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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
Other PLK3 203
TK ABL2 288
Other AURKA 133
Other AURKB 77
TK BMX 422
TK BTK 402
CMGC CDK2 4
CMGC CDK4 6
CAMK CHEK1 9
CAMK CHEK2 220
CMGC CSNK2A1 39
CMGC CSNK2A2 40
CAMK DAPK1 13
TK EGFR 712
TK FER 563
TK FGFR1 478
CMGC GSK3A 119
CMGC GSK3B 56
TKL IRAK4 186
TK ITK 363
TK LCK 245
STE MAP4K2 16
TK NTRK1 510
TK NTRK2 538
TK NTRK3 538
CAMK NUAK1 55
TK RET 724
STE SLK 34
TK SYK 371
TK TNK2 150
TK TXK 271
TK ZAP70 338
--YL--KGRLLGKGGFARCYEATDT-------ETGSAYAVKVIPQS--R-VAK---PH---Q-REKIL-----NEIELHRDL--Q---HRHIVRFSHHFED-----ADNIY--IFLELCSRK--SLAHIWK----ARH-------------------------TLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFIT-ENMEL----KVGDFGLAARL----EPPEQRK--------------KT---ICGTPNYVAPEV--LL-----RQGHGPEADVWSLGCVMYTLLC-GSPPFE-TA---DLKETY-RCIKQVHYTLPASLS----------------------------------LPARQLLAAILRASPRDRPSIDQILRHDFF---
----ITMKHKLGGGQYGEVYVGVWK-------KYSLTVAVKTLK-E--D-TM----EV---E-EFL-K------EAAVMKEI--K---HPNLVQLLGVCTL-----EPPFY--IVTEYMPYG--NLLDYLR-----EC----------------------NREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-ENHVV----KVADFGLSRLM----T--GDTY--------------TAHAGAKFPIKWTAPES--LA-----YNTFSIKSDVWAFGVLLWEIATYGMSPYP-GIDLSQVYDLL-EKGYRMEQPEGCP------------------------------------PKVYELMRACWKWSPADRPSFAETHQA--F---
----FEIGRPLGKGKFGNVYLAREK-------QSKFILALKVLFKA--QLEKA---GV---E-HQLRR------EVEIQSHL--R---HPNILRLYGYFHD-----ATRVY--LILEYAPLG--TVYRELQ----KLS-------------------------KFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG-SAGEL----KIADFGWSV------HAPSSRR--------------TT---LCGTLDYLPPEM--IE-----GRMHDEKVDLWSLGVLCYEFLV-GKPPFE-AN---TYQETY-KRISRVEFTFPDFVT----------------------------------EGARDLISRLLKHNPSQRPMLREVLEHPWI---
----FEIGRPLGKGKFGNVYLAREK-------KSHFIVALKVLFKS--Q-IEK---EG---V-EHQLR-----REIEIQAHL--H---HPNILRLYNYFYD-----RRRIY--LILEYAPRG--ELYKELQ----KSC-------------------------TFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGEL----KIADFGWSV------HAPSLRR--------------KT---MCGTLDYLPPEM--IE-----GRMHNEKVDLWCIGVLCYELLV-GNPPFE-SA---SHNETY-RRIVKVDLKFPASVP----------------------------------MGAQDLISKLLRHNPSERLPLAQVSAHPWV---
----ITLLKELGSGQFGVVQLGKWK--------GQYDVAVKMIK-E--G-SM----SE---D-EFF-Q------EAQTMMKL--S---HPKLVKFYGVCSK-----EYPIY--IVTEYISNG--CLLNYLR-----SH-----------------------GKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVD-RDLCV----KVSDFGMTRYV----L--DDQY--------------VSSVGTKFPVKWSAPEV--FH-----YFKYSSKSDVWAFGILMWEVFSLGKQPYD-LYDNSQVVLKV-SQGHRLYRPHLAS------------------------------------DTIYQIMYSCWHELPEKRPTFQQLLSS--I---
----LTFLKELGTGQFGVVKYGKWR--------GQYDVAIKMIK-E--G-SM----SE---D-EFI-E------EAKVMMNL--S---HEKLVQLYGVCTK-----QRPIF--IITEYMANG--CLLNYLR-----EM-----------------------RHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVN-DQGVV----KVSDFGLSRYV----L--DDEY--------------TSSVGSKFPVRWSPPEV--LM-----YSKFSSKSDIWAFGVLMWEIYSLGKMPYE-RFTNSETAEHI-AQGLRLYRPHLAS------------------------------------EKVYTIMYSCWHEKADERPTFKILLSN--I---
----FQKVEKIGEGTYGVVYKARNK-------LTGEVVALKKIRLD--T-ETE---GV---P-STAIR------EISLLKEL--N---HPNIVKLLDVIHT-----ENKLY--LVFEFLHQ---DLKKFMDA--SALT-------------------------GIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN-TEGAI----KLADFGLARAF----GVPVRTY--------------TH---EVVTLWYRAPEI--LL----GCKYYSTAVDIWSLGCIFAEMVT-RRALFP-GDSEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR--------QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF---
---Y-EPVAEIGVGAYGTVYKARDP-------HSGHFVALKSVRVP--N-GGGGGGGL---P-ISTVR------EVALLRRL--EAFEHPNVVRLMDVCATSRTDREIKVT--LVFEHVDQ---DLRTYLDK--APPP-------------------------GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTV----KLADFGLARI-----YSYQMAL--------------TP---VVVTLWYRAPEV--LL-----QSTYATPVDMWSVGCIFAEMFR-RKPLFC-GNSEADQLGKI-FDLIGLPPEDDWPRDVSLPRGAFPPRGPR----------PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL---
---W-DLVQTLGEGAYGEVQLAVNR-------VTEEAVAVKIVDMK--R-AVD---CP---E-NI-KK------EICINKML--N---HENVVKFYGHRRE-----GNIQY--LFLEYCSGG--ELFDRIE----PDI-------------------------GMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLD-ERDNL----KISDFGLATVFR--YNNRERLL--------------NK---MCGTLPYVAPEL--LK----RREFHAEPVDVWSCGIVLTAMLA-GELPWD-QP--SDSCQEY-SDWKEKKTYLNPWKKI--D------------------------------SAPLALLHKILVENPSARITIPDIKKDRW-Y--
--YI--MSKTLGSGACGEVKLAFER-------KTCKKVAIKIISKR--K-FAI---GS---A-READPALNVETEIEILKKL--N---HPCIIKIKNFF-D-----AEDYY--IVLELMEGG--ELFDKVV----GNK-------------------------RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLS-SQEEDC-LIKITDFGHSKI-----LGETSLM--------------RT---LCGTPTYLAPEV--LVS--VGTAGYNRAVDCWSLGVILFICLS-GYPPFS-EH--RTQVSLK-DQITSGKYNFIPEVWAEVS------------------------------EKALDLVKKLLVVDPKARFTTEEALRHPWL---
----YQLVRKLGRGKYSEVFEAINI-------TNNEKVVVKILKPV--K-KKK---IK---R------------EIKILENL-RG---GPNIITLADIVKDP---VSRTPA--LVFEHVNNT--DFKQLY-------Q-------------------------TLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKL----RLIDWGLAEF-----YHPGQEY--------------NV---RVASRYFKGPEL--LV----DYQMYDYSLDMWSLGCMLASMIF-RKEPFFHGHDNYDQLVRI-AKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYF---
----YQLVRKLGRGKYSEVFEAINI-------TNNERVVVKILKPV--K-KKK---IK---R------------EVKILENL-RG---GTNIIKLIDTVKDP---VSKTPA--LVFEYINNT--DFKQLY-------Q-------------------------ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKL----RLIDWGLAEF-----YHPAQEY--------------NV---RVASRYFKGPEL--LV----DYQMYDYSLDMWSLGCMLASMIF-RREPFFHGQDNYDQLVRI-AKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF---
----YDTGEELGSGQFAVVKKCREK-------STGLQYAAKFIKKR--R-TKS---SR---R-GVSREDI--EREVSILKEI--Q---HPNVITLHEVYEN-----KTDVI--LILELVAGG--ELFDFLA----EKE-------------------------SLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLL-DRNVPKPRIKIIDFGLAHK-----IDFGNEF--------------KN---IFGTPEFVAPEI--VN-----YEPLGLEADMWSIGVITYILLS-GASPFL-GD---TKQETL-ANVSAVNYEFEDEYFSNTS------------------------------ALAKDFIRRLLVKDPKKRMTIQDSLQHPWI---
---F-KKIKVLGSGAFGTVYKGLWIP---EGEKVKIPVAIKELR-E--A-TS----PKA-NK-EIL-D------EAYVMASV--D---NPHVCRLLGICL------TSTVQ--LITQLMPFG--CLLDYVR-----EH-----------------------KDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVK-TPQHV----KITDFGLAKLL--G-A--EEKE--------------YHAEGGKVPIKWMALES--IL-----HRIYTHQSDVWSYGVTVWELMTFGSKPYD-GIPASEISSIL-EKGERLPQPPICT------------------------------------IDVYMIMVKCWMIDADSRPKFRELI----IEF-
--VI--LGELLGKGNFGEVYKGTLK--------DKTSVAVKTCK-E--D-LP----QEL-KI-KFL-Q------EAKILKQY--D---HPNIVKLIGVCTQ-----RQPVY--IIMELVSGG--DFLTFLR-----RK-----------------------KDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVG-ENNVL----KISDFGMSRQE----D--GGVY--------------SSSGLKQIPIKWTAPEA--LN-----YGRYSSESDVWSFGILLWETFSLGVCPYP-GMTNQQAREQV-ERGYRMSAPQHCP------------------------------------EDISKIMMKCWDYKPENRPKFSELQKEL-----
---L-VLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK-S--D-AT----EKD-LS-DLI-S------EMEMMKMIG-K---HKNIINLLGACTQ-----DGPLY--VIVEYASKG--NLREYLQ-----ARRPPGLEY--------CYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT-EDNVM----KIADFGLARDI--H-H--IDYY--------------KKTTNGRLPVKWMAPEA--LF-----DRIYTHQSDVWSFGVLLWEIFTLGGSPYP-GVPVEELFKLL-KEGHRMDKPSNCT------------------------------------NELYMMMRDCWHAVPSQRPTFKQLVEDL-----
----YTDIKVIGNGSFGVVYQARLA-------ETRELVAIKKVLQD--K-RFK---NR----------------ELQIMRKL--D---HCNIVRLRYFFYSSG-EKKDELYLNLVLEYVPETVYRVARHFT---KAKL-------------------------TIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVL----KLCDFGSAKQ-----LVRGEPN--------------VS---YICSRYYRAPEL--IF----GATDYTSSIDVWSAGCVLAELLL-GQPIFP-GDSGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH--------PWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFF---
----YTDTKVIGNGSFGVVYQAKLC-------DSGELVAIKKVLQD--K-RFK---NR----------------ELQIMRKL--D---HCNIVRLRYFFYSSG-EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ-------------------------TLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVL----KLCDFGSAKQ-----LVRGEPN--------------VS---YICSRYYRAPEL--IF----GATDYTSSIDVWSAGCVLAELLL-GQPIFP-GDSGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH--------PWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF---
-VGG----NKMGEGGFGVVYKGYVN-------NTT--VAVKKLAAM--V-DIT---TE---ELKQQFD-----QEIKVMAKC--Q---HENLVELLGFSSD-----GDDLC--LVYVYMPNG--SLLDRLSC-LDGTP-------------------------PLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLD-EAFTA----KISDFGLARASE--KFAQTVMT--------------SR---IVGTTAYMAPEA--LR------GEITPKSDIYSFGVVLLEIIT-GLPAVD-EHREPQLLLDI-KEEIEDEEKTIEDYIDKKMNDAD----------------------STSVEAMYSVASQCLHEKKNKRPDIKKVQQ----LLQ
----LTFVQEIGSGQFGLVHLGYWL--------NKDKVAIKTIR-E--G-AM----SE---E-DFI-E------EAEVMMKL--S---HPKLVQLYGVCLE-----QAPIC--LVFEFMEHG--CLSDYLR-----TQ-----------------------RGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVG-ENQVI----KVSDFGMTRFV----L--DDQY--------------TSSTGTKFPVKWASPEV--FS-----FSRYSSKSDVWSFGVLMWEVFSEGKIPYE-NRSNSEVVEDI-STGFRLYKPRLAS------------------------------------THVYQIMNHCWKERPEDRPAFSRLLRQL-----
----LKLVERLGAGQFGEVWMGYYN--------GHTKVAVKSLK-Q--G-SM----SP---D-AFL-A------EANLMKQL--Q---HQRLVRLYAVVT------QEPIY--IITEYMENG--SLVDFLK-----TP----------------------SGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVS-DTLSC----KIADFGLARLI----E--DNEY--------------TAREGAKFPIKWTAPEA--IN-----YGTFTIKSDVWSFGILLTEIVTHGRIPYP-GMTNPEVIQNL-ERGYRMVRPDNCP------------------------------------EELYQLMRLCWKERPEDRPTFDYLRSV--L---
----FELLQRVGAGTYGDVYKARDT-------VTSELAAVKIVKLD--P-GDD---IS---S-L--QQ------EITILREC--R---HPNVVAYIGSYLR-----NDRLW--ICMEFCGGG--SLQEIYH----ATG-------------------------PLEERQIAYVCREALKGLHHLHSQGKIHRDIKGANLLLT-LQGDV----KLADFGVSGEL----TASVAKR--------------RS---FIGTPYWMAPEVAAVE----RKGGYNELCDVWALGITAIELGE-LQPPLF-HLHPMRALMLM-SKSSFQPPKLRDKTR--WT------------------------------QNFHHFLKLALTKNPKKRPTAEKLLQHPF-T--
--IV--LKWELGEGAFGKVFLAECHN--LLPEQDKMLVAVKALK-E--A-SE----SA--RQ-DFQ-R------EAELLTML--Q---HQHIVRFFGVCTE-----GRPLL--MVFEYMRHG--DLNRFLR-----SHGPDAKL---------LAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVG-QGLVV----KIGDFGMSRDI--Y-S--TDYY--------------RVGGRTMLPIRWMPPES--IL-----YRKFTTESDVWSFGVVLWEIFTYGKQPWY-QLSNTEAIDCI-TQGRELERPRACP------------------------------------PEVYAIMRGCWQREPQQRHSIKDVHARL-----
---I-VLKRELGEGAFGKVFLAECYN--LCPEQDKILVAVKTLK-D--A-SD----NA--RK-DFH-R------EAELLTNL--Q---HEHIVKFYGVCVE-----GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAV-----------LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVG-ENLLV----KIGDFGMSRDV--Y-S--TDYY--------------RVGGHTMLPIRWMPPES--IM-----YRKFTTESDVWSLGVVLWEIFTYGKQPWY-QLSNNEVIECI-TQGRVLQRPRTCP------------------------------------QEVYELMLGCWQREPHMRKNIKGIHTL--L---
---I-VLKRELGEGAFGKVFLAECYN--LSPTKDKMLVAVKALK-D--P-TL----AA--RK-DFQ-R------EAELLTNL--Q---HEHIVKFYGVCGD-----GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAMIL--------VDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVG-ANLLV----KIGDFGMSRDV--Y-S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPES--IM-----YRKFTTESDVWSFGVILWEIFTYGKQPWF-QLSNTEVIECI-TQGRVLERPRVCP------------------------------------KEVYDVMLGCWQREPQQRLNIKEIYKIL-----
----YELQETLGKGTYGKVKRATER-------FSGRVVAIKSIRKD--K-IKD---EQ---D-MVHIR-----REIEIMSSL--N---HPHIISIYEVFEN-----KDKIV--IIMEYASKG--ELYDYIS----ERR-------------------------RLSERETRHFFRQIVSAVHYCHKNGVVHRDLKLENILLD-DNCNI----KIADFGLSNL-----YQKDKFL--------------QT---FCGSPLYASPEI--VN----GRPYRGPEVDSWALGVLLYTLVY-GTMPFD-GF---DHKNLI-RQISSGEYREPTQP-----------------------------------SDARGLIRWMLMVNPDRRATIEDIANHWW-V--
---L-VLGKTLGEGEFGKVVKATAFH--LKGRAGYTTVAVKMLK-E--N-AS----PSE-LR-DLL-S------EFNVLKQV--N---HPHVIKLYGACSQ-----DGPLL--LIVEYAKYG--SLRGFLR-----ESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVA-EGRKM----KISDFGLSRDV--Y-E--EDSY--------------VKRSQGRIPVKWMAIES--LF-----DHIYTTQSDVWSFGVLLWEIVTLGGNPYP-GIPPERLFNLL-KTGHRMERPDNCS------------------------------------EEMYRLMLQCWKQEPDKRPVFADISKDL-----
----WEIIGELGDGAFGKVYKAQNK-------ETSVLAAAKVIDTK--S-EEE---LE---D-YM--V------EIDILASC--D---HPNIVKLLDAFYY-----ENNLW--ILIEFCAGG--AVDAVML---ELER-------------------------PLTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILFT-LDGDI----KLADFGVSAKN----TRTIQRR--------------DS---FIGTPYWMAPEV--VMCETSKDRPYDYKADVWSLGITLIEMAE-IEPPHH-ELNPMRVLLKI-AKSEPPTLAQPSRWS----------------------------------SNFKDFLKKCLEKNVDARWTTSQLLQHPFV---
-TLE---DKELGSGNFGTVKKGYYQ-----MKKVVKTVAVKILK-N--E-AN----DPALKD-ELL-A------EANVMQQL--D---NPYIVRMIGICE------AESWM--LVMEMAELG--PLNKYLQ-----QN------------------------RHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV-TQHYA----KISDFGLSKAL--R-A--DENY-------------YKAQTHGKWPVKWYAPEC--IN-----YYKFSSKSDVWSFGVLMWEAFSYGQKPYR-GMKGSEVTAML-EKGERMGCPAGCP------------------------------------REMYDLMNLCWTYDVENRPGFAAVE----LRL-
---L-RLLEKLGDGSFGVVRRGEWD----APSGKTVSVAVKCLK-PDVL-SQ----PEA-MD-DFI-R------EVNAMHSL--D---HRNLIRLYGVVL------TPPMK--MVTELAPLG--SLLDRLR-----KH-----------------------QGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLA-TRDLV----KIGDFGLMRAL-PQ-N--DDHY--------------VMQEHRKVPFAWCAPES--LK-----TRTFSHASDTWMFGVTLWEMFTYGQEPWI-GLNGSQILHKIDKEGERLPRPEDCP------------------------------------QDIYNVMVQCWAHKPEDRPTFVALRDF--L---
---L-AFIKEIGSGQFGVVHLGEWR--------SHIQVAIKAIN-E--G-SM----SE---E-DFI-E------EAKVMMKL--S---HSKLVQLYGVCIQ-----RKPLY--IVTEFMENG--CLLNYLR-----EN-----------------------KGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVS-STCIV----KISDFGMTRYV----L--DDEY--------------VSSFGAKFPIKWSPPEV--FL-----FNKYSSKSDVWSFGVLMWEVFTEGKMPFE-NKSNLQVVEAI-SEGFRLYRPHLAP------------------------------------MSIYEVMYSCWHEKPEGRPTFAELLR---AV--
LIAD----IELGCGNFGSVRQGVYR-----MRKKQIDVAIKVLK-Q--G-TE----KAD-TE-EMM-R------EAQIMHQL--D---NPYIVRLIGVCQ------AEALM--LVMEMAGGG--PLHKFLV-----GK-----------------------REEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLV-NRHYA----KISDFGLSKAL-GA-D--DSYY--------------TARSAGKWPLKWYAPEC--IN-----FRKFSSRSDVWSYGVTMWEALSYGQKPYK-KMKGPEVMAFI-EQGKRMECPPECP------------------------------------PELYALMSDCWIYKWEDRPDFLTVEQR--M---
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