|
|
Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other PLK3 203
TK ABL1 261
TK ABL2 288
TK BLK 241
TKL BRAF 456
TK BTK 402
CMGC CDK2 4
CMGC CDK5 4
CAMK CHEK1 9
TK CSF1R 582
TK CSK 195
TK DDR1 572
TK DDR2 563
TK EGFR 712
TK EPHA8 635
TK EPHB1 619
TK EPHB2 621
TK ERBB2 720
TK FRK 234
TK FYN 271
TK HCK 241
TK IGF1R 999
TK ITK 363
TK JAK2 849
TK JAK3 822
TK KIT 589
TK LCK 245
TK LTK 510
TK LYN 247
CMGC MAPK14 24
TK MUSK 575
CMGC NLK 126
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
TK PDGFRA 593
TK PDGFRB 600
Other PLK1 53
Other PLK2 82
TK PTK2 422
TK PTK2B 425
TKL RAF1 349
TK RET 724
TK SRC 270
STE STK10 36
TK TNK1 116
TK TNK2 150
TK YES1 277
-YL--KGRLLGKGGFARCYEATDT----------------ETGSAYAVKVI---PQS--RVAKPH--QREKILNEIELHRDL-QHRHIVRFSHHFE--D------ADNIYIFLELCSRKSLAHIWK--ARH----------------------------------------------------------------------------------------------------TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITE---NMELKVGDFGLAARL-----EPPEQRK--------------KT---ICGTPNYVAPEVLL-----RQG---HGPEADVWSLGCVMYTLLC-GS-PP---------------FETA----DLKETY----RC----IKQ----VHYTLPASLS-----------------------------LPARQ-LLAAILRASPRDRPSIDQILRHDFF--
---ITMKHKLGGGQYGEVYEGVWK----------------KYSLTVAVKTL---K-E--DTM-EV--EEFL-K-EAAVMKEI-KHPNLVQLLGVCT--R------EPPFYIITEFMTYGNLLDYLR---EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHLVKVADFGLSRLM-----T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNK---FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-DLSQVYELL----EK----DYR----MERPEGCP-------------------------------EKVYE-LMRACWQWNPSDRPSFAEIHQA--F--
---ITMKHKLGGGQYGEVYVGVWK----------------KYSLTVAVKTL---K-E--DTM-EV--EEFL-K-EAAVMKEI-KHPNLVQLLGVCT--L------EPPFYIVTEYMPYGNLLDYLR---EC-------------------------------------------------------------------------------------------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGE---NHVVKVADFGLSRLM-----T--GDTY--------------TAHAGAKFPIKWTAPESLA-----YNT---FSIKSDVWAFGVLLWEIATYGM-SP---------------YPGI-DLSQVYDLL----EK----GYR----MEQPEGCP-------------------------------PKVYE-LMRACWKWSPADRPSFAETHQA--F--
--L-RLVRKLGSGQFGEVWMGYYK-----------------NNMKVAIKTL---K-E--GTM-SP--EAFL-G-EANVMKAL-QHERLVRLYAVVT---------KEPIYIVTEYMARGCLLDFLK---TD-------------------------------------------------------------------------------------------------EGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSE---ALCCKIADFGLARII--------DSEY--------------TAQEGAKFPIKWTAPEAIH-----FGV---FTIKADVWSFGVLLMEVVTYGR-VP---------------YPGM-SNPEVIRNL----ER----GYR----MPRPDTCP-------------------------------PELYRGVIAECWRSRPEERPTFEFLQSV--L--
---ITVGQRIGSGSFGTVYKGKWH-------------------GDVAVKML---N-V-TAPT-PQQLQAFK-N-EVGVLRKT-RHVNILLFMGYST---------KPQLAIVTQWCEGSSLYHHLH---II--------------------------------------------------------------------------------------------------ETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHE---DLTVKIGDFGLATVK---S-R--WSGS--------------HQFEQLSGSILWMAPEVIR-----MQDKNPYSFQSDVYAFGIVLYELMT-GQ-LP---------------YSNINNRDQIIFMV----GR----GYLSPDLSKVRSNCP-------------------------------KAMKR-LMAECLKKKRDERPLFPQILA---SI-
---LTFLKELGTGQFGVVKYGKWR-----------------GQYDVAIKMI---K-E--GSM-SE--DEFI-E-EAKVMMNL-SHEKLVQLYGVCT--K------QRPIFIITEYMANGCLLNYLR---EM--------------------------------------------------------------------------------------------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVND---QGVVKVSDFGLSRYV-----L--DDEY--------------TSSVGSKFPVRWSPPEVLM-----YSK---FSSKSDIWAFGVLMWEIYSLGK-MP---------------YERF-TNSETAEHI----AQ----GLR----LYRPHLAS-------------------------------EKVYT-IMYSCWHEKADERPTFKILLSN--I--
---FQKVEKIGEGTYGVVYKARNK----------------LTGEVVALKKI---RLD--TETEGV--PSTAIR-EISLLKEL-NHPNIVKLLDVIH--T------ENKLYLVFEFLHQ-DLKKFMDASALT----------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINT---EGAIKLADFGLARAF-----GVPVRTY--------------TH---EVVTLWYRAPEILL----GCKY---YSTAVDIWSLGCIFAEMVT-RR-AL---------------FPGD-SEIDQLFRI----FR----TLG----TPDEVVWPGVTSMPDYKPSFPKWAR---QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRISAKAALAHPFF--
---YEKLEKIGEGTYGTVFKAKNR----------------ETHEIVALKRV---RLD--DDDEGV--PSSALR-EICLLKEL-KHKNIVRLHDVLH--S------DKKLTLVFEFCDQ-DLKKYFD-SCNG----------------------------------------------------------------------------------------------------DLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLINR---NGELKLADFGLARAF-----GIPVRCY--------------SA---EVVTLWYRPPDVLF----GAKL---YSTSIDMWSAGCIFAELANAGR-PL---------------FPGN-DVDDQLKRI----FR----LLG----TPTEEQWPSMTKLPDYKPYPMYPAT---TSLVNVVPKLNATGRD-LLQNLLKCNPVQRISAEEALQHPYF--
--W-DLVQTLGEGAYGEVQLAVNR----------------VTEEAVAVKIV---DMK--RAVDCP--ENI-KK-EICINKML-NHENVVKFYGHRR--E------GNIQYLFLEYCSGGELFDRIE--PDI----------------------------------------------------------------------------------------------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDE---RDNLKISDFGLATVFR---YNNRERLL--------------NK---MCGTLPYVAPELLK----RREF---HAEPVDVWSCGIVLTAMLA-GE-LP---------------WDQP---SDSCQEY----SD----WKE----KKTYLNPWKKI--D-------------------------SAPLA-LLHKILVENPSARITIPDIKKDRW-Y-
---LQFGKTLGAGAFGKVVEATAFG-----------LGKEDAVLKVAVKML---K-S--TAH-ADEKEALM-S-ELKIMSHLGQHENIVNLLGACT--H------GGPVLVITEYCCYGDLLNFLR---RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRR------------------------------DSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTN---GHVAKIGDFGLARDI---M-N--DSNY--------------IVKGNARLPVKWMAPESIF-----DCV---YTVQSDVWSYGILLWEIFSLGL-NP---------------YPGILVNSKFYKLV----KD----GYQ----MAQPAFAP-------------------------------KNIYS-IMQACWALEPTHRPTFQQICSFL----
---LKLLQTIGKGEFGDVMLGDYR------------------GNKVAVKCI---K-N--DAT-AQ---AFL-A-EASVMTQL-RHSNLVQLLGVIV-EE------KGGLYIVTEYMAKGSLVDYLR---SR-------------------------------------------------------------------------------------------------GRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSE---DNVAKVSDFGLTKEA-----------S--------------STQDTGKLPVKWTAPEALR-----EKK---FSTKSDVWSFGILLWEIYSFGR-VP---------------YPRI-PLKDVVPRV----EK----GYK----MDAPDGCP-------------------------------PAVYE-VMKNCWHLDAAMRPSFLQLREQL----
---LRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKIL---R-P--DAT-KNARNDFL-K-EVKIMSRL-KDPNIIRLLGVCV--Q------DDPLCMITDYMENGDLNQFLS---AHQLEDKAAE--------------------------------------------------------------------------------GAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGE---NFTIKIADFGMSRNL---Y-A--GDYY--------------RVQGRAVLPIRWMAWECIL-----MGK---FTTASDVWAFGVTLWEVLMLCRAQP---------------FGQL-TDEQVIENAGEFFRD----QGRQ-VYLSRPPACP-------------------------------QGLYE-LMLRCWSRESEQRPPFSQLHRFL----
---LTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKML---R-A--DAN-KNARNDFL-K-EIKIMSRL-KDPNIIHLLAVCI--T------DDPLCMITEYMENGDLNQFLS---RHEPPN-----------------------------------------------------------------------------------------SSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK---NYTIKIADFGMSRNL---Y-S--GDYY--------------RIQGRAVLPIRWMSWESIL-----LGK---FTTASDVWAFGVTLWETFTFCQEQP---------------YSQL-SDEQVIENT----GEFFRDQGRQ-TYLPQPAICP-------------------------------DSVYK-LMLSCWRRDTKNRPSFQEIHL---LL-
--F-KKIKVLGSGAFGTVYKGLWIP------------EGEKVKIPVAIKEL---R-E--ATS-PKANKEIL-D-EAYVMASV-DNPHVCRLLGICL---------TSTVQLITQLMPFGCLLDYVR---EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT---PQHVKITDFGLAKLL---G-A--EEKE--------------YHAEGGKVPIKWMALESIL-----HRI---YTHQSDVWSYGVTVWELMTFGS-KP---------------YDGI-PASEISSIL----EK----GER----LPQPPICT-------------------------------IDVYM-IMVKCWMIDADSRPKFRELI----IEF
---IHIEKIIGSGDSGEVCYGRLR-------------VPGQRDVPVAIKAL---K-A--GYT-ERQRRDFL-S-EASIMGQF-DHPNIIRLEGVVT--R------GRLAMIVTEYMENGSLDTFLR---TH--------------------------------------------------------------------------------------------------DGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDS---NLVCKVSDFGLSRVL---E-D--DPDA-------------AYTTTGGKIPIRWTAPEAIA-----FRT---FSSASDVWSFGVVMWEVLAYGE-RP---------------YWNM-TNRDVISSV----EE----GYR----LPAPMGCP-------------------------------HALHQ-LMLDCWHKDRAQRPRFSQIVSVL----
--V-KIEEVIGAGEFGEVYKGRLK-------------LPGKREIYVAIKTL---K-A--GYS-EKQRRDFL-S-EASIMGQF-DHPNIIRLEGVVT--K------SRPVMIITEFMENGALDSFLR---QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNS---NLVCKVSDFGLSRYLQDDT-S--DPTY--------------TSSLGGKIPVRWTAPEAIA-----YRK---FTSASDVWSYGIVMWEVMSFGE-RP---------------YWDM-SNQDVINAI----EQ----DYR----LPPPMDCP-------------------------------AALHQ-LMLDCWQKDRNSRPRFAEIVNTL----
--V-KIEQVIGAGEFGEVCSGHLK-------------LPGKREIFVAIKTL---K-S--GYT-EKQRRDFL-S-EASIMGQF-DHPNVIHLEGVVT--K------STPVMIITEFMENGSLDSFLR---QN--------------------------------------------------------------------------------------------------DGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNS---NLVCKVSDFGLSRFLEDDT-S--DPTY--------------TSALGGKIPIRWTAPEAIQ-----YRK---FTSASDVWSYGIVMWEVMSYGE-RP---------------YWDM-TNQDVINAI----EQ----DYR----LPPPMDCP-------------------------------SALHQ-LMLDCWQKDRNHRPKFGQIVNTL----
--L-RKVKVLGSGAFGTVYKGIWIP------------DGENVKIPVAIKVL---R-E--NTS-PKANKEIL-D-EAYVMAGV-GSPYVSRLLGICL---------TSTVQLVTQLMPYGCLLDHVR---EN--------------------------------------------------------------------------------------------------RGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKS---PNHVKITDFGLARLL---D-I--DETE--------------YHADGGKVPIKWMALESIL-----RRR---FTHQSDVWSYGVTVWELMTFGA-KP---------------YDGI-PAREIPDLL----EK----GER----LPQPPICT-------------------------------IDVYM-IMVKCWMIDSECRPRFRELVSE--F--
---IQLLKRLGSGQFGEVWEGLWN-----------------NTTPVAVKTL---K-P--GSM-DP--NDFL-R-EAQIMKNL-RHPKLIQLYAVCT--L------EDPIYIITELMRHGSLQEYLQ---ND-------------------------------------------------------------------------------------------------TGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGE---HNIYKVADFGLARVFK-VD-N--EDIY--------------ESRHEIKLPVKWTAPEAIR-----SNK---FSIKSDVWSFGILLYEIITYGK-MP---------------YSGM-TGAQVIQML----AQ----NYR----LPQPSNCP-------------------------------QQFYN-IMLECWNAEPKERPTFETLRWK--L--
---LQLIKRLGNGQFGEVWMGTWN-----------------GNTKVAIKTL---K-P--GTM-SP--ESFL-E-EAQIMKKL-KHDKLVQLYAVVS---------EEPIYIVTEYMNKGSLLDFLK---DG-------------------------------------------------------------------------------------------------EGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGN---GLICKIADFGLARLI-----E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILLTELVTKGR-VP---------------YPGM-NNREVLEQV----ER----GYR----MPCPQDCP-------------------------------ISLHE-LMIHCWKKDPEERPTFEYLQSFL----
---LKLEKKLGAGQFGEVWMATYN-----------------KHTKVAVKTM---K-P--GSM-SV--EAFL-A-EANVMKTL-QHDKLVKLHAVVT---------KEPIYIITEFMAKGSLLDFLK---SD-------------------------------------------------------------------------------------------------EGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA---SLVCKIADFGLARVI-----E--DNEY--------------TAREGAKFPIKWTAPEAIN-----FGS---FTIKSDVWSFGILLMEIVTYGR-IP---------------YPGM-SNPEVIRAL----ER----GYR----MPRPENCP-------------------------------EELYN-IMMRCWKNRPEERPTFEYIQSV--L--
---ITMSRELGQGSFGMVYEGVAKG-----------VVKDEPETRVAIKTV---N-E--AAS-MRERIEFL-N-EASVMKEF-NCHHVVRLLGVVS--Q------GQPTLVIMELMTRGDLKSYLR---SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAE---DFTVKIGDFGMTRDI---Y-E--TDYY--------------RKGGKGLLPVRWMSPESLK-----DGV---FTTYSDVWSFGVVLWEIATLAE-QP---------------YQGL-SNEQVLRFV----ME----GGL----LDKPDNCP-------------------------------DMLFE-LMRMCWQYNPKMRPSFLEIISS--I--
---LTFVQEIGSGQFGLVHLGYWL-----------------NKDKVAIKTI---R-E--GAM-SE--EDFI-E-EAEVMMKL-SHPKLVQLYGVCL--E------QAPICLVFEFMEHGCLSDYLR---TQ--------------------------------------------------------------------------------------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGE---NQVIKVSDFGMTRFV-----L--DDQY--------------TSSTGTKFPVKWASPEVFS-----FSR---YSSKSDVWSFGVLMWEVFSEGK-IP---------------YENR-SNSEVVEDI----ST----GFR----LYKPRLAS-------------------------------THVYQ-IMNHCWKERPEDRPAFSRLLRQL----
---LKFLQQLGKGNFGSVEMCRYDP------------LQDNTGEVVAVKKL---Q-H--STE--EHLRDFE-R-EIEILKSL-QHDNIVKYKGVCYSAG------RRNLKLIMEYLPYGSLRDYLQ---KH--------------------------------------------------------------------------------------------------KERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVEN---ENRVKIGDFGLTKVL--PQ-D--KEYY--------------KVKEPGESPIFWYAPESLT-----ESK---FSVASDVWSFGVVLYELFTYIE-KSKSPPAEFMRMIGNDKQGQM-IVFHLIELL----KN----NGR----LPRPDGCP-------------------------------DEIYM-IMTECWNNNVNQRPSFRDLA----LRV
--L-KYISQLGKGNFGSVELCRYDP------------LGDNTGALVAVKQL---Q-H--SGP-DQ-QRDFQ-R-EIQILKAL-HSDFIVKYRGVSYGPG------RQSLRLVMEYLPSGCLRDFLQ---RH--------------------------------------------------------------------------------------------------RARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVES---EAHVKIADFGLAKLL--PL-D--KDYY--------------VVREPGQSPIFWYAPESLS-----DNI---FSRQSDVWSFGVVLYELFTYCD-KSCSPSAE--FLRMMGCERDVPALCRLLELL----EE----GQR----LPAPPACP-------------------------------AEVHE-LMKLCWAPSPQDRPSFSALGP---QL-
---LSFGKTLGAGAFGKVVEATAYG-----------LIKSDAAMTVAVKML---K-P--SAH-LTEREALM-S-ELKVLSYLGNHMNIVNLLGACT--I------GGPTLVITEYCCYGDLLNFLR---RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH---GRITKICDFGLARDI---K-N--DSNY--------------VVKGNARLPVKWMAPESIF-----NCV---YTFESDVWSYGIFLWELFSLGS-SP---------------YPGMPVDSKFYKMI----KE----GFR----MLSPEHAP-------------------------------AEMYD-IMKTCWDADPLKRPTFKQIVQL--I--
---LKLVERLGAGQFGEVWMGYYN-----------------GHTKVAVKSL---K-Q--GSM-SP--DAFL-A-EANLMKQL-QHQRLVRLYAVVT---------QEPIYIITEYMENGSLVDFLK---TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSD---TLSCKIADFGLARLI-----E--DNEY--------------TAREGAKFPIKWTAPEAIN-----YGT---FTIKSDVWSFGILLTEIVTHGR-IP---------------YPGM-TNPEVIQNL----ER----GYR----MVRPDNCP-------------------------------EELYQ-LMRLCWKERPEDRPTFDYLRSV--L--
--V-TLLRALGHGAFGEVYEGLVIG-----------LPGDSSPLQVAIKTL---P-E--LCS-PQDELDFL-M-EALIISKF-RHQNIVRCVGLSL--R------ATPRLILLELMSGGDMKSFLR---HSRP--------------------------------------------------------------------------------------------HLGQPSPLVMRDLLQLAQDIAQGCHYLEENHFIHRDIAARNCLLSCAGPSRVAKIGDFGMARDI---Y-R--ASYY--------------RRGDRALLPVKWMPPEAFL-----EGI---FTSKTDSWSFGVLLWEIFSLGY-MP---------------YPGR-TNQEVLDFV----VG----GGR----MDPPRGCP-------------------------------GPVYR-IMTQCWQHEPELRPSFASILERL----
---IKLVKRLGAGQFGEVWMGYYN-----------------NSTKVAVKTL---K-P--GTM-SV--QAFL-E-EANLMKTL-QHDKLVRLYAVVT--R------EEPIYIITEYMAKGSLLDFLK---SD-------------------------------------------------------------------------------------------------EGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSE---SLMCKIADFGLARVI-----E--DNEY--------------TAREGAKFPIKWTAPEAIN-----FGC---FTIKSDVWSFGILLYEIVTYGK-IP---------------YPGR-TNADVMTAL----SQ----GYR----MPRVENCP-------------------------------DELYD-IMKMCWKEKAEERPTFDYLQSV--L--
---YQNLSPVGSGAYGSVCAAFDT----------------KTGLRVAVKKL---SRP--FQSIIH--AKRTYR-ELRLLKHM-KHENVIGLLDVFT--PARSLEEFNDVYLVTHLMGA-DLNNIVK---CQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNE---DCELKILDFGLAR--------HTDDEM--------------TG---YVATRWYRAPEIML----NWMH---YNQTVDIWSVGCIMAELLT-GR-TL---------------FPGT-DHIDQLKLI----LR----LVG----TPGAELLKKISSESARNYIQSLTQMP-KMNFANVFIGANPLAVD-LLEKMLVLDSDKRITAAQALAHAYF--
--I-EYVRDIGEGAFGRVFQARAPG-----------LLPYEPFTMVAVKML---K-E--EAS-ADMQADFQ-R-EAALMAEF-DNPNIVKLLGVCA--V------GKPMCLLFEYMAYGDLNEFLR---SMSPHTVCSLSHS---------------------------------------------------------------------------DLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGE---NMVVKIADFGLSRNI---Y-S--ADYY--------------KANENDAIPIRWMPPESIF-----YNR---YTTESDVWAYGVVLWEIFSYGL-QP---------------YYGM-AHEEVIYYV----RD----GNI----LSCPENCP-------------------------------VELYN-LMRLCWSKLPADRPSFTSIHRIL----
IEP---DRPIGYGAFGVVWSVTDP----------------RDGKRVALKKM---PNV--FQNLVS--CKRVFR-ELKMLCFF-KHDNVLSALDILQ--PPH-IDYFEEIYVVTELMQS-DLHKIIV--SPQ----------------------------------------------------------------------------------------------------PLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNS---NCVLKICDFGLARVE----ELDESRHM--------------TQ---EVVTQYYRAPEILM----GSRH---YSNAIDIWSVGCIFAELLG-RR-IL---------------FQAQ-SPIQQLDLI----TD----LLG----TPSLEAMRTACEGAKAHILRGPHKQPSLPVLYTLSSQATHEAVH-LLCRMLVFDPSKRISAKDALAHPYL--
-IV--LKWELGEGAFGKVFLAECHN-----------LLPEQDKMLVAVKAL---K-E--ASE-SA-RQDFQ-R-EAELLTML-QHQHIVRFFGVCT--E------GRPLLMVFEYMRHGDLNRFLR---SHGPDAKL------------------------------------------------------------------------------------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQ---GLVVKIGDFGMSRDI---Y-S--TDYY--------------RVGGRTMLPIRWMPPESIL-----YRK---FTTESDVWSFGVVLWEIFTYGK-QP---------------WYQL-SNTEAIDCI----TQ----GRE----LERPRACP-------------------------------PEVYA-IMRGCWQREPQQRHSIKDVHARL----
--I-VLKRELGEGAFGKVFLAECYN-----------LCPEQDKILVAVKTL---K-D--ASD-NA-RKDFH-R-EAELLTNL-QHEHIVKFYGVCV--E------GDPLIMVFEYMKHGDLNKFLR---AHGPDAV--------------------------------------------------------------------------------------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGE---NLLVKIGDFGMSRDV---Y-S--TDYY--------------RVGGHTMLPIRWMPPESIM-----YRK---FTTESDVWSLGVVLWEIFTYGK-QP---------------WYQL-SNNEVIECI----TQ----GRV----LQRPRTCP-------------------------------QEVYE-LMLGCWQREPHMRKNIKGIHTL--L--
--I-VLKRELGEGAFGKVFLAECYN-----------LSPTKDKMLVAVKAL---K-D--PTL-AA-RKDFQ-R-EAELLTNL-QHEHIVKFYGVCG--D------GDPLIMVFEYMKHGDLNKFLR---AHGPDAMIL-----------------------------------------------------------------------------------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGA---NLLVKIGDFGMSRDV---Y-S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM-----YRK---FTTESDVWSFGVILWEIFTYGK-QP---------------WFQL-SNTEVIECI----TQ----GRV----LERPRVCP-------------------------------KEVYD-VMLGCWQREPQQRLNIKEIYKIL----
--L-VLGRVLGSGAFGKVVEGTAYG-----------LSRSQPVMKVAVKML---K-P--TAR-SSEKQALM-S-ELKIMTHLGPHLNIVNLLGACT--K------SGPIYIITEYCFYGDLVNYLH---KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQ---GKIVKICDFGLARDI---M-H--DSNY--------------VSKGSTFLPVKWMAPESIF-----DNL---YTTLSDVWSYGILLWEIFSLGG-TP---------------YPGMMVDSTFYNKI----KS----GYR----MAKPDHAT-------------------------------SEVYE-IMVKCWNSEPEKRPSFYHLSE---IV-
--L-VLGRTLGSGAFGQVVEATAHG-----------LSHSQATMKVAVKML---K-S--TAR-SSEKQALM-S-ELKIMSHLGPHLNVVNLLGACT--K------GGPIYIITEYCRYGDLVDYLH---RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICE---GKLVKICDFGLARDI---M-R--DSNY--------------ISKGSTFLPLKWMAPESIF-----NSL---YTTLSDVWSFGILLWEIFTLGG-TP---------------YPELPMNEQFYNAI----KR----GYR----MAQPAHAS-------------------------------DEIYE-IMQKCWEEKFEIRPPFSQLVL---LL-
-YV--RGRFLGKGGFAKCFEISDA----------------DTKEVFAGKIV---PKS--LLLKPH--QREKMSMEISIHRSL-AHQHVVGFHGFFE--D------NDFVFVVLELCRRRSLLELHK--RRK----------------------------------------------------------------------------------------------------ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNE---DLEVKIGDFGLATKV-----EYDGERK--------------KT---LCGTPNYIAPEVLS-----KKG---HSFEVDVWSIGCIMYTLLV-GK-PP---------------FETS----CLKETY----LR----IKK----NEYSIPKHIN-----------------------------PVAAS-LIQKMLQTDPTARPTINELLNDEFF--
--Y-CRGKVLGKGGFAKCYEMTDL----------------TNNKVYAAKII---PHS--RVAKPH--QREKIDKEIELHRIL-HHKHVVQFYHYFE--D------KENIYILLEYCSRRSMAHILK--ARK----------------------------------------------------------------------------------------------------VLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINE---AMELKVGDFGLAARL-----EPLEHRR--------------RT---ICGTPNYLSPEVLN-----KQG---HGCESDIWALGCVMYTMLL-GR-PP---------------FETT----NLKETY----RC----IRE----ARYTMPSSLL-----------------------------APAKH-LIASMLSKNPEDRPSLDDIIRHDFF--
---IELGRCIGEGQFGDVHQGIYM-------------SPENPALAVAIKTC---K-N--CTS-DSVREKFL-Q-EALTMRQF-DHPHIVKLIGVIT---------ENPVWIIMELCTLGELRSFLQ---VR--------------------------------------------------------------------------------------------------KYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSS---NDCVKLGDFGLSRYM-----E--DSTY--------------YKASKGKLPIKWMAPESIN-----FRR---FTSASDVWMFGVCMWEILMHGV-KP---------------FQGV-KNNDVIGRI----EN----GER----LPMPPNCP-------------------------------PTLYS-LMTKCWAYDPSRRPRFTELKAQL----
--V-VLNRILGEGFFGEVYEGVYT-------------NHKGEKINVAVKTC---K-K--DCT-LDNKEKFM-S-EAVIMKNL-DHPHIVKLIGIIE---------EEPTWIIMELYPYGELGHYLE---RN--------------------------------------------------------------------------------------------------KNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVAS---PECVKLGDFGLSRYI-----E--DEDY--------------YKASVTRLPIKWMSPESIN-----FRR---FTTASDVWMFAVCMWEILSFGK-QP---------------FFWL-ENKDVIGVL----EK----GDR----LPKPDLCP-------------------------------PVLYT-LMTRCWDYDPSDRPRFTELVCS--L--
-VM--LSTRIGSGSFGTVYKGKWH-------------------GDVAVKIL---K-V-VDPT-PEQFQAFR-N-EVAVLRKT-RHVNILLFMGYMT---------KDNLAIVTQWCEGSSLYKHLH---VQ--------------------------------------------------------------------------------------------------ETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHE---GLTVKIGDFGLATVK---S-R--WSGS--------------QQVEQPTGSVLWMAPEVIR-----MQDNNPFSFQSDVYSYGIVLYELMT-GE-LP---------------YSHINNRDQIIFMV----GR----GYASPDLSKLYKNCP-------------------------------KAMKR-LVADCVKKVKEERPLFPQILSS--I--
--L-VLGKTLGEGEFGKVVKATAFH-----------LKGRAGYTTVAVKML---K-E--NAS-PSELRDLL-S-EFNVLKQV-NHPHVIKLYGACS--Q------DGPLLLIVEYAKYGSLRGFLR---ESRKVGPGYLGSG---------------------------------------------------------------------------GSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE---GRKMKISDFGLSRDV---Y-E--EDSY--------------VKRSQGRIPVKWMAIESLF-----DHI---YTTQSDVWSFGVLLWEIVTLGG-NP---------------YPGI-PPERLFNLL----KT----GHR----MERPDNCS-------------------------------EEMYR-LMLQCWKQEPDKRPVFADISKDL----
--L-RLEVKLGQGCFGEVWMGTWN-----------------GTTRVAIKTL---K-P--GTM-SP--EAFL-Q-EAQVMKKL-RHEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLK---GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLI-----E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILLTELTTKGR-VP---------------YPGM-VNREVLDQV----ER----GYR----MPCPPECP-------------------------------ESLHD-LMCQCWRKEPEERPTFEYLQAF--L--
---WEIVGELGDGAFGKVYKAKNK----------------ETGALAAAKVI---ETK--SEEELE--DYI--V-EIEILATC-DHPYIVKLLGAYY--H------DGKLWIMIEFCPGGAVDAIML-ELDR----------------------------------------------------------------------------------------------------GLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTL---EGDIRLADFGVSAKN-----LKTLQKR--------------DS---FIGTPYWMAPEVVMCETMKDTP---YDYKADIWSLGITLIEMAQ-IE-PP---------------HHEL-NPMRVLLKI----AK----SDP----PTLLTPSKWS-----------------------------VEFRD-FLKIALDKNPETRPSAAQLLEHPFV--
VCR---GELLGSGCFGVVHRGLWT-------------LPSGKSVPVAVKSLRVGP-E--GPM-GTELGDFL-R-EVSVMMNL-EHPHVLRLHGLVL---------GQPLQMVMELAPLGSLHARLT---AP------------------------------------------------------------------------------------------------APTPPLLVALLCLFLRQLAGAMAYLGARGLVHRDLATRNLLLAS---PRTIKVADFGLVRPL--GG-A--RGRY--------------VMGGPRPIPYAWCAPESLR-----HGA---FSSASDVWMFGVTLWEMFSGGE-EP---------------WAGV-PPYLILQRL----ED----RAR----LPRPPLCS-------------------------------RALYS-LALRCWAPHPADRPSFSHLE----GLL
--L-RLLEKLGDGSFGVVRRGEWD-------------APSGKTVSVAVKCL---K-PDVLSQ-PEAMDDFI-R-EVNAMHSL-DHRNLIRLYGVVL---------TPPMKMVTELAPLGSLLDRLR---KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLAT---RDLVKIGDFGLMRAL--PQ-N--DDHY--------------VMQEHRKVPFAWCAPESLK-----TRT---FSHASDTWMFGVTLWEMFTYGQ-EP---------------WIGL-NGSQILHKI---DKE----GER----LPRPEDCP-------------------------------QDIYN-VMVQCWAHKPEDRPTFVALRDF--L--
--L-RLEVKLGQGCFGEVWMGTWN-----------------GTTKVAIKTL---K-P--GTM-MP--EAFL-Q-EAQIMKKL-RHDKLVPLYAVVS---------EEPIYIVTEFMSKGSLLDFLK---EG-------------------------------------------------------------------------------------------------DGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGE---NLVCKIADFGLARLI-----E--DNEY--------------TARQGAKFPIKWTAPEAAL-----YGR---FTIKSDVWSFGILQTELVTKGR-VP---------------YPGM-VNREVLEQV----ER----GYR----MPCPQGCP-------------------------------ESLHE-LMNLCWKKDPDERPTFEYIQSFL----
|