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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK MAPKAPK3 203
CMGC CDK5 4
CAMK CHEK2 220
CAMK MAPKAPK2 64
Other NEK2 8
Other PLK1 53
QLS---KQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQ-------------EVDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQE--RGDQAFTEREAAEIMRDIGTAIQFLHSH-----NIAHRDVKPENLLYTSKEKDAVLKLTDFGFAK--ETTQNALQTPCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLC-GFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVS----------------------EDAKQLIRLLLKTDPTERLTITQFMNHPWI-
---YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALR------EICLLKEL-KHKNIVRLHDVLHS----DKKLTLVFEFCDQ-DLKKYFD---SCNGDLDPEIVKSFLFQLLKGLGFCHSR-----NVLHRDLKPQNLLINRNGEL---KLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLF--GAKLYSTSIDMWSAGCIFAELANAGRPLFPGN-DVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF-
-YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKL-NHPCIIKIKNFF-D----AEDYYIVLELMEGGELFDKVV----GNKRLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI-LGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH---RTQVSLKDQITSGKYNFIPEVWAEVS----------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL-
KVT---SQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR-------R------EVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQD--RGDQAFTEREASEIMKSIGEAIQYLHSI-----NIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE-TTSHNSLTTPCYTPYYVAPEVLG---PEKYDKSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVS----------------------EEVKMLIRNLLKTEPTQRMTITEFMNHPWI-
---YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVS------EVNLLREL-KHPNIVRYYDRIIDR--TNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNV---KLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMN---RMSYNEKSDIWSLGCLLYELCA-LMPPFTAF----SQKELAGKIREGKFRRIPYRY---S----------------------DELNEIITRMLNLKDYHRPSVEEILENPL-I
-YV--RGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMS-----MEISIHRSL-AHQHVVGFHGFFED----NDFVFVVLELCRRRSLLELHK----RRKALTEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLFLNEDLEV---KIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLS---KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS----CLKETYLRIKKNEYSIPKHIN--------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF-
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