|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK PIM1 203
Other AURKA 133
CAMK CASK 12
CMGC CDK2 4
CAMK DAPK1 13
AGC GRK6 186
CAMK PRKD1 583
--YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDR-ISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLF-DFIT---ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL----KLIDFGSGA--LLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD---------EEIIRGQVFFRQRVS--------------------------SECQHLIRWCLALRPSDRPT-----FEEIQNHPWM
--FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR----EVEIQSHLRHPN--ILRLYGYFHDATRVYLILEYAPLG-TVY-RELQ---KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL----KIADFGWSV--HAPSSRRTTLCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLVGKPPFEAN---TYQETYKRISRVEFTFPDFVT--------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI
--YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAK-FTSSPGLSTEDL-KREASICHMLKHPH--IVELLETYSSDGMLYMVFEFMDGA-DLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLA-SKENSA-PVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVK-REPYGKPVDVWGCGVILFILLSGCLPFYGT----KERLFEGIIKGKYKMNPRQWSHIS----------------------ESAKDLVRRMLMLDPAERIT-----VYEALNHPWL
--FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT-ETEGVPSTAIR----EISLLKELNHPN--IVKLLDVIHTENKLYLVFEFLHQ--DLK-KFMDA-SALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI----KLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF
--YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRR-TKSSRRGVSREDIEREVSILKEIQHPN--VITLHEVYENKTDVILILELVAGG-ELF-DFLA---EKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK-IDFGNEFKNIFGTPEFVAPEIVN-YEPLGLEADMWSIGVITYILLSGASPFLGD---TKQETLANVSAVNYEFEDEYFSNTS----------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI
-F-RQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKR-IKKRKGEAMAL---NEKQILEKVNSRF--VVSLAYAYETKDALCLVLTLMNGG-DLK-FHIYH-MGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLD-DHGHI----RISDLGLAVH-VPEGQTIKGRVGTVGYMAPEVVK-NERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVK-EVPEEYSER--FS----------------------PQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLF
PD----EVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLR-FPTKQESQLRN----EVAILQNLHHPG--VVNLECMFETPERVFVVMEKLHGD-MLE-MILS--SEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLA-SADPFP-QVKLCDFGFARI-IGEKSFRRSVVGTPAYLAPEVLR-NKGYNRSLDMWSVGVIIYVSLSGTFPFNED-----EDIHDQIQNAAFMYPPNPWKEIS----------------------HEAIDLINNLLQVKMRKRYS-----VDKTLSHPWL
|