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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK INSRR 203
TK ALK 1116
TK AXL 527
TK CSF1R 582
TK EGFR 712
TK ERBB2 720
TK ERBB4 718
TK FER 563
TK FES 561
TK FLT4 845
TK FYN 271
TK HCK 241
TK IGF1R 999
TK INSR 1023
TK JAK2 849
TK JAK3 822
TK KIT 589
TK LCK 245
TK LTK 510
TKL MAP3K7 36
TK MERTK 587
Other PLK1 53
TK PTK2 422
TK PTK2B 425
TK ROS1 1945
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA3 68
TK SRC 270
TK TEK 824
TK TNK1 116
STE YSK4 1162
TK ZAP70 338
---I-SIIRELGQGSFGMV---YEGLARG-LEAGEEST---PVALKTV---N-E-LAS-PRECIEFL-K----EASVMKAF-KCHHVVRLLGVVS--QGQP------TLVIMELMTRGDLKSHLR-SLRPEA------------------------------------------------------------------ENNPGL-PQPALGEMIQMAGEIADGMAYLAANK---FVHRDLAARNCMVSQ-----DF-TVKIGDFGMTRDV----Y---E--TDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQP---------------YQGL--SNEQVLKFVMDGGVLEELEGCP----LQLQELMSRCWQPNPRLRPS-----FTHILD---SI-
---I-TLIRGLGHGAFGEV---YEGQVSG-MPNDPSPL---QVAVKTL---P-E-VCS-EQDELDFL-M----EALIISKF-NHQNIVRCIGVSL--QSLP------RFILLELMAGGDLKSFLR-ETRP---------------------------------------------------------------------RPSQP-SSLAMLDLLHVARDIACGCQYLEENH---FIHRDIAARNCLLTCP--GPGR-VAKIGDFGMARDI----Y---R--ASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMP---------------YPSK--SNQEVLEFVTSGGRMDPPKNCP----GPVYRIMTQCWQHQPEDRPN-----FAIILER--I--
---V-ALGKTLGEGEFGAV---MEGQLN----QDDSIL---KVAVKTM---K-IAICT-RSELEDFL-S----EAVCMKEF-DHPNVMRLIGVCF--QGSERESFPAPVVILPFMKHGDLHSFLL-YSRL----------------------------------------------------------------------GDQP-VYLPTQMLVKFMADIASGMEYLSTKR---FIHRDLAARNCMLNE-----NM-SVCVADFGLSKKI----Y---N--GDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTP---------------YPGV--ENSEIYDYLRQGNRLKQPADCL----DGLYALMSRCWELNPQDRPS-----FTELREDL----
----LQFGKTLGAGAFGKV---VEATAFG-LGKEDAVL---KVAVKML---K-S-TAH-ADEKEALM-S----ELKIMSHLGQHENIVNLLGACT--HGGP------VLVITEYCCYGDLLNFLR-RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR-------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDG-RPLELRDLLHFSSQVAQGMAFLASKN---CIHRDVAARNVLLTN-----GH-VAKIGDFGLARDI----M---N--DSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNP---------------YPGI-LVNSKFYKLVKDGYQMAQPAFAP----KNIYSIMQACWALEPTHRPT-----FQQICSFL----
---F-KKIKVLGSGAFGTV---YKGLWIP--EGEKVKI---PVAIKEL---R-E-ATS-PKANKEIL-D----EAYVMASV-DNPHVCRLLGICL---TST------VQLITQLMPFGCLLDYVR-EH---------------------------------------------------------------------------K-DNIGSQYLLNWCVQIAKGMNYLEDRR---LVHRDLAARNVLVKT-----PQ-HVKITDFGLAKLL----G---A--EEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGI--PASEISSILEKGERLPQPPICT----IDVYMIMVKCWMIDADSRPK-----FRELI----IEF
---L-RKVKVLGSGAFGTV---YKGIWIP--DGENVKI---PVAIKVL---R-E-NTS-PKANKEIL-D----EAYVMAGV-GSPYVSRLLGICL---TST------VQLVTQLMPYGCLLDHVR-EN---------------------------------------------------------------------------R-GRLGSQDLLNWCMQIAKGMSYLEDVR---LVHRDLAARNVLVKS-----PN-HVKITDFGLARLL----D---I--DETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKP---------------YDGI--PAREIPDLLEKGERLPQPPICT----IDVYMIMVKCWMIDSECRPR-----FRELVSE--F--
---L-KRVKVLGSGAFGTV---YKGIWVP--EGETVKI---PVAIKIL---N-E-TTG-PKANVEFM-D----EALIMASM-DHPHLVRLLGVCL---SPT------IQLVTQLMPHGCLLEYVH-EH---------------------------------------------------------------------------K-DNIGSQLLLNWCVQIAKGMMYLEERR---LVHRDLAARNVLVKS-----PN-HVKITDFGLARLL----E---G--DEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKP---------------YDGI--PTREIPDLLEKGERLPQPPICT----IDVYMVMVKCWMIDADSRPK-----FKELAAE--F--
--VI--LGELLGKGNFGEV---YKGTLK-------DKT---SVAVKTC---K-E-DLP-QELKIKFL-Q----EAKILKQY-DHPNIVKLIGVCT--QRQP------VYIIMELVSGGDFLTFLR-RK---------------------------------------------------------------------------K-DELKLKQLVKFSLDAAAGMLYLESKN---CIHRDLAARNCLVGE-----NN-VLKISDFGMSRQE--------D--GGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCP---------------YPGM--TNQQAREQVERGYRMSAPQHCP----EDISKIMMKCWDYKPENRPK-----FSELQKEL----
---L-VLGEQIGRGNFGEV---FSGRLR------ADNT---LVAVKSC---R-E-TLP-PDLKAKFL-Q----EARILKQY-SHPNIVRLIGVCT--QKQP------IYIVMELVQGGDFLTFLR-TE---------------------------------------------------------------------------G-ARLRVKTLLQMVGDAAAGMEYLESKC---CIHRDLAARNCLVTE-----KN-VLKISDFGMSREE----A---D--GVYAASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASP---------------YPNL--SNQQTREFVEKGGRLPCPELCP----DAVFRLMEQCWAYEPGQRPS-----FSTIYQEL----
----LHLGRVLGYGAFGKV---VEASAFG-IHKGSSCD---TVAVKML---K-E-GAT-ASEHRALM-S----ELKILIHIGNHLNVVNLLGACT-KPQGP------LMVIVEFCKYGNLSNFLR-AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWL-SPLTMEDLVCYSFQVARGMEFLASRK---CIHRDLAARNILLSE-----SD-VVKICDFGLARDI----Y---K--DPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASP---------------YPGV-QINEEFCQRLRDGTRMRAPELAT----PAIRRIMLNCWSGDPKARPA-----FSELVEIL----
----LQLIKRLGNGQFGEV---WMGTWN-------GNT---KVAIKTL---K-P-GTM-SP--ESFL-E----EAQIMKKL-KHDKLVQLYAVVS---EEP------IYIVTEYMNKGSLLDFLK-DG--------------------------------------------------------------------------EG-RALKLPNLVDMAAQVAAGMAYIERMN---YIHRDLRSANILVGN-----GL-ICKIADFGLARLI--------E--DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVP---------------YPGM--NNREVLEQVERGYRMPCPQDCP----ISLHELMIHCWKKDPEERPT-----FEYLQSFL----
----LKLEKKLGAGQFGEV---WMATYN-------KHT---KVAVKTM---K-P-GSM-SV--EAFL-A----EANVMKTL-QHDKLVKLHAVVT---KEP------IYIITEFMAKGSLLDFLK-SD--------------------------------------------------------------------------EG-SKQPLPKLIDFSAQIAEGMAFIEQRN---YIHRDLRAANILVSA-----SL-VCKIADFGLARVI--------E--DNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIP---------------YPGM--SNPEVIRALERGYRMPRPENCP----EELYNIMMRCWKNRPEERPT-----FEYIQSV--L--
----ITMSRELGQGSFGMV---YEGVAKG-VVKDEPET---RVAIKTV---N-E-AAS-MRERIEFL-N----EASVMKEF-NCHHVVRLLGVVS--QGQP------TLVIMELMTRGDLKSYLR-SLRPEM------------------------------------------------------------------ENNPVL-APPSLSKMIQMAGEIADGMAYLNANK---FVHRDLAARNCMVAE-----DF-TVKIGDFGMTRDI----Y---E--TDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQP---------------YQGL--SNEQVLRFVMEGGLLDKPDNCP----DMLFELMRMCWQYNPKMRPS-----FLEIISS--I--
----ITLLRELGQGSFGMV---YEGNARD-IIKGEAET---RVAVKTV---N-E-SAS-LRERIEFL-N----EASVMKGF-TCHHVVRLLGVVS--KGQP------TLVVMELMAHGDLKSYLR-SLRPEA------------------------------------------------------------------ENNPGR-PPPTLQEMIQMAAEIADGMAYLNAKK---FVHRDLAARNCMVAH-----DF-TVKIGDFGMTRDI----Y---E--TDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQP---------------YQGL--SNEQVLKFVMDGGYLDQPDNCP----ERVTDLMRMCWQFNPKMRPT-----FLEIVNLL----
----LKFLQQLGKGNFGSV---EMCRYDP--LQDNTGE---VVAVKKL---Q-H-STE--EHLRDFE-R----EIEILKSL-QHDNIVKYKGVCYSAGRRN------LKLIMEYLPYGSLRDYLQ-KH---------------------------------------------------------------------------K-ERIDHIKLLQYTSQICKGMEYLGTKR---YIHRDLATRNILVEN-----EN-RVKIGDFGLTKVL---PQ---D--KEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM--IVFHLIELLKNNGRLPRPDGCP----DEIYMIMTECWNNNVNQRPS-----FRDLA----LRV
---L-KYISQLGKGNFGSV---ELCRYDP--LGDNTGA---LVAVKQL---Q-H-SGP-DQ-QRDFQ-R----EIQILKAL-HSDFIVKYRGVSYGPGRQS------LRLVMEYLPSGCLRDFLQ-RH---------------------------------------------------------------------------R-ARLDASRLLLYSSQICKGMEYLGSRR---CVHRDLAARNILVES-----EA-HVKIADFGLAKLL---PL---D--KDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDV-PALCRLLELLEEGQRLPAPPACP----AEVHELMKLCWAPSPQDRPS-----FSALGP---QL-
----LSFGKTLGAGAFGKV---VEATAYG-LIKSDAAM---TVAVKML---K-P-SAH-LTEREALM-S----ELKVLSYLGNHMNIVNLLGACT--IGGP------TLVITEYCCYGDLLNFLR-RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDE-LALDLEDLLSFSYQVAKGMAFLASKN---CIHRDLAARNILLTH-----GR-ITKICDFGLARDI----K---N--DSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSP---------------YPGM-PVDSKFYKMIKEGFRMLSPEHAP----AEMYDIMKTCWDADPLKRPT-----FKQIVQL--I--
----LKLVERLGAGQFGEV---WMGYYN-------GHT---KVAVKSL---K-Q-GSM-SP--DAFL-A----EANLMKQL-QHQRLVRLYAVVT---QEP------IYIITEYMENGSLVDFLK-TP--------------------------------------------------------------------------SG-IKLTINKLLDMAAQIAEGMAFIEERN---YIHRDLRAANILVSD-----TL-SCKIADFGLARLI--------E--DNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM--TNPEVIQNLERGYRMVRPDNCP----EELYQLMRLCWKERPEDRPT-----FDYLRSV--L--
---V-TLLRALGHGAFGEV---YEGLVIG-LPGDSSPL---QVAIKTL---P-E-LCS-PQDELDFL-M----EALIISKF-RHQNIVRCVGLSL--RATP------RLILLELMSGGDMKSFLR-HSRP---------------------------------------------------------------------HLGQP-SPLVMRDLLQLAQDIAQGCHYLEENH---FIHRDIAARNCLLSCA--GPSR-VAKIGDFGMARDI----Y---R--ASYYRRGDRALLPVKWMPPEAFLEGIFTSKTDSWSFGVLLWEIFSLGYMP---------------YPGR--TNQEVLDFVVGGGRMDPPRGCP----GPVYRIMTQCWQHEPELRPS-----FASILERL----
----IEVEEVVGRGAFGVV---CKAKWR--------AK---DVAIKQI---E-----S-ESERKAFI-V----ELRQLSRV-NHPNIVKLYGACL----NP------VCLVMEYAEGGSLYNVLH-GA--------------------------------------------------------------------------EPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVA-----GGTVLKICDFGTACDI--------------QTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITR-RKP---------------FDEIGGPAFRIMWAVHNGTRPPLIKNLP----KPIESLMTRCWSKDPSQRPS-----MEEIVKI--M--
---L-ILGKILGEGEFGSV---MEGNLK---QEDGTSL---KVAVKTM---KLD-NSS-QREIEEFL-S----EAACMKDF-SHPNVIRLLGVCI--EMSSQG-IPKPMVILPFMKYGDLHTYLL-YSRL----------------------------------------------------------------------ETGP-KHIPLQTLLKFMVDIALGMEYLSNRN---FLHRDLAARNCMLRD-----DM-TVCVADFGLSKKI----Y---S--GDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTP---------------YPGV--QNHEMYDYLLHGHRLKQPEDCL----DELYEIMYSCWRTDPLDRPT-----FSVLRLQ--L--
--YV--RGRFLGKGGFAKC---FEISDA------DTKE---VFAGKIV---PKS-LLLKPH--QREKMS---MEISIHRSL-AHQHVVGFHGFFE--DNDF------VFVVLELCRRRSLLELHKRRK------------------------------------------------------------------------------ALTEPEARYYLRQIVLGCQYLHRNR---VIHRDLKLGNLFLNE-----DL-EVKIGDFGLATKV--------EYDGERKKT---LCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLV-GKPP---------------FETS-----CLKETYLRIKKNEYSIPKHIN--PVAASLIQKMLQTDPTARPT-----INELLNDEFF--
----IELGRCIGEGQFGDV---HQGIYM---SPENPAL---AVAIKTC---K-N-CTS-DSVREKFL-Q----EALTMRQF-DHPHIVKLIGVIT---ENP------VWIIMELCTLGELRSFLQ-VR---------------------------------------------------------------------------K-YSLDLASLILYAYQLSTALAYLESKR---FVHRDIAARNVLVSS-----ND-CVKLGDFGLSRYM--------E--DSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKP---------------FQGV--KNNDVIGRIENGERLPMPPNCP----PTLYSLMTKCWAYDPSRRPR-----FTELKAQL----
---V-VLNRILGEGFFGEV---YEGVYT---NHKGEKI---NVAVKTC---K-K-DCT-LDNKEKFM-S----EAVIMKNL-DHPHIVKLIGIIE---EEP------TWIIMELYPYGELGHYLE-RN---------------------------------------------------------------------------K-NSLKVLTLVLYSLQICKAMAYLESIN---CVHRDIAVRNILVAS-----PE-CVKLGDFGLSRYI--------E--DEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQP---------------FFWL--ENKDVIGVLEKGDRLPKPDLCP----PVLYTLMTRCWDYDPSDRPR-----FTELVCS--L--
--LT--LRLLLGSGAFGEV---YEGTAVDILGVGSGEI---KVAVKTL---K-K-GST-DQEKIEFL-K----EAHLMSKF-NHPNILKQLGVCL--LNEP------QYIILELMEGGDLLTYLR-KARM---------------------------------------------------------------------ATFYG-PLLTLVDLVDLCVDISKGCVYLERMH---FIHRDLAARNCLVSVKDYTSPR-IVKIGDFGLARDI----Y---K--NDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQP---------------YPAH--SNLDVLNYVQTGGRLEPPRNCP----DDLWNLMTQCWAQEPDQRPT-----FHRIQDQL----
----FELLKVLGQGSFGKVFLVRKVTRP------DSGH---LYAMKVL---KKA-TLKVRD--RVRTKM----ERDILADV-NHPFVVKLHYAFQ--TEGK------LYLILDFLRGGDLFTRLSKEV------------------------------------------------------------------------------MFTEEDVKFYLAELALGLDHLHSLG---IIYRDLKPENILLDE-----EG-HIKLTDFGLSKEA--------IDHEKKAYS---FCGTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLT-GSLP---------------FQGK-----DRKETMTLILKAKLGMPQFLS--TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY
----FELLKVLGQGSYGKV---FLVRKV------KGSDAGQLYAMKVL---KKA-TLKVRD--RVRSKM----ERDILAEV-NHPFIVKLHYAFQ--TEGK------LYLILDFLRGGDLFTRLSKEV------------------------------------------------------------------------------MFTEEDVKFYLAELALALDHLHSLG---IIYRDLKPENILLDE-----EG-HIKITDFGLSKEA--------IDHDKRAYS---FCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLT-GSLP---------------FQGK-----DRKETMALILKAKLGMPQFLS--GEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF--
----FELLKVLGQGSFGKV---FLVKKI------SGSDARQLYAMKVL---KKA-TLKVRD--RVRTKM----ERDILVEV-NHPFIVKLHYAFQ--TEGK------LYLILDFLRGGDLFTRLSKEV------------------------------------------------------------------------------MFTEEDVKFYLAELALALDHLHSLG---IIYRDLKPENILLDE-----EG-HIKLTDFGLSKES--------IDHEKKAYS---FCGTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLT-GTLP---------------FQGK-----DRKETMTMILKAKLGMPQFLS--PEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF--
---L-RLEVKLGQGCFGEV---WMGTWN-------GTT---RVAIKTL---K-P-GTM-SP--EAFL-Q----EAQVMKKL-RHEKLVQLYAVVS---EEP------IYIVTEYMSKGSLLDFLK-GE--------------------------------------------------------------------------TG-KYLRLPQLVDMAAQIASGMAYVERMN---YVHRDLRAANILVGE-----NL-VCKVADFGLARLI--------E--DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGM--VNREVLDQVERGYRMPCPPECP----ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L--
----IKFQDVIGEGNFGQV---LKARIK----KDGLRM---DAAIKRM---K-E-YAS-KDDHRDFA-G----ELEVLCKLGHHPNIINLLGACE--HRGY------LYLAIEYAPHGNLLDFLR-KSRVLETDP------------------------------------------------------------AFAIANSTA-STLSSQQLLHFAADVARGMDYLSQKQ---FIHRDLAARNILVGE-----NY-VAKIADFGLSRGQ------------EVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTP---------------YCGM--TCAELYEKLPQGYRLEKPLNCD----DEVYDLMRQCWREKPYERPS-----FAQILV---SL-
-VCR---GELLGSGCFGVV---HRGLWT---LPSGKSV---PVAVKSLRVGP-E-GPM-GTELGDFL-R----EVSVMMNL-EHPHVLRLHGLVL---GQP------LQMVMELAPLGSLHARLT-AP-------------------------------------------------------------------------APT-PPLLVALLCLFLRQLAGAMAYLGARG---LVHRDLATRNLLLAS-----PR-TIKVADFGLVRPL---GG---A--RGRYVMGGPRPIPYAWCAPESLRHGAFSSASDVWMFGVTLWEMFSGGEEP---------------WAGV--PPYLILQRLEDRARLPRPPLCS----RALYSLALRCWAPHPADRPS-----FSHLE----GLL
----WTKGEILGKGAYGTV---YCGLTS------QGQ----LIAVKQV---ALD-TSNKLA--AEKEYRKLQEEVDLLKAL-KHVNIVAYLGTCL--QENT------VSIFMEFVPGGSISSIINRFG------------------------------------------------------------------------------PLPEMVFCKYTKQILQGVAYLHENC---VVHRDIKGNNVMLMP-----TG-IIKLIDFGCARRLAWA--GLNGTHSDMLKS---MHGTPYWMAPEVINESGYGRKSDIWSIGCTVFEMAT-GKPP---------------LASM----DRMAAMFYIGAHRGLMPPLPDHFSENAADFVRMCLTRDQHERPS-----ALQLLKHSFL--
LIAD----IELGCGNFGSV---RQGVYR----MRKKQI---DVAIKVL---K-Q-GTE-KADTEEMM-R----EAQIMHQL-DNPYIVRLIGVCQ---AEA------LMLVMEMAGGGPLHKFLV-GK---------------------------------------------------------------------------R-EEIPVSNVAELLHQVSMGMKYLEEKN---FVHRDLAARNVLLVN-----RH-YAKISDFGLSKAL---GA---D--DSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKP---------------YKKM--KGPEVMAFIEQGKRMECPPECP----PELYALMSDCWIYKWEDRPD-----FLTVEQR--M--
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