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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK14 203
TK FGFR1 478
CMGC MAPK10 64
CMGC MAPK11 24
CMGC MAPK8 26
CMGC MAPK9 26
CMGC NLK 126
AGC RPS6KA3 68
TK SRC 270
Other STK36 4
---YQNLSPVGSGAYGSVCAAFDT-------KTGL---RVAVKKLSRPFQSIIH--AKRTYRELRLLKHM-KHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVK-CQ-----------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF
--L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVT---KVAVKMLK-SDAT-EKDLSDLI-SEMEMMKMIGKHKNIINLLGACTQ------DGPLYVIVEYASKGNLREYLQ-ARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIH-H--IDYYKKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT-----------------------------------------NELYMMMRDCWHAVPSQRPT-----FKQLVEDL--
---YQNLKPIGSGAQGIVCAAYDA-------VLDR---NVAIKKLSRPFQNQTH--AKRAYRELVLMKCV-NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQ--M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART---AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI
LQG---LRPVGSGAYGSVCSAYDA-------RLRQ---KVAVKKLSRPFQSLIH--ARRTYRELRLLKHL-KHENVIGLLDVFTPATSIEDFSEVYLVTTLMGA-DLNNIVK-CQ-----------------ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR-----QADEEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP-----------QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS-----AAEALAHAYF
---YQNLKPIGSGAQGIVCAAYDA-------ILER---NVAIKKLSRPFQNQTH--AKRAYRELVLMKCV-NHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQ--M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART---AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVC-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-----VDEALQHPYI
---YQQLKPIGSGAQGIVCAAFDT-------VLGI---NVAVKKLSRPFQNQTH--AKRAYRELVLLKCV-NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIH--M-----------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLART---ACTNFMMTP---YVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGELVK-GCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS-----VDEALRHPYI
IEP---DRPIGYGAFGVVWSVTDP-------RDGK---RVALKKMPNVFQNLVS--CKRVFRELKMLCFF-KHDNVLSALDILQPPH-IDYFEEIYVVTELMQS-DLHKIIVSPQ-----------------PLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVE-ELDESRHMTQ---EVVTQYYRAPEILMGSRHYSNAIDIWSVGCIFAELLG-RRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQP----------SLPVLYTLSSQATHEAVHLLCRMLVFDPSKRIS-----AKDALAHPYL
---FELLKVLGQGSFGKVFLVKKI-------SGSDARQLYAMKVLKKATLKVRD--RVRTKMERDILVEV-NHPFIVKLHYAFQT------EGKLYLILDFLRGGDLFTRLSKEV-----------------MFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKES--IDHEKKAYS---FCGTVEYMAPEVVN-RRGHTQSADWWSFGVLMFEMLT-GTLPFQGK---DRKETMTMILKAKLGMPQFLS---------------------------------------PEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF
--L-RLEVKLGQGCFGEVWMGTWN--------GTT---RVAIKTLK-PGTM-SP--EAFL-QEAQVMKKL-RHEKLVQLYAVVS-------EEPIYIVTEYMSKGSLLDFLK-GE--------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--E--DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP-----------------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L
---YHVLEMIGEGSFGRVYKGRRK-------YSAQ---VVALKFIPKLGRSEKE--LRNLQREIEIMRGL-RHPNIVHMLDSFET------DKEVVVVTDYAEG-ELFQILEDDG-----------------KLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAM--STNTMVLTS---IKGTPLYMSPELVE-ERPYDHTADLWSVGCILYELAV-GTPPFYAT---SIFQLVSLILKDPVRWPSTIS---------------------------------------PCFKNFLQGLLTKDPRQRLS-----WPDLLYHPFI
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