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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PDPK1 203
CMGC CDK4 6
CAMK CHEK1 9
CAMK CHEK2 220
TK JAK2 849
TK JAK3 822
CMGC MAPK14 24
-F-KFGKILGEGSFSTVVLAREL----ATSREYAIKILEKRHIIK---EN--KVPYVTR------ERDVMSRLD---HPFFVKLYFTFQ--D------DEKLYFGLSYAKNGELLKYIR--KIG--SFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHI---QITDFGTAKVLS--PESKQARANS---FVGTAQYVSPELLT---EKSACKSSDLWALGCIIYQLVA-GLPP---------------FRAG----NEYLIFQKIIKLEYDFPEKFF----------------------------PKARDLVEKLLVLDATKRLGCEEM------EGYGPLKAHPF
-Y-EPVAEIGVGAYGTVYKARDP----HSGHFVALKSVRVPNGGGGGGGL--PI-STVR------EVALLRRLEAFEHPNVVRLMDVCA--TSR-TDREIKVTLVFEHVDQ-DLRTYLDKAPPP--GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTV---KLADFGLARI-----YSYQMALTP---VVVTLWYRAPEVLL---QSTYATPVDMWSVGCIFAEMFR-RKPL---------------FCGN-SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR----PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL-----------
-W-DLVQTLGEGAYGEVQLAVNR----VTEEAVAVKIVDMKRAVD---CP--EN-I-KK------EICINKMLN---HENVVKFYGHRR--E------GNIQYLFLEYCSGGELFDRIE--PDI--GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERDNL---KISDFGLATVFR--YNNRERLLNK---MCGTLPYVAPELLK--RREFHAEPVDVWSCGIVLTAMLA-GELP---------------WDQP---SDSCQEYSDWKEKKTYLNPWKKI--D------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y----------
YI--MSKTLGSGACGEVKLAFER----KTCKKVAIKIISKRKFAI---GS--AR-EADPALNVETEIEILKKLN---HPCIIKIKNFF---D------AEDYYIVLELMEGGELFDKVV--GNK--RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKI-----LGETSLMRT---LCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPP---------------FSEH---RTQVSLKDQITSGKYNFIPEVWAEVS------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL-----------
--LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQ-HSTE-----EHLRD-FE-R------EIEILKSLQ---HDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ---KHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRV---KIGDFGLTKVL-PQ-D--KEYYKVKEPGESPIFWYAPESLT---ESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM-IVFHLIELLKNNGRLPRPDGCP------------------------------DEIYMIMTECWNNNVNQRPSFRDLA----LRV---------
-L-KYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQ-HSGP----DQ-QRD-FQ-R------EIQILKALH---SDFIVKYRGVSYGPG------RQSLRLVMEYLPSGCLRDFLQ---RHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHV---KIADFGLAKLL-PL-D--KDYYVVREPGQSPIFWYAPESLS---DNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDVPALCRLLELLEEGQRLPAPPACP------------------------------AEVHELMKLCWAPSPQDRPSFSALGP---QL----------
--YQNLSPVGSGAYGSVCAAFDT----KTGLRVAVKKLSRPFQSI---IH--AK-RTYR------ELRLLKHMK---HENVIGLLDVFT--PARSLEEFNDVYLVTHLMGA-DLNNIVK---CQ--KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCEL---KILDFGLAR-------HTDDEMTG---YVATRWYRAPEIML--NWMHYNQTVDIWSVGCIMAELLT-GRTL---------------FPGT-DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-----------
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