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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PDPK1 203
TK ABL1 261
TK ABL2 288
AGC AKT1 150
Other AURKA 133
Other AURKB 77
Other AURKC 43
CAMK CAMK2D 14
TK CSK 195
CAMK DAPK3 13
CMGC DYRK2 222
TK EGFR 712
Other EIF2AK2 267
Other EIF2AK4 590
TK EPHA3 621
TK EPHA5 675
TK EPHB1 619
TK ERBB4 718
TK FGFR2 481
Other GAK 40
AGC GRK4 187
CMGC GSK3B 56
CMGC HIPK4 -1
TKL IRAK4 186
TK JAK2 849
TK JAK3 822
TK LYN 247
STE MAP3K2 356
STE MAP3K3 362
CMGC MAPK10 64
CMGC MAPK9 26
Other PLK4 12
AGC PRKCQ 380
TK RET 724
AGC RPS6KB1 91
Other SBK1 53
CAMK SIK2 20
STE SLK 34
CAMK STK17A 61
CAMK STK17B 33
Other STK36 4
Other TTK 525
TK TXK 271
Other ULK3 14
STE YSK4 1162
-------------------------------F-KFGKILGEGSFSTVVLARE---L-------ATSREYAIKILEKRH-IIKEN--K-VPYVTR----ERDVMSRL--D------HPFFVKLYFTFQ--D-----------------------------DEKLY--FGLSYAKNG--ELLKYIR----KIG-------------------------SF---DETCTRFYTAEIVSALEYLHG-K--GIIHRDLKPENILLN--EDMHI----QITDFGTAKVLS-------------------PESKQARA-NS---FVGTAQYVSPEL-LT-----------EKSACKSSDLWALGCIIYQLVA-GL-PP---------------FRAG----NE-YLIFQKIIKLEYDFPEKFF---------------------------------------------------------------------------PKARDLVEKLLVLDATKRLG-----CE-EM------EGYGPLKAHPF
--------------------------------ITMKHKLGGGQYGEVYEGVW---K-------KYSLTVAVKTLK-ED-TM-EV--E-E-FL-K----EAAVMKEI--K------HPNLVQLLGVCT--R-----------------------------EPPFY--IITEFMTYG--NLLDYLR-----EC----------------------NRQEV---NAVVLLYMATQISSAMEYLEK-K--NFIHRDLAARNCLVG--ENHLV----KVADFGLSRLM---------------------T--GDTY-TAHAGAKFPIKWTAPES-LA-----------YNKFSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-DLSQV-YELLEKDYRMERPEGCP-----------------------------------------------------------------------------EKVYELMRACWQWNPSDRPS-----FA-EIHQA--F-----------
--------------------------------ITMKHKLGGGQYGEVYVGVW---K-------KYSLTVAVKTLK-ED-TM-EV--E-E-FL-K----EAAVMKEI--K------HPNLVQLLGVCT--L-----------------------------EPPFY--IVTEYMPYG--NLLDYLR-----EC----------------------NREEV---TAVVLLYMATQISSAMEYLEK-K--NFIHRDLAARNCLVG--ENHVV----KVADFGLSRLM---------------------T--GDTY-TAHAGAKFPIKWTAPES-LA-----------YNTFSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-DLSQV-YDLLEKGYRMEQPEGCP-----------------------------------------------------------------------------PKVYELMRACWKWSPADRPS-----FA-ETHQA--F-----------
-------------------------------F-EYLKLLGKGTFGKVILVKE---K-------ATGRYYAMKILKKEV-IVAKD--E-V-AHTL---TENRVLQNS--R------HPFLTALKYSFQ--T-----------------------------HDRLC--FVMEYANGG--ELFFHLS----RER-------------------------VF---SEDRARFYGAEIVSALDYLHSEK--NVVYRDLKLENLMLD--KDGHI----KITDFGLCKEG---------------------IKDGATM-KT---FCGTPEYLAPEV-LE-----------DNDYGRAVDWWGLGVVMYEMMC-GR-LP---------------FYNQ----DH-EKLFELILMEEIRFPRTLG---------------------------------------------------------------------------PEAKSLLSGLLKKDPKQRLGGGSEDAK-EIMQHRFF-----------
--------------------------------FEIGRPLGKGKFGNVYLARE---K-------QSKFILALKVLFKAQLEKAGV--E-H-QLRR----EVEIQSHL--R------HPNILRLYGYFH--D-----------------------------ATRVY--LILEYAPLG--TVYRELQ----KLS-------------------------KF---DEQRTATYITELANALSYCHS-K--RVIHRDIKPENLLLG--SAGEL----KIADFGWSV-----------------------HAPSSRR-TT---LCGTLDYLPPEM-IE-----------GRMHDEKVDLWSLGVLCYEFLV-GK-PP---------------FEAN----TY-QETYKRISRVEFTFPDFVT---------------------------------------------------------------------------EGARDLISRLLKHNPSQRPM-----LR-EVLEHPWI-----------
--------------------------------FEIGRPLGKGKFGNVYLARE---K-------KSHFIVALKVLFKSQ-IEKEG--V-E-HQLR---REIEIQAHL--H------HPNILRLYNYFY--D-----------------------------RRRIY--LILEYAPRG--ELYKELQ----KSC-------------------------TF---DEQRTATIMEELADALMYCHG-K--KVIHRDIKPENLLLG--LKGEL----KIADFGWSV-----------------------HAPSLRR-KT---MCGTLDYLPPEM-IE-----------GRMHNEKVDLWCIGVLCYELLV-GN-PP---------------FESA----SH-NETYRRIVKVDLKFPASVP---------------------------------------------------------------------------MGAQDLISKLLRHNPSERLP-----LA-QVSAHPWV-----------
--------------------------------FEIGRPLGKGKFGNVYLARL---K-------ESHFIVALKVLFKSQ-IEKEG--L-E-HQLR---REIEIQAHL--Q------HPNILRLYNYFH--D-----------------------------ARRVY--LILEYAPRG--ELYKELQ----KSE-------------------------KL---DEQRTATIIEELADALTYCHD-K--KVIHRDIKPENLLLG--FRGEV----KIADFGWSV-----------------------HTPSLRR-KT---MCGTLDYLPPEM-IE-----------GRTYDEKVDLWCIGVLCYELLV-GY-PP---------------FESA----SH-SETYRRILKVDVRFPLSMP---------------------------------------------------------------------------LGARDLISRLLRYQPLERLP-----LA-QILKHPWV-----------
--------------------------------YQLFEELGKGAFSVVRRCMK---I-------PTGQEYAAKIINTKK-LSARD--H-Q-KLER----EARICRLL--K------HPNIVRLHDSIS--E-----------------------------EGFHY--LVFDLVTGG--ELFEDIV----ARE-------------------------YY---SEADASHCIQQILESVNHCHL-N--GIVHRDLKPENLLLA--SKSKGA-AVKLADFGLAIEV---------------------QGDQQAW-FG---FAGTPGYLSPEV-LR-----------KDPYGKPVDMWACGVILYILLV-GY-PP---------------FWDE----DQ-HRLYQQIKAGAYDFPSPEWDTVT-----------------------------------------------------------------------PEAKDLINKMLTINPAKRIT-----AS-EALKHPWI-----------
--------------------------------LKLLQTIGKGEFGDVMLGDY---R---------GNKVAVKCIK-ND-AT-AQ----A-FL-A----EASVMTQL--R------HSNLVQLLGVIV-EE-----------------------------KGGLY--IVTEYMAKG--SLVDYLR-----SR----------------------GRSVL---GGDCLLKFSLDVCEAMEYLEG-N--NFVHRDLAARNVLVS--EDNVA----KVSDFGLTKEA---------------------------S-STQDTGKLPVKWTAPEA-LR-----------EKKFSTKSDVWSFGILLWEIYSFGR-VP---------------YPRI-PLKDV-VPRVEKGYKMDAPDGCP-----------------------------------------------------------------------------PAVYEVMKNCWHLDAAMRPS-----FL-QLREQL-------------
--------------------------------YEMGEELGSGQFAIVRKCRQ---K-------GTGKEYAAKFIKKRR-LSSSR--R-G-VSREEIEREVNILREI--R------HPNIITLHDIFE--N-----------------------------KTDVV--LILELVSGG--ELFDFLA----EKE-------------------------SL---TEDEATQFLKQILDGVHYLHS-K--RIAHFDLKPENIMLL--DKNVPNPRIKLIDFGIAHK----------------------IEAGNEF-KN---IFGTPEFVAPEI-VN-----------YEPLGLEADMWSIGVITYILLS-GA-SP---------------FLGE----TK-QETLTNISAVNYDFDEEYFSNTS-----------------------------------------------------------------------ELAKDFIRRLLVKDPKRRMT-----IA-QSLEHSWI-----------
--------------------------------YEVLKVIGKGSFGQVVKAYD---H-------KVHQHVALKMVRNEK-RFHRQ--A-A-E-------EIRILEHL--RKQDKDNTMNVIHMLENFT--F-----------------------------RNHIC--MTFELLSM---NLYELIKK--NKFQ-------------------------GF---SLPLVRKFAHSILQCLDALHK-N--RIIHCDLKPENILLK--QQGRSG--IKVIDFGSSC------------------------YEHQRV-YT---YIQSRFYRAPEV-IL-----------GARYGMPIDMWSLGCILAELLT-GY-PL---------------LPGE-DEGDQ-LACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNG-------------------GRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMT-----PG-QALRHPWL-----------
-------------------------------F-KKIKVLGSGAFGTVYKGLW---IP---EGEKVKIPVAIKELR-EA-TS-PKANK-E-IL-D----EAYVMASV--D------NPHVCRLLGICL--------------------------------TSTVQ--LITQLMPFG--CLLDYVR-----EH-----------------------KDNI---GSQYLLNWCVQIAKGMNYLED-R--RLVHRDLAARNVLVK--TPQHV----KITDFGLAKLL-----------G---------A--EEKE-YHAEGGKVPIKWMALES-IL-----------HRIYTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI-PASEI-SSILEKGERLPQPPICT-----------------------------------------------------------------------------IDVYMIMVKCWMIDADSRPK-----FR-ELI----IEF---------
-------------------------------F-KEIELIGSGGFGQVFKAKH---R-------IDGKTYVIKRVKYNN-EKAER--------------EVKALAKL--D------HVNIVHYNGCWD--GFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEK--RRGE-------------------------KL---DKVLALELFEQITKGVDYIHS-K--KLIHRDLKPSNIFLV--DTKQV----KIGDFGLVTS----------------------LKNDGKR-TR---SKGTLRYMSPEQ-IS-----------SQDYGKEVDLYALGLILAELLH-VCDTA---------------FET---------SKFFTDLRDGIISDIFDK----------------------------------------------------------------------------KEKTLLQKLLSKKPEDRPN-----TS-EILR----TLT--------
EDENSKSQNQDEDCNEKNGCHESEPSVTTEAV--------------------------------------------------------------------------------------------------------------------------------HYLY--IQMEYCEKS--TLRDTID----QGL-------------------------YR---DTVRLWRLFREILDGLAYIHE-K--GMIHRDLKPVNIFLD--SDDHV----KIGDFGLATDHLAFSADSKQ---DDQTGDLIKSDPSGHL-TG---MVGTALYVSPEVQGS----------TKSAYNQKVDLFSLGIIFFEMSY-HP-MV---------------TASE----RI-FVLNQLRDPTSPKFPEDFDDGEH-----------------------------------------------------------------------AKQKSVISWLLNHDPAKRPT-----AT-ELLKSEL-L----------
-------------------------------I-SIDKVVGAGEFGEVCSGRL---K----LPSKKEISVAIKTLK-VG-YT-EKQRR-D-FL-G----EASIMGQF--D------HPNIIRLEGVVT--K-----------------------------SKPVM--IVTEYMENG--SLDSFLR-----KH-----------------------DAQF---TVIQLVGMLRGIASGMKYLSD-M--GYVHRDLAARNILIN--SNLVC----KVSDFGLSRVL-----------E---------D--DPEAAYTTRGGKIPIRWTSPEA-IA-----------YRKFTSASDVWSYGIVLWEVMSYGE-RP---------------YWEM-SNQDV-IKAVDEGYRLPPPMDCP-----------------------------------------------------------------------------AALYQLMLDCWQKDRNNRPK-----FE-QIVSIL-------------
--------------------------------ITIERVIGAGEFGEVCSGRL---K----LPGKRELPVAIKTLK-VG-YT-EKQRR-D-FL-G----EASIMGQF--D------HPNIIHLEGVVT--K-----------------------------SKPVM--IVTEYMENG--SLDTFLK-----KN-----------------------DGQF---TVIQLVGMLRGISAGMKYLSD-M--GYVHRDLAARNILIN--SNLVC----KVSDFGLSRVL-----------E---------D--DPEAAYTTRGGKIPIRWTAPEA-IA-----------FRKFTSASDVWSYGIVMWEVVSYGE-RP---------------YWEM-TNQDV-IKAVEEGYRLPSPMDCP-----------------------------------------------------------------------------AALYQLMLDCWQKERNSRPK-----FD-EIVNML-------------
-------------------------------V-KIEEVIGAGEFGEVYKGRL---K----LPGKREIYVAIKTLK-AG-YS-EKQRR-D-FL-S----EASIMGQF--D------HPNIIRLEGVVT--K-----------------------------SRPVM--IITEFMENG--ALDSFLR-----QN-----------------------DGQF---TVIQLVGMLRGIAAGMKYLAE-M--NYVHRDLAARNILVN--SNLVC----KVSDFGLSRYLQ--------DDT---------S--DPTY-TSSLGGKIPVRWTAPEA-IA-----------YRKFTSASDVWSYGIVMWEVMSFGE-RP---------------YWDM-SNQDV-INAIEQDYRLPPPMDCP-----------------------------------------------------------------------------AALHQLMLDCWQKDRNSRPR-----FA-EIVNTL-------------
-------------------------------L-KRVKVLGSGAFGTVYKGIW---VP---EGETVKIPVAIKILN-ET-TG-PKANV-E-FM-D----EALIMASM--D------HPHLVRLLGVCL--------------------------------SPTIQ--LVTQLMPHG--CLLEYVH-----EH-----------------------KDNI---GSQLLLNWCVQIAKGMMYLEE-R--RLVHRDLAARNVLVK--SPNHV----KITDFGLARLL-----------E---------G--DEKE-YNADGGKMPIKWMALEC-IH-----------YRKFTHQSDVWSYGVTIWELMTFGG-KP---------------YDGI-PTREI-PDLLEKGERLPQPPICT-----------------------------------------------------------------------------IDVYMVMVKCWMIDADSRPK-----FK-ELAAE--F-----------
--------------------------------LTLGKPLGEGCFGQVVMAEA---VGIDKDKPKEAVTVAVKMLK-DD-AT-EKDLS-D-LV-S----EMEMMKMIG-K------HKNIINLLGACT--Q-----------------------------DGPLY--VIVEYASKG--NLREYLR-----ARRPPGMEY--------SYDINRVPEEQM---TFKDLVSCTYQLARGMEYLAS-Q--KCIHRDLAARNVLVT--ENNVM----KIADFGLARDI-----------N---------N--IDYY-KKTTNGRLPVKWMAPEA-LF-----------DRVYTHQSDVWSFGVLMWEIFTLGG-SP---------------YPGI-PVEEL-FKLLKEGHRMDKPANCT-----------------------------------------------------------------------------NELYMMMRDCWHAVPSQRPT-----FK-QLVEDL-------------
------------------------------LR--VRRVLAEGGFAFVYEAQD---V-------GSGREYALKRLLSNE-EEKNR--A-I---IQ----EVCFMKKL-SG------HPNIVQFCSAAS--IGKEE---------------------SDTGQAEFL--LLTELCKG---QLVEFLKK-MESRG-------------------------PL---SCDTVLKIFYQTCRAVQHMHR-QKPPIIHRDLKVENLLLS--NQGTI----KLCDFGSATTISHYPDY---------SWSAQRRALVEEE-IT---RNTTPMYRTPEI-IDL--------YSNFPIGEKQDIWALGCILYLLCF-RQ-HP---------------FEDG----AK-LRIVNGKYS-IPPHDTQY----------------------------------------------------------------------------TVFHSLIRAMLQVNPEERLS-----IA-EVVHQ---L----------
------------------------------FR--HYRVLGKGGFGEVCACQV---R-------ATGKMYACKKLQKKR-IKKRK--G-E-AMAL---NEKRILEKV--Q------SRFVVSLAYAYE--T-----------------------------KDALC--LVLTIMNGG--DLKFHIYN--LGNP-------------------------GF---DEQRAVFYAAELCCGLEDLQR-E--RIVYRDLKPENILLD--DRGHI----RISDLGLATE----------------------IPEGQRV-RG---RVGTVGYMAPEV-VN-----------NEKYTFSPDWWGLGCLIYEMIQ-GH-SP---------------FKKY-KEKVK-WEEVDQRIKNDTEEYSE---KFS-----------------------------------------------------------------------EDAKSICRMLLTKNPSKRLGCRGEGAA-GVKQHPV-F----------
--------------------------------YTDTKVIGNGSFGVVYQAKL---C-------DSGELVAIKKVLQDK-RFKNR--------------ELQIMRKL--D------HCNIVRLRYFFY--SSG-------------------------EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-------------------------TL---PVIYVKLYMYQLFRSLAYIHS-F--GICHRDIKPQNLLLD-PDTAVL----KLCDFGSAKQ----------------------LVRGEPN-VS---YICSRYYRAPEL-IF----------GATDYTSSIDVWSAGCVLAELLL-GQ-PI---------------FPGD-SGVDQ-LVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------------------------------------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-----PL-EACAHSFF-----------
--------------------------------YDIIEVLGKGTFGEVAKGWR---R-------STGEMVAIKILKNDA-YRNRI--I-K-N-------ELKLLHCM--RGL-DPEEAHVIRFLEFFH--D-----------------------------ALKFY--LVFELLEQ---NLFEFQK-----EN-------------------------NFAPLPARHIRTVTLQVLTALARLKE-L--AIIHADLKPENIMLV--DQTRCPFRVKVIDFGSASIF---------------------SEVRYVK-EP---YIQSRFYRAPEI-LL-----------GLPFCEKVDVWSLGCVMAELHL-GW-PL---------------YPGN-NEYDQ-VRYICETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERIS-----PS-AALRHPFV-----------
-----------------------------VGG----NKMGEGGFGVVYKGYV---N-------NTT--VAVKKLAAMV-DITTE--ELK-QQFD---QEIKVMAKC--Q------HENLVELLGFSS--D-----------------------------GDDLC--LVYVYMPNG--SLLDRLSC-LDGTP-------------------------PL---SWHMRCKIAQGAANGINFLHE-N--HHIHRDIKSANILLD--EAFTA----KISDFGLARASE-------------------KFAQTVMT-SR---IVGTTAYMAPEA-LR------------GEITPKSDIYSFGVVLLEIIT-GL-PA---------------VDEH-REPQL-LLDIKEEIEDEEKTIEDYIDKKMNDAD---------------------------------------------------------------STSVEAMYSVASQCLHEKKNKRPD-----IK-KVQQ----LLQ--------
--------------------------------LKFLQQLGKGNFGSVEMCRY---DP---LQDNTGEVVAVKKLQ-HS-TE--EHLR-D-FE-R----EIEILKSL--Q------HDNIVKYKGVCYSAG-----------------------------RRNLK--LIMEYLPYG--SLRDYLQ-----KH-----------------------KERI---DHIKLLQYTSQICKGMEYLGT-K--RYIHRDLATRNILVE--NENRV----KIGDFGLTKVL----------PQ---------D--KEYY-KVKEPGESPIFWYAPES-LT-----------ESKFSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM-IVFHL-IELLKNNGRLPRPDGCP-----------------------------------------------------------------------------DEIYMIMTECWNNNVNQRPS-----FR-DLA----LRV---------
-------------------------------L-KYISQLGKGNFGSVELCRY---DP---LGDNTGALVAVKQLQ-HS-GP-DQ-QR-D-FQ-R----EIQILKAL--H------SDFIVKYRGVSYGPG-----------------------------RQSLR--LVMEYLPSG--CLRDFLQ-----RH-----------------------RARL---DASRLLLYSSQICKGMEYLGS-R--RCVHRDLAARNILVE--SEAHV----KIADFGLAKLL----------PL---------D--KDYY-VVREPGQSPIFWYAPES-LS-----------DNIFSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDVPALCRL-LELLEEGQRLPAPPACP-----------------------------------------------------------------------------AEVHELMKLCWAPSPQDRPS-----FS-ALGP---QL----------
--------------------------------IKLVKRLGAGQFGEVWMGYY---N--------NSTKVAVKTLK-PG-TM-SV--Q-A-FL-E----EANLMKTL--Q------HDKLVRLYAVVT--R-----------------------------EEPIY--IITEYMAKG--SLLDFLK-----SD----------------------EGGKV---LLPKLIDFSAQIAEGMAYIER-K--NYIHRDLRAANVLVS--ESLMC----KIADFGLARVI---------------------E--DNEY-TAREGAKFPIKWTAPEA-IN-----------FGCFTIKSDVWSFGILLYEIVTYGK-IP---------------YPGR-TNADV-MTALSQGYRMPRVENCP-----------------------------------------------------------------------------DELYDIMKMCWKEKAEERPT-----FD-YLQSV--L-----------
--------------------------------WRLGKLLGQGAFGRVYLCYD---V-------DTGRELAVKQVQFDP-DSPET--S-K-EVNAL-ECEIQLLKNL--L------HERIVQYYGCLR--DP---------------------------QEKTLS--IFMEYMPGG--SIKDQLK----AYG-------------------------AL---TENVTRKYTRQILEGVHYLHS-N--MIVHRDIKGANILRD--STGNV----KLGDFGASKRLQ------------------TICLSGTGM-KS---VTGTPYWMSPEV-IS-----------GEGYGRKADIWSVACTVVEMLT-EK-PP---------------WAEF----EA-MAAIFKIATQPTNPKLPPHVS-------------------------------------------------------------------------DYTRDFLKRIFV-EAKLRPS-----AD-ELLRHMF-V----------
-------------------------------W-RRGKLLGQGAFGRVYLCYD---V-------DTGRELASKQVQFDP-DSPET--S-K-EVSAL-ECEIQLLKNL--Q------HERIVQYYGCLR--DR---------------------------AEKTLT--IFMEYMPGG--SVKDQLK----AYG-------------------------AL---TESVTRKYTRQILEGMSYLHS-N--MIVHRDIKGANILRD--SAGNV----KLGDFGASKRLQ------------------TICMSGTGM-RS---VTGTPYWMSPEV-IS-----------GEGYGRKADVWSLGCTVVEMLT-EK-PP---------------WAEY----EA-MAAIFKIATQPTNPQLPSHIS-------------------------------------------------------------------------EHGRDFLRRIFV-EARQRPS-----AE-ELLTHHF-A----------
--------------------------------YQNLKPIGSGAQGIVCAAYD---A-------VLDRNVAIKKLSRPF-QNQTH--A-K-RAYR----ELVLMKCV--N------HKNIISLLNVFT--PQKT-----------------------LEEFQDVY--LVMELMDA---NLCQVIQ------M-------------------------EL---DHERMSYLLYQMLCGIKHLHS-A--GIIHRDLKPSNIVVK--SDCTL----KILDFGLART----------------------AGTSFMM-TP---YVVTRYYRAPEV-IL-----------GMGYKENVDIWSVGCIMGEMVR-HK-IL---------------FPGR-DYIDQ-WNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK------------------------------------LFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRIS-----VD-DALQHPYI-----------
--------------------------------YQQLKPIGSGAQGIVCAAFD---T-------VLGINVAVKKLSRPF-QNQTH--A-K-RAYR----ELVLLKCV--N------HKNIISLLNVFT--PQKT-----------------------LEEFQDVY--LVMELMDA---NLCQVIH------M-------------------------EL---DHERMSYLLYQMLCGIKHLHS-A--GIIHRDLKPSNIVVK--SDCTL----KILDFGLART----------------------ACTNFMM-TP---YVVTRYYRAPEV-IL-----------GMGYKENVDIWSVGCIMGELVK-GC-VI---------------FQGT-DHIDQ-WNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEE------------------------------------LFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS-----VD-EALRHPYI-----------
-------------------------------F-KVGNLLGKGSFAGVYRAES---I-------HTGLEVAIKMIDKKA-MYKAG--M-V-QRVQ---NEVKIHCQL--K------HPSILELYNYFE--D-----------------------------SNYVY--LVLEMCHNG--EMNRYLK---NRVK-------------------------PF---SENEARHFMHQIITGMLYLHS-H--GILHRDLTLSNLLLT--RNMNI----KIADFGLATQL---------------------KMPHEKH-YT---LCGTPNYISPEI-AT-----------RSAHGLESDVWSLGCMFYTLLI-GR-PP---------------FDTD----TV-KNTLNKVVLADYEMPSFLS---------------------------------------------------------------------------IEAKDLIHQLLRRNPADRLS-----LS-SVLDHPFM-----------
------------------------------FI--LHKMLGKGSFGKVFLAEF---K-------KTNQFFAIKALKKDV-VLMDD--D-V-ECTM---VEKRVLSLA-WE------HPFLTHMFCTFQ--T-----------------------------KENLF--FVMEYLNGG--DLMYHIQ----SCH-------------------------KF---DLSRATFYAAEIILGLQFLHS-K--GIVYRDLKLDNILLD--KDGHI----KIADFGMCKEN---------------------MLGDAKT-NT---FCGTPDYIAPEI-LL-----------GQKYNHSVDWWSFGVLLYEMLI-GQ-SP---------------FHGQ----DE-EELFHSIRMDNPFYPRWLE---------------------------------------------------------------------------KEAKDLLVKLFVREPEKRLG-----VRGDIRQHPLF-----------
-------------------------------L-VLGKTLGEGEFGKVVKATA---FH--LKGRAGYTTVAVKMLK-EN-AS-PSELR-D-LL-S----EFNVLKQV--N------HPHVIKLYGACS--Q-----------------------------DGPLL--LIVEYAKYG--SLRGFLR-----ESRKVGPGYLGSGGSRNSSSLDHPDERAL---TMGDLISFAWQISQGMQYLAE-M--KLVHRDLAARNILVA--EGRKM----KISDFGLSRDV-----------Y---------E--EDSY-VKRSQGRIPVKWMAIES-LF-----------DHIYTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI-PPERL-FNLLKTGHRMERPDNCS-----------------------------------------------------------------------------EEMYRLMLQCWKQEPDKRPV-----FA-DISKDL-------------
--------------------------------FELLRVLGKGGYGKVFQVRKVTGA-------NTGKIFAMKVLKKAM-IVRNA--K-D-TAHTK--AERNILEEV--K------HPFIVDLIYAFQ--T-----------------------------GGKLY--LILEYLSGG--ELFMQLE----REG-------------------------IF---MEDTACFYLAEISMALGHLHQ-K--GIIYRDLKPENIMLN--HQGHV----KLTDFGLCKES---------------------IHDGTVT-HT---FCGTIEYMAPEI-LM-----------RSGHNRAVDWWSLGALMYDMLT-GA-PP---------------FTGE----NR-KKTIDKILKCKLNLPPYLT---------------------------------------------------------------------------QEARDLLKKLLKRNAASRLGAGPGDAG-EVQAHPFF-----------
--------------------------------YELVRELGKGTYGKVDLVVY---K-------GTGTKMALKFVNKSK-TKLKN--F-----LR----EVSITNSL-SS------SPFIIKVFDVVF--E----------------------------TEDCYV--FAQEYAPAG--DLFDIIP----PQV-------------------------GL---PEDTVKRCVQQLGLALDFMHG-R--QLVHRDIKPENVLLFDRECRRV----KLADFGMTR------------------------RVGCRV-KR---VSGTIPYTAPEV-CQAG------RADGLAVDTGVDVWAFGVLIFCVLT-GN-FP---------------WEAA-SGADAFFEEFVRWQRGRLPGLPSQWRRFT-----------------------------------------------------------------------EPALRMFQRLLALEPERRGP-----AK-EVF-----RFLKH------
--------------------------------YDIEGTLGKGNFAVVKLGRH---R-------ITKTEVAIKIIDKSQ-LDAVN--L-E-KIYR----EVQIMKML--D------HPHIIKLYQVME--T-----------------------------KSMLY--LVTEYAKNG--EIFDYLA----NHG-------------------------RL---NESEARRKFWQILSAVDYCHG-R--KIVHRDLKAENLLLD--NNMNI----KIADFGFGNF----------------------FKSGELL-AT---WCGSPPYAAPEV-FE----------GQQYEGPQLDIWSMGVVLYVLVC-GA-LP---------------FDGP----TL-PILRQRVLEGRFRIPYFMS---------------------------------------------------------------------------EDCEHLIRRMLVLDPSKRLT-----IA-QIKEHKWM-----------
--------------------------------WEIIGELGDGAFGKVYKAQN---K-------ETSVLAAAKVIDTKS-EEELE--D-Y-M--V----EIDILASC--D------HPNIVKLLDAFY--Y-----------------------------ENNLW--ILIEFCAGG--AVDAVML---ELER-------------------------PL---TESQIQVVCKQTLDALNYLHD-N--KIIHRDLKAGNILFT--LDGDI----KLADFGVSAKN---------------------TRTIQRR-DS---FIGTPYWMAPEV-VMCE------TSKDRPYDYKADVWSLGITLIEMAE-IE-PP---------------HHEL-NPMRV-LLKIAKSEPPTLAQPSRWS---------------------------------------------------------------------------SNFKDFLKKCLEKNVDARWT-----TS-QLLQHPFV-----------
-----------------------------LCP---GRELGRGKFAVVRKCIK---K-------DSGKEFAAKFMRKRR-KGQDC--R-M-EIIH----EIAVLELA-QD------NPWVINLHEVYE--T-----------------------------ASEMI--LVLEYAAGG--EIFDQCVA--DREE-------------------------AF---KEKDVQRLMRQILEGVHFLHT-R--DVVHLDLKPQNILLT--SESPLG-DIKIVDFGLSRI----------------------LKNSEEL-RE---IMGTPEYVAPEI-LS-----------YDPISMATDMWSIGVLTYVMLT-GI-SP---------------FLGN----DK-QETFLNISQMNLSYSEEEFDVLS-----------------------------------------------------------------------ESAVDFIRTLLVKKPEDRAT-----AE-ECLKHPWL-----------
-----------------------------ILT---SKELGRGKFAVVRQCIS---K-------STGQEYAAKFLKKRR-RGQDC--R-A-EILH----EIAVLELA-KS------CPRVINLHEVYE--N-----------------------------TSEII--LILEYAAGG--EIFSLCLP--ELAE-------------------------MV---SENDVIRLIKQILEGVYYLHQ-N--NIVHLDLKPQNILLS--SIYPLG-DIKIVDFGMSRK----------------------IGHACEL-RE---IMGTPEYLAPEI-LN-----------YDPITTATDMWNIGIIAYMLLT-HT-SP---------------FVGE----DN-QETYLNISQVNVDYSEETFSSVS-----------------------------------------------------------------------QLATDFIQSLLVKNPEKRPT-----AE-ICLSHSWL-----------
--------------------------------YHVLEMIGEGSFGRVYKGRR---K-------YSAQVVALKFIPKLG-RSEKE--L-R-NLQR----EIEIMRGL--R------HPNIVHMLDSFE--T-----------------------------DKEVV--VVTDYAEG---ELFQILE----DDG-------------------------KL---PEDQVQAIAAQLVSALYYLHS-H--RILHRDMKPQNILLA--KGGGI----KLCDFGFARAM---------------------STNTMVL-TS---IKGTPLYMSPEL-VE-----------ERPYDHTADLWSVGCILYELAV-GT-PP---------------FYAT----SI-FQLVSLILKDPVRWPSTIS---------------------------------------------------------------------------PCFKNFLQGLLTKDPRQRLS-----WP-DLLYHPFI-----------
--------------------------------YSILKQIGSGGSSKVFQVLN---E-------KKQ-IYAIKYVNLEE-ADNQT--L-D-SYRN----EIAYLNKL-QQ-----HSDKIIRLYDYEI--T-----------------------------DQYIY--MVMECGNI---DLNSWLK----KKK-------------------------SI---DPWERKSYWKNMLEAVHTIHQ-H--GIVHSDLKPANFLIV---DGML----KLIDFGIANQMQ-------------------PDTTSVVK-DS---QVGTVNYMPPEA-IKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GK-TP---------------FQQI---INQ-ISKLHAIIDPNHEIEFPDIPE-------------------------------------------------------------------------KDLQDVLKCCLKRDPKQRIS-----IP-ELLAHPYV-----------
-------------------------------L-AFIKEIGSGQFGVVHLGEW---R--------SHIQVAIKAIN-EG-SM-SE--E-D-FI-E----EAKVMMKL--S------HSKLVQLYGVCI--Q-----------------------------RKPLY--IVTEFMENG--CLLNYLR-----EN-----------------------KGKL---RKEMLLSVCQDICEGMEYLER-N--GYIHRDLAARNCLVS--STCIV----KISDFGMTRYV---------------------L--DDEY-VSSFGAKFPIKWSPPEV-FL-----------FNKYSSKSDVWSFGVLMWEVFTEGK-MP---------------FENK-SNLQV-VEAISEGFRLYRPHLAP-----------------------------------------------------------------------------MSIYEVMYSCWHEKPEGRPT-----FA-ELLR---AV----------
------------------------------FI--LTERLGSGTYATVYKAYA---KK------DTREVVAIKCVAKKS-LNKAS--V-E-NLLT----EIEILKGI--R------HPHIVQLKDFQW--D-----------------------------SDNIY--LIMEFCAGG--DLSRFIH----TRR-------------------------IL---PEKVARVFMQQLASALQFLHE-R--NISHLDLKPQNILLSSLEKPHL----KLADFGFAQH----------------------MSPWDEK-HV---LRGSPLYMAPEM-VC-----------QRQYDARVDLWSMGVILYEALF-GQ-PP---------------FASR-SFSEL-EEKIRSNRVIELPLRPLLS---------------------------------------------------------------------------RDCRDLLQRLLERDPSRRIS-----FQ-DFFAHPWV-----------
--------------------------------WTKGEILGKGAYGTVYCGLT---S-------QGQ-LIAVKQVALDT-SNKLA--A-E-KEYRKLQEEVDLLKAL--K------HVNIVAYLGTCL--Q-----------------------------ENTVS--IFMEFVPGG--SISSIIN----RFG-------------------------PL---PEMVFCKYTKQILQGVAYLHE-N--CVVHRDIKGNNVMLM--PTGII----KLIDFGCARRLAWA---------------GLNGTHSDML-KS---MHGTPYWMAPEV-IN-----------ESGYGRKSDIWSIGCTVFEMAT-GK-PP---------------LASM---DRM-AAMFYIGAHRGLMPPLPDHFS-------------------------------------------------------------------------ENAADFVRMCLTRDQHERPS-----AL-QLLKHSFL-----------
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