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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC GSK3B 203
Other AURKA 133
Other AURKB 77
Other AURKC 43
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
Other EIF2AK2 267
AGC PDPK1 82
-YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-RFKNR--------ELQIMRKLDHCNIVRLRYFFYSSG-------------------------EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ---LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQ-PIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF-----------
-FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEH-QLRR-EVEIQSHLRHPNILRLYGYFHD-----------------------------ATRVY--LILEYAPLG--TVYRELQ----KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGELKIADFGWSV----HAPSSRRTTLCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GK-PPFEAN---TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI-----------
-FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQ-IEKEGVE-HQLRREIEIQAHLHHPNILRLYNYFYD-----------------------------RRRIY--LILEYAPRG--ELYKELQ----KSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGELKIADFGWSV----HAPSLRRKTMCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GN-PPFESA---SHNETYRRIVKVDLKFPASVP--------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV-----------
-FEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQ-IEKEGLE-HQLRREIEIQAHLQHPNILRLYNYFHD-----------------------------ARRVY--LILEYAPRG--ELYKELQ----KSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLG-FRGEVKIADFGWSV----HTPSLRRKTMCGTLDYLPPEMIE-GRTYDEKVDLWCIGVLCYELLV-GY-PPFESA---SHSETYRRILKVDVRFPLSMP--------------------------LGARDLISRLLRYQPLERLPLAQILKHPWV-----------
-YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES-EEEGVPS-TAIR-EISLLKELRHPNIVSLQDVLMQ-----------------------------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF--GIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KK-PLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF-----------
-FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPS-TAIR-EISLLKELNHPNIVKLLDVIHT-----------------------------ENKLY--LVFEFLHQ---DLKKFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RR-ALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF-----------
-YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDEGVPS-SALR-EICLLKELKHKNIVRLHDVLHS-----------------------------DKKLT--LVFEFCDQ---DLKKYFD---SCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGELKLADFGLARAF--GIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGR-PLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF-----------
F-KEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNN-EKAER--------EVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEK--RRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLV-DTKQVKIGDFGLVTS---LKNDGKRTRSKGTLRYMSPEQIS-SQDYGKEVDLYALGLILAELLH-VCDTAFET-------SKFFTDLRDGIISDIFDK---------------------------KEKTLLQKLLSKKPEDRPNTSEILR----TLT--------
F-KFGKILGEGSFSTVVLARELATSREYAIKILEKRH-IIKENKVPYVTR-ERDVMSRLDHPFFVKLYFTFQD-----------------------------DEKLY--FGLSYAKNG--ELLKYIR----KIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVA-GL-PPFRAG---NEYLIFQKIIKLEYDFPEKFF--------------------------PKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
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