|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other NEK1 203
TK ABL1 261
Other NEK2 8
TK SRC 270
Y-VRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEE--NGSLYIVMDYCEGGDLFKRINA--QKGV---LFQEDQILDWFVQICLALKHVHDR-----KILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELART---CIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCT-LKHAFEAG---SMKNLVLKIISGSFPPVSLHYS-YDLRSLVSQLFKRNPRDRPSVNSILEKGF-I
-ITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLK-EDTM-EVEEFL-KEAAVMKEIKHPNLVQLLGVCTR--EPPFYIITEFMTYGNLLDYLR-----ECNRQEVNAVVLLYMATQISSAMEYLEKK-----NFIHRDLAARNCLVGENHLVKVADFGLSRLMT--GDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP----EKVYELMRACWQWNPSDRPSFAEIHQA--F-
-YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQ---YLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKT---FVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCA-LMPPFTAF---SQKELAGKIREGKFRRIPYRY-SDELNEIITRMLNLKDYHRPSVEEILENPL-I
L-RLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLK-PGTM-SPEAFL-QEAQVMKKLRHEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLK-----GETGKYLRLPQLVDMAAQIASGMAYVERM-----NYVHRDLRAANILVGENLVCKVADFGLARLIE--DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP----ESLHDLMCQCWRKEPEERPTFEYLQAF--L-
|