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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK10 203
Other AURKB 77
CMGC CDC2 4
CMGC CDK2 4
CAMK CHEK1 9
CMGC GSK3A 119
CMGC GSK3B 56
CMGC MAPK14 24
CMGC MAPK8 26
CMGC MAPK9 26
AGC PDPK1 82
AGC PRKCD 349
AGC PRKCQ 380
--YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAK-RAYR-ELVLMKCV-NHKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ------MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART---AGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-VD-DALQHPYI-----------
--FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVE-HQLRREIEIQAHL-HHPNILRLYNYFYD------RRRIY--LILEYAPRG--ELYKELQ----KSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGELKIADFGWSV----HAPSLRRKTMCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLVGNPPFESA---SHNETYRRIVKVDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSERLP-LA-QVSAHPWV-----------
--YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPS-TAIR-EISLLKEL-RHPNIVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAF--GIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-GK-MALNHPYF-----------
--FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPS-TAIR-EISLLKEL-NHPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF--GVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-AK-AALAHPFF-----------
-W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPEN-I-KK-EICINKML-NHENVVKFYGHRRE------GNIQY--LFLEYCSGG--ELFDRIE----PDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQP--SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARIT-IP-DIKKDRW-Y----------
--YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNR--------ELQIMRKL-DHCNIVRLRYFFYSSG--EKKDELYLNLVLEYVPETVYRVARHFT---KAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQ---LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLS-PL-EACAHSFF-----------
--YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR--------ELQIMRKL-DHCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ---LVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-PL-EACAHSFF-----------
--YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAK-RTYR-ELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR-----HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-AA-QALAHAYF-----------
--YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAK-RAYR-ELVLMKCV-NHKNIIGLLNVFTPQKSLEEFQDVY--IVMELMDA---NLCQVIQ------MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART---AGTSFMMTPYVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-VD-EALQHPYI-----------
--YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAK-RAYR-ELVLLKCV-NHKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIH------MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART---ACTNFMMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS-VD-EALRHPYI-----------
-F-KFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTR-ERDVMSRL-DHPFFVKLYFTFQD------DEKLY--FGLSYAKNG--ELLKYIR----KIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVAGLPPFRAG---NEYLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATKRLG-CE-EM------EGYGPLKAHPF
FI--FHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDV-ECTMVEKRVLTLAAENPFLTHLICTFQT------KDHLF--FVMEFLNGG--DLMYHIQ----DKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLD-RDGHIKIADFGMCKEN--IFGESRASTFCGTPDYIAPEILQ-GLKYTFSVDWWSFGVLLYEMLIGQSPFHGD---DEDELFESIRVDTPHYPRWIT---------------------------------------KESKDILEKLFEREPTKRLGVTG-NIKIHPFF-----------
FI--LHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDV-ECTMVEKRVLSLAWEHPFLTHMFCTFQT------KENLF--FVMEYLNGG--DLMYHIQ----SCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILLD-KDGHIKIADFGMCKEN--MLGDAKTNTFCGTPDYIAPEILL-GQKYNHSVDWWSFGVLLYEMLIGQSPFHGQ---DEEELFHSIRMDNPFYPRWLE---------------------------------------KEAKDLLVKLFVREPEKRLG-VRGDIRQHPLF-----------
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