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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3B 203
Other AURKA 133
CMGC CDK2 4
CMGC CDK9 2.7.11.23
CAMK CHEK2 220
CMGC CSNK2A1 39
Other EIF2AK2 267
AGC GRK6 186
STE MAP2K1 68
CMGC MAPK10 64
CMGC MAPK12 27
CAMK MAPKAPK2 64
AGC PDPK1 82
Other PLK1 53
AGC RPS6KA1 62
CAMK STK11 49
---YTDTKVIGNGSFGVV---YQAKLCDSGELVAIKKVLQDK-RFKNR-------------ELQIMRKL-DHCNIVRLRYFFYSSG-------------------------EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHS-FGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ-----LVRGEPNVSYICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLLGQ-PIFP-GD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH---------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF-----------
---FEIGRPLGKGKFGNV---YLAREKQSKFILALKVLFKAQLEKAGVEH-QLRR------EVEIQSHL-RHPNILRLYGYFHD-----------------------------ATRVY--LILEYAPLG--TVYRELQ----KLSKFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLG-SAGEL---KIADFGWSV------HAPSSRRTTLCGTLDYLPPEMIE---GRMHDEKVDLWSLGVLCYEFLVGK-PPFE-AN----TYQETYKRISRVEFTFPDFVT-----------------------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI-----------
---FQKVEKIGEGTYGVV---YKARNKLTGEVVALKKIRLDT-ETEGVPS-TAIR------EISLLKEL-NHPNIVKLLDVIHT-----------------------------ENKLY--LVFEFLHQ---DLKKFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF----GVPVRTYTHEVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVTRR-ALFP-GD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF-----------
---YEKLAKIGQGTFGEV---FKARHRKTGQKVALKKVLMEN-EKEGFPI-TALR------EIKILQLL-KHENVVNLIEICRTKASP---------------------YNRCKGSIY--LVFDFCEH---DLAGLLS---NVLVKFTLSEIKRVMQMLLNGLYYIHR-NKILHRDMKAANVLIT-RDGVL---KLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLL--GERDYGPPIDLWGAGCIMAEMWTRS-PIMQ-GN-TEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK------------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SDDALNHDFF-----------
-YI--MSKTLGSGACGEV---KLAFERKTCKKVAIKIISKRK-FAIGSAR-EADPALNVETEIEILKKL-NHPCIIKIKNFF-D-----------------------------AEDYY--IVLELMEGG--ELFDKVV----GNKRLKEATCKLYFYQMLLAVQYLHE-NGIIHRDLKPENVLLS-SQEEDCLIKITDFGHSKI-----LGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGY-PPFS-EH---RTQVSLKDQITSGKYNFIPEVWAEVS-------------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL-----------
---YQLVRKLGRGKYSEV---FEAINITNNEKVVVKILKPVK-KKKIKR------------EIKILENLRGGPNIITLADIVKDP---------------------------VSRTPA--LVFEHVNNT--DFKQLY-------QTLTDYDIRFYMYEILKALDYCHS-MGIMHRDVKPHNVMIDHEHRKL---RLIDWGLAEF-----YHPGQEYNVRVASRYFKGPELLV--DYQMYDYSLDMWSLGCMLASMIFRK-EPFFHGH-DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-------RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAMEHPYF-----------
--F-KEIELIGSGGFGQV---FKAKHRIDGKTYVIKRVKYNN-EKAER-------------EVKALAKL-DHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEK--RRGEKLDKVLALELFEQITKGVDYIHS-KKLIHRDLKPSNIFLV-DTKQV---KIGDFGLVTS-----LKNDGKRTRSKGTLRYMSPEQIS---SQDYGKEVDLYALGLILAELLHVCDTAFE-T--------SKFFTDLRDGIISDIFDK------------------------------------------KEKTLLQKLLSKKPEDRPN-----TSEILR----TLT--------
--F-RQYRVLGKGGFGEV---CACQVRATGKMYACKKLEKKR-IKKRKGE-AMAL-----NEKQILEKV-NSRFVVSLAYAYET-----------------------------KDALC--LVLTLMNGG--DLKFHIYH--MGQAGFPEARAVFYAAEICCGLEDLHR-ERIVYRDLKPENILLD-DHGHI---RISDLGLAVH-----VPEGQTIKGRVGTVGYMAPEVVK---NERYTFSPDWWALGCLLYEMIAGQ-SPFQ-QR-KKKIKREEVERLVK-EVPEEYSER--FS-------------------------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF-----------
---FEKISELGAGNGGVV---FKVSHKPSGL-VMARKLIHLE-IKPAIRN-QIIR------ELQVLHEC-NSPYIVGFYGAFYS-----------------------------DGEIS--ICMEHMDGG--SLDQVLK----KAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVN-SRGEI---KLCDFGVSG------QLIDSMANSFVGTRSYMSPERLQ---GTHYSVQSDIWSMGLSLVEMAVGR-YPIP-PP-DAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERAD-----LKQLMVHAFI-----------
---YQNLKPIGSGAQGIV---CAAYDAVLDRNVAIKKLSRPF-QNQTHAK-RAYR------ELVLMKCV-NHKNIISLLNVFTPQKT-----------------------LEEFQDVY--LVMELMDA---NLCQVIQ------MELDHERMSYLLYQMLCGIKHLHS-AGIIHRDLKPSNIVVK-SDCTL---KILDFGLART-----AGTSFMMTPYVVTRYYRAPEVIL---GMGYKENVDIWSVGCIMGEMVRHK-ILFP-GR-DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK--LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI-----------
---YRDLQPVGSGAYGAV---CSAVDGRTGAKVAIKKLYRPF-QSELFAK-RAYR------ELRLLKHM-RHENVIGLLDVFTPDET-----------------------LDDFTDFY--LVMPFMGT---DLGKLMK-----HEKLGEDRIQFLVYQMLKGLRYIHA-AGIIHRDLKPGNLAVN-EDCEL---KILDFGLAR-------QADSEMTGYVVTRWYRAPEVIL--NWMRYTQTVDIWSVGCIMAEMITGK-TLFK-GS-DHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE-------------KKDFASILTNASPLAVNLLEKMLVLDAEQRVT-----AGEALAHPYF-----------
KVT---SQVLGLGINGKV---LQIFNKRTQEKFALKMLQDCP-KAR--------R------EVELHWRASQCPHIVRIVDVYENLY-------------------------AGRKCLL--IVMECLDGG--ELFSRIQD--RGDQAFTEREASEIMKSIGEAIQYLHS-INIAHRDVKPENLLYT-SKRPNAILKLTDFGFAKE-----TTSHNSLTTPCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLCGY-PPFY-SNHGLAISPGMKTRIRMGQYEFPNPEWSEVS-------------------------------------EEVKMLIRNLLKTEPTQRMT-----ITEFMNHPWI-----------
--F-KFGKILGEGSFSTV---VLARELATSREYAIKILEKRH-IIKENKVPYVTR------ERDVMSRL-DHPFFVKLYFTFQD-----------------------------DEKLY--FGLSYAKNG--ELLKYIR----KIGSFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLN-EDMHI---QITDFGTAKVLS--PESKQARANSFVGTAQYVSPELLT---EKSACKSSDLWALGCIIYQLVAGL-PPFR-AG----NEYLIFQKIIKLEYDFPEKFF-----------------------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
-YV--RGRFLGKGGFAKC---FEISDADTKEVFAGKIVPKSL-LLKPHQR-EKMS-----MEISIHRSL-AHQHVVGFHGFFED-----------------------------NDFVF--VVLELCRRR--SLLELHK----RRKALTEPEARYYLRQIVLGCQYLHR-NRVIHRDLKLGNLFLN-EDLEV---KIGDFGLATKV----EYDGERKKTLCGTPNYIAPEVLS---KKGHSFEVDVWSIGCIMYTLLVGK-PPFE-TS----CLKETYLRIKKNEYSIPKHIN-----------------------------------------PVAASLIQKMLQTDPTARPT-----INELLNDEFF-----------
---FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKAT-LKVRDRV-RTKM------ERDILADV-NHPFVVKLHYAFQT-----------------------------EGKLY--LILDFLRGG--DLFTRLS----KEVMFTEEDVKFYLAELALGLDHLHS-LGIIYRDLKPENILLD-EEGHI---KLTDFGLSKEA----IDHEKKAYSFCGTVEYMAPEVVN---RQGHSHSADWWSYGVLMFEMLTGS-LPFQ-GK----DRKETMTLILKAKLGMPQFLS-----------------------------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY---------
YLM---GDLLGEGSYGKV---KEVLDSETLCRRAVKILKKKK-LRRIPNG-EANVK----KEIQLLRRL-RHKNVIQLVDVLYNE---------------------------EKQKMY--MVMEYCVCGMQEMLDSVP-----EKRFPVCQAHGYFCQLIDGLEYLHS-QGIVHKDIKPGNLLLT-TGGTL---KISDLGVAEALH--PFAADDTCRTSQGSPAFQPPEIAN-GLDTFSGFKVDIWSAGVTLYNITTGL-YPFE-GD----NIYKLFENIGKGSYAIPGDCG-----------------------------------------PPLSDLLKGMLEYEPAKRFS-----IRQIRQHSWF-----------
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