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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3A 203
Other AURKA 133
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
CMGC GSK3B 56
TK LCK 245
CMGC MAPK1 13
CMGC MAPK10 64
CMGC MAPK14 24
CAMK MARK1 60
CAMK PIM2 132
TK PTK2 422
TK SRC 270
-YTDIKVIGNGSFGVVYQARLA---ETRELVAIKKVLQDK-RFK---NR------------ELQIMRKLD----HCNIVRLRYFFYSSG--EKKDELYLNLVLEY-VPETVYRVARHFT---KAKL---TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQ----LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF
-FEIGRPLGKGKFGNVYLAREK---QSKFILALKVLFKAQLEKA---GV--EHQLRR----EVEIQSHLR----HPNILRLYGYFHD------ATRVY--LILEY-APLG--TVYRELQ----KLS---KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGELKIADFGWSV-----HAPSSRRTT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI
-YTKIEKIGEGTYGVVYKGRHK---TTGQVVAMKKIRLES-EEE---GV--PSTAIR----EISLLKELR----HPNIVSLQDVLMQ------DSRLY--LIFEF-LSM---DLKKYLDS-IPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF---GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
-FQKVEKIGEGTYGVVYKARNK---LTGEVVALKKIRLDT-ETE---GV--PSTAIR----EISLLKELN----HPNIVKLLDVIHT------ENKLY--LVFEF-LHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF---GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
Y-EPVAEIGVGAYGTVYKARDP---HSGHFVALKSVRVPN-GGGGGGGL--PISTVR----EVALLRRLEA-FEHPNVVRLMDVCATSR-TDREIKVT--LVFEH-VDQ---DLRTYLDK--APPP---GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARI----YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL
-YTDTKVIGNGSFGVVYQAKLC---DSGELVAIKKVLQDK-RFK---NR------------ELQIMRKLD----HCNIVRLRYFFYSSG--EKKDEVYLNLVLDY-VPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ----LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF
-LKLVERLGAGQFGEVWMGYYN----GHTKVAVKSLK-QG-SM----SP--DAFL-A----EANLMKQLQ----HQRLVRLYAVVT-------QEPIY--IITEY-MENG--SLVDFLK-----TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLI---E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L
-YTNLSYIGEGAYGMVCSAYDN---VNKVRVAIKKISPFE-HQT---YC--QRT-LR----EIKILLRFR----HENIIGINDIIRAPT-IEQMKDVY--IVQDL-MET---DLYKLLK-----TQ---HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICDFGLARVADPDHDHTGFLTE---YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-----------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL
-YQNLKPIGSGAQGIVCAAYDA---VLDRNVAIKKLSRPF-QNQ---TH--AKRAYR----ELVLMKCVN----HKNIISLLNVFTPQKTLEEFQDVY--LVMEL-MDA---NLCQVIQ------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART----AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI
-YQNLSPVGSGAYGSVCAAFDT---KTGLRVAVKKLSRPF-QSI---IH--AKRTYR----ELRLLKHMK----HENVIGLLDVFTPARSLEEFNDVY--LVTHL-MGA---DLNNIVK-----CQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR------HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
-YRLQKTIGKGNFAKVKLARHV---LTGREVAVKIIDKTQ-LNP---TS--LQKLFR----EVRIMKILN----HPNIVKLFEVIET------EKTLY--LVMEY-ASGG--EVFDYLV----AHG---RMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLD-GDMNIKIADFGFSNE----FTVGNKLDT---FCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVS-GSLPFDGQ---NLKELRERVLRGKYRIPFYMS---------------------------------------TDCENLLKKLLVLNPIKRGSLEQIMKDRWM
-YRLGPLLGKGGFGTVFAGHRL---TDRLQVAIKVIPRNR-VLG---WS--PLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFET------QEGFM--LVLERPLPAQ--DLFDYIT----EKG---PLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGA-----LLHDEPYTD---FDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVC-GDIPFERD---------QEILEAELHFPAHVS---------------------------------------PDCCALIRRCLAPKPSSRPSLEEILLDPWM
-IELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCK-NC-TS----DSVREKFL-Q----EALTMRQFD----HPHIVKLIGVIT-------ENPVW--IIMEL-CTLG--ELRSFLQ-----VR-KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVS-SNDCVKLGDFGLSRYM---E--DSTYYKASKGKLPIKWMAPESIN-FRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCP-----------------------------------------PTLYSLMTKCWAYDPSRRPRFTELKAQL--
L-RLEVKLGQGCFGEVWMGTWN----GTTRVAIKTLK-PG-TM----SP--EAFL-Q----EAQVMKKLR----HEKLVQLYAVVS-------EEPIY--IVTEY-MSKG--SLLDFLK-----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLI---E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP-----------------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L
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