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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PDPK1 203
TK ABL1 261
AGC AKT1 150
AGC AKT3 148
Other AURKA 133
CMGC CDK2 4
CAMK CHEK2 220
TK EGFR 712
TK ERBB4 718
TKL IRAK4 186
TK JAK2 849
TK JAK3 822
AGC PRKCB 342
AGC PRKCZ 252
AGC RPS6KB1 91
--F-KFGKILGEGSFSTVVLARE---L----ATSREYAIKILEKRH-IIKEN--K-VPYVTR------ERDVMSRL-DHPFFVKLYFTFQ--DDEKLYFGLSYAKNGELLKYIR---KIG---SFDETCTRFYTAEIVSALEYLHG-KGIIHRDLKPENILLNEDMHI---QITDFGTAKVLS--PESKQARANS---FVGTAQYVSPELLT---EKSACKSSDLWALGCIIYQLVA-GLPP---------------FRAG-------NEYLIFQKIIKLEYDFPEKFF--------------------------PKARDLVEKLLVLDATKRLG------CEEM------EGYGPLKAHPF---
---ITMKHKLGGGQYGEVYEGVW---K----KYSLTVAVKTLK-ED-TM-EV--E-E-FL-K------EAAVMKEI-KHPNLVQLLGVCT--REPPFYIITEFMTYGNLLDYLR----ECNRQEVNAVVLLYMATQISSAMEYLEK-KNFIHRDLAARNCLVGENHLV---KVADFGLSRLM----T--GDTYTAHAGAKFPIKWTAPESLA---YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YPGI----DLSQVYELLEKDYRMERPEGCP----------------------------EKVYELMRACWQWNPSDRPS------FAEIHQA--F--------------
--F-EYLKLLGKGTFGKVILVKE---K----ATGRYYAMKILKKEV-IVAKD--E-V-AHTL-----TENRVLQNS-RHPFLTALKYSFQ--THDRLCFVMEYANGGELFFHLS---RER---VFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHI---KITDFGLCKEG----IKDGATMKT---FCGTPEYLAPEVLE---DNDYGRAVDWWGLGVVMYEMMC-GRLP---------------FYNQ-------DHEKLFELILMEEIRFPRTLG--------------------------PEAKSLLSGLLKKDPKQRLGGG-SEDAKEIMQHRFF--------------
-FD--YLKLLGKGTFGKVILVRE---K----ASGKYYAMKILKKEV-IIAKD--E-V-AHTL-----TESRVLKNT-RHPFLTSLKYSFQ--TKDRLCFVMEYVNGGELFFHLS---RER---VFSEDRTRFYGAEIVSALDYLHS-GKIVYRDLKLENLMLDKDGHI---KITDFGLCKEG----ITDAATMKT---FCGTPEYLAPEVLE---DNDYGRAVDWWGLGVVMYEMMC-GRLP---------------FYNQ-------DHEKLFELILMEDIKFPRTLS--------------------------SDAKSLLSGLLIKDPNKRLGGG-PDDAKEIMRHSFF--------------
---FEIGRPLGKGKFGNVYLARE---K----QSKFILALKVLFKAQLEKAGV--E-H-QLRR------EVEIQSHL-RHPNILRLYGYFH--DATRVYLILEYAPLGTVYRELQ---KLS---KFDEQRTATYITELANALSYCHS-KRVIHRDIKPENLLLGSAGEL---KIADFGWSV------HAPSSRRTT---LCGTLDYLPPEMIE---GRMHDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN-------TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPM------LREVLEHPWI--------------
---FQKVEKIGEGTYGVVYKARN---K----LTGEVVALKKIRLDT-ETEGV--P-S-TAIR------EISLLKEL-NHPNIVKLLDVIH--TENKLYLVFEFLHQ-DLKKFMDA-SALT---GIPLPLIKSYLFQLLQGLAFCHS-HRVLHRDLKPQNLLINTEGAI---KLADFGLARAF----GVPVRTYTH---EVVTLWYRAPEILL--GCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD----SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS------AKAALAHPFF--------------
-YI--MSKTLGSGACGEVKLAFE---R----KTCKKVAIKIISKRK-FAIGS--A-R-EADPALNVETEIEILKKL-NHPCIIKIKNFF---DAEDYYIVLELMEGGELFDKVV---GNK---RLKEATCKLYFYQMLLAVQYLHE-NGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI-----LGETSLMRT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPP---------------FSEH------RTQVSLKDQITSGKYNFIPEVWAEVS----------------------EKALDLVKKLLVVDPKARFT------TEEALRHPWL--------------
--F-KKIKVLGSGAFGTVYKGLW---IPEGEKVKIPVAIKELR-EA-TS-PKANK-E-IL-D------EAYVMASV-DNPHVCRLLGICL---TSTVQLITQLMPFGCLLDYVR----EH-KDNIGSQYLLNWCVQIAKGMNYLED-RRLVHRDLAARNVLVKTPQHV---KITDFGLAKLL--G-A--EEKEYHAEGGKVPIKWMALESIL---HRIYTHQSDVWSYGVTVWELMTFGSKP---------------YDGI----PASEISSILEKGERLPQPPICT----------------------------IDVYMIMVKCWMIDADSRPK------FRELI----IEF------------
--L-KRVKVLGSGAFGTVYKGIW---VPEGETVKIPVAIKILN-ET-TG-PKANV-E-FM-D------EALIMASM-DHPHLVRLLGVCL---SPTIQLVTQLMPHGCLLEYVH----EH-KDNIGSQLLLNWCVQIAKGMMYLEE-RRLVHRDLAARNVLVKSPNHV---KITDFGLARLL--E-G--DEKEYNADGGKMPIKWMALECIH---YRKFTHQSDVWSYGVTIWELMTFGGKP---------------YDGI----PTREIPDLLEKGERLPQPPICT----------------------------IDVYMVMVKCWMIDADSRPK------FKELAAE--F--------------
VGG----NKMGEGGFGVVYKGYV---N----NTT--VAVKKLAAMV-DITTE--ELK-QQFD-----QEIKVMAKC-QHENLVELLGFSS--DGDDLCLVYVYMPNGSLLDRLSCLDGTP---PLSWHMRCKIAQGAANGINFLHE-NHHIHRDIKSANILLDEAFTA---KISDFGLARASE--KFAQTVMTSR---IVGTTAYMAPEALR----GEITPKSDIYSFGVVLLEIIT-GLPA---------------VDEH----REPQLLLDIKEEIEDEEKTIEDYIDKKMNDAD--------------STSVEAMYSVASQCLHEKKNKRPD------IKKVQQ----LLQ-----------
---LKFLQQLGKGNFGSVEMCRY---DPLQDNTGEVVAVKKLQ-HS-TE--EHLR-D-FE-R------EIEILKSL-QHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQ----KH-KERIDHIKLLQYTSQICKGMEYLGT-KRYIHRDLATRNILVENENRV---KIGDFGLTKVL-PQ-D--KEYYKVKEPGESPIFWYAPESLT---ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM----IVFHLIELLKNNGRLPRPDGCP----------------------------DEIYMIMTECWNNNVNQRPS------FRDLA----LRV------------
--L-KYISQLGKGNFGSVELCRY---DPLGDNTGALVAVKQLQ-HS-GP-DQ-QR-D-FQ-R------EIQILKAL-HSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQ----RH-RARLDASRLLLYSSQICKGMEYLGS-RRCVHRDLAARNILVESEAHV---KIADFGLAKLL-PL-D--KDYYVVREPGQSPIFWYAPESLS---DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDV-P--ALCRLLELLEEGQRLPAPPACP----------------------------AEVHELMKLCWAPSPQDRPS------FSALGP---QL-------------
--F-NFLMVLGKGSFGKVMLSER---K----GTDELYAVKILKKDV-VIQDD--D-V-ECTM-----VEKRVLALPGKPPFLTQLHSCFQ--TMDRLYFVMEYVNGGDLMYHIQ---QVG---RFKEPHAVFYAAEIAIGLFFLQS-KGIIYRDLKLDNVMLDSEGHI---KIADFGMCKEN----IWDGVTTKT---FCGTPDYIAPEIIA---YQPYGKSVDWWAFGVLLYEMLA-GQAP---------------FEGE-------DEDELFQSIMEHNVAYPKSMS--------------------------KEAVAICKGLMTKHPGKRLG------C---------GPEGERDIKEHAFF
--F-DLIRVIGRGSYAKVLLVRL---K----KNDQIYAMKVVKKEL-VHDDE--D-I-DWVQ-----TEKHVFEQASSNPFLVGLHSCFQ--TTSRLFLVIEYVNGGDLMFHMQ---RQR---KLPEEHARFYAAEICIALNFLHE-RGIIYRDLKLDNVLLDADGHI---KLTDYGMCKEG----LGPGDTTST---FCGTPNYIAPEILR---GEEYGFSVDWWALGVLMFEMMA-GRSP---------------FDIITDNPDMNTEDYLFQVILEKPIRIPRFLS--------------------------VKASHVLKGFLNKDPKERLGCRPQTGF---------SDIKSHAFF-----
---FELLRVLGKGGYGKVFQVRKVTGA----NTGKIFAMKVLKKAM-IVRNA--K-D-TAHTK----AERNILEEV-KHPFIVDLIYAFQ--TGGKLYLILEYLSGGELFMQLE---REG---IFMEDTACFYLAEISMALGHLHQ-KGIIYRDLKPENIMLNHQGHV---KLTDFGLCKES----IHDGTVTHT---FCGTIEYMAPEILM---RSGHNRAVDWWSLGALMYDMLT-GAPP---------------FTGE-------NRKKTIDKILKCKLNLPPYLT--------------------------QEARDLLKKLLKRNAASRLGAG-PGDAGEVQAHPFF--------------
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