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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK MAPKAPK2 203
Other AURKA 133
CAMK CHEK2 220
CMGC CSNK2A1 39
CAMK DAPK1 13
Other EIF2AK2 267
AGC GRK6 186
CMGC GSK3B 56
Other NEK2 8
AGC PDPK1 82
CAMK PIM1 38
Other PLK1 53
AGC PRKCI 245
AGC RPS6KA1 62
AGC SGK1 98
CAMK STK11 49
STE STK24 24
KVT---SQVLGLGINGKV---LQIFNKRTQEKFALKMLQDCP-KAR--------R------EVELH-WRASQCPH--IVRIVDVYENLY-------------------------AGRKCLL--IVMECLDGG--ELFSRIQD--RGDQAFTEREASEIMKSIGEAIQYLHSI-----NIAHRDVKPENLLYT-SKRPNA-ILKLTDFGFAKE---TTSHNSLTTPCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLCGY-PPFY-SN-----HGLAISPGMKTRIRMGQYEFPNPEWSEVS------------------------------EEVKMLIRNLLKTEPTQRMT------ITEFMNHPWI-----------
---FEIGRPLGKGKFGNV---YLAREKQSKFILALKVLFKAQLEKAGVEH-QLRR------EVEIQ-SHL-RHPN--ILRLYGYFHD-----------------------------ATRVY--LILEYAPLG--TVYRELQ----KLSKFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLG-SAGEL----KIADFGWSV----HAPSSRRTTLCGTLDYLPPEMIE---GRMHDEKVDLWSLGVLCYEFLVGK-PPFE-AN---------TYQETYKRISRVEFTFPDFVT----------------------------------EGARDLISRLLKHNPSQRPM------LREVLEHPWI-----------
-YI--MSKTLGSGACGEV---KLAFERKTCKKVAIKIISKRK-FAIGSAR-EADPALNVETEIEIL-KKL-NHPC--IIKIKNFF-D-----------------------------AEDYY--IVLELMEGG--ELFDKVV----GNKRLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI---LGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGY-PPFS-EH--------RTQVSLKDQITSGKYNFIPEVWAEVS------------------------------EKALDLVKKLLVVDPKARFT------TEEALRHPWL-----------
---YQLVRKLGRGKYSEV---FEAINITNNEKVVVKILKPVK-KKKIKR------------EIKIL-ENLRGGPN--IITLADIVKDP---------------------------VSRTPA--LVFEHVNNT--DFKQLY-------QTLTDYDIRFYMYEILKALDYCHSM-----GIMHRDVKPHNVMIDHEHRKL----RLIDWGLAEF---YHPGQEYNVRVASRYFKGPELLV--DYQMYDYSLDMWSLGCMLASMIFRK-EPFFHGH------DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT------AREAMEHPYF-----------
---YDTGEELGSGQFAVV---KKCREKSTGLQYAAKFIKKRR-TKSSRRG-VSREDI--EREVSIL-KEI-QHPN--VITLHEVYEN-----------------------------KTDVI--LILELVAGG--ELFDFLA----EKESLTEEEATEFLKQILNGVYYLHSL-----QIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK---IDFGNEFKNIFGTPEFVAPEIVN---YEPLGLEADMWSIGVITYILLSGA-SPFL-GD---------TKQETLANVSAVNYEFEDEYFSNTS------------------------------ALAKDFIRRLLVKDPKKRMT------IQDSLQHPWI-----------
--F-KEIELIGSGGFGQV---FKAKHRIDGKTYVIKRVKYNN-EKAER-------------EVKAL-AKL-DHVN--IVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEK--RRGEKLDKVLALELFEQITKGVDYIHSK-----KLIHRDLKPSNIFLV-DTKQV----KIGDFGLVTS---LKNDGKRTRSKGTLRYMSPEQIS---SQDYGKEVDLYALGLILAELLHVCDTAFE-T-------------SKFFTDLRDGIISDIFDK-----------------------------------KEKTLLQKLLSKKPEDRPN------TSEILR----TLT--------
--F-RQYRVLGKGGFGEV---CACQVRATGKMYACKKLEKKR-IKKRKGE-AMAL-----NEKQIL-EKV-NSRF--VVSLAYAYET-----------------------------KDALC--LVLTLMNGG--DLKFHIYH--MGQAGFPEARAVFYAAEICCGLEDLHRE-----RIVYRDLKPENILLD-DHGHI----RISDLGLAVH---VPEGQTIKGRVGTVGYMAPEVVK---NERYTFSPDWWALGCLLYEMIAGQ-SPFQ-QR------KKKIKREEVERLVK-EVPEEYSER--FS------------------------------PQARSLCSQLLCKDPAERLGCR-GGSAREVKEHPLF-----------
---YTDTKVIGNGSFGVV---YQAKLCDSGELVAIKKVLQDK-RFKNR-------------ELQIM-RKL-DHCN--IVRLRYFFYSSG-------------------------EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSF-----GICHRDIKPQNLLLDPDTAVL----KLCDFGSAKQ---LVRGEPNVSYICSRYYRAPELIF--GATDYTSSIDVWSAGCVLAELLLGQ-PIFP-GD------SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH--------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT------PLEACAHSFF-----------
---YEVLYTIGTGSYGRC---QKIRRKSDGKILVWKELDYGS-MTEAEKQ-MLVS------EVNLL-REL-KHPN--IVRYYDRIIDR---------------------------TNTTLY--IVMEYCEGG--DLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLD-GKQNV----KLGDFGLARIL--NHDTSFAKTFVGTPYYMSPEQMN---RMSYNEKSDIWSLGCLLYELCALM-PPFT-AF---------SQKELAGKIREGKFRRIPYRY---S------------------------------DELNEIITRMLNLKDYHRPS------VEEILENPL-I----------
--F-KFGKILGEGSFSTV---VLARELATSREYAIKILEKRH-IIKENKVPYVTR------ERDVM-SRL-DHPF--FVKLYFTFQD-----------------------------DEKLY--FGLSYAKNG--ELLKYIR----KIGSFDETCTRFYTAEIVSALEYLHGK-----GIIHRDLKPENILLN-EDMHI----QITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT---EKSACKSSDLWALGCIIYQLVAGL-PPFR-AG---------NEYLIFQKIIKLEYDFPEKFF----------------------------------PKARDLVEKLLVLDATKRLG------CEEM------EGYGPLKAHPF
---YQVGPLLGSGGFGSV---YSGIRVSDNLPVAIKHVEKDR-ISDWGEL-PNGTRV--PMEVVLL-KKV-SSGFSGVIRLLDWFER-----------------------------PDSFV--LILERPEPV-QDLFDFIT----ERGALQEELARSFFWQVLEAVRHCHNC-----GVLHRDIKDENILIDLNRGEL----KLIDFGSGA----LLKDTVYTDFDGTRVYSPPEWIR--YHRYHGRSAAVWSLGILLYDMVCGD-IPFE-HD---------------EEIIRGQVFFRQRVS----------------------------------SECQHLIRWCLALRPSDRPT------FEEIQNHPWM-----------
-YV--RGRFLGKGGFAKC---FEISDADTKEVFAGKIVPKSL-LLKPHQR-EKMS-----MEISIH-RSL-AHQH--VVGFHGFFED-----------------------------NDFVF--VVLELCRRR--SLLELHK----RRKALTEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLFLN-EDLEV----KIGDFGLATKV--EYDGERKKTLCGTPNYIAPEVLS---KKGHSFEVDVWSIGCIMYTLLVGK-PPFE-TS---------CLKETYLRIKKNEYSIPKHIN----------------------------------PVAASLIQKMLQTDPTARPT------INELLNDEFF-----------
--F-DLLRVIGRGSYAKV---LLVRLKKTDRIYAMKVVKKEL-VNDDEDI-DWVQ-----TEKHVF-EQASNHPF--LVGLHSCFQT-----------------------------ESRLF--FVIEYVNGG--DLMFHMQ----RQRKLPEEHARFYSAEISLALNYLHER-----GIIYRDLKLDNVLLD-SEGHI----KLTDYGMCKEG--LRPGDTTSTFCGTPNYIAPEILR---GEDYGFSVDWWALGVLMFEMMAGR-SPFD-IVGSSDNPDQNTEDYLFQVILEKQIRIPRSLS----------------------------------VKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPF-F----------
---FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKAT-LKVRDRV-RTKM------ERDIL-ADV-NHPF--VVKLHYAFQT-----------------------------EGKLY--LILDFLRGG--DLFTRLS----KEVMFTEEDVKFYLAELALGLDHLHSL-----GIIYRDLKPENILLD-EEGHI----KLTDFGLSKEA--IDHEKKAYSFCGTVEYMAPEVVN---RQGHSHSADWWSYGVLMFEMLTGS-LPFQ-GK---------DRKETMTLILKAKLGMPQFLS----------------------------------TEAQSLLRALFKRNPANRLGSG-PDGAEEIKRHV--FY---------
---FHFLKVIGKGSFGKV---LLARHKAEEVFYAVKVLQKKA-ILKKKEE-KHIM-----SERNVLLKNV-KHPF--LVGLHFSFQT-----------------------------ADKLY--FVLDYINGG--ELFYHLQ----RERCFLEPRARFYAAEIASALGYLHSL-----NIVYRDLKPENILLD-SQGHI----VLTDFGLCKEN--IEHNSTTSTFCGTPEYLAPEVLH---KQPYDRTVDWWCLGAVLYEMLYGL-PPFY-SR---------NTAEMYDNILNKPLQLKPNIT----------------------------------NSARHLLEGLLQKDRTKRLGAK--DDFMEIKSHV--FF---------
YLM---GDLLGEGSYGKV---KEVLDSETLCRRAVKILKKKK-LRRIPNG-EANVK----KEIQLL-RRL-RHKN--VIQLVDVLYNE---------------------------EKQKMY--MVMEYCVCGMQEMLDSVP-----EKRFPVCQAHGYFCQLIDGLEYLHSQ-----GIVHKDIKPGNLLLT-TGGTL----KISDLGVAEALHPFAADDTCRTSQGSPAFQPPEIAN-GLDTFSGFKVDIWSAGVTLYNITTGL-YPFE-GD---------NIYKLFENIGKGSYAIPGDCG----------------------------------PPLSDLLKGMLEYEPAKRFS------IRQIRQHSWF-----------
---FTKLEKIGKGSFGEV---FKGIDNRTQKVVAIKIIDLEE-AEDEIED-IQ-Q------EITVL-SQC-DSPY--VTKYYGSYLK-----------------------------DTKLW--IIMEYLGGG--SALDLLE-----PGPLDETQIATILREILKGLDYLHSE-----KKIHRDIKAANVLLS-EHGEV----KLADFGVAGQL--TDTQIKRNTFVGTPFWMAPEVIK---QSAYDSKADIWSLGITAIELARGE-PPHS-EL------HPMKVLFLIPKNNPPTLEGNYS------------------------------------KPLKEFVEACLNKEPSFRPT------AKELLKHKFI-----------
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