Protein Surface  Ribbon
Inhibitor NR9
  ATP Location
Motifs All P-loop B3 Hinge
C-loop A-loop
Select Anchor
Summary of 6 kinases in KIF 3NR9A_NR9 (CLK2, PDB code: 3NR9, chain A)

Multiple sequence alignment of family kinases

Conserved residues:   
                            
Group      Kinase           
CMGC       GSK3A        203 
CMGC       CDC2           4 
CMGC       CDK2           4 
CMGC       CDK9       2.7.11.23 
CMGC       CLK2         163 
CMGC       MAPK1         13 



YTDIKVIGNGSFGVVYQARLAETRE-LVAIKKVLQDKRFKNR------ELQIMRKLD-----HCN-IVRLRYFFYSSG----EKKDELYLNLVLEYVPETVYRVARHFT--KAKLTI--PILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVL-------------------KLCDFGSAKQ-----LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF
YTKIEKIGEGTYGVVYKGRHKTTGQ-VVAMKKIRLESEEEGVPSTAIREISLLKELR-----HPN-IVSLQDVLMQ--------DSRLY--LIFEFLSM---DLKKYLDSIPPGQYM--DSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI-------------------KLADFGLARAF----GIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP---------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
FQKVEKIGEGTYGVVYKARNKLTGE-VVALKKIRLDTETEGVPSTAIREISLLKELN-----HPN-IVKLLDVIHT--------ENKLY--LVFEFLHQ---DLKKFMDA-SALTGI--PLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI-------------------KLADFGLARAF----GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
YEKLAKIGQGTFGEVFKARHRKTGQ-KVALKKVLMENEKEGFPITALREIKILQLLK-----HEN-VVNLIEICRTKASPYNRCKGSIY--LVFDFCEH---DLAGLLS--NVLVKF--TLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLIT-RDGVL-------------------KLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF
YEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAAR---LEINVLEKINEKDPDNKNLCVQMFDWFDY--------HGHMC--ISFELLGL---STFDFLK---DNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFV-NSDYELTYNLEKKRDERSVKSTAVRVVDFGSAT-------FDHEHHSTIVSTRHYRAPEVIL-ELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF
YTNLSYIGEGAYGMVCSAYDNVNKV-RVAIKKISPFEHQTYCQRT-LREIKILLRFR-----HEN-IIGINDIIRAPT---IEQMKDVY--IVQDLMET---DLYKLLK----TQHL--SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDL-------------------KICDFGLARVAD-PDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-------------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL