Protein Surface  Ribbon
Inhibitor WI2
  ATP Location
Motifs All P-loop B3 Hinge
C-loop A-loop
Select Anchor
Summary of 2 kinases in KIF 2XKEA_WI2 (NEK2, PDB code: 2XKE, chain A)

Multiple sequence alignment of family kinases

Conserved residues:   
                            
Group      Kinase           
Other      NEK2         203 
Other      NEK1           4 



-YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRY-SDELNEIITRMLNLKDYHRPSVEEILENPLI
Y-VRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEE--NGSLYIVMDYCEGGDLFKRINA--QKGVLFQEDQILDWFVQICLALKHVHDR-----KILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYS-YDLRSLVSQLFKRNPRDRPSVNSILEKGFI