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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
TK MUSK 203
TK ABL1 261
TK ABL2 288
TK ALK 1116
TK BTK 402
CMGC CDK5 4
CMGC CDK9 2.7.11.23
CAMK CHEK1 9
TK EGFR 712
TK FGR 263
TK FYN 271
TK HCK 241
TK INSR 1023
TK INSRR 979
TKL IRAK4 186
TK JAK2 849
TK LCK 245
TK LYN 247
CMGC MAPK14 24
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
CMGC PCTK1 165
TK SRC 270
TK TNK2 150
TK TXK 271
TK YES1 277
--I-EYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLK-E--EAS-ADMQA-DFQ-R-EAALMAEFDNPNIVKLLGVCA--V--------GKPMCLLFEYMAYGDLNEFLR----SMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGE---NMVVKIADFGLSRNI---Y--S--ADYY--------------KANENDAIPIRWMPPESIF-YNRYTTESDVWAYGVVLWEIFSYGLQP---------------YYGMAHEEVIYYV-RDGNILSCPENCP-------------------------------VELYNLMRLCWSKLPADRPSFTSIHRIL-----
---ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLK-E--DTM-EV--E-EFL-K-EAAVMKEIKHPNLVQLLGVCT--R--------EPPFYIITEFMTYGNLLDYLR----EC----------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLVKVADFGLSRLM------T--GDTY--------------TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGIDLSQVYELL-EKDYRMERPEGCP-------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F---
---ITMKHKLGGGQYGEVYVGVWK-----KYSLTVAVKTLK-E--DTM-EV--E-EFL-K-EAAVMKEIKHPNLVQLLGVCT--L--------EPPFYIVTEYMPYGNLLDYLR----EC----------------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHVVKVADFGLSRLM------T--GDTY--------------TAHAGAKFPIKWTAPESLA-YNTFSIKSDVWAFGVLLWEIATYGMSP---------------YPGIDLSQVYDLL-EKGYRMEQPEGCP-------------------------------PKVYELMRACWKWSPADRPSFAETHQA--F---
--I-TLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLP-E--VCS-EQDEL-DFL-M-EALIISKFNHQNIVRCIGVSL--Q--------SLPRFILLELMAGGDLKSFLR----ETRP-----------------RPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDI---Y--R--ASYY--------------RKGGCAMLPVKWMPPEAFM-EGIFTSKTDTWSFGVLLWEIFSLGYMP---------------YPSKSNQEVLEFV-TSGGRMDPPKNCP-------------------------------GPVYRIMTQCWQHQPEDRPNFAIILER--I---
---LTFLKELGTGQFGVVKYGKWR------GQYDVAIKMIK-E--GSM-SE--D-EFI-E-EAKVMMNLSHEKLVQLYGVCT--K--------QRPIFIITEYMANGCLLNYLR----EM-----------------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVND---QGVVKVSDFGLSRYV------L--DDEY--------------TSSVGSKFPVRWSPPEVLM-YSKFSSKSDIWAFGVLMWEIYSLGKMP---------------YERFTNSETAEHI-AQGLRLYRPHLAS-------------------------------EKVYTIMYSCWHEKADERPTFKILLSN--I---
---YEKLEKIGEGTYGTVFKAKNR-----ETHEIVALKRVRLD--DDDEGV--P-SSALR-EICLLKELKHKNIVRLHDVLH--S--------DKKLTLVFEFCDQ-DLKKYFD--SCNG-------------------------DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINR---NGELKLADFGLARAF------GIPVRCY--------------SA---EVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPL---------------FPGNDVDDQLKRI-FRLLGTPTEEQWPSMTKLPDYKPYPMYPAT---TSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF---
---YEKLAKIGQGTFGEVFKARHR-----KTGQKVALKKVLME--NEKEGF--P-ITALR-EIKILQLLKHENVVNLIEICR--TKASPYNRCKGSIYLVFDFCEH-DLAGLLS--NVLV-------------------------KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITR---DGVLKLADFGLARAFSL--AKNSQPNRY--------------TN---RVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWT-RSPI---------------MQGNTEQHQLALI-SQLCGSITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF---
--W-DLVQTLGEGAYGEVQLAVNR-----VTEEAVAVKIVDMK--RAVDCP--E-NI-KK-EICINKMLNHENVVKFYGHRR--E--------GNIQYLFLEYCSGGELFDRIE---PDI-------------------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDE---RDNLKISDFGLATVFR----YNNRERLL--------------NK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELP---------------WDQP--SDSCQEY-SDWKEKKTYLNPWKKI--D-------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y--
--F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELR-E--ATS-PKANK-EIL-D-EAYVMASVDNPHVCRLLGICL-----------TSTVQLITQLMPFGCLLDYVR----EH-----------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL---G--A--EEKE--------------YHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGIPASEISSIL-EKGERLPQPPICT-------------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF-
---ITLERRLGTGCFGDVWLGTWN------GSTKVAVKTLK-P--GTM-SP--K-AFL-E-EAQVMKLLRHDKLVQLYAVVS-----------EEPIYIVTEFMCHGSLLDFLK----NP----------------------EGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGE---RLACKIADFGLARLI------K--DDEY--------------NPCQGSKFPIKWTAPEAAL-FGRFTIKSDVWSFGILLTELITKGRIP---------------YPGMNKREVLEQV-EQGYHMPCPPGCP-------------------------------ASLYEAMEQTWRLDPEERPTFEYLQSFL-----
---LQLIKRLGNGQFGEVWMGTWN------GNTKVAIKTLK-P--GTM-SP--E-SFL-E-EAQIMKKLKHDKLVQLYAVVS-----------EEPIYIVTEYMNKGSLLDFLK----DG----------------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGN---GLICKIADFGLARLI------E--DNEY--------------TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELVTKGRVP---------------YPGMNNREVLEQV-ERGYRMPCPQDCP-------------------------------ISLHELMIHCWKKDPEERPTFEYLQSFL-----
---LKLEKKLGAGQFGEVWMATYN------KHTKVAVKTMK-P--GSM-SV--E-AFL-A-EANVMKTLQHDKLVKLHAVVT-----------KEPIYIITEFMAKGSLLDFLK----SD----------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA---SLVCKIADFGLARVI------E--DNEY--------------TAREGAKFPIKWTAPEAIN-FGSFTIKSDVWSFGILLMEIVTYGRIP---------------YPGMSNPEVIRAL-ERGYRMPRPENCP-------------------------------EELYNIMMRCWKNRPEERPTFEYIQSV--L---
---ITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN-E--SAS-LRERI-EFL-N-EASVMKGFTCHHVVRLLGVVS--K--------GQPTLVVMELMAHGDLKSYLR----SLRPEA--------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH---DFTVKIGDFGMTRDI---Y--E--TDYY--------------RKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEITSLAEQP---------------YQGLSNEQVLKFV-MDGGYLDQPDNCP-------------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL-----
--I-SIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVN-E--LAS-PRECI-EFL-K-EASVMKAFKCHHVVRLLGVVS--Q--------GQPTLVIMELMTRGDLKSHLR----SLRPEA--------------ENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQ---DFTVKIGDFGMTRDV---Y--E--TDYY--------------RKGGKGLLPVRWMAPESLK-DGIFTTHSDVWSFGVVLWEIVTLAEQP---------------YQGLSNEQVLKFV-MDGGVLEELEGCP-------------------------------LQLQELMSRCWQPNPRLRPSFTHILD---SI--
VGG----NKMGEGGFGVVYKGYVN-----NTT--VAVKKLAAM--VDITTE--ELKQQFDQEIKVMAKCQHENLVELLGFSS--D--------GDDLCLVYVYMPNGSLLDRLSCLDGTP-------------------------PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDE---AFTAKISDFGLARASE----KFAQTVMT--------------SR---IVGTTAYMAPEALR--GEITPKSDIYSFGVVLLEIIT-GLPA---------------VDEHREPQLLLDI-KEEIEDEEKTIEDYIDKKMNDAD-----------------STSVEAMYSVASQCLHEKKNKRPDIKKVQQ----LLQ
---LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKLQ-H--STE--EHLR-DFE-R-EIEILKSLQHDNIVKYKGVCYSAG--------RRNLKLIMEYLPYGSLRDYLQ----KH-----------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN---ENRVKIGDFGLTKVL--PQ--D--KEYY--------------KVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELL-KNNGRLPRPDGCP-------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV-
---LKLVERLGAGQFGEVWMGYYN------GHTKVAVKSLK-Q--GSM-SP--D-AFL-A-EANLMKQLQHQRLVRLYAVVT-----------QEPIYIITEYMENGSLVDFLK----TP----------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI------E--DNEY--------------TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIP---------------YPGMTNPEVIQNL-ERGYRMVRPDNCP-------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L---
---IKLVKRLGAGQFGEVWMGYYN------NSTKVAVKTLK-P--GTM-SV--Q-AFL-E-EANLMKTLQHDKLVRLYAVVT--R--------EEPIYIITEYMAKGSLLDFLK----SD----------------------EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSE---SLMCKIADFGLARVI------E--DNEY--------------TAREGAKFPIKWTAPEAIN-FGCFTIKSDVWSFGILLYEIVTYGKIP---------------YPGRTNADVMTAL-SQGYRMPRVENCP-------------------------------DELYDIMKMCWKEKAEERPTFDYLQSV--L---
---YQNLSPVGSGAYGSVCAAFDT-----KTGLRVAVKKLSRP--FQSIIH--A-KRTYR-ELRLLKHMKHENVIGLLDVFT--PARS--LEEFNDVYLVTHLMGA-DLNNIVK----CQ-------------------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE---DCELKILDFGLAR---------HTDDEM--------------TG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FPGTDHIDQLKLI-LRLVGTPGAELLKKISSESARNYIQSLTQMP-KMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF---
-IV--LKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALK-E--ASE-SA-RQ-DFQ-R-EAELLTMLQHQHIVRFFGVCT--E--------GRPLLMVFEYMRHGDLNRFLR----SHGPDAKL---------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ---GLVVKIGDFGMSRDI---Y--S--TDYY--------------RVGGRTMLPIRWMPPESIL-YRKFTTESDVWSFGVVLWEIFTYGKQP---------------WYQLSNTEAIDCI-TQGRELERPRACP-------------------------------PEVYAIMRGCWQREPQQRHSIKDVHARL-----
--I-VLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLK-D--ASD-NA-RK-DFH-R-EAELLTNLQHEHIVKFYGVCV--E--------GDPLIMVFEYMKHGDLNKFLR----AHGPDAV-----------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGE---NLLVKIGDFGMSRDV---Y--S--TDYY--------------RVGGHTMLPIRWMPPESIM-YRKFTTESDVWSLGVVLWEIFTYGKQP---------------WYQLSNNEVIECI-TQGRVLQRPRTCP-------------------------------QEVYELMLGCWQREPHMRKNIKGIHTL--L---
--I-VLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALK-D--PTL-AA-RK-DFQ-R-EAELLTNLQHEHIVKFYGVCG--D--------GDPLIMVFEYMKHGDLNKFLR----AHGPDAMIL--------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA---NLLVKIGDFGMSRDV---Y--S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-YRKFTTESDVWSFGVILWEIFTYGKQP---------------WFQLSNTEVIECI-TQGRVLERPRVCP-------------------------------KEVYDVMLGCWQREPQQRLNIKEIYKIL-----
--Y-IKLDKLGEGTYATVYKGKSK-----LTDNLVALKEIRLE--HEEGAP--C--TAIR-EVSLLKDLKHANIVTLHDIIH--T--------EKSLTLVFEYLDK-DLKQYLD--DCGN-------------------------IINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINE---RGELKLADFGLARAK------SIPTKTY--------------SN---EVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMAT-GRPL---------------FPGSTVEEQLHFI-FRILGTPTEETWPGILSNEEFKTYNYPKYR--AEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF---
--L-RLEVKLGQGCFGEVWMGTWN------GTTRVAIKTLK-P--GTM-SP--E-AFL-Q-EAQVMKKLRHEKLVQLYAVVS-----------EEPIYIVTEYMSKGSLLDFLK----GE----------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI------E--DNEY--------------TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVP---------------YPGMVNREVLDQV-ERGYRMPCPPECP-------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L---
--L-RLLEKLGDGSFGVVRRGEWD--APSGKTVSVAVKCLK-PDVLSQ-PEAMD-DFI-R-EVNAMHSLDHRNLIRLYGVVL-----------TPPMKMVTELAPLGSLLDRLR----KH-----------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLAT---RDLVKIGDFGLMRAL--PQ--N--DDHY--------------VMQEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEP---------------WIGLNGSQILHKIDKEGERLPRPEDCP-------------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L---
--L-AFIKEIGSGQFGVVHLGEWR------SHIQVAIKAIN-E--GSM-SE--E-DFI-E-EAKVMMKLSHSKLVQLYGVCI--Q--------RKPLYIVTEFMENGCLLNYLR----EN-----------------------KGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSS---TCIVKISDFGMTRYV------L--DDEY--------------VSSFGAKFPIKWSPPEVFL-FNKYSSKSDVWSFGVLMWEVFTEGKMP---------------FENKSNLQVVEAI-SEGFRLYRPHLAP-------------------------------MSIYEVMYSCWHEKPEGRPTFAELLR---AV--
--L-RLEVKLGQGCFGEVWMGTWN------GTTKVAIKTLK-P--GTM-MP--E-AFL-Q-EAQIMKKLRHDKLVPLYAVVS-----------EEPIYIVTEFMSKGSLLDFLK----EG----------------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGE---NLVCKIADFGLARLI------E--DNEY--------------TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILQTELVTKGRVP---------------YPGMVNREVLEQV-ERGYRMPCPQGCP-------------------------------ESLHELMNLCWKKDPDERPTFEYIQSFL-----
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