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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CMGC MAPK14 203
TK ABL1 261
TK EPHB2 621
CMGC GSK3B 56
CAMK KIAA0999 66
TK LCK 245
CMGC MAPK1 13
CMGC MAPK10 64
CMGC MAPK11 24
CMGC MAPK12 27
CMGC MAPK8 26
CMGC MAPK9 26
CMGC NLK 126
TK PTK6 191
AGC RPS6KA1 62
AGC RPS6KA6 73
STE SLK 34
TK SRC 270
AGC STK32A 23
AGC STK32B 23
Other STK36 4
---YQNLSPVGSGAYGSV---CAAFDT---KTGL---RVAVKKLSRPFQSIIH--AKRTYR-ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ---KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR---------HTDDEMTG---YVATRWYRAPEI--ML----NWMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF----
---ITMKHKLGGGQYGEV---YEGVWK---KYSL---TVAVKTLK-EDTM-EV--EEFL-K-EAAVMKEIKHPNLVQLLGVCTR------EPPFY--IITEFMTYG--NLLDYLR-----ECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLVKVADFGLSRLM------T--GDTYTAHAGAKFPIKWTAPES--LA-----YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPS-----FAEIHQA--F----
--V-KIEQVIGAGEFGEV---CSGHLKLPGKREI---FVAIKTLK-SGYT-EKQRRDFL-S-EASIMGQFDHPNVIHLEGVVTK------STPVM--IITEFMENG--SLDSFLR-----QN-DGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVN-SNLVCKVSDFGLSRFLEDDT--S--DPTYTSALGGKIPIRWTAPEA--IQ-----YRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCP-----------------------------------------SALHQLMLDCWQKDRNHRPK-----FGQIVNTL------
---YTDTKVIGNGSFGVV---YQAKLC---DSGE---LVAIKKVLQDKRFKNR---------ELQIMRKLDHCNIVRLRYFFYSSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ---TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQ-------LVRGEPNVS---YICSRYYRAPEL--IF----GATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PLEACAHSFF----
---YEIDRTIGKGNFAVV---KRATHL---VTKA---KVAIKIIDKTQLDEEN--LKKIFR-EVQIMKMLCHPHIIRLYQVMET------ERMIY--LVTEYASGG--EIFDHLV----AHG---RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLD-ANLNIKIADFGFSNL-------FTPGQLLKT---WCGSPPYAAPEL--FE----GKEYDGPKVDIWSLGVVLYVLVC-GALPFDGS---TLQNLRARVLSGKFRIPFFMS---------------------------------------TECEHLIRHMLVLDPNKRLS-----MEQICKHKWM----
---LKLVERLGAGQFGEV---WMGYYN----GHT---KVAVKSLK-QGSM-SP--DAFL-A-EANLMKQLQHQRLVRLYAVVT-------QEPIY--IITEYMENG--SLVDFLK-----TPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSCKIADFGLARLI------E--DNEYTAREGAKFPIKWTAPEA--IN-----YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP-----------------------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L----
---YTNLSYIGEGAYGMV---CSAYDN---VNKV---RVAIKKISPFEHQTYC--QRT-LR-EIKILLRFRHENIIGINDIIRAPT-IEQMKDVY--IVQDLMET---DLYKLLK-----TQ---HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICDFGLARVAD---PDHDHTGFLTE---YVATRWYRAPEI--ML----NSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-----------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIE-----VEQALAHPYL----
---YQNLKPIGSGAQGIV---CAAYDA---VLDR---NVAIKKLSRPFQNQTH--AKRAYR-ELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIQ------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART-------AGTSFMMTP---YVVTRYYRAPEV--IL-----GMGYKENVDIWSVGCIMGEMVR-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VDDALQHPYI----
LQG---LRPVGSGAYGSV---CSAYDA---RLRQ---KVAVKKLSRPFQSLIH--ARRTYR-ELRLLKHLKHENVIGLLDVFTPATSIEDFSEVY--LVTTLMGA---DLNNIVK-----CQ---ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDCELRILDFGLAR---------QADEEMTG---YVATRWYRAPEI--ML----NWMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP-----------QKDLSSIFRGANPLAIDLLGRMLVLDSDQRVS-----AAEALAHAYF----
---YRDLQPVGSGAYGAV---CSAVDG---RTGA---KVAIKKLYRPFQSELF--AKRAYR-ELRLLKHMRHENVIGLLDVFTPDETLDDFTDFY--LVMPFMGT---DLGKLMK-----HE---KLGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILDFGLAR---------QADSEMTG---YVVTRWYRAPEV--IL----NWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELE-----------KKDFASILTNASPLAVNLLEKMLVLDAEQRVT-----AGEALAHPYF----
---YQNLKPIGSGAQGIV---CAAYDA---ILER---NVAIKKLSRPFQNQTH--AKRAYR-ELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVY--IVMELMDA---NLCQVIQ------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART-------AGTSFMMTP---YVVTRYYRAPEV--IL-----GMGYKENVDLWSVGCIMGEMVC-HKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-----VDEALQHPYI----
---YQQLKPIGSGAQGIV---CAAFDT---VLGI---NVAVKKLSRPFQNQTH--AKRAYR-ELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVY--LVMELMDA---NLCQVIH------M---ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLART-------ACTNFMMTP---YVVTRYYRAPEV--IL-----GMGYKENVDIWSVGCIMGELVK-GCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS-----VDEALRHPYI----
IEP---DRPIGYGAFGVV---WSVTDP---RDGK---RVALKKMPNVFQNLVS--CKRVFR-ELKMLCFFKHDNVLSALDILQPPH-IDYFEEIY--VVTELMQS---DLHKIIV----SPQ---PLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVN-SNCVLKICDFGLARVE-----ELDESRHMTQ---EVVTQYYRAPEI--LM----GSRHYSNAIDIWSVGCIFAELLG-RRILFQAQSPIQQLDLITDLLGTPSLEAMRTACEGAKAHILRGPHKQP----------SLPVLYTLSSQATHEAVHLLCRMLVFDPSKRIS-----AKDALAHPYL----
--F-TLCRKLGSGYFGEV---FEGLWK----DRV---QVAIKVIS-RDNL-LH-QQMLQ-S-EIQAMKKLRHKHILALYAVVSV------GDPVY--IITELMAKG--SLLELLR-----DSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVG-ENTLCKVGDFGLARLI---------KEDVYLSHDHNIPYKWTAPEA--LS-----RGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECP-----------------------------------------PSVHKLMLTCWCRDPEQRPC-----FKALRERL------
---FELLKVLGQGSFGKVFLVRKVTRP---DSGH---LYAMKVLKKATLKVRD--RVRTKM-ERDILADVNHPFVVKLHYAFQT------EGKLY--LILDFLRGG--DLFTRLS----KEV---MFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLD-EEGHIKLTDFGLSKEA------IDHEKKAYS---FCGTVEYMAPEV--VN-----RQGHSHSADWWSYGVLMFEMLT-GSLPFQGK---DRKETMTLILKAKLGMPQFLS---------------------------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY--
---FELLKVLGQGSFGKV---FLVRKK---TGPDAGQLYAMKVLKKASLKVRD--RVRTKM-ERDILVEVNHPFIVKLHYAFQT------EGKLY--LILDFLRGG--DVFTRLS----KEV---LFTEEDVKFYLAELALALDHLHQLGIVYRDLKPENILLD-EIGHIKLTDFGLSKES------VDQEKKAYS---FCGTVEYMAPEV--VN-----RRGHSQSADWWSYGVLMFEMLT-GTLPFQGK---DRNETMNMILKAKLGMPQFLS---------------------------------------AEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFF----
---WEIIGELGDGAFGKV---YKAQNK---ETSV---LAAAKVIDTKSEEELE--DYM--V-EIDILASCDHPNIVKLLDAFYY------ENNLW--ILIEFCAGG--AVDAVML---ELER---PLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFT-LDGDIKLADFGVSAKN------TRTIQRRDS---FIGTPYWMAPEV--VMCETSKDRPYDYKADVWSLGITLIEMAE-IEPPHHELNPMRVLLKIAKSEPPTLAQPSRWS---------------------------------------SNFKDFLKKCLEKNVDARWT-----TSQLLQHPFV----
--L-RLEVKLGQGCFGEV---WMGTWN----GTT---RVAIKTLK-PGTM-SP--EAFL-Q-EAQVMKKLRHEKLVQLYAVVS-------EEPIY--IVTEYMSKG--SLLDFLK-----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLI------E--DNEYTARQGAKFPIKWTAPEA--AL-----YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP-----------------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L----
---FEILRAIGKGSFGKV---CIVQKN---DTKK---MYAMKYMNKQKCVERN--EVRNVFKELQIMQGLEHPFLVNLWYSFQD------EEDMF--MVVDLLLGG--DLRYHLQ----QNV---HFKEETVKLFICELVMALDYLQNQRIIHRDMKPDNILLD-EHGHVHITDFNIAAM-------LPRETQITT---MAGTKPYMAPEMFSSR----KGAGYSFAVDWWSLGVTAYELLR-GRRPYHIRSSTSSKEIVHTFETTVVTYPSAWS---------------------------------------QEMVSLLKKLLEPNPDQRFS----QLSDVQNFPY-M---
---FQILRAIGKGSFGKV---CIVQKR---DTKK---MYAMKYMNKQKCIERD--EVRNVFRELQIMQGLEHPFLVNLWYSFQD------EEDMF--MVVDLLLGG--DLRYHLQ----QNV---HFTEGTVKLYICELALALEYLQRYHIIHRDIKPDNILLD-EHGHVHITDFNIATV-------VKGAERASS---MAGTKPYMAPEV--FQVYMDRGPGYSYPVDWWSLGITAYELLR-GWRPYEIHSVTPIDEILNMFKVERVHYSSTWC---------------------------------------KGMVALLRKLLTKDPESRVS----SLHDIQS----VPYL
---YHVLEMIGEGSFGRV---YKGRRK---YSAQ---VVALKFIPKLGRSEKE--LRNLQR-EIEIMRGLRHPNIVHMLDSFET------DKEVV--VVTDYAEG---ELFQILE----DDG---KLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLA-KGGGIKLCDFGFARAM------STNTMVLTS---IKGTPLYMSPEL--VE-----ERPYDHTADLWSVGCILYELAV-GTPPFYAT---SIFQLVSLILKDPVRWPSTIS---------------------------------------PCFKNFLQGLLTKDPRQRLS-----WPDLLYHPFI----
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