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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PDPK1 203
TK ABL1 261
Other AURKB 77
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
CAMK CHEK1 9
TK CSK 195
CMGC CSNK2A1 39
CMGC GSK3B 56
TKL IRAK4 186
TK JAK2 849
TK JAK3 822
CMGC MAPK1 13
CMGC MAPK14 24
CMGC MAPK8 26
CAMK PIM1 38
AGC PRKCD 349
CAMK PRKD1 583
TK RET 724
--F-KFGKILGEGSFSTVVLAREL-----ATSREYAIKILEKRHIIK---EN--K-VPYVTR----ERDVMSRL-D---HPF--FVKLYFTFQ--D------DEKLY--FGLSYAKNG--ELLKYIR----KIG-------------------------SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHI---QITDFGTAKVLS---PESKQARANS---FVGTAQYVSPELLT-EKSACKSSDLWALGCIIYQLVA-GLPP---------------FR-AG----NEYLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATKRLG-CEEM------EGYGPLKAHPF
---ITMKHKLGGGQYGEVYEGVWK-----KYSLTVAVKTLK-EDTM----EV--E-E-FL-K----EAAVMKEI-K---HPN--LVQLLGVCT--R------EPPFY--IITEFMTYG--NLLDYLR-----EC----------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHLV---KVADFGLSRLM-----T--GDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSP---------------YP-GI-DLSQVYELLEKDYRMERPEGCP-----------------------------------------EKVYELMRACWQWNPSDRPS-FAEIHQA--F-----------
---FEIGRPLGKGKFGNVYLAREK-----KSHFIVALKVLFKSQIEK---EG--V-E-HQLR---REIEIQAHL-H---HPN--ILRLYNYFY--D------RRRIY--LILEYAPRG--ELYKELQ----KSC-------------------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGEL---KIADFGWSV-------HAPSLRRKT---MCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLV-GNPP---------------FE-SA----SHNETYRRIVKVDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSERLP-LAQVSAHPWV-----------
---YTKIEKIGEGTYGVVYKGRHK-----TTGQVVAMKKIRLESEEE---GV--P-S-TAIR----EISLLKEL-R---HPN--IVSLQDVLM--Q------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ-------------------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID-DKGTI---KLADFGLARAF-----GIPIRVYTH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPL---------------FH-GD-SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAKRIS-GKMALNHPYF-----------
---FQKVEKIGEGTYGVVYKARNK-----LTGEVVALKKIRLDTETE---GV--P-S-TAIR----EISLLKEL-N---HPN--IVKLLDVIH--T------ENKLY--LVFEFLHQ---DLKKFMDA--SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI---KLADFGLARAF-----GVPVRTYTH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRAL---------------FP-GD-SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-AKAALAHPFF-----------
--Y-EPVAEIGVGAYGTVYKARDP-----HSGHFVALKSVRVPNGGGGGGGL--P-I-STVR----EVALLRRL-EAFEHPN--VVRLMDVCA--TSR-TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP-------------------------GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTV---KLADFGLARI------YSYQMALTP---VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FC-GN-SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR---------------PVQSVVPEMEESGAQLLLEMLTFNPHKRIS-AFRALQHSYL-----------
--W-DLVQTLGEGAYGEVQLAVNR-----VTEEAVAVKIVDMKRAVD---CP--E-N-I-KK----EICINKML-N---HEN--VVKFYGHRR--E------GNIQY--LFLEYCSGG--ELFDRIE----PDI-------------------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL---KISDFGLATVFR---YNNRERLLNK---MCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLA-GELP---------------WD-QP---SDSCQEYSDWKEKKTYLNPWKKI--D-----------------------------------SAPLALLHKILVENPSARIT-IPDIKKDRW-Y----------
---LKLLQTIGKGEFGDVMLGDYR-------GNKVAVKCIK-NDAT----AQ----A-FL-A----EASVMTQL-R---HSN--LVQLLGVIV-EE------KGGLY--IVTEYMAKG--SLVDYLR-----SR----------------------GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVS-EDNVA---KVSDFGLTKEA-----------SSTQDTGKLPVKWTAPEALR-EKKFSTKSDVWSFGILLWEIYSFGRVP---------------YP-RI-PLKDVVPRVEKGYKMDAPDGCP-----------------------------------------PAVYEVMKNCWHLDAAMRPS-FLQLREQL-------------
---YQLVRKLGRGKYSEVFEAINI-----TNNEKVVVKILKPVKKKK---IK--R-----------EIKILENLRG---GPN--IITLADIVK--DP----VSRTPA--LVFEHVNNT--DFKQLY-------Q-------------------------TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL---RLIDWGLAEF------YHPGQEYNV---RVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIF-RKEP---------------FFHGH-DNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRK-----RWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-AREAMEHPYF-----------
---YTDTKVIGNGSFGVVYQAKLC-----DSGELVAIKKVLQDKRFK---NR--------------ELQIMRKL-D---HCN--IVRLRYFFY--SSG--EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-------------------------TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL---KLCDFGSAKQ------LVRGEPNVS---YICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPI---------------FP-GD-SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTARLT-PLEACAHSFF-----------
VGG----NKMGEGGFGVVYKGYVN-----NTT--VAVKKLAAMVDIT---TE--ELK-QQFD---QEIKVMAKC-Q---HEN--LVELLGFSS--D------GDDLC--LVYVYMPNG--SLLDRLSC-LDGTP-------------------------PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLD-EAFTA---KISDFGLARASE---KFAQTVMTSR---IVGTTAYMAPEALR--GEITPKSDIYSFGVVLLEIIT-GLPA---------------VD-EH-REPQLLLDIKEEIEDEEKTIEDYIDKKMNDAD---------------------------STSVEAMYSVASQCLHEKKNKRPD-IKKVQQ----LLQ--------
---LKFLQQLGKGNFGSVEMCRYDP-LQDNTGEVVAVKKLQ-HSTE-----EHLR-D-FE-R----EIEILKSL-Q---HDN--IVKYKGVCYSAG------RRNLK--LIMEYLPYG--SLRDYLQ-----KH-----------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVE-NENRV---KIGDFGLTKVL-PQ--D--KEYYKVKEPGESPIFWYAPESLT-ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQG-QM-IVFHLIELLKNNGRLPRPDGCP-----------------------------------------DEIYMIMTECWNNNVNQRPS-FRDLA----LRV---------
--L-KYISQLGKGNFGSVELCRYDP-LGDNTGALVAVKQLQ-HSGP----DQ-QR-D-FQ-R----EIQILKAL-H---SDF--IVKYRGVSYGPG------RQSLR--LVMEYLPSG--CLRDFLQ-----RH-----------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVE-SEAHV---KIADFGLAKLL-PL--D--KDYYVVREPGQSPIFWYAPESLS-DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCER-DVPALCRLLELLEEGQRLPAPPACP-----------------------------------------AEVHELMKLCWAPSPQDRPS-FSALGP---QL----------
---YTNLSYIGEGAYGMVCSAYDN-----VNKVRVAIKKISPFEHQT---YC--Q-R-T-LR----EIKILLRF-R---HEN--IIGINDIIR--APT-IEQMKDVY--IVQDLMET---DLYKLLK-----TQ-------------------------HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDL---KICDFGLARVAD--PDHDHTGFLTE---YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPI---------------FP-GK-HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKN-----------KVPWNRLFPNADSKALDLLDKMLTFNPHKRIE-VEQALAHPYL-----------
---YQNLSPVGSGAYGSVCAAFDT-----KTGLRVAVKKLSRPFQSI---IH--A-K-RTYR----ELRLLKHM-K---HEN--VIGLLDVFT--PARSLEEFNDVY--LVTHLMGA---DLNNIVK-----CQ-------------------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCEL---KILDFGLAR--------HTDDEMTG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FP-GT-DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMP-----------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-AAQALAHAYF-----------
---YQNLKPIGSGAQGIVCAAYDA-----ILERNVAIKKLSRPFQNQ---TH--A-K-RAYR----ELVLMKCV-N---HKN--IIGLLNVFT--PQKSLEEFQDVY--IVMELMDA---NLCQVIQ------M-------------------------ELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTL---KILDFGLART------AGTSFMMTP---YVVTRYYRAPEVIL-GMGYKENVDLWSVGCIMGEMVC-HKIL---------------FP-GR-DYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRIS-VDEALQHPYI-----------
---YQVGPLLGSGGFGSVYSGIRV-----SDNLPVAIKHVEKDRISD---WG--E-L-PNGTRVPMEVVLLKKV-S---SGFSGVIRLLDWFE--R------PDSFV--LILERPEPV-QDLFDFIT----ERG-------------------------ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL---KLIDFGSGA-------LLKDTVYTD---FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIP---------------FE-HD----------EEIIRGQVFFRQRVS---------------------------------------SECQHLIRWCLALRPSDRPT-FEEIQNHPWM-----------
-FI--FHKVLGKGSFGKVLLGELK-----GRGEYFAIKALKKDVVLI---DD--D-V-ECTM---VEKRVLTLAAE---NPF--LTHLICTFQ--T------KDHLF--FVMEFLNGG--DLMYHIQ----DKG-------------------------RFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLD-RDGHI---KIADFGMCKEN-----IFGESRAST---FCGTPDYIAPEILQ-GLKYTFSVDWWSFGVLLYEMLI-GQSP---------------FH-GD----DEDELFESIRVDTPHYPRWIT---------------------------------------KESKDILEKLFEREPTKRLGVTGNIKIHPFF-----------
-PD----EVLGSGQFGIVYGGKHR-----KTGRDVAIKIIDKLRFPT---KQ--E-S-QLRN----EVAILQNL-H---HPG--VVNLECMFE--T------PERVF--VVMEKLHGD--MLEMILS---SEKG-------------------------RLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLA-SADPFPQVKLCDFGFARI------IGEKSFRRS---VVGTPAYLAPEVLR-NKGYNRSLDMWSVGVIIYVSLS-GTFP---------------FN-ED------EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------HEAIDLINNLLQVKMRKRYS-VDKTLSHPWL-----------
--L-VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK-ENAS----PSELR-D-LL-S----EFNVLKQV-N---HPH--VIKLYGACS--Q------DGPLL--LIVEYAKYG--SLRGFLR-----ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVA-EGRKM---KISDFGLSRDV--Y--E--EDSYVKRSQGRIPVKWMAIESLF-DHIYTTQSDVWSFGVLLWEIVTLGGNP---------------YP-GI-PPERLFNLLKTGHRMERPDNCS-----------------------------------------EEMYRLMLQCWKQEPDKRPV-FADISKDL-------------
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