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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK JAK3 203
CMGC GSK3B 56
TK JAK1 875
TK JAK2 849
AGC PRKCA 339
AGC PRKCB 342
AGC PRKCH 355
AGC PRKCQ 380
-L-KYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQ-HSGP-DQ-QRDFQ-R-EIQILKAL-HSDFIVKYRGVSYGPG----RQS--LR--LVMEYLPSG--CLRDFLQ-----RHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVE-SEAHVKIADFGLAKLLPLD--KDYYVVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACP----------------------------AEVHELMKLCWAPSPQDRPS------FS-ALGP---QL-------------
--YTDTKVIGNGSFGVVYQAKLC----DSGELVAIKKVLQDKRFKNR---------ELQIMRKL-DHCNIVRLRYFFY--SSGEKKDE--VYLNLVLDYVPETVYRVA---RHYSRAKQ--TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ---LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPI---------------FPGD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT------PL-EACAHSFF--------------
-L-KRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLK-PESG-GNHIADLK-K-EIEILRNL-YHENIVKYKGICT-ED-----GGNGIK--LIMEFLPSG--SLKEYLP-----KNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVE-SEHQVKIGDFGLTKAIETD--KEYYTVKDDRDSPVFWYAPECLM-QSKFYIASDVWSFGVTLHELLTYCDSDSSPMALF-LKMIGPTHGQM-TVTRLVNTLKEGKRLPCPPNCP----------------------------DEVYQLMRKCWEFQPSNRTS------FQ-NLIE---GF-------------
--LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ-HSTE--EHLRDFE-R-EIEILKSL-QHDNIVKYKGVCYSAG----RRN--LK--LIMEYLPYG--SLRDYLQ-----KHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-NENRVKIGDFGLTKVLPQD--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPS------FR-DLA----LRV------------
-F-NFLMVLGKGSFGKVMLADRK----GTEELYAIKILKKDVVIQDD--DVECTMVEKRVLALLDKPPFLTQLHSCFQ--T----VDR--LY--FVMEYVNGG--DLMYHIQ----QVG--KFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLD-SEGHIKIADFGMCKEH--MMDGVTTRT---FCGTPDYIAPEIIA-YQPYGKSVDWWAYGVLLYEMLA-GQPP---------------FDGE----DEDELFQSIMEHNVSYPKSLS--------------------------KEAVSVCKGLMTKHPAKRLG------C----------GPEGERDVREHAFF
-F-NFLMVLGKGSFGKVMLSERK----GTDELYAVKILKKDVVIQDD--DVECTMVEKRVLALPGKPPFLTQLHSCFQ--T----MDR--LY--FVMEYVNGG--DLMYHIQ----QVG--RFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLD-SEGHIKIADFGMCKEN--IWDGVTTKT---FCGTPDYIAPEIIA-YQPYGKSVDWWAFGVLLYEMLA-GQAP---------------FEGE----DEDELFQSIMEHNVAYPKSMS--------------------------KEAVAICKGLMTKHPGKRLG------C----------GPEGERDIKEHAFF
--FEFIRVLGKGSFGKVMLARVK----ETGDLYAVKVLKKDVILQDD--DVECTMTEKRILSLARNHPFLTQLFCCFQ--T----PDR--LF--FVMEFVNGG--DLMFHIQ----KSR--RFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLD-HEGHCKLADFGMCKEG--ICNGVTTAT---FCGTPDYIAPEILQ-EMLYGPAVDWWAMGVLLYEMLC-GHAP---------------FEAE----NEDDLFEAILNDEVVYPTWLH--------------------------EDATGILKSFMTKNPTMRLGSLTQGGEH-AILRHPF-F-------------
FI--LHKMLGKGSFGKVFLAEFK----KTNQFFAIKALKKDVVLMDD--DVECTMVEKRVLSLAWEHPFLTHMFCTFQ--T----KEN--LF--FVMEYLNGG--DLMYHIQ----SCH--KFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLD-KDGHIKIADFGMCKEN--MLGDAKTNT---FCGTPDYIAPEILL-GQKYNHSVDWWSFGVLLYEMLI-GQSP---------------FHGQ----DEEELFHSIRMDNPFYPRWLE--------------------------KEAKDLLVKLFVREPEKRLG------VRGDIRQHPLF--------------
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