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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3A 203
AGC AKT1 150
Other AURKA 133
Other AURKB 77
CMGC CDK2 4
CMGC GSK3B 56
CMGC MAPK10 64
CMGC MAPK14 24
AGC PRKACA 44
AGC ROCK2 92
-YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDK-RFKNR-------ELQIMRKLDHCNIVRLRYFFYSSG--EKKDELYLNLVLEYVPETVYRVARHFT---KAKLTIPILYVKVYMYQLFRSLAYIHS-QGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQ--LVRGEPNVSYICSRYYRAPELIF---GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFKSRTPPEAIALCSSLLEYTPSS--RLS-----PLEACAHSFF
F-EYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEV-IVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQT------HDRLC--FVMEYANGG--ELFFHLS----RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD-KDGHIKITDFGLCKEG-IKDGATMKTFCGTPEYLAPEVLE----DNDYGRAVDWWGLGVVMYEMMCGRLPFYNQ---DHEKLFELILMEEIRFPRTLG---------------------------------------PEAKSLLSGLLKKDPKQ--RLGGGSEDAKEIMQHRFF
-FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR-EVEIQSHLRHPNILRLYGYFHD------ATRVY--LILEYAPLG--TVYRELQ----KLSKFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLG-SAGELKIADFGWSV---HAPSSRRTTLCGTLDYLPPEMIE----GRMHDEKVDLWSLGVLCYEFLVGKPPFEAN---TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQ--RPM-----LREVLEHPWI
-FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ-IEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYD------RRRIY--LILEYAPRG--ELYKELQ----KSCTFDEQRTATIMEELADALMYCHG-KKVIHRDIKPENLLLG-LKGELKIADFGWSV---HAPSLRRKTMCGTLDYLPPEMIE----GRMHNEKVDLWCIGVLCYELLVGNPPFESA---SHNETYRRIVKVDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSE--RLP-----LAQVSAHPWV
-FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIR-EISLLKELNHPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF-GVPVRTYTHEVVTLWYRAPEILL---GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-----AKAALAHPFF
-YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-RFKNR-------ELQIMRKLDHCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS-FGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ--LVRGEPNVSYICSRYYRAPELIF---GATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT-----PLEACAHSFF
-YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF-QNQTHAKRAYR-ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ------MELDHERMSYLLYQMLCGIKHLHS-AGIIHRDLKPSNIVVK-SDCTLKILDFGLART--AGTSFMMTPYVVTRYYRAPEVIL----GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK--RIS-----VDDALQHPYI
-YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPF-QSIIHAKRTYR-ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQKLTDDHVQFLIYQILRGLKYIHS-ADIIHRDLKPSNLAVN-EDCELKILDFGLAR----HTDDEMTGYVATRWYRAPEIML---NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDK--RIT-----AAQALAHAYF
F-ERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQK-VVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKD------NSNLY--MVMEYVPGG--EMFSHLR----RIGRFSEPHARFYAAQIVLTFEYLHS-LDLIYRDLKPENLLID-QQGYIQVTDFGFAK----RVKGRTWTLCGTPEYLAPEIIL----SKGYNKAVDWWALGVLIYEMAAGYPPFFAD---QPIQIYEKIVSGKVRFPSHFS---------------------------------------SDLKDLLRNLLQVDLTK--RFGNLKNGVNDIKNHKWF
-YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFE-MIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQD------DRYLY--MVMEYMPGG--DLVNLMS-----NYDVPEKWAKFYTAEVVLALDAIHS-MGLIHRDVKPDNMLLD-KHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYAD---SLVGTYSKIMDHKNSLCFPEDAEIS-----------------------------------KHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF
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