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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK LCK 203
TK ABL1 261
Other AURKA 133
TKL BRAF 456
TK BTK 402
TK CSF1R 582
TK EPHA3 621
TK EPHA7 633
TK FGFR1 478
TK FLT1 827
TK FLT4 845
TK INSR 1023
TK KDR 834
TK KIT 589
CMGC MAPK14 24
TK MET 1078
TK PDGFRA 593
TK PDGFRB 600
TK SRC 270
TK TEK 824
-LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q-G-SM-SP--DAFL-AEANLMKQL-QHQRLVRLYAVVT--------QEPIYIITEYMENGSLVDFLK-TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI-E--DNEY--TAREGAKFPIKWTAPEAIN-YGT---FTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNLERGYR----MVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L-
-ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E-D-TM-EV--EEFL-KEAAVMKEI-KHPNLVQLLGVCT-R------EPPFYIITEFMTYGNLLDYLR-EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM-T--GDTY--TAHAGAKFPIKWTAPESLA-YNK---FSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELLEKDYR----MERPEGCP------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F-
-FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA-QLEKAGV--EHQLRREVEIQSHL-RHPNILRLYGYFH-D------ATRVYLILEYAPLGTVYRELQKLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV---HAPSSRR--TT---LCGTLDYLPPEMIE-GRM---HDEKVDLWSLGVLCYEFLV-GKPPFEAN----TYQETYKRISR----VEFTFPDFVT----------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI-
-ITVGQRIGSGSFGTVYKGKWH----------GDVAVKMLN-VTA-PT-PQQLQAFK-NEVGVLRKT-RHVNILLFMGYST--------KPQLAIVTQWCEGSSLYHHLH-II--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSR--WSGS--HQFEQLSGSILWMAPEVIR-MQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCP------------------------------KAMKRLMAECLKKKRDERPLFPQILA---SI
-LTFLKELGTGQFGVVKYGKWR--------GQYDVAIKMIK-E-G-SM-SE--DEFI-EEAKVMMNL-SHEKLVQLYGVCT-K------QRPIFIITEYMANGCLLNYLR-EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYV-L--DDEY--TSSVGSKFPVRWSPPEVLM-YSK---FSSKSDIWAFGVLMWEIYSLGKMPYERF-TNSETAEHIAQGLR----LYRPHLAS------------------------------EKVYTIMYSCWHEKADERPTFKILLSN--I-
-LQFGKTLGAGAFGKVVEATAFG--LGKEDAVLKVAVKMLK-S-T-AH-ADEKEALM-SELKIMSHLGQHENIVNLLGACT-H------GGPVLVITEYCCYGDLLNFLR-RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMN--DSNY--IVKGNARLPVKWMAPESIF-DCV---YTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQ----MAQPAFAP------------------------------KNIYSIMQACWALEPTHRPTFQQICSFL---
I-SIDKVVGAGEFGEVCSGRLK----LPSKKEISVAIKTLK-V-G-YT-EKQRRDFL-GEASIMGQF-DHPNIIRLEGVVT-K------SKPVMIVTEYMENGSLDSFLR-KH--------------------------------------------------------------------------------------------------DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLED--DPEA-AYTTRGGKIPIRWTSPEAIA-YRK---FTSASDVWSYGIVLWEVMSYGERPYWEM-SNQDVIKAVDEGYR----LPPPMDCP------------------------------AALYQLMLDCWQKDRNNRPKFEQIVSIL---
-IKIERVIGAGEFGEVCSGRLK----LPGKRDVAVAIKTLK-V-G-YT-EKQRRDFL-CEASIMGQF-DHPNVVHLEGVVT-R------GKPVMIVIEFMENGALDAFLR-KH--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIED--DPEA-VYTTTGGKIPVRWTAPEAIQ-YRK---FTSASDVWSYGIVMWEVMSYGERPYWDM-SNQDVIKAIEEGYR----LPAPMDCP------------------------------AGLHQLMLDCWQKERAERPKFEQIVGI--L-
L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S-D-AT-EKDLSDLI-SEMEMMKMIGKHKNIINLLGACT-Q------DGPLYVIVEYASKGNLREYLQ-ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHH--IDYY--KKTTNGRLPVKWMAPEALF-DRI---YTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLLKEGHR----MDKPSNCT------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL---
-LKLGKSLGRGAFGKVVQASAFG--IKKSPTCRTVAVKMLK-E-G-AT-ASEYKALM-TELKILTHIGHHLNVVNLLGACTKQ------GGPLMVIVEYCKYGNLSNYLK-SKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPR--------------------------------LDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYK--NPDY--VRKGDTRLPLKWMAPESIF-DKI---YSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMR----MRAPEYST------------------------------PEIYQIMLDCWHRDPKERPRFAELVEKL---
-LHLGRVLGYGAFGKVVEASAFG--IHKGSSCDTVAVKMLK-E-G-AT-ASEHRALM-SELKILIHIGNHLNVVNLLGACTKP------QGPLMVIVEFCKYGNLSNFLR-AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYK--DPDY--VRKGSARLPLKWMAPESIF-DKV---YTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTR----MRAPELAT------------------------------PAIRRIMLNCWSGDPKARPAFSELVEIL---
-ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-E-S-AS-LRERIEFL-NEASVMKGF-TCHHVVRLLGVVS-K------GQPTLVVMELMAHGDLKSYLR-SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYE--TDYY--RKGGKGLLPVRWMAPESLK-DGV---FTTSSDMWSFGVVLWEITSLAEQPYQGL-SNEQVLKFVMDGGY----LDQPDNCP------------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL---
-LKLGKPLGRGAFGQVIEADAFG--IDKTATCRTVAVKMLK-E-G-AT-HSEHRALM-SELKILIHIGHHLNVVNLLGACTKP------GGPLMVIVEFCKFGNLSTYLR-SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYK--DPDY--VRKGDARLPLKWMAPETIF-DRV---YTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTR----MRAPDYTT------------------------------PEMYQTMLDCWHGEPSQRPTFSELVEHL---
-LSFGKTLGAGAFGKVVEATAYG--LIKSDAAMTVAVKMLK-P-S-AH-LTEREALM-SELKVLSYLGNHMNIVNLLGACT-I------GGPTLVITEYCCYGDLLNFLR-RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKN--DSNY--VVKGNARLPVKWMAPESIF-NCV---YTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFR----MLSPEHAP------------------------------AEMYDIMKTCWDADPLKRPTFKQIVQL--I-
-YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKLSRP-F-QSIIH--AKRTYRELRLLKHM-KHENVIGLLDVFT-PARSLEEFNDVYLVTHLMGA-DLNNIVK-CQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR----HTDDEM--TG---YVATRWYRAPEIMLNWMH---YNQTVDIWSVGCIMAELLT-GRTLFPGT-DHIDQLKLILRLVG----TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-
-VHFNEVIGRGHFGCVYHGTLL----DNDGKKIHCAVKSLN-R-I-TD-IGEVSQFL-TEGIIMKDF-SHPNVLSLLGICLRS------EGSPLVVLPYMKHGDLRNFIR-NE--------------------------------------------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYD--KEYYSVHNKTGAKLPVKWMALESLQ-TQK---FTTKSDVWSFGVLLWELMTRGAPPYPDV-NTFDITVYLLQGRR----LLQPEYCP------------------------------DPLYEVMLKCWHPKAEMRPSFSELVSR--I-
L-VLGRVLGSGAFGKVVEGTAYG--LSRSQPVMKVAVKMLK-P-T-AR-SSEKQALM-SELKIMTHLGPHLNIVNLLGACT-K------SGPIYIITEYCFYGDLVNYLH-KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMH--DSNY--VSKGSTFLPVKWMAPESIF-DNL---YTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYR----MAKPDHAT------------------------------SEVYEIMVKCWNSEPEKRPSFYHLSE---IV
L-VLGRTLGSGAFGQVVEATAHG--LSHSQATMKVAVKMLK-S-T-AR-SSEKQALM-SELKIMSHLGPHLNVVNLLGACT-K------GGPIYIITEYCRYGDLVDYLH-RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMR--DSNY--ISKGSTFLPLKWMAPESIF-NSL---YTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYR----MAQPAHAS------------------------------DEIYEIMQKCWEEKFEIRPPFSQLVL---LL
L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-P-G-TM-SP--EAFL-QEAQVMKKL-RHEKLVQLYAVVS--------EEPIYIVTEYMSKGSLLDFLK-GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI-E--DNEY--TARQGAKFPIKWTAPEAAL-YGR---FTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQVERGYR----MPCPPECP------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L-
-IKFQDVIGEGNFGQVLKARIK-----KDGLRMDAAIKRMK-E-Y-AS-KDDHRDFA-GELEVLCKLGHHPNIINLLGACE-H------RGYLYLAIEYAPHGNLLDFLR-KSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ-----EVY--VKKTMGRLPVRWMAIESLN-YSV---YTTNSDVWSYGVLLWEIVSLGGTPYCGM-TCAELYEKLPQGYR----LEKPLNCD------------------------------DEVYDLMRQCWREKPYERPSFAQILV---SL
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