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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other PLK3 203
CAMK CHEK2 220
CAMK DAPK3 13
CMGC MAPK14 24
Other NEK1 4
Other NEK2 8
Other NEK5 4
Other NEK9 52
Other PLK1 53
Other PLK2 82
CAMK PRKD3 576
STE SLK 34
-YL--KGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKIL-----NEIELHRDLQHRHIVRFSHHFED------ADNIYIFLELCSRKSLAHIWK----ARHTLLEPEVRYYLRQILSGLKYLHQR-----GILHRDLKLGNFFITENMEL----KVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-----RQGHGPEADVWSLGCVMYTLLCGSPPFETA---DLKETYRCIKQVHYTLPASLS----------------------------LPARQLLAAILRASPRDRPSIDQILRHDFF-
-YI--MSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCIIKIKNFF-D------AEDYYIVLELMEGGELFDKVV----GNKRLKEATCKLYFYQMLLAVQYLHEN-----GIIHRDLKPENVLLSSQEEDC-LIKITDFGHSKI-LGETSLMRTLCGTPTYLAPEVLVS--VGTAGYNRAVDCWSLGVILFICLSGYPPFSEH--RTQVSLKDQITSGKYNFIPEVWAEVS------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL-
---YEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEI--EREVNILREIRHPNIITLHDIFEN------KTDVVLILELVSGGELFDFLA----EKESLTEDEATQFLKQILDGVHYLHSK-----RIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHK-IEAGNEFKNIFGTPEFVAPEIVN-----YEPLGLEADMWSIGVITYILLSGASPFLGE---TKQETLTNISAVNYDFDEEYFSNTS------------------------ELAKDFIRRLLVKDPKRRMTIAQSLEHSWI-
---YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR------ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-DLNNIVK-----CQKLTDDHVQFLIYQILRGLKYIHSA-----DIIHRDLKPSNLAVNEDCEL----KILDFGLAR---HTDDEMTGYVATRWYRAPEIML----NWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF-
--Y-VRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRR------EVAVLANMKHPNIVQYRESFEE------NGSLYIVMDYCEGGDLFKRINA--QKGVLFQEDQILDWFVQICLALKHVHDR-----KILHRDIKSQNIFLTKDGTV----QLGDFGIARVLNSTVELARTCIGTPYYLSPEICE-----NKPYNNKSDIWALGCVLYELCTLKHAFEAG---SMKNLVLKIISGSFPPVSLHYS---------------------------YDLRSLVSQLFKRNPRDRPSVNSILEKGF-I
---YEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVS------EVNLLRELKHPNIVRYYDRIIDR----TNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNV----KLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMN-----RMSYNEKSDIWSLGCLLYELCALMPPFTAF---SQKELAGKIREGKFRRIPYRY---S------------------------DELNEIITRMLNLKDYHRPSVEEILENPL-I
---YDVIKAIGQGAFGKAYLAKGKSDSKHCVIKEINFEKMPIQEKEASKK------EVILLEKMKHPNIVAFFNSFQE------NGRLFIVMEYCDGGDLMKRINR--QRGVLFSEDQILGWFVQISLGLKHIHDR-----KILHRDIKAQNIFLSKNGMV---AKLGDFGIARVLNNSMELARTCIGTPYYLSPEICQ-----NKPYNNKTDIWSLGCVLYELCTLKHPFEGN---NLQQLVLKICQAHFAPISPGF---S------------------------RELHSLISQLFQVSPRDRPSINSILKRPFL-
YIP---IRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALN------EIVILALLQHDNIIAYYNHFMD------NTTLLIELEYCNGGNLYDKILR--QKDKLFEEEMVVWYLFQIVSAVSCIHKA-----GILHRDIKTLNIFLTKANLI----KLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQ-----GVKYNFKSDIWAVGCVIFELLTLKRTFDAT---NPLNLCVKIVQGIRAMEVDSS-QYS------------------------LELIQMVHSCLDQDPEQRPTADELLDRPL-L
-YV--RGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMS-----MEISIHRSLAHQHVVGFHGFFED------NDFVFVVLELCRRRSLLELHK----RRKALTEPEARYYLRQIVLGCQYLHRN-----RVIHRDLKLGNLFLNEDLEV----KIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLS-----KKGHSFEVDVWSIGCIMYTLLVGKPPFETS---CLKETYLRIKKNEYSIPKHIN----------------------------PVAASLIQKMLQTDPTARPTINELLNDEFF-
--Y-CRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKID-----KEIELHRILHHKHVVQFYHYFED------KENIYILLEYCSRRSMAHILK----ARKVLTEPEVRYYLRQIVSGLKYLHEQ-----EILHRDLKLGNFFINEAMEL----KVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLN-----KQGHGCESDIWALGCVMYTMLLGRPPFETT---NLKETYRCIREARYTMPSSLL----------------------------APAKHLIASMLSKNPEDRPSLDDIIRHDFF-
FAD----EVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRN------EVAILQNLHHPGIVNLECMFET------PERVFVVMEKLHGDMLEMILS---SEKSRLPERITKFMVTQILVALRNLHFK-----NIVHCDLKPENVLLASAEPFP-QVKLCDFGFARI-IGEKSFRRSVVGTPAYLAPEVLR-----SKGYNRSLDMWSVGVIIYVSLSGTFPFNED-----EDINDQIQNAAFMYPPNPWREIS------------------------GEAIDLINNLLQVKMRKRYSVDKSLSHPWL-
---WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYM--V------EIDILASCDHPNIVKLLDAFYY------ENNLWILIEFCAGGAVDAVML---ELERPLTESQIQVVCKQTLDALNYLHDN-----KIIHRDLKAGNILFTLDGDI----KLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIAKSEPPTLAQPSRWS----------------------------SNFKDFLKKCLEKNVDARWTTSQLLQHPFV-
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