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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3A 203
CMGC CDK2 4
CMGC DYRK1A 150
Other EIF2AK2 267
CMGC GSK3B 56
-YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNR------ELQIMRKL-DHCN-----IVRLRYFFYSSG-------------------------EKKDELYLNLVLEYVPETVYRVARHFT---KAKLTI---PILYVKVYMYQLFRSLAYIHS--QGVCHRDIKPQNLLVD-PDTAVLKLCDFGSAKQ-LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ-PIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF---
-FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL-NHPN-----IVKLLDVIHT-----------------------------ENKLY--LVFEFLHQ---DLKKFMDA--SALTGI---PLPLIKSYLFQLLQGLAFCHS--HRVLHRDLKPQNLLIN--TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRR-ALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF---
-YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQI---EVRLLELMNKHDTEMKYYIVHLKRHFMF-----------------------------RNHLC--LVFEMLSY---NLYDLLR-----NTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQ---LGQRIYQYIQSRFYRSPEVLL-GMPYDLAIDMWSLGCILVEMHTGE-PLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF---
F-KEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAER------EVKALAKL-DHVN-----IVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEK--RRGEKL---DKVLALELFEQITKGVDYIHS--KKLIHRDLKPSNIFLV--DTKQVKIGDFGLVTS-LKNDGKRTRSKGTLRYMSPEQIS-SQDYGKEVDLYALGLILAELLHVCDTAFET-------SKFFTDLRDGIISDIFDK--------------------------------------------------------------KEKTLLQKLLSKKPEDRPNTSEILR----TLT
-YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR------ELQIMRKL-DHCN-----IVRLRYFFYSSG-------------------------EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTL---PVIYVKLYMYQLFRSLAYIHS--FGICHRDIKPQNLLLD-PDTAVLKLCDFGSAKQ-LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ-PIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF---
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