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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
STE MAP2K4 203
Other AURKA 133
CMGC CDK2 4
CMGC CDK7 2.7.11.23
STE MAP2K1 68
STE MAP2K2 72
STE OXSR1 17
LK--DLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTV-DEKEQKQL-LM---DLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYS------VLDDVIPEEILGKITLATVKALNHLKE-NLKIIHRDIKPSNILLDRSGNIKLCDFGISGQ------LVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKW-NSVFDQLTQVVKGDPPQLSNSEEREFS------------------------------------------PSFINFVNLCLTKDESKRPKYKELLKHPFI
--FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR---EVEIQSHL-RHPNILRLYGYFHDATRVYLILEYAPLG--TVYRELQ--------KLSKFDEQRTATYITELANALSYCHS-K-RVIHRDIKPENLLLGSAGELKIADFGWSV-------HAPSSRRTTLCGTLDYLPPEMIE----GRMHDEKVDLWSLGVLCYEFLVGKPPFEAN---TYQETYKRISRVEFTFPDFVT----------------------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI
--FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIR---EISLLKEL-NHPNIVKLLDVIHTENKLYLVFEFLHQ---DLKKFMDA------SALTGIPLPLIKSYLFQLLQGLAFCHS-H-RVLHRDLKPQNLLINTEGAIKLADFGLARAF-----GVPVRTYTHEVVTLWYRAPEILL---GCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF
--YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGH-RSEAKDGINRTALREIKLLQEL-SHPNIIGLLDAFGHKSNISLVFDFMET---DLEVIIK-------DNSLVLTPSHIKAYMLMTLQGLEYLHQ-H-WILHRDLKPNNLLLDENGVLKLADFGLAKSF-----GSPNRAYTHQVVTRWYRAPELLF---GARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPG---------------------IPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYF
--FEKISELGAGNGGVVFKVSHKPSGL-VMARKLIHLE-IKPAIRNQIIR---ELQVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGG--SLDQVLK--------KAGRIPEQILGKVSIAVIKGLTYLREKH-KIMHRDVKPSNILVNSRGEIKLCDFGVSG-------QLIDSMANSFVGTRSYMSPERLQ----GTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFE-----LLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFI
-F-ERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEI-KPA-IRNQIIR---ELQVLHEC-NSPYIVGFYGAFYSDGEISICMEHMDGG--SLDQVLK--------EAKRIPEEILGKVSIAVLRGLAYLREKH-QIMHRDVKPSNILVNSRGEIKLCDFGVSG-------QLIDSMANSFVGTRSYMAPERLQ----GTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKE-LEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFI
--YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEK-CQTSMDE-LLK---EIQAMSQC-HHPNIVSYYTSFVVKDELWLVMKLLSGG--SVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHK-N-GQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVME---QVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKE--MLK-------------------------------------KYGKSFRKMISLCLQKDPEKRPTAAELLRHKFF
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