|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK LCK 203
Other AURKA 133
CMGC CDC2 4
CMGC CDK2 4
TK CSF1R 582
TK ITK 363
TK JAK2 849
CMGC MAPK14 24
AGC PRKCB 342
TK SYK 371
TK ZAP70 338
----LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLK-QG-SM-SP---DAFL-A-EANLMKQL--QHQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK----TP-------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--E--DNEY-TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGM-TNPEVIQNLERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--------------
----FEIGRPLGKGKFGNVYLAREK-----QSKFILALKVLFKAQLEKAGV---EHQLRR-EVEIQSHL--RHPNILRLYGYFH--D------ATRVYLILEYAPLGTVYRELQ---KLS----------------------------------------------------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV----HAPSSRR-TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN----TYQETYKRISRVEFTFPDFVT----------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--------------
----YTKIEKIGEGTYGVVYKGRHK-----TTGQVVAMKKIRLES-EEEGV---PSTAIR-EISLLKEL--RHPNIVSLQDVLM--Q------DSRLYLIFEFLSM-DLKKYLDSIPPGQ----------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVY-TH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FHGD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--------------
----FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDT-ETEGV---PSTAIR-EISLLKEL--NHPNIVKLLDVIH--T------ENKLYLVFEFLHQ-DLKKFMDA-SALT----------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTY-TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--------------
----LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK-ST-AH-ADE-KEALM-S-ELKIMSHLG-QHENIVNLLGACT--H------GGPVLVITEYCCYGDLLNFLR----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI-MN--DSNY-IVKGNARLPVKWMAPESIF-DCVYTVQSDVWSYGILLWEIFSLGLNP---------------YPGILVNSKFYKLVKDGYQMAQPAFAP------------------------------KNIYSIMQACWALEPTHRPTFQQICSFL----------------
----LTFVQEIGSGQFGLVHLGYWL------NKDKVAIKTIR-EG-AM-SE---EDFI-E-EAEVMMKL--SHPKLVQLYGVCL--E------QAPICLVFEFMEHGCLSDYLR----TQ--------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFV--L--DDQY-TSSTGTKFPVKWASPEVFS-FSRYSSKSDVWSFGVLMWEVFSEGKIP---------------YENR-SNSEVVEDISTGFRLYKPRLAS------------------------------THVYQIMNHCWKERPEDRPAFSRLLRQL----------------
----LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKLQ-HS-TE--EH-LRDFE-R-EIEILKSL--QHDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ----KH--------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD--KEYY-KVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV------------
----YQNLSPVGSGAYGSVCAAFDT-----KTGLRVAVKKLSRPF-QSIIH---AKRTYR-ELRLLKHM--KHENVIGLLDVFT--PARSLEEFNDVYLVTHLMGA-DLNNIVK----CQ----------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDEM-TG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FPGT-DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF--------------
---F-NFLMVLGKGSFGKVMLSERK-----GTDELYAVKILKKDV-VIQDD---DVECTMVEKRVLALP-GKPPFLTQLHSCFQ--T------MDRLYFVMEYVNGGDLMYHIQ---QVG----------------------------------------------------------------------RFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKEN--IWDGVTT-KT---FCGTPDYIAPEIIA-YQPYGKSVDWWAFGVLLYEMLA-GQAP---------------FEGE----DEDELFQSIMEHNVAYPKSMS----------------------------KEAVAICKGLMTKHPGKRLGC---------GPEGERDIKEHAFF
-TLE---DKELGSGNFGTVKKGYYQ---MKKVVKTVAVKILK-NE-AN-DPALKDELL-A-EANVMQQL--DNPYIVRMIGICE---------AESWMLVMEMAELGPLNKYLQ----QN---------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL-RA--DENYYKAQTHGKWPVKWYAPECIN-YYKFSSKSDVWSFGVLMWEAFSYGQKP---------------YRGM-KGSEVTAMLEKGERMGCPAGCP------------------------------REMYDLMNLCWTYDVENRPGFAAVE----LRL------------
LIAD----IELGCGNFGSVRQGVYR---MRKKQIDVAIKVLK-QG-TE-KAD-TEEMM-R-EAQIMHQL--DNPYIVRLIGVCQ---------AEALMLVMEMAGGGPLHKFLV----GK--------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD--DSYY-TARSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQKP---------------YKKM-KGPEVMAFIEQGKRMECPPECP------------------------------PELYALMSDCWIYKWEDRPDFLTVEQR--M--------------
|