Protein Surface  Ribbon
Inhibitor X4Z
  ATP Location
Motifs All P-loop B3 Hinge
C-loop A-loop
Select Anchor
Summary of 2 kinases in KIF 2X4ZA_X4Z (PAK4, PDB code: 2X4Z, chain A)

Multiple sequence alignment of family kinases

Conserved residues:   
                            
Group      Kinase           
STE        PAK4         203 
TK         LCK          245 



DNFI-----KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRREL--LFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHT---RMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKS---LVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVD-GEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL
----LKLVERLGAGQFGEVWMGYYN-GHTKVAVKSLK-QGSM-SPDAFL-AEANLMKQLQHQRLVRLYAVVT-QEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIE--DNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP--EELYQLMRLCWKERPEDRPTFDYLRSV--L