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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
CAMK PIM1 203
Other AURKA 133
Other AURKB 77
CMGC CDK2 4
CMGC CSNK2A1 39
CMGC CSNK2A2 40
CAMK PIM3 40
AGC RPS6KA3 68
YQVGPLLGSGGFGSVYSGIRVSDNL---PVAIKHVEKDR-ISDWGELPNGTRVPMEVVLLKKV-S----SGFSGVIRLLDWFER--PDSFVLILERPEPVQDLFDFIT--ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA--LLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE-HD---------EEIIRGQVFFRQRVS----------------------------------SECQHLIRWCLALRPSDRPT-----FEEIQNHPWM
FEIGRPLGKGKFGNVYLAREKQSKF---ILALKVLFKAQLEKAGVEHQLRR----EVEIQSHL-R----HPN--ILRLYGYFHD--ATRVYLILEYAPLG-TVYRELQ--KLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGELKIADFGWSV--HAPSSRRTTLCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLVGKPPFE-AN---TYQETYKRISRVEFTFPDFVT----------------------------------EGARDLISRLLKHNPSQRPM-----LREVLEHPWI
FEIGRPLGKGKFGNVYLAREKKSHF---IVALKVLFKSQ-IEKEGVEHQLR---REIEIQAHL-H----HPN--ILRLYNYFYD--RRRIYLILEYAPRG-ELYKELQ--KSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGELKIADFGWSV--HAPSLRRKTMCGTLDYLPPEMIE-GRMHNEKVDLWCIGVLCYELLVGNPPFE-SA---SHNETYRRIVKVDLKFPASVP----------------------------------MGAQDLISKLLRHNPSERLP-----LAQVSAHPWV
FQKVEKIGEGTYGVVYKARNKLTGE---VVALKKIRLDT-ETEGVPSTAIR----EISLLKEL-N----HPN--IVKLLDVIHT--ENKLYLVFEFLHQ--DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFP-GDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF
YQLVRKLGRGKYSEVFEAINITNNE---KVVVKILKPVK-KKKIKR---------EIKILENLRG----GPN--IITLADIVKDPVSRTPALVFEHVNNT-DFKQLY-----QTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEF-YHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT-----AREAMEHPYF
YQLVRKLGRGKYSEVFEAINITNNE---RVVVKILKPVK-KKKIKR---------EVKILENLRG----GTN--IIKLIDTVKDPVSKTPALVFEYINNT-DFKQLY-----QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF-YHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT-----AKEAMEHPYF
YQVGAVLGSGGFGTVYAGSRIADGL---PVAVKHVVKER-VTEWGSLGGATV-PLEVVLLRKV-GAAGGARG--VIRLLDWFER--PDGFLLVLERPEPAQDLFDFIT--ERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGA--LLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFE-QD---------EEILRGRLLFRRRVS----------------------------------PECQQLIRWCLSLRPSERPS-----LDQIAAHPWM
FELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKAT-LKVRDRVRTKM----ERDILVEV-N----HPF--IVKLHYAFQT--EGKLYLILDFLRGG-DLFTRLS--KEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLD-EEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVN-RRGHTQSADWWSFGVLMFEMLTGTLPFQ-GK---DRKETMTMILKAKLGMPQFLS----------------------------------PEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFF
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