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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other PLK3 203
TK ABL1 261
Other AURKA 133
CMGC CDC2 4
CMGC CDK2 4
TK EGFR 712
TK FGFR1 478
TK FGFR3 472
TK FLT4 845
TK IGF1R 999
TK INSR 1023
TK KDR 834
TK KIT 589
TK LCK 245
CMGC MAPK14 24
TK PDGFRA 593
TK PDGFRB 600
Other PLK1 53
Other PLK2 82
TK SRC 270
TK SYK 371
TK TEK 824
TK TNK2 150
TK ZAP70 338
--YL--KGRLLGKGGFARCYEATDT-------ETGSAYAVKVIPQS--R-VAKPH---QREKILNEIELHRDL-QHRHIVRFSHHFE-D------ADNIYIFLELCSRKSLAHIWK---ARH----------------------------------------------------------------------------------------------------TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARL--EPPEQRK-KT---ICGTPNYVAPEVLL-RQGHGPEADVWSLGCVMYTLLC-GSPPFETA----DLKETY-RCIKQVHYTLPASLS----------------------------LPARQLLAAILRASPRDRPSIDQILRHDFF--
----ITMKHKLGGGQYGEVYEGVWK-------KYSLTVAVKTLK-E--D-TM-EV---EEFL-K-EAAVMKEI-KHPNLVQLLGVCT-R------EPPFYIITEFMTYGNLLDYLR----EC-------------------------------------------------------------------------------------------------NRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM--T--GDTY-TAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLLWEIATYGMSPYPGI-DLSQVYELL-EKDYRMERPEGCP------------------------------EKVYELMRACWQWNPSDRPSFAEIHQA--F--
----FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA--QLEKAGV---EHQLRR-EVEIQSHL-RHPNILRLYGYFH-D------ATRVYLILEYAPLGTVYRELQ---KLS----------------------------------------------------------------------------------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV----HAPSSRR-TT---LCGTLDYLPPEMIE-GRMHDEKVDLWSLGVLCYEFLV-GKPPFEAN----TYQETY-KRISRVEFTFPDFVT----------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI--
----YTKIEKIGEGTYGVVYKGRHK-------TTGQVVAMKKIRLE--S-EEEGV---PSTAIR-EISLLKEL-RHPNIVSLQDVLM-Q------DSRLYLIFEFLSM-DLKKYLDSIPPGQ----------------------------------------------------------------------------------------------------YMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF--GIPIRVY-TH---EVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELAT-KKPLFHGD-SEIDQLFRI-FRALGTPNNEVWPEVESLQDYKNTFPKWKP--GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYF--
----FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLD--T-ETEGV---PSTAIR-EISLLKEL-NHPNIVKLLDVIH-T------ENKLYLVFEFLHQ-DLKKFMDA-SALT----------------------------------------------------------------------------------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF--GVPVRTY-TH---EVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVT-RRALFPGD-SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF--
---F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E--A-TS-PKA-NKEIL-D-EAYVMASV-DNPHVCRLLGICL--------TSTVQLITQLMPFGCLLDYVR----EH--------------------------------------------------------------------------------------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLL-GA--EEKE-YHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSIL-EKGERLPQPPICT------------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S--D-AT-EKD-LSDLI-S-EMEMMKMIGKHKNIINLLGACT-Q------DGPLYVIVEYASKGNLREYLQ----ARRPPGLEY-----------------------------------------------------------------------------------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDI-HH--IDYY-KKTTNGRLPVKWMAPEALF-DRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLL-KEGHRMDKPSNCT------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL----
----LTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLK-D--D-AT-DKD-LSDLV-S-EMEMMKMIGKHKNIINLLGACT-Q------GGPLYVLVEYAAKGNLREFLR----ARRPPGLDY-----------------------------------------------------------------------------------SFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDV-HN--LDYY-KKTTNGRLPVKWMAPEALF-DRVYTHQSDVWSFGVLLWEIFTLGGSPYPGI-PVEELFKLL-KEGHRMDKPANCT------------------------------HDLYMIMRECWHAAPSQRPTFKQLVEDL----
----LHLGRVLGYGAFGKVVEASAFG--IHKGSSCDTVAVKMLK-E--G-AT-ASE-HRALM-S-ELKILIHIGNHLNVVNLLGACTKP------QGPLMVIVEFCKYGNLSNFLR----AKRDAFSPCAEKSPEQRGRFRAMVELARLDRRR-----------------------------------PGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDI-YK--DPDY-VRKGSARLPLKWMAPESIF-DKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRL-RDGTRMRAPELAT------------------------------PAIRRIMLNCWSGDPKARPAFSELVEIL----
----ITMSRELGQGSFGMVYEGVAKG--VVKDEPETRVAIKTVN-E--A-AS-MRE-RIEFL-N-EASVMKEF-NCHHVVRLLGVVS-Q------GQPTLVIMELMTRGDLKSYLR----SLRPEM-----------------------------------------------------------------------------------------ENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDI-YE--TDYY-RKGGKGLLPVRWMSPESLK-DGVFTTYSDVWSFGVVLWEIATLAEQPYQGL-SNEQVLRFV-MEGGLLDKPDNCP------------------------------DMLFELMRMCWQYNPKMRPSFLEIISS--I--
----ITLLRELGQGSFGMVYEGNARD--IIKGEAETRVAVKTVN-E--S-AS-LRE-RIEFL-N-EASVMKGF-TCHHVVRLLGVVS-K------GQPTLVVMELMAHGDLKSYLR----SLRPEA-----------------------------------------------------------------------------------------ENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDI-YE--TDYY-RKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEITSLAEQPYQGL-SNEQVLKFV-MDGGYLDQPDNCP------------------------------ERVTDLMRMCWQFNPKMRPTFLEIVNLL----
----LKLGKPLGRGAFGQVIEADAFG--IDKTATCRTVAVKMLK-E--G-AT-HSE-HRALM-S-ELKILIHIGHHLNVVNLLGACTKP------GGPLMVIVEFCKFGNLSTYLR----SKRNEFVPYKTKGARFRQGKDYVGAIPVDLKRRL---------------------------------DSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDI-YK--DPDY-VRKGDARLPLKWMAPETIF-DRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRL-KEGTRMRAPDYTT------------------------------PEMYQTMLDCWHGEPSQRPTFSELVEHL----
----LSFGKTLGAGAFGKVVEATAYG--LIKSDAAMTVAVKMLK-P--S-AH-LTE-REALM-S-ELKVLSYLGNHMNIVNLLGACT-I------GGPTLVITEYCCYGDLLNFLR----RKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYM-----------------------DMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDI-KN--DSNY-VVKGNARLPVKWMAPESIF-NCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMI-KEGFRMLSPEHAP------------------------------AEMYDIMKTCWDADPLKRPTFKQIVQL--I--
----LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q--G-SM-SP---DAFL-A-EANLMKQL-QHQRLVRLYAVVT--------QEPIYIITEYMENGSLVDFLK----TP-------------------------------------------------------------------------------------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--E--DNEY-TAREGAKFPIKWTAPEAIN-YGTFTIKSDVWSFGILLTEIVTHGRIPYPGM-TNPEVIQNL-ERGYRMVRPDNCP------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L--
----YQNLSPVGSGAYGSVCAAFDT-------KTGLRVAVKKLSRP--F-QSIIH---AKRTYR-ELRLLKHM-KHENVIGLLDVFT-PARSLEEFNDVYLVTHLMGA-DLNNIVK----CQ----------------------------------------------------------------------------------------------------KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDEM-TG---YVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT-DHIDQLKLI-LRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF--
---L-VLGRVLGSGAFGKVVEGTAYG--LSRSQPVMKVAVKMLK-P--T-AR-SSE-KQALM-S-ELKIMTHLGPHLNIVNLLGACT-K------SGPIYIITEYCFYGDLVNYLH----KNRDSFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQA-DTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDI-MH--DSNY-VSKGSTFLPVKWMAPESIF-DNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKI-KSGYRMAKPDHAT------------------------------SEVYEIMVKCWNSEPEKRPSFYHLSE---IV-
---L-VLGRTLGSGAFGQVVEATAHG--LSHSQATMKVAVKMLK-S--T-AR-SSE-KQALM-S-ELKIMSHLGPHLNVVNLLGACT-K------GGPIYIITEYCRYGDLVDYLH----RNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDI-MR--DSNY-ISKGSTFLPLKWMAPESIF-NSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAI-KRGYRMAQPAHAS------------------------------DEIYEIMQKCWEEKFEIRPPFSQLVL---LL-
--YV--RGRFLGKGGFAKCFEISDA-------DTKEVFAGKIVPKS--L-LLKPH---QREKMSMEISIHRSL-AHQHVVGFHGFFE-D------NDFVFVVLELCRRRSLLELHK---RRK----------------------------------------------------------------------------------------------------ALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKV--EYDGERK-KT---LCGTPNYIAPEVLS-KKGHSFEVDVWSIGCIMYTLLV-GKPPFETS----CLKETY-LRIKKNEYSIPKHIN----------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF--
---Y-CRGKVLGKGGFAKCYEMTDL-------TNNKVYAAKIIPHS--R-VAKPH---QREKIDKEIELHRIL-HHKHVVQFYHYFE-D------KENIYILLEYCSRRSMAHILK---ARK----------------------------------------------------------------------------------------------------VLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARL--EPLEHRR-RT---ICGTPNYLSPEVLN-KQGHGCESDIWALGCVMYTMLL-GRPPFETT----NLKETY-RCIREARYTMPSSLL----------------------------APAKHLIASMLSKNPEDRPSLDDIIRHDFF--
---L-RLEVKLGQGCFGEVWMGTWN--------GTTRVAIKTLK-P--G-TM-SP---EAFL-Q-EAQVMKKL-RHEKLVQLYAVVS--------EEPIYIVTEYMSKGSLLDFLK----GE-------------------------------------------------------------------------------------------------TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--E--DNEY-TARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQV-ERGYRMPCPPECP------------------------------ESLHDLMCQCWRKEPEERPTFEYLQAF--L--
-TLE---DKELGSGNFGTVKKGYYQ-----MKKVVKTVAVKILK-N--E-AN-DPALKDELL-A-EANVMQQL-DNPYIVRMIGICE--------AESWMLVMEMAELGPLNKYLQ----QN---------------------------------------------------------------------------------------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL-RA--DENYYKAQTHGKWPVKWYAPECIN-YYKFSSKSDVWSFGVLMWEAFSYGQKPYRGM-KGSEVTAML-EKGERMGCPAGCP------------------------------REMYDLMNLCWTYDVENRPGFAAVE----LRL
----IKFQDVIGEGNFGQVLKARIK-----KDGLRMDAAIKRMK-E--Y-AS-KDD-HRDFA-G-ELEVLCKLGHHPNIINLLGACE-H------RGYLYLAIEYAPHGNLLDFLR----KSRVLETDP-----------------------------------------------------------------------------------AFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQ------EVY-VKKTMGRLPVRWMAIESLN-YSVYTTNSDVWSYGVLLWEIVSLGGTPYCGM-TCAELYEKL-PQGYRLEKPLNCD------------------------------DEVYDLMRQCWREKPYERPSFAQILV---SL-
---L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVL-SQ-PEA-MDDFI-R-EVNAMHSL-DHRNLIRLYGVVL--------TPPMKMVTELAPLGSLLDRLR----KH--------------------------------------------------------------------------------------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQN--DDHY-VMQEHRKVPFAWCAPESLK-TRTFSHASDTWMFGVTLWEMFTYGQEPWIGL-NGSQILHKIDKEGERLPRPEDCP------------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L--
LIAD----IELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLK-Q--G-TE-KAD-TEEMM-R-EAQIMHQL-DNPYIVRLIGVCQ--------AEALMLVMEMAGGGPLHKFLV----GK--------------------------------------------------------------------------------------------------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGAD--DSYY-TARSAGKWPLKWYAPECIN-FRKFSSRSDVWSYGVTMWEALSYGQKPYKKM-KGPEVMAFI-EQGKRMECPPECP------------------------------PELYALMSDCWIYKWEDRPDFLTVEQR--M--
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