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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK HCK 203
TK ABL1 261
CMGC CDK2 4
CMGC CDK5 4
TK EGFR 712
TK INSR 1023
CMGC MAPK14 24
TK SRC 270
-LKLEKKLGAGQFGEVWMATYN------KHTKVAVKTMK-PGSM-SV--EAFL-AEANVMKTLQHDKLVKLHAVVT-------KEPIYIITEFMAKGSLLDFLK---SD--------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVI-E--DNEYTAREGAKFPIKWTAPEAIN-FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCP------------------------------EELYNIMMRCWKNRPEERPTFEYIQSV--L--
-ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLK-EDTM-EV--EEFL-KEAAVMKEIKHPNLVQLLGVCTR------EPPFYIITEFMTYGNLLDYLR---EC--------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM-T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F--
-FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDTETEGV--PSTAIREISLLKELNHPNIVKLLDVIHT------ENKLYLVFEFLHQ-DLKKFMDASALT-----------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
-YEKLEKIGEGTYGTVFKAKNR-----ETHEIVALKRVRLDDDDEGV--PSSALREICLLKELKHKNIVRLHDVLHS------DKKLTLVFEFCDQ-DLKKYFD-SCNG-----------DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYSA---EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT--TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF--
F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELR-EATS-PKANKEIL-DEAYVMASVDNPHVCRLLGICL-------TSTVQLITQLMPFGCLLDYVR---EH---------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGA--EEKEYHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICT------------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF
-ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN-ESAS-LRERIEFL-NEASVMKGFTCHHVVRLLGVVSK------GQPTLVVMELMAHGDLKSYLR---SLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYE--TDYYRKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCP------------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL----
-YQNLSPVGSGAYGSVCAAFDT-----KTGLRVAVKKLSRPFQSIIH--AKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVK---CQ-----------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR----HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF--
L-RLEVKLGQGCFGEVWMGTWN------GTTRVAIKTLK-PGTM-SP--EAFL-QEAQVMKKLRHEKLVQLYAVVS-------EEPIYIVTEYMSKGSLLDFLK---GE--------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI-E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L--
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