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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
STE OXSR1 203
TK ABL1 261
Other AURKA 133
CMGC CDK2 4
CAMK CHEK2 220
TK EGFR 712
AGC GRK6 186
TK HCK 241
TK IGF1R 999
STE MAP2K4 102
Other NEK2 8
Other NEK7 34
AGC PDPK1 82
AGC PRKCI 245
TK RET 724
TK SRC 270
TK ZAP70 338
----YELQEVIGSGATAVVQAAYCA-----PKKEKVAIKRINLEK-CQTSM--DE--LLK------EIQAMSQC-HHPNIVSYYTSFVV--KDELWLVMKLLSGG--SVLDIIKHIVAKGEHKSG-------------------------VLDESTIATILREVLEGLEYLHKN-----GQIHRDVKAGNILLGEDGSV---QIADFGVSAFLAT--GGDITRNKVRKT---FVGTPCWMAPEVME---QVRGYDFKADIWSFGITAIELAT-GAAPYHKY------PPMKVLMLTLQNDPPSLETGVQDKE--MLK-----------------KYGKSFRKMISLCLQKDPEKRPT------AAELLRHKFF-----------
----ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLK-ED-TM-EV--EE-FL-K------EAAVMKEI-KHPNLVQLLGVCTR--EPPFYIITEFMTYG--NLLDYLR---------EC----------------------NRQEVNAVVLLYMATQISSAMEYLEKK-----NFIHRDLAARNCLVGENHLV---KVADFGLSRLM-------T--GDTYTAHAGAKFPIKWTAPESLA----YNKFSIKSDVWAFGVLLWEIATYGMSPYPGI------DLSQVYELLEKDYRMERPEGCP----------------------------EKVYELMRACWQWNPSDRPS------FAEIHQA--F-----------
----FEIGRPLGKGKFGNVYLAREK-----QSKFILALKVLFKAQLEKAGV--EH-QLRR------EVEIQSHL-RHPNILRLYGYFHD--ATRVYLILEYAPLG--TVYRELQ--------KLS-------------------------KFDEQRTATYITELANALSYCHSK-----RVIHRDIKPENLLLGSAGEL---KIADFGWSV---------HAPSSRRTT---LCGTLDYLPPEMIE----GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN---------TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPM------LREVLEHPWI-----------
----FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDT-ETEGV--PS-TAIR------EISLLKEL-NHPNIVKLLDVIHT--ENKLYLVFEFLHQ---DLKKFMDA------SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLINTEGAI---KLADFGLARAF-------GVPVRTYTH---EVVTLWYRAPEILL---GCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD------SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS------AKAALAHPFF-----------
--YI--MSKTLGSGACGEVKLAFER-----KTCKKVAIKIISKRK-FAIGS--AR-EADPALNVETEIEILKKL-NHPCIIKIKNFF-D--AEDYYIVLELMEGG--ELFDKVV--------GNK-------------------------RLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI--------LGETSLMRT---LCGTPTYLAPEVLVS-VGTAGYNRAVDCWSLGVILFICLS-GYPPFSEH--------RTQVSLKDQITSGKYNFIPEVWAEVS----------------------EKALDLVKKLLVVDPKARFT------TEEALRHPWL-----------
---F-KKIKVLGSGAFGTVYKGLWIP-EGEKVKIPVAIKELR-EA-TS-PKANKE-IL-D------EAYVMASV-DNPHVCRLLGICL---TSTVQLITQLMPFG--CLLDYVR---------EH-----------------------KDNIGSQYLLNWCVQIAKGMNYLEDR-----RLVHRDLAARNVLVKTPQHV---KITDFGLAKLL---G---A--EEKEYHAEGGKVPIKWMALESIL----HRIYTHQSDVWSYGVTVWELMTFGSKPYDGI------PASEISSILEKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPK------FRELI----IEF---------
---F-RQYRVLGKGGFGEVCACQVR-----ATGKMYACKKLEKKR-IKKRK--GE-AMAL-----NEKQILEKV-NSRFVVSLAYAYET--KDALCLVLTLMNGG--DLKFHIYH------MGQA-------------------------GFPEARAVFYAAEICCGLEDLHRE-----RIVYRDLKPENILLDDHGHI---RISDLGLAVH--------VPEGQTIKG---RVGTVGYMAPEVVK----NERYTFSPDWWALGCLLYEMIA-GQSPFQQR------KKKIKREEVERLVK-EVPEEYSER--FS----------------------PQARSLCSQLLCKDPAERLGCR-GGSAREVKEHPLF-----------
----LKLEKKLGAGQFGEVWMATYN------KHTKVAVKTMK-PG-SM-SV--EA-FL-A------EANVMKTL-QHDKLVKLHAVVT---KEPIYIITEFMAKG--SLLDFLK---------SD----------------------EGSKQPLPKLIDFSAQIAEGMAFIEQR-----NYIHRDLRAANILVSASLVC---KIADFGLARVI-------E--DNEYTAREGAKFPIKWTAPEAIN----FGSFTIKSDVWSFGILLMEIVTYGRIPYPGM------SNPEVIRALERGYRMPRPENCP----------------------------EELYNIMMRCWKNRPEERPT------FEYIQSV--L-----------
----ITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN-EA-AS-MRERIE-FL-N------EASVMKEF-NCHHVVRLLGVVSQ--GQPTLVIMELMTRG--DLKSYLR---------SLRPEM--------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNAN-----KFVHRDLAARNCMVAEDFTV---KIGDFGMTRDI---Y---E--TDYYRKGGKGLLPVRWMSPESLK----DGVFTTYSDVWSFGVVLWEIATLAEQPYQGL------SNEQVLRFVMEGGLLDKPDNCP----------------------------DMLFELMRMCWQYNPKMRPS------FLEIISS--I-----------
--LK--DLGEIGRGAYGSVNKMVHK-----PSGQIMAVKRIRSTV-DEKEQ--KQ-L-LM------DLDVVMRSSDCPYIVQFYGALFR--EGDCWICMELMSTSFDKFYKYVYS------VLDD-------------------------VIPEEILGKITLATVKALNHLKEN----LKIIHRDIKPSNILLDRSGNI---KLCDFGISGQ--------LVDSIAKTR---DAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELAT-GRFPYPKW-------NSVFDQLTQVVKGDPPQLSNSEEREFS----------------------PSFINFVNLCLTKDESKRPK------YKELLKHPFI-----------
----YEVLYTIGTGSYGRCQKIRRK-----SDGKILVWKELDYGS-MTEAE--KQ-MLVS------EVNLLREL-KHPNIVRYYDRIIDRTNTTLYIVMEYCEGG--DLASVITKG----TKERQ-------------------------YLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNV---KLGDFGLARIL-------NHDTSFAKT---FVGTPYYMSPEQMN----RMSYNEKSDIWSLGCLLYELCA-LMPPFTAF---------SQKELAGKIREGKFRRIPYRY---S----------------------DELNEIITRMLNLKDYHRPS------VEEILENPL-I----------
----FRIEKKIGRGQFSEVYRAACL-----LDGVPVALKKVQIFD-LMDAK--AR-ADCI-----KEIDLLKQL-NHPNVIKYYASFIE--DNELNIVLELADAG--DLSRMIKHF----KKQKR-------------------------LIPERTVWKYFVQLCSALEHMHSR-----RVMHRDIKPANVFITATGVV---KLGDLGLGRFF-------SSKTTAAHS---LVGTPYYMSPERIH----ENGYNFKSDIWSLGCLLYEMAA-LQSPFYGD-------KMNLYSLCKKIEQCDYPPLPSDHYS------------------------EELRQLVNMCINPDPEKRPD------VTYV------YDVA-------
---F-KFGKILGEGSFSTVVLAREL-----ATSREYAIKILEKRH-IIKEN--KVPYVTR------ERDVMSRL-DHPFFVKLYFTFQD--DEKLYFGLSYAKNG--ELLKYIR--------KIG-------------------------SFDETCTRFYTAEIVSALEYLHGK-----GIIHRDLKPENILLNEDMHI---QITDFGTAKVLS-----PESKQARANS---FVGTAQYVSPELLT----EKSACKSSDLWALGCIIYQLVA-GLPPFRAG---------NEYLIFQKIIKLEYDFPEKFF--------------------------PKARDLVEKLLVLDATKRLG------CEEM------EGYGPLKAHPF
---F-DLLRVIGRGSYAKVLLVRLK-----KTDRIYAMKVVKKEL-VNDDE--DI-DWVQ-----TEKHVFEQASNHPFLVGLHSCFQT--ESRLFFVIEYVNGG--DLMFHMQ--------RQR-------------------------KLPEEHARFYSAEISLALNYLHER-----GIIYRDLKLDNVLLDSEGHI---KLTDYGMCKEG-------LRPGDTTST---FCGTPNYIAPEILR----GEDYGFSVDWWALGVLMFEMMA-GRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLS--------------------------VKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPF-F----------
---L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-EN-AS-PSELRD-LL-S------EFNVLKQV-NHPHVIKLYGACSQ--DGPLLLIVEYAKYG--SLRGFLR---------ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEM-----KLVHRDLAARNILVAEGRKM---KISDFGLSRDV---Y---E--EDSYVKRSQGRIPVKWMAIESLF----DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI------PPERLFNLLKTGHRMERPDNCS----------------------------EEMYRLMLQCWKQEPDKRPV------FADISKDL-------------
---L-RLEVKLGQGCFGEVWMGTWN------GTTRVAIKTLK-PG-TM-SP--EA-FL-Q------EAQVMKKL-RHEKLVQLYAVVS---EEPIYIVTEYMSKG--SLLDFLK---------GE----------------------TGKYLRLPQLVDMAAQIASGMAYVERM-----NYVHRDLRAANILVGENLVC---KVADFGLARLI-------E--DNEYTARQGAKFPIKWTAPEAAL----YGRFTIKSDVWSFGILLTELTTKGRVPYPGM------VNREVLDQVERGYRMPCPPECP----------------------------ESLHDLMCQCWRKEPEERPT------FEYLQAF--L-----------
LIAD----IELGCGNFGSVRQGVYR---MRKKQIDVAIKVLK-QG-TE-KADTEE-MM-R------EAQIMHQL-DNPYIVRLIGVCQ---AEALMLVMEMAGGG--PLHKFLV---------GK-----------------------REEIPVSNVAELLHQVSMGMKYLEEK-----NFVHRDLAARNVLLVNRHYA---KISDFGLSKAL--GA---D--DSYYTARSAGKWPLKWYAPECIN----FRKFSSRSDVWSYGVTMWEALSYGQKPYKKM------KGPEVMAFIEQGKRMECPPECP----------------------------PELYALMSDCWIYKWEDRPD------FLTVEQR--M-----------
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