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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK IGF1R 203
TK ALK 1116
CMGC CDC2 4
TK ITK 363
TK MET 1078
TK RET 724
TK TEK 824
-ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-EAAS-MRERIEFL-NEASVMKEF-NCHHVVRLLGVVS-QGQPTLVIMELMTRGDLKSYLR----SLRPEM--------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDIYE--TDYY--RKGGKGLLPVRWMSPESLK-DGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCP----------------------------DMLFELMRMCWQYNPKMRPSFLEIISS--I-
I-TLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP-EVCS-EQDELDFL-MEALIISKF-NHQNIVRCIGVSL-QSLPRFILLELMAGGDLKSFLR----ETRP-----------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYR--ASYY--RKGGCAMLPVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCP----------------------------GPVYRIMTQCWQHQPEDRPNFAIILER--I-
-YTKIEKIGEGTYGVVYKGRHK-----TTGQVVAMKKIRLESEEEGV--PSTAIREISLLKEL-RHPNIVSLQDVLM-QDSRLYLIFEFLSM-DLKKYLDSIPPGQ-------------------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDD---KGTIKLADFGLARAF-GIPIRVY--TH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF-
-LTFVQEIGSGQFGLVHLGYWL------NKDKVAIKTIR-EGAM-SE--EDFI-EEAEVMMKL-SHPKLVQLYGVCL-EQAPICLVFEFMEHGCLSDYLR----TQ-----------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGE---NQVIKVSDFGMTRFV-L--DDQY--TSSTGTKFPVKWASPEVFS-FSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLAS----------------------------THVYQIMNHCWKERPEDRPAFSRLLRQL---
-VHFNEVIGRGHFGCVYHGTLL--DNDGKKIHCAVKSLN-RITD-IGEVSQFL-TEGIIMKDF-SHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIR----NE-----------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDE---KFTVKVADFGLARDMYD--KEYYSVHNKTGAKLPVKWMALESLQ-TQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCP----------------------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I-
L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENAS-PSELRDLL-SEFNVLKQV-NHPHVIKLYGACS-QDGPLLLIVEYAKYGSLRGFLR----ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDVYE--EDSY--VKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL---
-IKFQDVIGEGNFGQVLKARIK---KDGLRMDAAIKRMK-EYAS-KDDHRDFA-GELEVLCKLGHHPNIINLLGACE-HRGYLYLAIEYAPHGNLLDFLR----KSRVLETDP--------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGE---NYVAKIADFGLSRGQ-----EVY--VKKTMGRLPVRWMAIESLN-YSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCD----------------------------DEVYDLMRQCWREKPYERPSFAQILV---SL
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