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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK14 203
TK ABL1 261
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK5 4
CAMK CHEK1 9
CAMK CHEK2 220
Other CHUK 15
CMGC CSNK2A1 39
CMGC GSK3A 119
CMGC GSK3B 56
TK LCK 245
CMGC MAPK1 13
CMGC MAPK10 64
CMGC MAPK11 24
CMGC MAPK12 27
CMGC MAPK13 25
CMGC MAPK8 26
CMGC MAPK9 26
CAMK PRKD1 583
TK SRC 270
----YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR------ELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL---KILDFGLAR------HTDDEMTG---YVATRWYRAPEIML--NWMHYNQTVDIWSVGCIMAELLT-GRTLFP-GT-----------DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF---------
----ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK-EDTM-EVEEFL-K------EAAVMKEI-KHPNLVQLLGVCTR------EPPFY--IITEFMTYG--NLLDYLR-----ECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLV---KVADFGLSRLM---T--GDTYTAHAGAKFPIKWTAPESLA---YNKFSIKSDVWAFGVLLWEIATYGMSPYP-GI-----------DLSQVYELLEKDYRMERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F---------
----YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIR------EISLLKEL-RHPNIVSLQDVLMQ------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ---YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---KLADFGLARAF---GIPIRVYTH---EVVTLWYRSPEVLL--GSARYSTPVDIWSIGTIFAELAT-KKPLFH-GD-----------SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF---------
----FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIR------EISLLKEL-NHPNIVKLLDVIHT------ENKLY--LVFEFLHQ---DLKKFMDA--SALT---GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF---GVPVRTYTH---EVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GD-----------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF---------
----YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR------EICLLKEL-KHKNIVRLHDVLHS------DKKLT--LVFEFCDQ---DLKKYFD---SCNG---DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGEL---KLADFGLARAF---GIPVRCYSA---EVVTLWYRPPDVLF--GAKLYSTSIDMWSAGCIFAELANAGRPLFP-GN-----------DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPAT-------------TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF---------
---W-DLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENI-KK------EICINKML-NHENVVKFYGHRRE------GNIQY--LFLEYCSGG--ELFDRIE----PDI---GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---KISDFGLATVFR-YNNRERLLNK---MCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLA-GELPWD-QP-------------SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y--------
--YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKL-NHPCIIKIKNFF-D------AEDYY--IVLELMEGG--ELFDKVV----GNK---RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDCLIKITDFGHSKI----LGETSLMRT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFS-EH-------------RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL---------
---W-EMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRER-WCH------EIQIMKKL-NHANVVKACDVPEELN-ILIHDVPL--LAMEYCSGG--DLRKLLNK-PENCC---GLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQ-DVGGKIIHKIIDLGYAKD----VDQGSLCTS---FVGTLQYLAPELFE---NKPYTATVDYWSFGTMVFECIA-GYRPFL-HHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCS-----------------------------LVVEPMENWLQLMLNWDPQQRG-----------GPVDLTLKQ
----YQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKR-----------EIKILENLRGGPNIITLADIVKDP----VSRTPA--LVFEHVNNT--DFKQLY-------Q---TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL---RLIDWGLAEF----YHPGQEYNV---RVASRYFKGPELLV--DYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGH-----------DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF---------
----YTDIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNR------------ELQIMRKL-DHCNIVRLRYFFYSSG--EKKDELYLNLVLEYVPETVYRVARHFT---KAKL---TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVL---KLCDFGSAKQ----LVRGEPNVS---YICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLL-GQPIFP-GD-----------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF---------
----YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNR------------ELQIMRKL-DHCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ----LVRGEPNVS---YICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLL-GQPIFP-GD-----------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF---------
----LKLVERLGAGQFGEVWMGYYN-GHTKVAVKSLK-QGSM-SPDAFL-A------EANLMKQL-QHQRLVRLYAVVT-------QEPIY--IITEYMENG--SLVDFLK-----TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSC---KIADFGLARLI---E--DNEYTAREGAKFPIKWTAPEAIN---YGTFTIKSDVWSFGILLTEIVTHGRIPYP-GM-----------TNPEVIQNLERGYRMVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L---------
----YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRT-LR------EIKILLRF-RHENIIGINDIIRAPT-IEQMKDVY--IVQDLMET---DLYKLLK-----TQ---HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDL---KICDFGLARVADPDHDHTGFLTE---YVATRWYRAPEIML--NSKGYTKSIDIWSVGCILAEMLS-NRPIFP-GK-----------HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-----------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL---------
----YQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYR------ELVLMKCV-NHKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART----AGTSFMMTP---YVVTRYYRAPEVIL---GMGYKENVDIWSVGCIMGEMVR-HKILFP-GR-----------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI---------
-LQG---LRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYR------ELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVY--LVTTLMGA---DLNNIVK-----CQ---ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCEL---RILDFGLAR------QADEEMTG---YVATRWYRAPEIML--NWMHYNQTVDIWSVGCIMAELLQ-GKALFP-GS-----------DYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP-----------QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF---------
----YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYR------ELRLLKHM-RHENVIGLLDVFTPDETLDDFTDFY--LVMPFMGT---DLGKLMK-----HE---KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCEL---KILDFGLAR------QADSEMTG---YVVTRWYRAPEVIL--NWMRYTQTVDIWSVGCIMAEMIT-GKTLFK-GS-----------DHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE-----------KKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYF---------
YVSP----THVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYR------ELLLLKHM-QHENVIGLLDVFTPASSLRNFYDFY--LVMPFMQT---DLQKIM------GM---EFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCEL---KILDFGLAR------HADAEMTG---YVVTRWYRAPEVIL--SWMHYNQTVDIWSVGCIMAEMLT-GKTLFK-GK-----------DYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTP-----------RKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF---------
----YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYR------ELVLMKCV-NHKNIIGLLNVFTPQKSLEEFQDVY--IVMELMDA---NLCQVIQ------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART----AGTSFMMTP---YVVTRYYRAPEVIL---GMGYKENVDLWSVGCIMGEMVC-HKILFP-GR-----------DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI---------
----YQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYR------ELVLLKCV-NHKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIH------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART----ACTNFMMTP---YVVTRYYRAPEVIL---GMGYKENVDIWSVGCIMGELVK-GCVIFQ-GT-----------DHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYI---------
--PD----EVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRN------EVAILQNL-HHPGVVNLECMFET------PERVF--VVMEKLHGD--MLEMILS---SEKG---RLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLA-SADPFPQVKLCDFGFARI----IGEKSFRRS---VVGTPAYLAPEVLR---NKGYNRSLDMWSVGVIIYVSLS-GTFPFN-ED----------------EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------HEAIDLINNLLQVKMRKRYSVDKTLSHPWL---------
---L-RLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLK-PGTM-SPEAFL-Q------EAQVMKKL-RHEKLVQLYAVVS-------EEPIY--IVTEYMSKG--SLLDFLK-----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVC---KVADFGLARLI---E--DNEYTARQGAKFPIKWTAPEAAL---YGRFTIKSDVWSFGILLTELTTKGRVPYP-GM-----------VNREVLDQVERGYRMPCPPECP-----------------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L---------
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