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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK MET 203
TK KDR 834
TK NTRK1 510
TK PTK2B 425
--VHFNEVIGRGHFGCVYHGTLL--DNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDF-SHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNE-----------------------------------------------------------------THNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDV-NTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSR-I
--LKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDY--VRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL-
IV--LKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA-RQDFQREAELLTML-QHQHIVRFFGVCT-EGRPLLMVFEYMRHGDLNRFLRSHGPDAKL---------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYY--RVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQL-SNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARL-
-V-VLNRILGEGFFGEVYEGVYT--NHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNL-DHPHIVKLIGIIE--EEPTWIIMELYPYGELGHYLERN-----------------------------------------------------------------KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYI-EDEDY--YKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWL-ENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCS-L
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