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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other PLK3 203
Other AAK1 46
TK ABL1 261
TK ALK 1116
Other AURKA 133
Other AURKB 77
Other AURKC 43
TK BLK 241
TK BTK 402
CMGC CDC2L5 705
CMGC CDC2L6 20
CMGC CDK11A 438
CMGC CDK2 4
CMGC CDK8 2.7.11.23
CMGC CDKL2 4
CAMK CHEK2 220
TK CSK 195
TK EGFR 712
TK FGFR1 478
TK FGFR2 481
TK FGFR3 472
TK JAK2 849
TK JAK3 822
TK LCK 245
CMGC MAPK8 26
CMGC MAPK9 26
CAMK MAPKAPK2 64
Other PLK1 53
Other PLK2 82
Other PLK4 12
AGC PRKCD 349
AGC PRKCQ 380
TK PTK2 422
TK PTK2B 425
TKL RAF1 349
TK RET 724
AGC RPS6KB1 91
STE STK10 36
Other STK36 4
TK TEK 824
TK TIE1 839
TK TNK1 116
TK TNK2 150
Other TTK 525
-YL--KGRLLGKGGFARCYEATD---T-------ETGS--AYAVKVI---PQS--R-VAKPH--QREKIL-----NEIELHRDL--Q-HRHIVRFSHHFE--D----------ADNIYIFLELCSRKSLAHIWK---------ARH-------------------------TL--LEPEVRYYLRQILSGLKYLHQR--GILHRDLKLGNFFIT----E---NMEL---KVGDFGLAARL----------EPPEQRKKT---ICGTPNYVAPEVLL-----------RQG---HGPEADVWSLGCVMYTLLC-GSPP---------------FETA------------DLKETY-RCIKQ----VHYTLPASLS---------------------------------------LPARQ-LLAAILRASPRDRPS-----ID-QILRHDFF-----
--V-TVDEVLAEGGFAIVFLVRT---S-------NGM---KCALKRM---FVN--N-EHDLQ--VCK--R------EIQIMRDL-SG-HKNIVGYIDSSI--NNVS----SGDVWEVLILMDFCRGGQVVNLMNQ-------RLQT-------------------------GF--TENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLH----D---RGHY---VLCDFGSATNKFQNP--QTEGVNAVEDEIK---KYTTLSYRAPEMVNL--------YSGKI---ITTKADIWALGCLLYKLCY-FTLP---------------FGES--------------QVAI-CDGNF----TIPD-----NSRYS-----------------------------------QDMHC-LIRYMLEPDPDKRPD-----IY-QV------SYFSF
---ITMKHKLGGGQYGEVYEGVW---K-------KYSL--TVAVKTL---K-E--D-TM-EV--EEFL-K------EAAVMKEI--K-HPNLVQLLGVCT--R----------EPPFYIITEFMTYGNLLDYLR----------EC----------------------NRQEV--NAVVLLYMATQISSAMEYLEKK--NFIHRDLAARNCLVG----E---NHLV---KVADFGLSRLM----------T--GDTYTAHAGAKFPIKWTAPESLA-----------YNK---FSIKSDVWAFGVLLWEIATYGMSP---------------YPGI---------DLSQVYELL-EKDYR----MERPEGCP-----------------------------------------EKVYE-LMRACWQWNPSDRPS-----FA-EIHQA--F-----
--I-TLIRGLGHGAFGEVYEGQV---SG--MPNDPSPL--QVAVKTL---P-E--V-CS-EQDELDFL-M------EALIISKF--N-HQNIVRCIGVSL--Q----------SLPRFILLELMAGGDLKSFLR----------ETRP-----------------RPSQPSSL--AMLDLLHVARDIACGCQYLEEN--HFIHRDIAARNCLLT----CPGPGRVA---KIGDFGMARDI-----Y----R--ASYYRKGGCAMLPVKWMPPEAFM-----------EGI---FTSKTDTWSFGVLLWEIFSLGYMP---------------YPSK---------SNQEVLEFV-TSGGR----MDPPKNCP-----------------------------------------GPVYR-IMTQCWQHQPEDRPN-----FA-IILER--I-----
---FEIGRPLGKGKFGNVYLARE---K-------QSKF--ILALKVL---FKA--QLEKAGV--EHQLRR------EVEIQSHL--R-HPNILRLYGYFH--D----------ATRVYLILEYAPLGTVYRELQ---------KLS-------------------------KF--DEQRTATYITELANALSYCHSK--RVIHRDIKPENLLLG----S---AGEL---KIADFGWSV------------HAPSSRRTT---LCGTLDYLPPEMIE-----------GRM---HDEKVDLWSLGVLCYEFLV-GKPP---------------FEAN------------TYQETY-KRISR----VEFTFPDFVT---------------------------------------EGARD-LISRLLKHNPSQRPM-----LR-EVLEHPWI-----
---FEIGRPLGKGKFGNVYLARE---K-------KSHF--IVALKVL---FKS--Q-IEKEG--VEHQLR-----REIEIQAHL--H-HPNILRLYNYFY--D----------RRRIYLILEYAPRGELYKELQ---------KSC-------------------------TF--DEQRTATIMEELADALMYCHGK--KVIHRDIKPENLLLG----L---KGEL---KIADFGWSV------------HAPSLRRKT---MCGTLDYLPPEMIE-----------GRM---HNEKVDLWCIGVLCYELLV-GNPP---------------FESA------------SHNETY-RRIVK----VDLKFPASVP---------------------------------------MGAQD-LISKLLRHNPSERLP-----LA-QVSAHPWV-----
---FEIGRPLGKGKFGNVYLARL---K-------ESHF--IVALKVL---FKS--Q-IEKEG--LEHQLR-----REIEIQAHL--Q-HPNILRLYNYFH--D----------ARRVYLILEYAPRGELYKELQ---------KSE-------------------------KL--DEQRTATIIEELADALTYCHDK--KVIHRDIKPENLLLG----F---RGEV---KIADFGWSV------------HTPSLRRKT---MCGTLDYLPPEMIE-----------GRT---YDEKVDLWCIGVLCYELLV-GYPP---------------FESA------------SHSETY-RRILK----VDVRFPLSMP---------------------------------------LGARD-LISRLLRYQPLERLP-----LA-QILKHPWV-----
--L-RLVRKLGSGQFGEVWMGYY---K--------NNM--KVAIKTL---K-E--G-TM-SP--EAFL-G------EANVMKAL--Q-HERLVRLYAVVT-------------KEPIYIVTEYMARGCLLDFLK----------TD----------------------EGSRL--SLPRLIDMSAQIAEGMAYIERM--NSIHRDLRAANILVS----E---ALCC---KIADFGLARII-------------DSEYTAQEGAKFPIKWTAPEAIH-----------FGV---FTIKADVWSFGVLLMEVVTYGRVP---------------YPGM---------SNPEVIRNL-ERGYR----MPRPDTCP-----------------------------------------PELYRGVIAECWRSRPEERPT-----FE-FLQSV--L-----
---LTFLKELGTGQFGVVKYGKW---R--------GQY--DVAIKMI---K-E--G-SM-SE--DEFI-E------EAKVMMNL--S-HEKLVQLYGVCT--K----------QRPIFIITEYMANGCLLNYLR----------EM-----------------------RHRF--QTQQLLEMCKDVCEAMEYLESK--QFLHRDLAARNCLVN----D---QGVV---KVSDFGLSRYV----------L--DDEYTSSVGSKFPVRWSPPEVLM-----------YSK---FSSKSDIWAFGVLMWEIYSLGKMP---------------YERF---------TNSETAEHI-AQGLR----LYRPHLAS-----------------------------------------EKVYT-IMYSCWHEKADERPT-----FK-ILLSN--I-----
--F-DIIGIIGEGTYGQVYKARD---K-------DTGE--MVALKKV---RLD--N-EKEGF--PITAIR------EIKILRQL--T-HQSIINMKEIVT--DKEDALDFKKDKGAFYLVFEYMDH-DLMGLLE--------SGLV-------------------------HF--NENHIKSFMRQLMEGLDYCHKK--NFLHRDIKCSNILLN----N---RGQI---KLADFGLARLY---------SSEESRPYTN---KVITLWYRPPELLL----------GEER---YTPAIDVWSCGCILGELFT-KKPI---------------FQAN---------QELAQLELI-SRICG----SPCPAVWPDVIKLPYFNTMKPKKQY------------RRKLREEFVFIPAAALD-LFDYMLALDPSKRCT-----AE-QALQCEF-L----
EGC-----KVGRGTYGHVYKARR---K-------DGKDEKEYALKQI---EGT--G-ISMSA--C----R------EIALLREL--K-HPNVIALQKVFL--SH--------SDRKVWLLFDYAEH-DLWHIIKFHR--ASKANKK-------------------------PMQLPRSMVKSLLYQILDGIHYLHAN--WVLHRDLKPANILVMGEGPE---RGRV---KIADMGFARLFN-------SPLKPLADLDP---VVVTFWYRAPELLL----------GARH---YTKAIDIWAIGCIFAELLT-SEPI---------------FHCRQEDIKTSNPFHHDQLDRI-FSVMG----FPADKDWEDIRKMPEYPTLQKDFRRTTYA----NSSLIKYMEKHKVKPDSKVFL-LLQKLLTMDPTKRIT-----SE-QALQDPYF-----
---FQCLNRIEEGTYGVVYRAKD---K-------KTDE--IVALKRL---KME--K-EKEGF--PITSLR------EINTILKA--Q-HPNIVTVREIVV--GS--------NMDKIYIVMNYVEH-DLKSLME--------TMKQ-------------------------PF--LPGEVKTLMIQLLRGVKHLHDN--WILHRDLKTSNLLLS----H---AGIL---KVGDFGLAREY----------GSPLKAYTP---VVVTLWYRAPELLL----------GAKE---YSTAVDMWSVGCIFGELLT-QKPL---------------FPGK---------SEIDQINKV-FKDLG----TPSEKIWPGYSELPAVKKMTFSEHPY-----------NNLRKRFGALLSDQGFD-LMNKFLTYFPGRRIS-----AE-DGLKHEYF-----
---FQKVEKIGEGTYGVVYKARN---K-------LTGE--VVALKKI---RLD--T-ETEGV--PSTAIR------EISLLKEL--N-HPNIVKLLDVIH--T----------ENKLYLVFEFLHQ-DLKKFMDA-------SALT-------------------------GI--PLPLIKSYLFQLLQGLAFCHSH--RVLHRDLKPQNLLIN----T---EGAI---KLADFGLARAF----------GVPVRTYTH---EVVTLWYRAPEILL----------GCKY---YSTAVDIWSLGCIFAEMVT-RRAL---------------FPGD---------SEIDQLFRI-FRTLG----TPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-----AK-AALAHPFF-----
EGC-----KVGRGTYGHVYKAKR---K-------DGKDDKDYALKQI---EGT--G-ISMSA--C----R------EIALLREL--K-HPNVISLQKVFL--SH--------ADRKVWLLFDYAEH-DLWHIIKFHRASKANKKPV-------------------------QL--PRGMVKSLLYQILDGIHYLHAN--WVLHRDLKPANILVMGEGPE---RGRV---KIADMGFARLFN-------SPLKPLADLDP---VVVTFWYRAPELLL----------GARH---YTKAIDIWAIGCIFAELLT-SEPI---------------FHCRQEDIKTSNPYHHDQLDRI-FNVMG----FPADKDWEDIKKMPEHSTLMKDFRRNTYT----NCSLIKYMEKHKVKPDSKAFH-LLQKLLTMDPIKRIT-----SE-QAMQDPYF-----
---YENLGLVGEGSYGMVMKCRN---K-------DTGR--IVAIKKF---LES--D-DDKMV--KKIAMR------EIKLLKQL--R-HENLVNLLEVCK--K----------KKRWYLVFEFVDHTILDDLEL---------FPN-------------------------GL--DYQVVQKYLFQIINGIGFCHSH--NIIHRDIKPENILVS----Q---SGVV---KLCDFGFARTL----------AAPGEVYTD---YVATRWYRAPELLV----------GDVK---YGKAVDVWAIGCLVTEMFM-GEPL---------------FPGD---------SDIDQLYHI-MMCLG----NLIPRHQELFNKNPVFAGVRLPEIKE-----------REPLERRYPKLSEVVID-LAKKCLHIDPDKRPF-----CA-ELLHHDFF-----
-YI--MSKTLGSGACGEVKLAFE---R-------KTCK--KVAIKII---SKR--K-FAIGS--AREADPALNVETEIEILKKL--N-HPCIIKIKNFF---D----------AEDYYIVLELMEGGELFDKVV---------GNK-------------------------RL--KEATCKLYFYQMLLAVQYLHEN--GIIHRDLKPENVLLS----S---QEEDCLIKITDFGHSKI-----------LGETSLMRT---LCGTPTYLAPEVLVS--------VGTAG---YNRAVDCWSLGVILFICLS-GYPP---------------FSEH-----------RTQVSLK-DQITS----GKYNFIPEVWAEVS-----------------------------------EKALD-LVKKLLVVDPKARFT-----TE-EALRHPWL-----
---LKLLQTIGKGEFGDVMLGDY---R---------GN--KVAVKCI---K-N--D-AT-AQ---AFL-A------EASVMTQL--R-HSNLVQLLGVIV-EE----------KGGLYIVTEYMAKGSLVDYLR----------SR----------------------GRSVL--GGDCLLKFSLDVCEAMEYLEGN--NFVHRDLAARNVLVS----E---DNVA---KVSDFGLTKEA----------------SSTQDTGKLPVKWTAPEALR-----------EKK---FSTKSDVWSFGILLWEIYSFGRVP---------------YPRI---------PLKDVVPRV-EKGYK----MDAPDGCP-----------------------------------------PAVYE-VMKNCWHLDAAMRPS-----FL-QLREQL-------
--F-KKIKVLGSGAFGTVYKGLW---IP---EGEKVKI--PVAIKEL---R-E--A-TS-PKANKEIL-D------EAYVMASV--D-NPHVCRLLGICL-------------TSTVQLITQLMPFGCLLDYVR----------EH-----------------------KDNI--GSQYLLNWCVQIAKGMNYLEDR--RLVHRDLAARNVLVK----T---PQHV---KITDFGLAKLL-----G----A--EEKEYHAEGGKVPIKWMALESIL-----------HRI---YTHQSDVWSYGVTVWELMTFGSKP---------------YDGI---------PASEISSIL-EKGER----LPQPPICT-----------------------------------------IDVYM-IMVKCWMIDADSRPK-----FR-ELI----IEF---
--L-VLGKPLGEGCFGQVVLAEA---IGLDKDKPNRVT--KVAVKML---K-S--D-AT-EKDLSDLI-S------EMEMMKMIG-K-HKNIINLLGACT--Q----------DGPLYVIVEYASKGNLREYLQ----------ARRPPGLEY--------CYNPSHNPEEQL--SSKDLVSCAYQVARGMEYLASK--KCIHRDLAARNVLVT----E---DNVM---KIADFGLARDI-----H----H--IDYYKKTTNGRLPVKWMAPEALF-----------DRI---YTHQSDVWSFGVLLWEIFTLGGSP---------------YPGV---------PVEELFKLL-KEGHR----MDKPSNCT-----------------------------------------NELYM-MMRDCWHAVPSQRPT-----FK-QLVEDL-------
---LTLGKPLGEGCFGQVVMAEA---VGIDKDKPKEAV--TVAVKML---K-D--D-AT-EKDLSDLV-S------EMEMMKMIG-K-HKNIINLLGACT--Q----------DGPLYVIVEYASKGNLREYLR----------ARRPPGMEY--------SYDINRVPEEQM--TFKDLVSCTYQLARGMEYLASQ--KCIHRDLAARNVLVT----E---NNVM---KIADFGLARDI-----N----N--IDYYKKTTNGRLPVKWMAPEALF-----------DRV---YTHQSDVWSFGVLMWEIFTLGGSP---------------YPGI---------PVEELFKLL-KEGHR----MDKPANCT-----------------------------------------NELYM-MMRDCWHAVPSQRPT-----FK-QLVEDL-------
---LTLGKPLGEGCFGQVVMAEA---IGIDKDRAAKPV--TVAVKML---K-D--D-AT-DKDLSDLV-S------EMEMMKMIG-K-HKNIINLLGACT--Q----------GGPLYVLVEYAAKGNLREFLR----------ARRPPGLDY--------SFDTCKPPEEQL--TFKDLVSCAYQVARGMEYLASQ--KCIHRDLAARNVLVT----E---DNVM---KIADFGLARDV-----H----N--LDYYKKTTNGRLPVKWMAPEALF-----------DRV---YTHQSDVWSFGVLLWEIFTLGGSP---------------YPGI---------PVEELFKLL-KEGHR----MDKPANCT-----------------------------------------HDLYM-IMRECWHAAPSQRPT-----FK-QLVEDL-------
---LKFLQQLGKGNFGSVEMCRY---DP---LQDNTGE--VVAVKKL---Q-H--S-TE--EHLRDFE-R------EIEILKSL--Q-HDNIVKYKGVCYSAG----------RRNLKLIMEYLPYGSLRDYLQ----------KH-----------------------KERI--DHIKLLQYTSQICKGMEYLGTK--RYIHRDLATRNILVE----N---ENRV---KIGDFGLTKVL----PQ----D--KEYYKVKEPGESPIFWYAPESLT-----------ESK---FSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQM---------IVFHLIELL-KNNGR----LPRPDGCP-----------------------------------------DEIYM-IMTECWNNNVNQRPS-----FR-DLA----LRV---
--L-KYISQLGKGNFGSVELCRY---DP---LGDNTGA--LVAVKQL---Q-H--S-GP-DQ-QRDFQ-R------EIQILKAL--H-SDFIVKYRGVSYGPG----------RQSLRLVMEYLPSGCLRDFLQ----------RH-----------------------RARL--DASRLLLYSSQICKGMEYLGSR--RCVHRDLAARNILVE----S---EAHV---KIADFGLAKLL----PL----D--KDYYVVREPGQSPIFWYAPESLS-----------DNI---FSRQSDVWSFGVVLYELFTYCDKSCSPSAE--FLRMMGCERDV-P-------ALCRLLELL-EEGQR----LPAPPACP-----------------------------------------AEVHE-LMKLCWAPSPQDRPS-----FS-ALGP---QL----
---LKLVERLGAGQFGEVWMGYY---N--------GHT--KVAVKSL---K-Q--G-SM-SP--DAFL-A------EANLMKQL--Q-HQRLVRLYAVVT-------------QEPIYIITEYMENGSLVDFLK----------TP----------------------SGIKL--TINKLLDMAAQIAEGMAFIEER--NYIHRDLRAANILVS----D---TLSC---KIADFGLARLI----------E--DNEYTAREGAKFPIKWTAPEAIN-----------YGT---FTIKSDVWSFGILLTEIVTHGRIP---------------YPGM---------TNPEVIQNL-ERGYR----MVRPDNCP-----------------------------------------EELYQ-LMRLCWKERPEDRPT-----FD-YLRSV--L-----
---YQNLKPIGSGAQGIVCAAYD---A-------ILER--NVAIKKL---SRP--F-QNQTH--AKRAYR------ELVLMKCV--N-HKNIIGLLNVFT--PQKS----LEEFQDVYIVMELMDA-NLCQVIQ-----------M-------------------------EL--DHERMSYLLYQMLCGIKHLHSA--GIIHRDLKPSNIVVK----S---DCTL---KILDFGLART-----------AGTSFMMTP---YVVTRYYRAPEVIL-----------GMG---YKENVDLWSVGCIMGEMVC-HKIL---------------FPGR---------DYIDQWNKV-IEQLG----TPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARD-LLSKMLVIDASKRIS-----VD-EALQHPYI-----
---YQQLKPIGSGAQGIVCAAFD---T-------VLGI--NVAVKKL---SRP--F-QNQTH--AKRAYR------ELVLLKCV--N-HKNIISLLNVFT--PQKT----LEEFQDVYLVMELMDA-NLCQVIH-----------M-------------------------EL--DHERMSYLLYQMLCGIKHLHSA--GIIHRDLKPSNIVVK----S---DCTL---KILDFGLART-----------ACTNFMMTP---YVVTRYYRAPEVIL-----------GMG---YKENVDIWSVGCIMGELVK-GCVI---------------FQGT---------DHIDQWNKV-IEQLG----TPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARD-LLSKMLVIDPDKRIS-----VD-EALRHPYI-----
KVT---SQVLGLGINGKVLQIFN---K-------RTQE--KFALKML---QDC--P-KAR---------R------EVELHWRA-SQ-CPHIVRIVDVYE--NLY------AGRKCLLIVMECLDGGELFSRIQD-------RGDQ-------------------------AF--TEREASEIMKSIGEAIQYLHSI--NIAHRDVKPENLLYT----S---KRPNAILKLTDFGFAKE-----------TTSHNSLTT---PCYTPYYVAPEVLG-----------PEK---YDKSCDMWSLGVIMYILLC-GYPP---------------FYSN--------HGLAISPGMK-TRIRM----GQYEFPNPEWSEVS-----------------------------------EEVKM-LIRNLLKTEPTQRMT-----IT-EFMNHPWI-----
-YV--RGRFLGKGGFAKCFEISD---A-------DTKE--VFAGKIV---PKS--L-LLKPH--QREKMS-----MEISIHRSL--A-HQHVVGFHGFFE--D----------NDFVFVVLELCRRRSLLELHK---------RRK-------------------------AL--TEPEARYYLRQIVLGCQYLHRN--RVIHRDLKLGNLFLN----E---DLEV---KIGDFGLATKV----------EYDGERKKT---LCGTPNYIAPEVLS-----------KKG---HSFEVDVWSIGCIMYTLLV-GKPP---------------FETS------------CLKETY-LRIKK----NEYSIPKHIN---------------------------------------PVAAS-LIQKMLQTDPTARPT-----IN-ELLNDEFF-----
--Y-CRGKVLGKGGFAKCYEMTD---L-------TNNK--VYAAKII---PHS--R-VAKPH--QREKID-----KEIELHRIL--H-HKHVVQFYHYFE--D----------KENIYILLEYCSRRSMAHILK---------ARK-------------------------VL--TEPEVRYYLRQIVSGLKYLHEQ--EILHRDLKLGNFFIN----E---AMEL---KVGDFGLAARL----------EPLEHRRRT---ICGTPNYLSPEVLN-----------KQG---HGCESDIWALGCVMYTMLL-GRPP---------------FETT------------NLKETY-RCIRE----ARYTMPSSLL---------------------------------------APAKH-LIASMLSKNPEDRPS-----LD-DIIRHDFF-----
--F-KVGNLLGKGSFAGVYRAES---I-------HTGL--EVAIKMI---DKK--A-MYKAG--MVQRVQ-----NEVKIHCQL--K-HPSILELYNYFE--D----------SNYVYLVLEMCHNGEMNRYLK--------NRVK-------------------------PF--SENEARHFMHQIITGMLYLHSH--GILHRDLTLSNLLLT----R---NMNI---KIADFGLATQL----------KMPHEKHYT---LCGTPNYISPEIAT-----------RSA---HGLESDVWSLGCMFYTLLI-GRPP---------------FDTD------------TVKNTL-NKVVL----ADYEMPSFLS---------------------------------------IEAKD-LIHQLLRRNPADRLS-----LS-SVLDHPFM-----
-FI--FHKVLGKGSFGKVLLGEL---K-------GRGE--YFAIKAL---KKD--V-VLIDD--DVECTM-----VEKRVLTLA-AE-NPFLTHLICTFQ--T----------KDHLFFVMEFLNGGDLMYHIQ---------DKG-------------------------RF--ELYRATFYAAEIMCGLQFLHSK--GIIYRDLKLDNVLLD----R---DGHI---KIADFGMCKEN----------IFGESRAST---FCGTPDYIAPEILQ-----------GLK---YTFSVDWWSFGVLLYEMLI-GQSP---------------FHGD------------DEDELF-ESIRV----DTPHYPRWIT---------------------------------------KESKD-ILEKLFEREPTKRLG----VTG-NIKIHPFF-----
-FI--LHKMLGKGSFGKVFLAEF---K-------KTNQ--FFAIKAL---KKD--V-VLMDD--DVECTM-----VEKRVLSLA-WE-HPFLTHMFCTFQ--T----------KENLFFVMEYLNGGDLMYHIQ---------SCH-------------------------KF--DLSRATFYAAEIILGLQFLHSK--GIVYRDLKLDNILLD----K---DGHI---KIADFGMCKEN----------MLGDAKTNT---FCGTPDYIAPEILL-----------GQK---YNHSVDWWSFGVLLYEMLI-GQSP---------------FHGQ------------DEEELF-HSIRM----DNPFYPRWLE---------------------------------------KEAKD-LLVKLFVREPEKRLG-----VRGDIRQHPLF-----
---IELGRCIGEGQFGDVHQGIY---M----SPENPAL--AVAIKTC---K-N--C-TS-DSVREKFL-Q------EALTMRQF--D-HPHIVKLIGVIT-------------ENPVWIIMELCTLGELRSFLQ----------VR-----------------------KYSL--DLASLILYAYQLSTALAYLESK--RFVHRDIAARNVLVS----S---NDCV---KLGDFGLSRYM----------E--DSTYYKASKGKLPIKWMAPESIN-----------FRR---FTSASDVWMFGVCMWEILMHGVKP---------------FQGV---------KNNDVIGRI-ENGER----LPMPPNCP-----------------------------------------PTLYS-LMTKCWAYDPSRRPR-----FT-ELKAQL-------
--V-VLNRILGEGFFGEVYEGVY---T----NHKGEKI--NVAVKTC---K-K--D-CT-LDNKEKFM-S------EAVIMKNL--D-HPHIVKLIGIIE-------------EEPTWIIMELYPYGELGHYLE----------RN-----------------------KNSL--KVLTLVLYSLQICKAMAYLESI--NCVHRDIAVRNILVA----S---PECV---KLGDFGLSRYI----------E--DEDYYKASVTRLPIKWMSPESIN-----------FRR---FTTASDVWMFAVCMWEILSFGKQP---------------FFWL---------ENKDVIGVL-EKGDR----LPKPDLCP-----------------------------------------PVLYT-LMTRCWDYDPSDRPR-----FT-ELVCS--L-----
-VM--LSTRIGSGSFGTVYKGKW---H----------G--DVAVKIL---K-V-VD-PT-PEQFQAFR-N------EVAVLRKT--R-HVNILLFMGYMT-------------KDNLAIVTQWCEGSSLYKHLH----------VQ-----------------------ETKF--QMFQLIDIARQTAQGMDYLHAK--NIIHRDMKSNNIFLH----E---GLTV---KIGDFGLATVK-----S----R--WSGSQQVEQPTGSVLWMAPEVIR-----------MQDNNPFSFQSDVYSYGIVLYELMT-GELP---------------YSHI-N-------NRDQIIFMV-GRGYASPDLSKLYKNCP-----------------------------------------KAMKR-LVADCVKKVKEERPL-----FP-QILSS--I-----
--L-VLGKTLGEGEFGKVVKATA---FH--LKGRAGYT--TVAVKML---K-E--N-AS-PSELRDLL-S------EFNVLKQV--N-HPHVIKLYGACS--Q----------DGPLLLIVEYAKYGSLRGFLR----------ESRKVGPGYLGSGGSRNSSSLDHPDERAL--TMGDLISFAWQISQGMQYLAEM--KLVHRDLAARNILVA----E---GRKM---KISDFGLSRDV-----Y----E--EDSYVKRSQGRIPVKWMAIESLF-----------DHI---YTTQSDVWSFGVLLWEIVTLGGNP---------------YPGI---------PPERLFNLL-KTGHR----MERPDNCS-----------------------------------------EEMYR-LMLQCWKQEPDKRPV-----FA-DISKDL-------
---FELLRVLGKGGYGKVFQVRKVTGA-------NTGK--IFAMKVL---KKA--M-IVRNA--KDTAHTK----AERNILEEV--K-HPFIVDLIYAFQ--T----------GGKLYLILEYLSGGELFMQLE---------REG-------------------------IF--MEDTACFYLAEISMALGHLHQK--GIIYRDLKPENIMLN----H---QGHV---KLTDFGLCKES----------IHDGTVTHT---FCGTIEYMAPEILM-----------RSG---HNRAVDWWSLGALMYDMLT-GAPP---------------FTGE------------NRKKTI-DKILK----CKLNLPPYLT---------------------------------------QEARD-LLKKLLKRNAASRLGAGPGDAG-EVQAHPFF-----
---WEIVGELGDGAFGKVYKAKN---K-------ETGA--LAAAKVI---ETK--S-EEELE--DYI--V------EIEILATC--D-HPYIVKLLGAYY--H----------DGKLWIMIEFCPGGAVDAIML--------ELDR-------------------------GL--TEPQIQVVCRQMLEALNFLHSK--RIIHRDLKAGNVLMT----L---EGDI---RLADFGVSAKN----------LKTLQKRDS---FIGTPYWMAPEVVMCE------TMKDTP---YDYKADIWSLGITLIEMAQ-IEPP---------------HHEL---------NPMRVLLKI-AKSDP----PTLLTPSKWS---------------------------------------VEFRD-FLKIALDKNPETRPS-----AA-QLLEHPFV-----
---YHVLEMIGEGSFGRVYKGRR---K-------YSAQ--VVALKFI---PKL--G-RSEKE--LRNLQR------EIEIMRGL--R-HPNIVHMLDSFE--T----------DKEVVVVTDYAEG-ELFQILE---------DDG-------------------------KL--PEDQVQAIAAQLVSALYYLHSH--RILHRDMKPQNILLA----K---GGGI---KLCDFGFARAM----------STNTMVLTS---IKGTPLYMSPELVE-----------ERP---YDHTADLWSVGCILYELAV-GTPP---------------FYAT------------SIFQLV-SLILK----DPVRWPSTIS---------------------------------------PCFKN-FLQGLLTKDPRQRLS-----WP-DLLYHPFI-----
---IKFQDVIGEGNFGQVLKARI---K-----KDGLRM--DAAIKRM---K-E--Y-AS-KDDHRDFA-G------ELEVLCKLG-H-HPNIINLLGACE--H----------RGYLYLAIEYAPHGNLLDFLR----------KSRVLETDP--------AFAIANSTASTL--SSQQLLHFAADVARGMDYLSQK--QFIHRDLAARNILVG----E---NYVA---KIADFGLSRGQ--------------EVYVKKTMGRLPVRWMAIESLN-----------YSV---YTTNSDVWSYGVLLWEIVSLGGTP---------------YCGM---------TCAELYEKL-PQGYR----LEKPLNCD-----------------------------------------DEVYD-LMRQCWREKPYERPS-----FA-QILV---SL----
---ITFEDLIGEGNFGQVIRAMI---K-----KDGLKM--NAAIKML---K-E--Y-AS-ENDHRDFA-G------ELEVLCKLG-H-HPNIINLLGACK--N----------RGYLYIAIEYAPYGNLLDFLR----------KSRVLETDP--------AFAREHGTASTL--SSRQLLRFASDAANGMQYLSEK--QFIHRDLAARNVLVG----E---NLAS---KIADFGLSRGE--------------EVYVKKTMGRLPVRWMAIESLN-----------YSV---YTTKSDVWSFGVLLWEIVSLGGTP---------------YCGM---------TCAELYEKL-PQGYR----MEQPRNCD-----------------------------------------DEVYE-LMRQCWRDRPYERPP-----FA-QIALQ--L-----
VCR---GELLGSGCFGVVHRGLW---T----LPSGKSV--PVAVKSLRVGP-E--G-PM-GTELGDFL-R------EVSVMMNL--E-HPHVLRLHGLVL-------------GQPLQMVMELAPLGSLHARLT----------AP---------------------APTPPL--LVALLCLFLRQLAGAMAYLGAR--GLVHRDLATRNLLLA----S---PRTI---KVADFGLVRPL----GG----A--RGRYVMGGPRPIPYAWCAPESLR-----------HGA---FSSASDVWMFGVTLWEMFSGGEEP---------------WAGV---------PPYLILQRL-EDRAR----LPRPPLCS-----------------------------------------RALYS-LALRCWAPHPADRPS-----FS-HLE----GLL---
--L-RLLEKLGDGSFGVVRRGEW---D----APSGKTV--SVAVKCL---K-PDVL-SQ-PEAMDDFI-R------EVNAMHSL--D-HRNLIRLYGVVL-------------TPPMKMVTELAPLGSLLDRLR----------KH-----------------------QGHF--LLGTLSRYAVQVAEGMGYLESK--RFIHRDLAARNLLLA----T---RDLV---KIGDFGLMRAL----PQ----N--DDHYVMQEHRKVPFAWCAPESLK-----------TRT---FSHASDTWMFGVTLWEMFTYGQEP---------------WIGL---------NGSQILHKIDKEGER----LPRPEDCP-----------------------------------------QDIYN-VMVQCWAHKPEDRPT-----FV-ALRDF--L-----
---YSILKQIGSGGSSKVFQVLN---E-------KKQ---IYAIKYV---NLE--E-ADNQT--LDSYRN------EIAYLNKL-QQHSDKIIRLYDYEI--T----------DQYIYMVMECGNI-DLNSWLK---------KKK-------------------------SI--DPWERKSYWKNMLEAVHTIHQH--GIVHSDLKPANFLIV--------DGML---KLIDFGIANQMQ--------PDTTSVVKDS---QVGTVNYMPPEAIKDMSSSRENGKSKSK---ISPKSDVWSLGCILYYMTY-GKTP---------------FQQI-----------INQISKL-HAIID----PNHEIEFPDIPE-------------------------------------KDLQD-VLKCCLKRDPKQRIS-----IP-ELLAHPYV-----
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