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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
STE MAP2K2 203
STE MAP2K1 68
STE MAP2K4 102
TK ZAP70 338
---F-ERISELGAGNGGVVTKVQHR--PSGLIMARKLIHLEIKPA-I--RNQIIRELQVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGG--SLDQVLK--EAK--RIPEEILGKVSIAVLRGLAYLREKH-QIMHRDVKPSNILVNSRGEIKLCDFGVSG----QLIDSMANS---FVGTRSYMAPERLQ----GTHYSVQSDIWSMGLSLVELAV-GRYPIPPPDAKE-LEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFI
----FEKISELGAGNGGVVFKVSHK--PSGL-VMARKLIHLEIKPAI--RNQIIRELQVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGG--SLDQVLK--KAG--RIPEQILGKVSIAVIKGLTYLREKH-KIMHRDVKPSNILVNSRGEIKLCDFGVSG----QLIDSMANS---FVGTRSYMSPERLQ----GTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFE-----LLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI
--LK--DLGEIGRGAYGSVNKMVHK--PSGQIMAVKRIRSTVDEKEQ--KQL-LMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDD--VIPEEILGKITLATVKALNHLKE-NLKIIHRDIKPSNILLDRSGNIKLCDFGISGQ---LVDSIAKTR---DAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELAT-GRFPYPKW-NSVFDQLTQVVKGDPPQLSNSEEREFS------------------------------------------PSFINFVNLCLTKDESKRPKYKELLKHPFI
LIAD----IELGCGNFGSVRQGVYRMRKKQIDVAIKVLK-QGTE-KADTEEMM-REAQIMHQL-DNPYIVRLIGVCQ-AEALMLVMEMAGGG--PLHKFLV---GKREEIPVSNVAELLHQVSMGMKYLEE-K-NFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD--DSYYTARSAGKWPLKWYAPECIN----FRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECP------------------------------------------------PELYALMSDCWIYKWEDRPDFLTVEQR--M
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