|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK LCK 203
Other AURKA 133
TK BTK 402
CMGC CDC2 4
CMGC CDK2 4
TK CSF1R 582
CMGC MAPK14 24
Other NEK2 8
AGC PRKCB 342
TK SYK 371
TK TNK2 150
TK ZAP70 338
----LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLK-Q--G-SM-SP---DAFL-A-EANLMKQL--QHQRLVRLYAVVT-------QEPIYIITEYMENGSLVDFLK-----TP-------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER-----NYIHRDLRAANILVSDTLSCKIADFGLARLI--E--DNEY-TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNL-ERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--------------
----FEIGRPLGKGKFGNVYLAREK-----QSKFILALKVLFKA--QLEKAGV---EHQLRR-EVEIQSHL--RHPNILRLYGYFHD------ATRVYLILEYAPLGTVYRELQ----KLS----------------------------------------------------------------------KFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLGSAGELKIADFGWSV----HAPSSRR-TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN----TYQETY-KRISRVEFTFPDFVT----------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--------------
----LTFLKELGTGQFGVVKYGKWR------GQYDVAIKMIK-E--G-SM-SE---DEFI-E-EAKVMMNL--SHEKLVQLYGVCTK------QRPIFIITEYMANGCLLNYLR-----EM--------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESK-----QFLHRDLAARNCLVNDQGVVKVSDFGLSRYV--L--DDEY-TSSVGSKFPVRWSPPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMPYERF-TNSETAEHI-AQGLRLYRPHLAS------------------------------EKVYTIMYSCWHEKADERPTFKILLSN--I--------------
----YTKIEKIGEGTYGVVYKGRHK-----TTGQVVAMKKIRLE--S-EEEGV---PSTAIR-EISLLKEL--RHPNIVSLQDVLMQ------DSRLYLIFEFLSM-DLKKYLDS-IPPGQ----------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSR-----RVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVY-TH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGD-SEIDQLFRI-FRALGTPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--------------
----FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLD--T-ETEGV---PSTAIR-EISLLKEL--NHPNIVKLLDVIHT------ENKLYLVFEFLHQ-DLKKFMDA--SALT----------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTY-TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD-SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--------------
----LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK-S--T-AH-ADE-KEALM-S-ELKIMSHLG-QHENIVNLLGACTH------GGPVLVITEYCCYGDLLNFLR-----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASK-----NCIHRDVAARNVLLTNGHVAKIGDFGLARDI-MN--DSNY-IVKGNARLPVKWMAPESIF-DCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLV-KDGYQMAQPAFAP------------------------------KNIYSIMQACWALEPTHRPTFQQICSFL----------------
----YQNLSPVGSGAYGSVCAAFDT-----KTGLRVAVKKLSRP--F-QSIIH---AKRTYR-ELRLLKHM--KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVK-----CQ----------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSA-----DIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDEM-TG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT-DHIDQLKLI-LRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF--------------
----YEVLYTIGTGSYGRCQKIRRK-----SDGKILVWKELDYG--S-MTEAE---KQMLVS-EVNLLREL--KHPNIVRYYDRIIDR----TNTTLYIVMEYCEGGDLASVITKGTKERQ----------------------------------------------------------------------YLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARIL--NHDTSFA-KT---FVGTPYYMSPEQMN-RMSYNEKSDIWSLGCLLYELCA-LMPPFTAF----SQKELA-GKIREGKFRRIPYRY---S------------------------DELNEIITRMLNLKDYHRPSVEEILENPL-I-------------
---F-NFLMVLGKGSFGKVMLSERK-----GTDELYAVKILKKD--V-VIQDD---DVECTMVEKRVLALP-GKPPFLTQLHSCFQT------MDRLYFVMEYVNGGDLMYHIQ----QVG----------------------------------------------------------------------RFKEPHAVFYAAEIAIGLFFLQSK-----GIIYRDLKLDNVMLDSEGHIKIADFGMCKEN--IWDGVTT-KT---FCGTPDYIAPEIIA-YQPYGKSVDWWAFGVLLYEMLA-GQAPFEGE----DEDELF-QSIMEHNVAYPKSMS----------------------------KEAVAICKGLMTKHPGKRLGC---------GPEGERDIKEHAFF
-TLE---DKELGSGNFGTVKKGYYQ---MKKVVKTVAVKILK-N--E-AN-DPALKDELL-A-EANVMQQL--DNPYIVRMIGICE-------AESWMLVMEMAELGPLNKYLQ-----QN---------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEES-----NFVHRDLAARNVLLVTQHYAKISDFGLSKAL-RA--DENYYKAQTHGKWPVKWYAPECIN-YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGM-KGSEVTAML-EKGERMGCPAGCP------------------------------REMYDLMNLCWTYDVENRPGFAAVE----LRL------------
---L-RLLEKLGDGSFGVVRRGEWD--APSGKTVSVAVKCLK-PDVL-SQ-PEA-MDDFI-R-EVNAMHSL--DHRNLIRLYGVVL-------TPPMKMVTELAPLGSLLDRLR-----KH--------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESK-----RFIHRDLAARNLLLATRDLVKIGDFGLMRALPQN--DDHY-VMQEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEPWIGL-NGSQILHKIDKEGERLPRPEDCP------------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L--------------
LIAD----IELGCGNFGSVRQGVYR---MRKKQIDVAIKVLK-Q--G-TE-KAD-TEEMM-R-EAQIMHQL--DNPYIVRLIGVCQ-------AEALMLVMEMAGGGPLHKFLV-----GK--------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEK-----NFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD--DSYY-TARSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQKPYKKM-KGPEVMAFI-EQGKRMECPPECP------------------------------PELYALMSDCWIYKWEDRPDFLTVEQR--M--------------
|