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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK14 203
TK ABL1 261
CMGC CDK2 4
CAMK CHEK1 9
CMGC CSNK2A1 39
TK FGFR1 478
CMGC GSK3B 56
TK HCK 241
TK LCK 245
TK LYN 247
CMGC MAPK1 13
CMGC MAPK11 24
CMGC MAPK9 26
CAMK MARK3 56
AGC PDPK1 82
Other PLK1 53
Other PLK2 82
Other PLK3 62
AGC PRKACA 44
TK SRC 270
---YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKLSRPFQSIIH--AK-RTYR-ELRLLKHM--KHENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK------------------------CQ-----------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR-------HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFP-GTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF-----------
---ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-EDTM-EV--EE-FL-K-EAAVMKEI--KHPNLVQLLGVCTR------EPPFY--IITEFMTYG--NLLDYLR------------------------EC--------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLVKVADFGLSRLM----T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYP-GIDLSQVYELLEKDYRMERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPS-----FAEIHQA--F-----------
---FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLDTETEGV--PS-TAIR-EISLLKEL--NHPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA---------------------SALT-----------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF-----------
--W-DLVQTLGEGAYGEVQLAVNR-------VTEEAVAVKIVDMKRAVDCP--EN-I-KK-EICINKML--NHENVVKFYGHRRE------GNIQY--LFLEYCSGG--ELFDRIE-----------------------PDI-----------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNLKISDFGLATVFR--YNNRERLLNK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELPWD-QP--SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y----------
---YQLVRKLGRGKYSEVFEAINI-------TNNEKVVVKILKPVKKKKIK--R-------EIKILENL-RGGPNIITLADIVKDP----VSRTPA--LVFEHVNNT--DFKQLY--------------------------Q-----------------TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-----YHPGQEYNV---RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAMEHPYF-----------
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-SDAT-EKDLSD-LI-S-EMEMMKMIG-KHKNIINLLGACTQ------DGPLY--VIVEYASKG--NLREYLQ------------------------ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVMKIADFGLARDI-H--H--IDYYKKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYP-GVPVEELFKLLKEGHRMDKPSNCT-----------------------------------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL-------------
---YTDTKVIGNGSFGVVYQAKLC-------DSGELVAIKKVLQDKRFKNR----------ELQIMRKL--DHCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHY-------------------SRAKQ-----------------TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-----LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFP-GDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF-----------
---LKLEKKLGAGQFGEVWMATYN--------KHTKVAVKTMK-PGSM-SV--EA-FL-A-EANVMKTL--QHDKLVKLHAVVT-------KEPIY--IITEFMAKG--SLLDFLK------------------------SD--------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVS-ASLVCKIADFGLARVI----E--DNEYTAREGAKFPIKWTAPEAIN-FGSFTIKSDVWSFGILLMEIVTYGRIPYP-GMSNPEVIRALERGYRMPRPENCP-----------------------------------------EELYNIMMRCWKNRPEERPT-----FEYIQSV--L-----------
---LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-QGSM-SP--DA-FL-A-EANLMKQL--QHQRLVRLYAVVT-------QEPIY--IITEYMENG--SLVDFLK------------------------TP--------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLI----E--DNEYTAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYP-GMTNPEVIQNLERGYRMVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L-----------
---IKLVKRLGAGQFGEVWMGYYN--------NSTKVAVKTLK-PGTM-SV--QA-FL-E-EANLMKTL--QHDKLVRLYAVVTR------EEPIY--IITEYMAKG--SLLDFLK------------------------SD--------------EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVS-ESLMCKIADFGLARVI----E--DNEYTAREGAKFPIKWTAPEAIN-FGCFTIKSDVWSFGILLYEIVTYGKIPYP-GRTNADVMTALSQGYRMPRVENCP-----------------------------------------DELYDIMKMCWKEKAEERPT-----FDYLQSV--L-----------
---YTNLSYIGEGAYGMVCSAYDN-------VNKVRVAIKKISPFEHQTYC--QR-T-LR-EIKILLRF--RHENIIGINDIIRAPT-IEQMKDVY--IVQDLMET---DLYKLLK------------------------TQ-----------------HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICDFGLARVAD-PDHDHTGFLTE---YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFP-GKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-----------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIE-----VEQALAHPYL-----------
LQG---LRPVGSGAYGSVCSAYDA-------RLRQKVAVKKLSRPFQSLIH--AR-RTYR-ELRLLKHL--KHENVIGLLDVFTPATSIEDFSEVY--LVTTLMGA---DLNNIVK------------------------CQ-----------------ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGLAR-------QADEEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFP-GSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP-----------QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS-----AAEALAHAYF-----------
---YQQLKPIGSGAQGIVCAAFDT-------VLGINVAVKKLSRPFQNQTH--AK-RAYR-ELVLLKCV--NHKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIH-------------------------M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART-----ACTNFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGELVK-GCVIFQ-GTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS-----VDEALRHPYI-----------
---YRLLKTIGKGNFAKVKLARHI-------LTGREVAIKIIDKTQLNPTS--LQ-KLFR-EVRIMKIL--NHPNIVKLFEVIET------EKTLY--LIMEYASGG--EVFDYLVAHGRMKEKEARSKFRQGCQAGQTIKV-----------------QVSFDLLSLMFTFIVSAVQYCHQKRIVHRDLKAENLLLD-ADMNIKIADFGFSNE-----FTVGGKLDT---FCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVS-GSLPFD-GQ---NLKELRERVLRGKYRIPFYMS---------------------------------------TDCENLLKRFLVLNPIKRGT-----LEQIMKDRWI-----------
--F-KFGKILGEGSFSTVVLAREL-------ATSREYAIKILEKRHIIKEN--KVPYVTR-ERDVMSRL--DHPFFVKLYFTFQD------DEKLY--FGLSYAKNG--ELLKYIR-----------------------KIG-----------------SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHIQITDFGTAKVLS--PESKQARANS---FVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVA-GLPPFR-AG---NEYLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATKRLG-----CEEM------EGYGPLKAHPF
-YV--RGRFLGKGGFAKCFEISDA-------DTKEVFAGKIVPKSLLLKPH--QR-EKMSMEISIHRSL--AHQHVVGFHGFFED------NDFVF--VVLELCRRR--SLLELHK-----------------------RRK-----------------ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEVKIGDFGLATKV----EYDGERKKT---LCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPPFE-TS---CLKETYLRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTARPT-----INELLNDEFF-----------
--Y-CRGKVLGKGGFAKCYEMTDL-------TNNKVYAAKIIPHSRVAKPH--QR-EKIDKEIELHRIL--HHKHVVQFYHYFED------KENIY--ILLEYCSRR--SMAHILK-----------------------ARK-----------------VLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFIN-EAMELKVGDFGLAARL----EPLEHRRRT---ICGTPNYLSPEVLN-KQGHGCESDIWALGCVMYTMLL-GRPPFE-TT---NLKETYRCIREARYTMPSSLL---------------------------------------APAKHLIASMLSKNPEDRPS-----LDDIIRHDFF-----------
-YL--KGRLLGKGGFARCYEATDT-------ETGSAYAVKVIPQSRVAKPH--QR-EKILNEIELHRDL--QHRHIVRFSHHFED------ADNIY--IFLELCSRK--SLAHIWK-----------------------ARH-----------------TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFIT-ENMELKVGDFGLAARL----EPPEQRKKT---ICGTPNYVAPEVLL-RQGHGPEADVWSLGCVMYTLLC-GSPPFE-TA---DLKETYRCIKQVHYTLPASLS---------------------------------------LPARQLLAAILRASPRDRPS-----IDQILRHDFF-----------
--F-ERIKTLGTGSFGRVMLVKHK-------ETGNHYAMKILDKQKVVKLK--QI-EHTLNEKRILQAV--NFPFLVKLEFSFKD------NSNLY--MVMEYVPGG--EMFSHLR-----------------------RIG-----------------RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYIQVTDFGFAK-------RVKGRTWT---LCGTPEYLAPEIIL-SKGYNKAVDWWALGVLIYEMAA-GYPPFF-AD---QPIQIYEKIVSGKVRFPSHFS---------------------------------------SDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF-----------
--L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-PGTM-SP--EA-FL-Q-EAQVMKKL--RHEKLVQLYAVVS-------EEPIY--IVTEYMSKG--SLLDFLK------------------------GE--------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLI----E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYP-GMVNREVLDQVERGYRMPCPPECP-----------------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L-----------
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