLLYTLVY-GTMP---------------FDGF-----DHKNLI-RQISS----GEYREPTQP---------------------------------------------------------SDARGLIRWMLMVNPDRRAT-----IEDIANHWW-V----------
-----YEFLETLGKGTYGKVKKARE---S-----SGR----LVAIKSIRKD--K-IKD---EQ---DL-MHIR------------------------REIEIMSSL--N------HPH--IIAIHEVFE--N--------SSK--IV--IVMEYASRG--DLYDYIS----ERQ-------------------------QLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLENILLD-A---NGNI---KIADFGLSNL-------YHQGKFL--------------QT---FCGSPLYASPEI--VN-----GKPY----TGPEVDSWSLGVLLYILVH-GTMP---------------FDGH-----DHKILV-KQISN----GAYREPPK-----P----------------------------------------------------SDACGLIRWLLMVNPTRRAT-----LEDVASHWW-V----------
-DNFI-----KIGEGSTGIVCIATV---R-----SSGK---LVAVKKMDLR--K-QQR---RE---L---LFN-------------------------EVVIMRDY--Q------HEN--VVEMYNSYL--V--------GDE--LW--VVMEFLEGG--ALTDIVT-----HT-------------------------RMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLT-H---DGRV---KLSDFGFCAQV------SKEVPRR--------------KS---LVGTPYWMAPEL--IS------RLP----YGPEVDIWSLGIMVIEMVD-GEPP---------------YFNE--PPLKAMKMI-RDNLP----PRLKNLHKVS--------------------------------------------------------PSLKGFLDRLLVRDPAQRAT-----AAELLKHPFL-----------
----F-KFGKILGEGSFSTVVLARE---L-----ATSR---EYAIKILEKR--H-IIK---EN---KVPYVTR-------------------------ERDVMSRL--D------HPF--FVKLYFTFQ--D--------DEK--LY--FGLSYAKNG--ELLKYIR----KIG-------------------------SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-E---DMHI---QITDFGTAKVLS----PESKQARA--------------NS---FVGTAQYVSPEL--LT------EKS----ACKSSDLWALGCIIYQLVA-GLPP---------------FRAG-----NEYLIF-QKIIK----LEYDFPEKFF--------------------------------------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
-----YEPKEILGRGVSSVVRRCIH---K-----PTSQ---EYAVKVIDVT--G-GGS---FS---PE-EVRELRE------------------ATLKEVDILRKV-SG------HPN--IIQLKDTYE--T--------NTF--FF--LVFDLMKRG--ELFDYLT----EKV-------------------------TLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLD-D---NMNI---KLTDFGFSCQ-------LEPGERL--------------RE---VCGTPSYLAPEI--IECSMNEDHPG----YGKEVDMWSTGVIMYTLLA-GSPP---------------FWHR-----KQMLML-RMIMS----GNYQFGSPEWDDYS----------------------------------------------------DTVKDLVSRFLVVQPQNRYT-----AEEALAHPFF-----------
--YDP---KDVIGRGVSSVVRRCVH---R-----ATGH---EFAVKIMEVT--A-ERL---SP---EQ-LEEVREA-------------------TRRETHILRQV-AG------HPH--IITLIDSYE--S--------SSF--MF--LVFDLMRKG--ELFDYLT----EKV-------------------------ALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLD-D---NMQI---RLSDFGFSCH-------LEPGEKL--------------RE---LCGTPGYLAPEI--LKCSMDETHPG----YGKEVDLWACGVILFTLLA-GSPP---------------FWHR-----RQILML-RMIME----GQYQFSSPEWDDRS----------------------------------------------------STVKDLISRLLQVDPEARLT-----AEQALQHPFF-----------
-----YQVGPLLGSGGFGSVYSGIR---V-----SDNL---PVAIKHVEKD--R-ISD---WG---EL-PNGTRV---------------------PMEVVLLKKV--S------SGFSGVIRLLDWFE--R--------PDS--FV--LILERPEPV-QDLFDFIT----ERG-------------------------ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLN---RGEL---KLIDFGSGA--------LLKDTVY--------------TD---FDGTRVYSPPEW--IR-----YHRY----HGRSAAVWSLGILLYDMVC-GDIP---------------FEHD------------EEIIR----GQVFFRQRVS--------------------------------------------------------SECQHLIRWCLALRPSDRPT-----FEEIQNHPWM-----------
-----YQVGAVLGSGGFGTVYAGSR---I-----ADGL---PVAVKHVVKE--R-VTE---WG---SL-GGATV----------------------PLEVVLLRKV--GAA--GGARG--VIRLLDWFE--R--------PDG--FL--LVLERPEPA-QDLFDFIT----ERG-------------------------ALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLR---SGEL---KLIDFGSGA--------LLKDTVY--------------TD---FDGTRVYSPPEW--IR-----YHRY----HGRSATVWSLGVLLYDMVC-GDIP---------------FEQD------------EEILR----GRLLFRRRVS--------------------------------------------------------PECQQLIRWCLSLRPSERPS-----LDQIAAHPWM-----------
----F-KVGNLLGKGSFAGVYRAES---I-----HTGL---EVAIKMIDKK--A-MYK---AG---MV-QRVQ------------------------NEVKIHCQL--K------HPS--ILELYNYFE--D--------SNY--VY--LVLEMCHNG--EMNRYLK---NRVK-------------------------PFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLT-R---NMNI---KIADFGLATQL------KMPHEKH--------------YT---LCGTPNYISPEI--AT------RSA----HGLESDVWSLGCMFYTLLI-GRPP---------------FDTD-----TVKNTL-NKVVL----ADYEMPSFLS--------------------------------------------------------IEAKDLIHQLLRRNPADRLS-----LSSVLDHPFM-----------
---FI--FHKVLGKGSFGKVLLGEL---K-----GRGE---YFAIKALKKD--V-VLI---DD---DV-ECTM------------------------VEKRVLTLA-AE------NPF--LTHLICTFQ--T--------KDH--LF--FVMEFLNGG--DLMYHIQ----DKG-------------------------RFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLD-R---DGHI---KIADFGMCKEN------IFGESRA--------------ST---FCGTPDYIAPEI--LQ------GLK----YTFSVDWWSFGVLLYEMLI-GQSP---------------FHGD-----DEDELF-ESIRV----DTPHYPRWIT--------------------------------------------------------KESKDILEKLFEREPTKRLG----VTGNIKIHPFF-----------
---PD----EVLGSGQFGIVYGGKH---R-----KTGR---DVAIKIIDKL--R-FPT---KQ---ES-QLRN-------------------------EVAILQNL--H------HPG--VVNLECMFE--T--------PER--VF--VVMEKLHGD--MLEMILS---SEKG-------------------------RLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLA-S---ADPFPQVKLCDFGFARI-------IGEKSFR--------------RS---VVGTPAYLAPEV--LR------NKG----YNRSLDMWSVGVIIYVSLS-GTFP---------------FNED-------EDIH-DQIQN----AAFMYPPNPWKEIS----------------------------------------------------HEAIDLINNLLQVKMRKRYS-----VDKTLSHPWL-----------
---PD----EVLGSGQFGVVYGGKH---R-----KTGR---DVAVKVIDKL--R-FPT---KQ---ES-QLRN-------------------------EVAILQSL--R------HPG--IVNLECMFE--T--------PEK--VF--VVMEKLHGD--MLEMILS---SEKG-------------------------RLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLA-S---ADPFPQVKLCDFGFARI-------IGEKSFR--------------RS---VVGTPAYLAPEV--LL------NQG----YNRSLDMWSVGVIMYVSLS-GTFP---------------FNED-------EDIN-DQIQN----AAFMYPASPWSHIS----------------------------------------------------AGAIDLINNLLQVKMRKRYS-----VDKSLSHPWL-----------
--FAD----EVLGSGQFGIVYGGKH---R-----KTGR---DVAIKVIDKM--R-FPT---KQ---ES-QLRN-------------------------EVAILQNL--H------HPG--IVNLECMFE--T--------PER--VF--VVMEKLHGD--MLEMILS---SEKS-------------------------RLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLA-S---AEPFPQVKLCDFGFARI-------IGEKSFR--------------RS---VVGTPAYLAPEV--LR------SKG----YNRSLDMWSVGVIIYVSLS-GTFP---------------FNED-------EDIN-DQIQN----AAFMYPPNPWREIS----------------------------------------------------GEAIDLINNLLQVKMRKRYS-----VDKSLSHPWL-----------
----L-EIIATLGVGGFGRVELVKV---K-----NENV---AFAMKCIRKK--H-IVD---TK---QQ-EHVY------------------------SEKRILEEL--C------SPF--IVKLYRTFK--D--------NKY--VY--MLLEACLGG--ELWSILR----DRG-------------------------SFDEPTSKFCVACVTEAFDYLHRLGIIYRDLKPENLILD-A---EGYL---KLVDFGFAKK-------IGSGQKT--------------WT---FCGTPEYVAPEV--IL------NKG----HDFSVDFWSLGILVYELLT-GNPP---------------FSGV-----DQMMTY-NLILK----GIEKMDFPRKIT------------------------------------------------------RRPEDLIRRLCRQNPTERLGNLKNGINDIKKHRWL-----------
----V-VLNRILGEGFFGEVYEGVY---T--NHKGEKI---NVAVKTCK-K--D-CT----LDN-KEK-FM-S-------------------------EAVIMKNL--D------HPH--IVKLIGIIE-----------EEP--TW--IIMELYPYG--ELGHYLE-----RN-----------------------KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVA-S---PECV---KLGDFGLSRYI------E--DEDY--------------YKASVTRLPIKWMSPES--IN------FRR----FTTASDVWMFAVCMWEILSFGKQP---------------FFWL--ENKDVIGVL-EKGDR----LPKPDLCP----------------------------------------------------------PVLYTLMTRCWDYDPSDRPR-----FTELVCS--L-----------
---VM--LSTRIGSGSFGTVYKGKW---H--------G---DVAVKILK-V-VD-PT----PEQ-FQA-FR-N-------------------------EVAVLRKT--R------HVN--ILLFMGYMT-----------KDN--LA--IVTQWCEGS--SLYKHLH-----VQ-----------------------ETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLH-E---GLTV---KIGDFGLATVK---S--R--WSGS--------------QQVEQPTGSVLWMAPEV--IR------MQDN-NPFSFQSDVYSYGIVLYELMT-GELP---------------YSHIN-NRDQIIFMV-GRGYASPDLSKLYKNCP----------------------------------------------------------KAMKRLVADCVKKVKEERPL-----FPQILSS--I-----------
----L-VLGKTLGEGEFGKVVKATA---FHLKGRAGYT---TVAVKMLK-E--N-AS----PSE-LRD-LL-S-------------------------EFNVLKQV--N------HPH--VIKLYGACS--Q--------DGP--LL--LIVEYAKYG--SLRGFLR-----ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVA-E---GRKM---KISDFGLSRDV---Y--E--EDSY--------------VKRSQGRIPVKWMAIES--LF------DHI----YTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI--PPERLFNLL-KTGHR----MERPDNCS----------------------------------------------------------EEMYRLMLQCWKQEPDKRPV-----FADISKDL-------------
-----FELLRVLGKGGYGKVFQVRKVTGA-----NTGK---IFAMKVLKKA--M-IVR---NA---KD-TAHTK-----------------------AERNILEEV--K------HPF--IVDLIYAFQ--T--------GGK--LY--LILEYLSGG--ELFMQLE----REG-------------------------IFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLN-H---QGHV---KLTDFGLCKES------IHDGTVT--------------HT---FCGTIEYMAPEI--LM------RSG----HNRAVDWWSLGALMYDMLT-GAPP---------------FTGE-----NRKKTI-DKILK----CKLNLPPYLT--------------------------------------------------------QEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF-----------
-----FELLRVLGKGGYGKVFQVRK---V-----QGTNLGKIYAMKVLRKA--K-IVR---NA---KD-TAHTR-----------------------AERNILESV--K------HPF--IVELAYAFQ--T--------GGK--LY--LILECLSGG--ELFTHLE----REG-------------------------IFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLS-S---QGHI---KLTDFGLCKES------IHEGAVT--------------HT---FCGTIEYMAPEI--LV------RSG----HNRAVDWWSLGALMYDMLT-GSPP---------------FTAE-----NRKKTM-DKIIR----GKLALPPYLT--------------------------------------------------------PDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFF-----------
-----YDIEGTLGKGNFAVVKLGRH---R-----ITKT---EVAIKIIDKS--Q-LDA---VN---LE-KIYR-------------------------EVQIMKML--D------HPH--IIKLYQVME--T--------KSM--LY--LVTEYAKNG--EIFDYLA----NHG-------------------------RLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLD-N---NMNI---KIADFGFGNF-------FKSGELL--------------AT---WCGSPPYAAPEV--FE-----GQQY----EGPQLDIWSMGVVLYVLVC-GALP---------------FDGP-----TLPILR-QRVLE----GRFRIPYFMS--------------------------------------------------------EDCEHLIRRMLVLDPSKRLT-----IAQIKEHKWM-----------
-----WEIIGELGDGAFGKVYKAQN---K-----ETSV---LAAAKVIDTK--S-EEE---LE---DY-M--V-------------------------EIDILASC--D------HPN--IVKLLDAFY--Y--------ENN--LW--ILIEFCAGG--AVDAVML---ELER-------------------------PLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFT-L---DGDI---KLADFGVSAKN------TRTIQRR--------------DS---FIGTPYWMAPEV--VMCE-TSKDRP----YDYKADVWSLGITLIEMAE-IEPP---------------HHEL--NPMRVLLKI-AKSEP----PTLAQPSRWS--------------------------------------------------------SNFKDFLKKCLEKNVDARWT-----TSQLLQHPFV-----------
-----WEIVGELGDGAFGKVYKAKN---K-----ETGA---LAAAKVIETK--S-EEE---LE---DY-I--V-------------------------EIEILATC--D------HPY--IVKLLGAYY--H--------DGK--LW--IMIEFCPGG--AVDAIML---ELDR-------------------------GLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMT-L---EGDI---RLADFGVSAKN------LKTLQKR--------------DS---FIGTPYWMAPEV--VMCE-TMKDTP----YDYKADIWSLGITLIEMAQ-IEPP---------------HHEL--NPMRVLLKI-AKSDP----PTLLTPSKWS--------------------------------------------------------VEFRDFLKIALDKNPETRPS-----AAQLLEHPFV-----------
--LCP---GRELGRGKFAVVRKCIK---K-----DSGK---EFAAKFMRKR--R-KGQ---DC---RM-EIIH-------------------------EIAVLELA-QD------NPW--VINLHEVYE--T--------ASE--MI--LVLEYAAGG--EIFDQCVA--DREE-------------------------AFKEKDVQRLMRQILEGVHFLHTRDVVHLDLKPQNILLT-S---ESPLGDIKIVDFGLSRI-------LKNSEEL--------------RE---IMGTPEYVAPEI--LS------YDP----ISMATDMWSIGVLTYVMLT-GISP---------------FLGN-----DKQETF-LNISQ----MNLSYSEEEFDVLS----------------------------------------------------ESAVDFIRTLLVKKPEDRAT-----AEECLKHPWL-----------
----F-DVLEKLGEGSYGSVFKAIH---K-----ESGQ---VVAIKQVPVE--S-DLQ---EI--------IK-------------------------EISIMQQC--D------SPY--VVKYYGSYF--K--------NTD--LW--IVMEYCGAG--SVSDIIR---LRNK-------------------------TLIEDEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLN-T---EGHA---KLADFGVAGQL------TDTMAKR--------------NT---VIGTPFWMAPEV--IQ------EIG----YNCVADIWSLGITSIEMAE-GKPP---------------YADI--HPMRAIFMI-PTNPP----PTFRKPELWS--------------------------------------------------------DDFTDFVKKCLVKNPEQRAT-----ATQLLQHPFI-----------
----F-DVLEKLGEGSYGSVYKAIH---K-----ETGQ---IVAIKQVPVE--S-DLQ---EI--------IK-------------------------EISIMQQC--D------SPH--VVKYYGSYF--K--------NTD--LW--IVMEYCGAG--SVSDIIR---LRNK-------------------------TLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLN-T---EGHA---KLADFGVAGQL------TDTMAKR--------------NT---VIGTPFWMAPEV--IQ------EIG----YNCVADIWSLGITAIEMAE-GKPP---------------YADI--HPMRAIFMI-PTNPP----PTFRKPELWS--------------------------------------------------------DNFTDFVKQCLVKSPEQRAT-----ATQLLQHPFV-----------
--TLE---DKELGSGNFGTVKKGYY---Q---MKKVVK---TVAVKILK-N--E-AN----DPALKDE-LL-A-------------------------EANVMQQL--D------NPY--IVRMIGICE-----------AES--WM--LVMEMAELG--PLNKYLQ-----QN------------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV-T---QHYA---KISDFGLSKAL---R--A--DENY-------------YKAQTHGKWPVKWYAPEC--IN------YYK----FSSKSDVWSFGVLMWEAFSYGQKP---------------YRGM--KGSEVTAML-EKGER----MGCPAGCP----------------------------------------------------------REMYDLMNLCWTYDVENRPG-----FAAVE----LRL---------
----F-TDLREIGHGSFGAVYFARD---V-----RTNE---VVAIKKMSYS--G-KQS---TE---KW-QDII------------------------KEVKFLQRI--K------HPN--SIEYKGCYL--R--------EHT--AW--LVMEYCLG---SASDLLE---VHKK-------------------------PLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLT-E---PGQV---KLADFGSASM----------ASPA--------------NS---FVGTPYWMAPEV--ILA---MDEGQ----YDGKVDVWSLGITCIELAE-RKPP---------------LFNM--NAMSALYHI-AQNES----PTLQSNEWS---------------------------------------------------------DYFRNFVDSCLQKIPQDRPT-----SEELLKHIF-V----------
---FS--DLREIGHGSFGAVYFARD---V-----RNSE---VVAIKKMSYS--G-KQS---NE---KW-QDII------------------------KEVRFLQKL--R------HPN--TIQYRGCYL--R--------EHT--AW--LVMEYCLG---SASDLLE---VHKK-------------------------PLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLS-E---PGLV---KLGDFGSASI----------MAPA--------------NS---FVGTPYWMAPEV--ILA---MDEGQ----YDGKVDVWSLGITCIELAE-RKPP---------------LFNM--NAMSALYHI-AQNES----PVLQSGHWS---------------------------------------------------------EYFRNFVDSCLQKIPQDRPT-----SEVLLKHRFV-----------
-----IKFQDVIGEGNFGQVLKARI---K---KDGLRM---DAAIKRMK-E--Y-AS----KDD-HRD-FA-G-------------------------ELEVLCKLG-H------HPN--IINLLGACE--H--------RGY--LY--LAIEYAPHG--NLLDFLR-----KSRVLETDP--------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVG-E---NYVA---KIADFGLSRGQ----------EVY--------------VKKTMGRLPVRWMAIES--LN------YSV----YTTNSDVWSYGVLLWEIVSLGGTP---------------YCGM--TCAELYEKL-PQGYR----LEKPLNCD----------------------------------------------------------DEVYDLMRQCWREKPYERPS-----FAQILV---SL----------
----L-RLLEKLGDGSFGVVRRGEW---D--APSGKTV---SVAVKCLK-PDVL-SQ----PEA-MDD-FI-R-------------------------EVNAMHSL--D------HRN--LIRLYGVVL-----------TPP--MK--MVTELAPLG--SLLDRLR-----KH-----------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLA-T---RDLV---KIGDFGLMRAL--PQ--N--DDHY--------------VMQEHRKVPFAWCAPES--LK------TRT----FSHASDTWMFGVTLWEMFTYGQEP---------------WIGL--NGSQILHKIDKEGER----LPRPEDCP----------------------------------------------------------QDIYNVMVQCWAHKPEDRPT-----FVALRDF--L-----------
YLLGI-----NLGEGSYAKVKSAYS---E-----RLKF---NVAIKIIDRK--K-APA---DF---LE-KFLP------------------------REIEILAML--N------HCS--IIKTYEIFE--T-------SHGK--VY--IVMELAVQG--DLLELIK----TRG-------------------------ALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLD-K---DFNI---KLSDFSFSKRCLR--DDSGRMALS--------------KT---FCGSPAYAAPEV--LQ-----GIPY----QPKVYDIWSLGVILYIMVC-GSMP---------------YDDS-----NIKKML-RIQKE----HRVNFPRSKHLT------------------------------------------------------GECKDLIYHMLQPDVNRRLH-----IDEILSHCWM-----------
----L-AFIKEIGSGQFGVVHLGEW---R------SHI---QVAIKAIN-E--G-SM----SE---ED-FI-E-------------------------EAKVMMKL--S------HSK--LVQLYGVCI--Q--------RKP--LY--IVTEFMENG--CLLNYLR-----EN-----------------------KGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVS-S---TCIV---KISDFGMTRYV------L--DDEY--------------VSSFGAKFPIKWSPPEV--FL------FNK----YSSKSDVWSFGVLMWEVFTEGKMP---------------FENK--SNLQVVEAI-SEGFR----LYRPHLAP----------------------------------------------------------MSIYEVMYSCWHEKPEGRPT-----FAELLR---AV----------
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