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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other PLK3 203
TK ABL1 261
TK ALK 1116
CMGC CDK2 4
CAMK CHEK1 9
TK CSF1R 582
TK CSK 195
CAMK DAPK1 13
CAMK DAPK3 13
TK EGFR 712
TK ERBB2 720
TK FES 561
TK FYN 271
TK HCK 241
TK IGF1R 999
TK INSR 1023
TKL IRAK1 212
TKL IRAK4 186
TK ITK 363
TK JAK2 849
TK JAK3 822
TK KIT 589
TK LCK 245
TK LTK 510
TK LYN 247
CMGC MAPK14 24
Other NEK2 8
Other NEK3 4
Other PLK1 53
Other PLK2 82
TK PTK2 422
TK PTK2B 425
TKL RAF1 349
AGC RPS6KA1 62
AGC RPS6KA2 59
AGC RPS6KA6 73
TK SRC 270
STE STK10 36
TK SYK 371
TK TNK1 116
TK TNK2 150
--YL--KGRLLGKGGFARC---YEATDT-----ETGS---AYAVKVI---PQS--RVAKPH---Q-REKIL---NEIELHRDL-QHRHIVRFSHHFE--D------ADNIYIFLELCSRKSLAHIWK----ARH-----------------------------------------------------------------------------TLLEPEVRYYLRQILSGLKYLHQR-----GILHRDLKLGNFFITE---NMEL----KVGDFGLAARL-----------EPPEQRK-KT---ICGTPNYVAPEVLL-----RQG---HGPEADVWSLGCVMYTLLC-GSPP---------------FETA------DLKETY-RCIKQ----VHYTLPASLS-----------------------------------------LPARQLLAAILRASPRDRPS-----IDQILRHDFF----
----ITMKHKLGGGQYGEV---YEGVWK-----KYSL---TVAVKTL---K-E--DTM-EV---E-EFL-K----EAAVMKEI-KHPNLVQLLGVCT--R------EPPFYIITEFMTYGNLLDYLR-----EC--------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKK-----NFIHRDLAARNCLVGE---NHLV----KVADFGLSRLM-----------T--GDTY-TAHAGAKFPIKWTAPESLA-----YNK---FSIKSDVWAFGVLLWEIATYGMSP---------------YPGI---DLSQVYELL-EKDYR----MERPEGCP-------------------------------------------EKVYELMRACWQWNPSDRPS-----FAEIHQA--F----
---I-TLIRGLGHGAFGEV---YEGQVSGMPNDPSPL---QVAVKTL---P-E--VCS-EQD-EL-DFL-M----EALIISKF-NHQNIVRCIGVSL--Q------SLPRFILLELMAGGDLKSFLR-----ETRP---------------------------------------------------------------------RPSQPSSLAMLDLLHVARDIACGCQYLEEN-----HFIHRDIAARNCLLTCPGPGRVA----KIGDFGMARDI-----Y-----R--ASYY-RKGGCAMLPVKWMPPEAFM-----EGI---FTSKTDTWSFGVLLWEIFSLGYMP---------------YPSK---SNQEVLEFV-TSGGR----MDPPKNCP-------------------------------------------GPVYRIMTQCWQHQPEDRPN-----FAIILER--I----
----FQKVEKIGEGTYGVV---YKARNK-----LTGE---VVALKKI---RLD--TETEGV---P-STAIR----EISLLKEL-NHPNIVKLLDVIH--T------ENKLYLVFEFLHQ-DLKKFMDA--SALT-----------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSH-----RVLHRDLKPQNLLINT---EGAI----KLADFGLARAF-----------GVPVRTY-TH---EVVTLWYRAPEILL----GCKY---YSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD---SEIDQLFRI-FRTLG----TPDEVVWPGVTSMPDYKPSFPKWAR---------------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRIS-----AKAALAHPFF----
---W-DLVQTLGEGAYGEV---QLAVNR-----VTEE---AVAVKIV---DMK--RAVDCP---E-NI-KK----EICINKML-NHENVVKFYGHRR--E------GNIQYLFLEYCSGGELFDRIE----PDI-----------------------------------------------------------------------------GMPEPDAQRFFHQLMAGVVYLHGI-----GITHRDIKPENLLLDE---RDNL----KISDFGLATVFR---------YNNRERLL-NK---MCGTLPYVAPELLK----RREF---HAEPVDVWSCGIVLTAMLA-GELP---------------WDQP-----SDSCQEY-SDWKE----KKTYLNPWKKI--D-------------------------------------SAPLALLHKILVENPSARIT-----IPDIKKDRW-Y---
----LQFGKTLGAGAFGKV---VEATAFGLGKEDAVL---KVAVKML---K-S--TAH-ADE-KE-ALM-S----ELKIMSHLGQHENIVNLLGACT--H------GGPVLVITEYCCYGDLLNFLR-----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR-------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASK-----NCIHRDVAARNVLLTN---GHVA----KIGDFGLARDI-----M-----N--DSNY-IVKGNARLPVKWMAPESIF-----DCV---YTVQSDVWSYGILLWEIFSLGLNP---------------YPGI-L-VNSKFYKLV-KDGYQ----MAQPAFAP-------------------------------------------KNIYSIMQACWALEPTHRPT-----FQQICSFL------
----LKLLQTIGKGEFGDV---MLGDYR-------GN---KVAVKCI---K-N--DAT-AQ-----AFL-A----EASVMTQL-RHSNLVQLLGVIV-EE------KGGLYIVTEYMAKGSLVDYLR-----SR--------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGN-----NFVHRDLAARNVLVSE---DNVA----KVSDFGLTKEA-----------------S-STQDTGKLPVKWTAPEALR-----EKK---FSTKSDVWSFGILLWEIYSFGRVP---------------YPRI---PLKDVVPRV-EKGYK----MDAPDGCP-------------------------------------------PAVYEVMKNCWHLDAAMRPS-----FLQLREQL------
----YDTGEELGSGQFAVV---KKCREK-----STGL---QYAAKFI---KKR--RTKSSR---R-GVSREDIEREVSILKEI-QHPNVITLHEVYE--N------KTDVILILELVAGGELFDFLA----EKE-----------------------------------------------------------------------------SLTEEEATEFLKQILNGVYYLHSL-----QIAHFDLKPENIMLLD---RNVPKPRIKIIDFGLAHK------------IDFGNEF-KN---IFGTPEFVAPEIVN-----YEP---LGLEADMWSIGVITYILLS-GASP---------------FLGD------TKQETL-ANVSA----VNYEFEDEYFSNTS-------------------------------------ALAKDFIRRLLVKDPKKRMT-----IQDSLQHPWI----
----YEMGEELGSGQFAIV---RKCRQK-----GTGK---EYAAKFI---KKR--RLSSSR---R-GVSREEIEREVNILREI-RHPNIITLHDIFE--N------KTDVVLILELVSGGELFDFLA----EKE-----------------------------------------------------------------------------SLTEDEATQFLKQILDGVHYLHSK-----RIAHFDLKPENIMLLD---KNVPNPRIKLIDFGIAHK------------IEAGNEF-KN---IFGTPEFVAPEIVN-----YEP---LGLEADMWSIGVITYILLS-GASP---------------FLGE------TKQETL-TNISA----VNYDFDEEYFSNTS-------------------------------------ELAKDFIRRLLVKDPKRRMT-----IAQSLEHSWI----
---F-KKIKVLGSGAFGTV---YKGLWIP-EGEKVKI---PVAIKEL---R-E--ATS-PKA-NK-EIL-D----EAYVMASV-DNPHVCRLLGICL---------TSTVQLITQLMPFGCLLDYVR-----EH---------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDR-----RLVHRDLAARNVLVKT---PQHV----KITDFGLAKLL-----G-----A--EEKE-YHAEGGKVPIKWMALESIL-----HRI---YTHQSDVWSYGVTVWELMTFGSKP---------------YDGI---PASEISSIL-EKGER----LPQPPICT-------------------------------------------IDVYMIMVKCWMIDADSRPK-----FRELI----IEF--
---L-RKVKVLGSGAFGTV---YKGIWIP-DGENVKI---PVAIKVL---R-E--NTS-PKA-NK-EIL-D----EAYVMAGV-GSPYVSRLLGICL---------TSTVQLVTQLMPYGCLLDHVR-----EN---------------------------------------------------------------------------RGRLGSQDLLNWCMQIAKGMSYLEDV-----RLVHRDLAARNVLVKS---PNHV----KITDFGLARLL-----D-----I--DETE-YHADGGKVPIKWMALESIL-----RRR---FTHQSDVWSYGVTVWELMTFGAKP---------------YDGI---PAREIPDLL-EKGER----LPQPPICT-------------------------------------------IDVYMIMVKCWMIDSECRPR-----FRELVSE--F----
---L-VLGEQIGRGNFGEV---FSGRLR-----ADNT---LVAVKSC---R-E--TLP-PDL-KA-KFL-Q----EARILKQY-SHPNIVRLIGVCT--Q------KQPIYIVMELVQGGDFLTFLR-----TE---------------------------------------------------------------------------GARLRVKTLLQMVGDAAAGMEYLESK-----CCIHRDLAARNCLVTE---KNVL----KISDFGMSREE-----A-----D--GVYA-ASGGLRQVPVKWTAPEALN-----YGR---YSSESDVWSFGILLWETFSLGASP---------------YPNL---SNQQTREFV-EKGGR----LPCPELCP-------------------------------------------DAVFRLMEQCWAYEPGQRPS-----FSTIYQEL------
----LQLIKRLGNGQFGEV---WMGTWN------GNT---KVAIKTL---K-P--GTM-SP---E-SFL-E----EAQIMKKL-KHDKLVQLYAVVS---------EEPIYIVTEYMNKGSLLDFLK-----DG--------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERM-----NYIHRDLRSANILVGN---GLIC----KIADFGLARLI-----------E--DNEY-TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILLTELVTKGRVP---------------YPGM---NNREVLEQV-ERGYR----MPCPQDCP-------------------------------------------ISLHELMIHCWKKDPEERPT-----FEYLQSFL------
----LKLEKKLGAGQFGEV---WMATYN------KHT---KVAVKTM---K-P--GSM-SV---E-AFL-A----EANVMKTL-QHDKLVKLHAVVT---------KEPIYIITEFMAKGSLLDFLK-----SD--------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQR-----NYIHRDLRAANILVSA---SLVC----KIADFGLARVI-----------E--DNEY-TAREGAKFPIKWTAPEAIN-----FGS---FTIKSDVWSFGILLMEIVTYGRIP---------------YPGM---SNPEVIRAL-ERGYR----MPRPENCP-------------------------------------------EELYNIMMRCWKNRPEERPT-----FEYIQSV--L----
----ITMSRELGQGSFGMV---YEGVAKGVVKDEPET---RVAIKTV---N-E--AAS-MRE-RI-EFL-N----EASVMKEF-NCHHVVRLLGVVS--Q------GQPTLVIMELMTRGDLKSYLR-----SLRPEM------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNAN-----KFVHRDLAARNCMVAE---DFTV----KIGDFGMTRDI-----Y-----E--TDYY-RKGGKGLLPVRWMSPESLK-----DGV---FTTYSDVWSFGVVLWEIATLAEQP---------------YQGL---SNEQVLRFV-MEGGL----LDKPDNCP-------------------------------------------DMLFELMRMCWQYNPKMRPS-----FLEIISS--I----
----ITLLRELGQGSFGMV---YEGNARDIIKGEAET---RVAVKTV---N-E--SAS-LRE-RI-EFL-N----EASVMKGF-TCHHVVRLLGVVS--K------GQPTLVVMELMAHGDLKSYLR-----SLRPEA------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAK-----KFVHRDLAARNCMVAH---DFTV----KIGDFGMTRDI-----Y-----E--TDYY-RKGGKGLLPVRWMAPESLK-----DGV---FTTSSDMWSFGVVLWEITSLAEQP---------------YQGL---SNEQVLKFV-MDGGY----LDQPDNCP-------------------------------------------ERVTDLMRMCWQFNPKMRPT-----FLEIVNLL------
FSEE----LKIGEGGFGCV---YRAVMR-----NTV-----YAVKRL---KEN--ADLEWT---A-VKQSFL--TEVEQLSRF-RHPNIVDFAGYCA--Q------NGFYCLVYGFLPNGSLEDRLHCQTQACP-----------------------------------------------------------------------------PLSWPQRLDILLGTARAIQFLHQDS---PSLIHGDIKSSNVLLDE---RLTP----KLGDFGLARFSRFAG--SSPSQSSMVART-QT---VRGTLAYLPEEYIK-----TGR---LAVDTDTFSFGVVVLETLA-GQRA---------------VKTHG-AR-TKYLKDL-VEEEA----EEAGVALRST---QSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPP-----MTQVYE----RL--
-VGG----NKMGEGGFGVV---YKGYVN-----NTT-----VAVKKL---AAM--VDITTE---ELKQQFD---QEIKVMAKC-QHENLVELLGFSS--D------GDDLCLVYVYMPNGSLLDRLSC-LDGTP-----------------------------------------------------------------------------PLSWHMRCKIAQGAANGINFLHEN-----HHIHRDIKSANILLDE---AFTA----KISDFGLARASE---------KFAQTVMT-SR---IVGTTAYMAPEALR------GE---ITPKSDIYSFGVVLLEIIT-GLPA---------------VDEH---REPQLLLDI-KEEIE----DEEKTIEDYIDKKMNDAD-----------------------------STSVEAMYSVASQCLHEKKNKRPD-----IKKVQQ----LLQ-
----LTFVQEIGSGQFGLV---HLGYWL------NKD---KVAIKTI---R-E--GAM-SE---E-DFI-E----EAEVMMKL-SHPKLVQLYGVCL--E------QAPICLVFEFMEHGCLSDYLR-----TQ---------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEA-----CVIHRDLAARNCLVGE---NQVI----KVSDFGMTRFV-----------L--DDQY-TSSTGTKFPVKWASPEVFS-----FSR---YSSKSDVWSFGVLMWEVFSEGKIP---------------YENR---SNSEVVEDI-STGFR----LYKPRLAS-------------------------------------------THVYQIMNHCWKERPEDRPA-----FSRLLRQL------
----LKFLQQLGKGNFGSV---EMCRYDP-LQDNTGE---VVAVKKL---Q-H--STE--EH-LR-DFE-R----EIEILKSL-QHDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ-----KH---------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTK-----RYIHRDLATRNILVEN---ENRV----KIGDFGLTKVL----PQ-----D--KEYY-KVKEPGESPIFWYAPESLT-----ESK---FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM---IVFHLIELL-KNNGR----LPRPDGCP-------------------------------------------DEIYMIMTECWNNNVNQRPS-----FRDLA----LRV--
---L-KYISQLGKGNFGSV---ELCRYDP-LGDNTGA---LVAVKQL---Q-H--SGP-DQ--QR-DFQ-R----EIQILKAL-HSDFIVKYRGVSYGPG------RQSLRLVMEYLPSGCLRDFLQ-----RH---------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSR-----RCVHRDLAARNILVES---EAHV----KIADFGLAKLL----PL-----D--KDYY-VVREPGQSPIFWYAPESLS-----DNI---FSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDV-P-ALCRLLELL-EEGQR----LPAPPACP-------------------------------------------AEVHELMKLCWAPSPQDRPS-----FSALGP---QL---
----LSFGKTLGAGAFGKV---VEATAYGLIKSDAAM---TVAVKML---K-P--SAH-LTE-RE-ALM-S----ELKVLSYLGNHMNIVNLLGACT--I------GGPTLVITEYCCYGDLLNFLR-----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASK-----NCIHRDLAARNILLTH---GRIT----KICDFGLARDI-----K-----N--DSNY-VVKGNARLPVKWMAPESIF-----NCV---YTFESDVWSYGIFLWELFSLGSSP---------------YPGM-P-VDSKFYKMI-KEGFR----MLSPEHAP-------------------------------------------AEMYDIMKTCWDADPLKRPT-----FKQIVQL--I----
----LKLVERLGAGQFGEV---WMGYYN------GHT---KVAVKSL---K-Q--GSM-SP---D-AFL-A----EANLMKQL-QHQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK-----TP--------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEER-----NYIHRDLRAANILVSD---TLSC----KIADFGLARLI-----------E--DNEY-TAREGAKFPIKWTAPEAIN-----YGT---FTIKSDVWSFGILLTEIVTHGRIP---------------YPGM---TNPEVIQNL-ERGYR----MVRPDNCP-------------------------------------------EELYQLMRLCWKERPEDRPT-----FDYLRSV--L----
---V-TLLRALGHGAFGEV---YEGLVIGLPGDSSPL---QVAIKTL---P-E--LCS-PQD-EL-DFL-M----EALIISKF-RHQNIVRCVGLSL--R------ATPRLILLELMSGGDMKSFLR-----HSRP---------------------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEEN-----HFIHRDIAARNCLLSCAGPSRVA----KIGDFGMARDI-----Y-----R--ASYY-RRGDRALLPVKWMPPEAFL-----EGI---FTSKTDSWSFGVLLWEIFSLGYMP---------------YPGR---TNQEVLDFV-VGGGR----MDPPRGCP-------------------------------------------GPVYRIMTQCWQHEPELRPS-----FASILERL------
----IKLVKRLGAGQFGEV---WMGYYN------NST---KVAVKTL---K-P--GTM-SV---Q-AFL-E----EANLMKTL-QHDKLVRLYAVVT--R------EEPIYIITEYMAKGSLLDFLK-----SD--------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERK-----NYIHRDLRAANVLVSE---SLMC----KIADFGLARVI-----------E--DNEY-TAREGAKFPIKWTAPEAIN-----FGC---FTIKSDVWSFGILLYEIVTYGKIP---------------YPGR---TNADVMTAL-SQGYR----MPRVENCP-------------------------------------------DELYDIMKMCWKEKAEERPT-----FDYLQSV--L----
----YQNLSPVGSGAYGSV---CAAFDT-----KTGL---RVAVKKL---SRP--FQSIIH---A-KRTYR----ELRLLKHM-KHENVIGLLDVFT--PARSLEEFNDVYLVTHLMGA-DLNNIVK-----CQ-----------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSA-----DIIHRDLKPSNLAVNE---DCEL----KILDFGLAR--------------HTDDEM-TG---YVATRWYRAPEIML----NWMH---YNQTVDIWSVGCIMAELLT-GRTL---------------FPGT---DHIDQLKLI-LRLVG----TPGAELLKKISSESARNYIQSLTQMP-------------KMNFANVFIGANPLAVDLLEKMLVLDSDKRIT-----AAQALAHAYF----
----YEVLYTIGTGSYGRC---QKIRRK-----SDGK---ILVWKEL---DYG--SMTEAE---K-QMLVS----EVNLLREL-KHPNIVRYYDRII--DR----TNTTLYIVMEYCEGGDLASVITKGTKERQ-----------------------------------------------------------------------------YLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDG---KQNV----KLGDFGLARIL-----------NHDTSFA-KT---FVGTPYYMSPEQMN-----RMS---YNEKSDIWSLGCLLYELCA-LMPP---------------FTAF------SQKELA-GKIRE----GKFRRIPYRY---S-------------------------------------DELNEIITRMLNLKDYHRPS-----VEEILENPL-I---
---Y-MVLRMIGEGSFGRA---LLVQHE-----SSNQ---MFAMKEI---RLP--KSFSNT---Q-N-SRK----EAVLLAKM-KHPNIVAFKESFE--A------EGHLYIVMEYCDGGDLMQKIKQ--QKGK-----------------------------------------------------------------------------LFPEDMILNWFTQMCLGVNHIHKK-----RVLHRDIKSKNIFLTQ---NGKV----KLGDFGSARLL-----------SNPMAFA-CT---YVGTPYYVPPEIWE-----NLP---YNNKSDIWSLGCILYELCT-LKHP---------------FQAN---SWKNLILKV-CQGCI----SPLPSHYS-------------------------------------------YELQFLVKQMFKRNPSHRPS-----ATTLLS----RGIV
--YV--RGRFLGKGGFAKC---FEISDA-----DTKE---VFAGKIV---PKS--LLLKPH---Q-REKMS---MEISIHRSL-AHQHVVGFHGFFE--D------NDFVFVVLELCRRRSLLELHK----RRK-----------------------------------------------------------------------------ALTEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLFLNE---DLEV----KIGDFGLATKV-----------EYDGERK-KT---LCGTPNYIAPEVLS-----KKG---HSFEVDVWSIGCIMYTLLV-GKPP---------------FETS------CLKETY-LRIKK----NEYSIPKHIN-----------------------------------------PVAASLIQKMLQTDPTARPT-----INELLNDEFF----
---Y-CRGKVLGKGGFAKC---YEMTDL-----TNNK---VYAAKII---PHS--RVAKPH---Q-REKID---KEIELHRIL-HHKHVVQFYHYFE--D------KENIYILLEYCSRRSMAHILK----ARK-----------------------------------------------------------------------------VLTEPEVRYYLRQIVSGLKYLHEQ-----EILHRDLKLGNFFINE---AMEL----KVGDFGLAARL-----------EPLEHRR-RT---ICGTPNYLSPEVLN-----KQG---HGCESDIWALGCVMYTMLL-GRPP---------------FETT------NLKETY-RCIRE----ARYTMPSSLL-----------------------------------------APAKHLIASMLSKNPEDRPS-----LDDIIRHDFF----
----IELGRCIGEGQFGDV---HQGIYM--SPENPAL---AVAIKTC---K-N--CTS-DSV-RE-KFL-Q----EALTMRQF-DHPHIVKLIGVIT---------ENPVWIIMELCTLGELRSFLQ-----VR---------------------------------------------------------------------------KYSLDLASLILYAYQLSTALAYLESK-----RFVHRDIAARNVLVSS---NDCV----KLGDFGLSRYM-----------E--DSTY-YKASKGKLPIKWMAPESIN-----FRR---FTSASDVWMFGVCMWEILMHGVKP---------------FQGV---KNNDVIGRI-ENGER----LPMPPNCP-------------------------------------------PTLYSLMTKCWAYDPSRRPR-----FTELKAQL------
---V-VLNRILGEGFFGEV---YEGVYT--NHKGEKI---NVAVKTC---K-K--DCT-LDN-KE-KFM-S----EAVIMKNL-DHPHIVKLIGIIE---------EEPTWIIMELYPYGELGHYLE-----RN---------------------------------------------------------------------------KNSLKVLTLVLYSLQICKAMAYLESI-----NCVHRDIAVRNILVAS---PECV----KLGDFGLSRYI-----------E--DEDY-YKASVTRLPIKWMSPESIN-----FRR---FTTASDVWMFAVCMWEILSFGKQP---------------FFWL---ENKDVIGVL-EKGDR----LPKPDLCP-------------------------------------------PVLYTLMTRCWDYDPSDRPR-----FTELVCS--L----
--VM--LSTRIGSGSFGTV---YKGKWH--------G---DVAVKIL---K-V-VDPT-PEQ-FQ-AFR-N----EVAVLRKT-RHVNILLFMGYMT---------KDNLAIVTQWCEGSSLYKHLH-----VQ---------------------------------------------------------------------------ETKFQMFQLIDIARQTAQGMDYLHAK-----NIIHRDMKSNNIFLHE---GLTV----KIGDFGLATVK-----S-----R--WSGS-QQVEQPTGSVLWMAPEVIR-----MQDNNPFSFQSDVYSYGIVLYELMT-GELP---------------YSHI-N-NRDQIIFMV-GRGYASPDLSKLYKNCP-------------------------------------------KAMKRLVADCVKKVKEERPL-----FPQILSS--I----
----FELLKVLGQGSFGKVFLVRKVTRP-----DSGH---LYAMKVL---KKA--TLKVRD---R-VRTKM----ERDILADV-NHPFVVKLHYAFQ--T------EGKLYLILDFLRGGDLFTRLS----KEV-----------------------------------------------------------------------------MFTEEDVKFYLAELALGLDHLHSL-----GIIYRDLKPENILLDE---EGHI----KLTDFGLSKEA-----------IDHEKKA-YS---FCGTVEYMAPEVVN-----RQG---HSHSADWWSYGVLMFEMLT-GSLP---------------FQGK------DRKETM-TLILK----AKLGMPQFLS-----------------------------------------TEAQSLLRALFKRNPANRLGSGPDGAEEIKRHV--FY--
----FELLKVLGQGSYGKV---FLVRKV-----KGSDAGQLYAMKVL---KKA--TLKVRD---R-VRSKM----ERDILAEV-NHPFIVKLHYAFQ--T------EGKLYLILDFLRGGDLFTRLS----KEV-----------------------------------------------------------------------------MFTEEDVKFYLAELALALDHLHSL-----GIIYRDLKPENILLDE---EGHI----KITDFGLSKEA-----------IDHDKRA-YS---FCGTIEYMAPEVVN-----RRG---HTQSADWWSFGVLMFEMLT-GSLP---------------FQGK------DRKETM-ALILK----AKLGMPQFLS-----------------------------------------GEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFF----
----FELLKVLGQGSFGKV---FLVRKK-----TGPDAGQLYAMKVL---KKA--SLKVRD---R-VRTKM----ERDILVEV-NHPFIVKLHYAFQ--T------EGKLYLILDFLRGGDVFTRLS----KEV-----------------------------------------------------------------------------LFTEEDVKFYLAELALALDHLHQL-----GIVYRDLKPENILLDE---IGHI----KLTDFGLSKES-----------VDQEKKA-YS---FCGTVEYMAPEVVN-----RRG---HSQSADWWSYGVLMFEMLT-GTLP---------------FQGK------DRNETM-NMILK----AKLGMPQFLS-----------------------------------------AEAQSLLRMLFKRNPANRLGS--EGVEEIKRHLFF----
---L-RLEVKLGQGCFGEV---WMGTWN------GTT---RVAIKTL---K-P--GTM-SP---E-AFL-Q----EAQVMKKL-RHEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLK-----GE--------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERM-----NYVHRDLRAANILVGE---NLVC----KVADFGLARLI-----------E--DNEY-TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILLTELTTKGRVP---------------YPGM---VNREVLDQV-ERGYR----MPCPPECP-------------------------------------------ESLHDLMCQCWRKEPEERPT-----FEYLQAF--L----
----WEIVGELGDGAFGKV---YKAKNK-----ETGA---LAAAKVI---ETK--SEEELE---D-YI--V----EIEILATC-DHPYIVKLLGAYY--H------DGKLWIMIEFCPGGAVDAIML---ELDR-----------------------------------------------------------------------------GLTEPQIQVVCRQMLEALNFLHSK-----RIIHRDLKAGNVLMTL---EGDI----RLADFGVSAKN-----------LKTLQKR-DS---FIGTPYWMAPEVVMCETMKDTP---YDYKADIWSLGITLIEMAQ-IEPP---------------HHEL---NPMRVLLKI-AKSDP----PTLLTPSKWS-----------------------------------------VEFRDFLKIALDKNPETRPS-----AAQLLEHPFV----
-TLE---DKELGSGNFGTV---KKGYYQ---MKKVVK---TVAVKIL---K-N--EAN-DPALKD-ELL-A----EANVMQQL-DNPYIVRMIGICE---------AESWMLVMEMAELGPLNKYLQ-----QN----------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEES-----NFVHRDLAARNVLLVT---QHYA----KISDFGLSKAL-----R-----A--DENYYKAQTHGKWPVKWYAPECIN-----YYK---FSSKSDVWSFGVLMWEAFSYGQKP---------------YRGM---KGSEVTAML-EKGER----MGCPAGCP-------------------------------------------REMYDLMNLCWTYDVENRPG-----FAAVE----LRL--
-VCR---GELLGSGCFGVV---HRGLWT--LPSGKSV---PVAVKSLRVGP-E--GPM-GTE-LG-DFL-R----EVSVMMNL-EHPHVLRLHGLVL---------GQPLQMVMELAPLGSLHARLT-----AP-------------------------------------------------------------------------APTPPLLVALLCLFLRQLAGAMAYLGAR-----GLVHRDLATRNLLLAS---PRTI----KVADFGLVRPL----GG-----A--RGRY-VMGGPRPIPYAWCAPESLR-----HGA---FSSASDVWMFGVTLWEMFSGGEEP---------------WAGV---PPYLILQRL-EDRAR----LPRPPLCS-------------------------------------------RALYSLALRCWAPHPADRPS-----FSHLE----GLL--
---L-RLLEKLGDGSFGVV---RRGEWD--APSGKTV---SVAVKCL---K-PDVLSQ-PEA-MD-DFI-R----EVNAMHSL-DHRNLIRLYGVVL---------TPPMKMVTELAPLGSLLDRLR-----KH---------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESK-----RFIHRDLAARNLLLAT---RDLV----KIGDFGLMRAL----PQ-----N--DDHY-VMQEHRKVPFAWCAPESLK-----TRT---FSHASDTWMFGVTLWEMFTYGQEP---------------WIGL---NGSQILHKIDKEGER----LPRPEDCP-------------------------------------------QDIYNVMVQCWAHKPEDRPT-----FVALRDF--L----
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