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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK10 203
Other AURKA 133
CAMK CASK 12
CMGC CDK2 4
CMGC CDK9 2.7.11.23
CAMK CHEK2 220
CMGC CSNK2A1 39
CAMK DAPK1 13
AGC GRK6 186
CMGC GSK3B 56
CMGC MAPK12 27
Other NEK2 8
CAMK PASK 999
AGC PDPK1 82
STE STK24 24
--YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPF-QNQTHAK-RAYR------ELVLMKCV-NHKNIISLLNVFTPQKT--LEEFQDVY--LVMELMDA---NLC-QVIQ------MELDHERMSYLLYQMLCGIKHLHSA-----GIIHRDLKPSNIVVK-SDCTL----KILDFGLART-----AGTSFMMTPYVVTRYYRAPEVIL---GMGYKENVDIWSVGCIMGEMVRHKILFP-GRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI-----------
--FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEH-QLRR------EVEIQSHL-RHPNILRLYGYFHD--------ATRVY--LILEYAPLG--TVY-RELQ----KLSKFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLG-SAGEL----KIADFGWSV------HAPSSRRTTLCGTLDYLPPEMIE---GRMHDEKVDLWSLGVLCYEFLVGKPPFE-AN---TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI-----------
--YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAK-FTSSPGL-STEDL---KREASICHML-KHPHIVELLETYSS--------DGMLY--MVFEFMDGA--DLCFEIVKR-ADAGFVYSEAVASHYMRQILEALRYCHDN-----NIIHRDVKPHCVLLA-SKENSA-PVKLGGFGVAIQL----GESGLVAGGRVGTPHFMAPEVVK---REPYGKPVDVWGCGVILFILLSGCLPFY-GT----KERLFEGIIKGKYKMNPRQWSHIS-----------------------------------ESAKDLVRRMLMLDPAERIT-----VYEALNHPWL-----------
--FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPS-TAIR------EISLLKEL-NHPNIVKLLDVIHT--------ENKLY--LVFEFLHQ---DLK-KFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF----GVPVRTYTHEVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVTRRALFP-GDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF-----------
--YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN-EKEGFPI-TALR------EIKILQLL-KHENVVNLIEICRTKASPYNRCKGSIY--LVFDFCEH---DLA-GLLS---NVLVKFTLSEIKRVMQMLLNGLYYIHRN-----KILHRDMKAANVLIT-RDGVL----KLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLL--GERDYGPPIDLWGAGCIMAEMWTRSPIMQ-GNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQK----------RKVKDRLKAYVRDPYALDLIDKLLVLDPAQRID-----SDDALNHDFF-----------
YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRK-FAIGSAR-EADPALNVETEIEILKKL-NHPCIIKIKNFF-D--------AEDYY--IVLELMEGG--ELF-DKVV----GNKRLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI-----LGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFS-EH--RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKARFT-----TEEALRHPWL-----------
--YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVK-KKKIKR------------EIKILENLRGGPNIITLADIVKDP------VSRTPA--LVFEHVNNT--DFK-QLY-------QTLTDYDIRFYMYEILKALDYCHSM-----GIMHRDVKPHNVMIDHEHRKL----RLIDWGLAEF-----YHPGQEYNVRVASRYFKGPELLV--DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAMEHPYF-----------
--YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRR-TKSSRRG-VSREDI--EREVSILKEI-QHPNVITLHEVYEN--------KTDVI--LILELVAGG--ELF-DFLA----EKESLTEEEATEFLKQILNGVYYLHSL-----QIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK-----IDFGNEFKNIFGTPEFVAPEIVN---YEPLGLEADMWSIGVITYILLSGASPFL-GD---TKQETLANVSAVNYEFEDEYFSNTS-----------------------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI-----------
-F-RQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKR-IKKRKGE-AMAL-----NEKQILEKV-NSRFVVSLAYAYET--------KDALC--LVLTLMNGG--DLK-FHIYH--MGQAGFPEARAVFYAAEICCGLEDLHRE-----RIVYRDLKPENILLD-DHGHI----RISDLGLAVH-----VPEGQTIKGRVGTVGYMAPEVVK---NERYTFSPDWWALGCLLYEMIAGQSPFQ-QRKKKIKREEVERLVK-EVPEEYSER--FS-----------------------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF-----------
--YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDK-RFKNR-------------ELQIMRKL-DHCNIVRLRYFFYSSG----EKKDEVYLNLVLDYVPETVYRVA----RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF-----GICHRDIKPQNLLLDPDTAVL----KLCDFGSAKQ-----LVRGEPNVSYICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLLGQPIFP-GDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF-----------
--YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPF-QSELFAK-RAYR------ELRLLKHM-RHENVIGLLDVFTPDET--LDDFTDFY--LVMPFMGT---DLG-KLMK-----HEKLGEDRIQFLVYQMLKGLRYIHAA-----GIIHRDLKPGNLAVN-EDCEL----KILDFGLAR-------QADSEMTGYVVTRWYRAPEVIL--NWMRYTQTVDIWSVGCIMAEMITGKTLFK-GSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE-----------KKDFASILTNASPLAVNLLEKMLVLDAEQRVT-----AGEALAHPYF-----------
--YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGS-MTEAEKQ-MLVS------EVNLLREL-KHPNIVRYYDRIIDR------TNTTLY--IVMEYCEGG--DLA-SVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD-GKQNV----KLGDFGLARIL----NHDTSFAKTFVGTPYYMSPEQMN---RMSYNEKSDIWSLGCLLYELCALMPPFT-AF---SQKELAGKIREGKFRRIPYRY---S-----------------------------------DELNEIITRMLNLKDYHRPS-----VEEILENPL-I----------
--YSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEK-VLEDCWI-EDPKLGKVTLEIAILSRV-EHANIIKVLDIFEN--------QGFFQ--LVMEKHGSG-LDLF-AFID----RHPRLDEPLASYIFRQLVSAVGYLRLK-----DIIHRDIKDENIVIA-EDFTI----KLIDFGSAAY-----LERGKLFYTFCGTIEYCAPEVLM--GNPYRGPELEMWSLGVTLYTLVFEENPFC-EL-----EETVEAAIHPPYLVS-------------------------------------------KELMSLVSGLLQPVPERRTT-----LEKLVTDPWV-----------
-F-KFGKILGEGSFSTVVLARELATSREYAIKILEKRH-IIKENKVPYVTR------ERDVMSRL-DHPFFVKLYFTFQD--------DEKLY--FGLSYAKNG--ELL-KYIR----KIGSFDETCTRFYTAEIVSALEYLHGK-----GIIHRDLKPENILLN-EDMHI----QITDFGTAKVLS--PESKQARANSFVGTAQYVSPELLT---EKSACKSSDLWALGCIIYQLVAGLPPFR-AG---NEYLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
--FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEE-AEDEIED-IQ-Q------EITVLSQC-DSPYVTKYYGSYLK--------DTKLW--IIMEYLGGG--SAL-DLLE-----PGPLDETQIATILREILKGLDYLHSE-----KKIHRDIKAANVLLS-EHGEV----KLADFGVAGQL----TDTQIKRNTFVGTPFWMAPEVIK---QSAYDSKADIWSLGITAIELARGEPPHS-ELHPMKVLFLIPKNNPPTLEGNYS-----------------------------------------KPLKEFVEACLNKEPSFRPT-----AKELLKHKFI-----------
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