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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK IGF1R 203
TK ABL1 261
TK FGFR1 478
TK FLT4 845
TK JAK2 849
TK KDR 834
TK LCK 245
TK PTK2 422
TK SRC 270
TK TEK 824
-ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEF-NCHHVVRLLGVVS--QGQPTLVIMELMTRGDLKSYLRSLRPEM--------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI-YETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQP---------------YQGL-SNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISS-I--
-ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLKEDTMEV--EEFLKEAAVMKEI-KHPNLVQLLGVCT--REPPFYIITEFMTYGNLLDYLREC----------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--TGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI-DLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQA-F--
L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT--QDGPLYVIVEYASKGNLREYLQARRPPGLEY--------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI-HHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV-PVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL---
-LHLGRVLGYGAFGKVVEASAFG--IHKGSSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACT-KPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR--PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDI-YKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASP---------------YPGVQINEEFCQRLRDGTRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEIL---
-LKFLQQLGKGNFGSVEMCRYDP---LQDNTGEVVAVKKLQHSTE-EHLRDFEREIEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKH-----------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLA---LRV
-LKLGKPLGRGAFGQVIEADAFG--IDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACT-KPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI-YKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASP---------------YPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL---
-LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLKQGSMSP--DAFLAEANLMKQL-QHQRLVRLYAVVT---QEPIYIITEYMENGSLVDFLKTP----------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--EDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSV-L--
-IELGRCIGEGQFGDVHQGIYM----SPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQF-DHPHIVKLIGVIT---ENPVWIIMELCTLGELRSFLQVR-----------------------------------------------------------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM--EDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKP---------------FQGV-KNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQL---
L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLKPGTMSP--EAFLQEAQVMKKL-RHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLKGE----------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM-VNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAF-L--
-IKFQDVIGEGNFGQVLKARIK-----KDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACE--HRGYLYLAIEYAPHGNLLDFLRKSRVLETDP--------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ----EVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTP---------------YCGM-TCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILV--SL-
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