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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PRKACA 203
TK ABL1 261
Other AURKA 133
Other AURKB 77
Other AURKC 43
CAMK BRSK1 50
CAMK BRSK2 19
CAMK CAMK2A 13
CAMK CAMK2B 14
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK3 4
CAMK CHEK2 220
Other EIF2AK2 267
TK FER 563
TK FES 561
CMGC GSK3A 119
CMGC GSK3B 56
TKL MAP3K7 36
CMGC MAPK10 64
CAMK MARK2 53
CAMK MARK4 59
Other NEK1 4
Other NEK3 4
Other NEK8 4
CAMK NUAK1 55
CAMK NUAK2 97
STE PAK7 449
AGC PDPK1 82
Other PLK1 53
Other PLK3 62
Other PLK4 12
CAMK PRKD1 583
CAMK PRKD2 551
CAMK PRKD3 576
AGC ROCK1 76
AGC ROCK2 92
CAMK SIK1 27
CAMK SIK2 20
STE SLK 34
STE STK10 36
Other TLK1 477
Other TLK2 440
CAMK TSSK1B 12
Other ULK1 16
Other ULK2 9
----F-ERIKTLGTGSFGRVMLVKHKETGN-HYAMKILDKQK-VVKLK--QI-EHTL-----NEKRILQAVNFPFLVKLEFSFKD-----------------------------NSNLY--MVMEYVPGG--EMFSHLR----RIG----RFSEPHARFYAAQIVLTFEYLHSL--D---LIYRDLKPENLLID-QQG-YI---------QVTDFGFAK-----------RVKGRTWT---LCGTPEYLAPEIIL-----SKGYNKAVDWWALGVLIYEMAA-GY-PPFFAD-----QPIQIYEKIVSGKVRFPSHFS---------------------------------------SDLKDLLRNLLQVDLTK--RFGNLKNGVNDIKNHKWF-----------
-----ITMKHKLGGGQYGEVYEGVWKKYSL-TVAVKTLK-ED-TM-EV--EE-FL-K------EAAVMKEIKHPNLVQLLGVCTR-----------------------------EPPFY--IITEFMTYG--NLLDYLR-----ECNR-QEVNAVVLLYMATQISSAMEYLEKK--N---FIHRDLAARNCLVG-ENH-LV---------KVADFGLSRLM--------T--GDTYTAHAGAKFPIKWTAPESLA-----YNKFSIKSDVWAFGVLLWEIATYGM-SPYPGI--DLSQVYELLEKDYRMERPEGCP-----------------------------------------EKVYELMRACWQWNPSD--RPS-----FAEIHQA--F-----------
-----FEIGRPLGKGKFGNVYLAREKQSKF-ILALKVLFKAQLEKAGV--EH-QLRR------EVEIQSHLRHPNILRLYGYFHD-----------------------------ATRVY--LILEYAPLG--TVYRELQ----KLS----KFDEQRTATYITELANALSYCHSK--R---VIHRDIKPENLLLG-SAG-EL---------KIADFGWSV----------HAPSSRRTT---LCGTLDYLPPEMIE-----GRMHDEKVDLWSLGVLCYEFLV-GK-PPFEAN-----TYQETYKRISRVEFTFPDFVT---------------------------------------EGARDLISRLLKHNPSQ--RPM-----LREVLEHPWI-----------
-----FEIGRPLGKGKFGNVYLAREKKSHF-IVALKVLFKSQ-IEKEG--VE-HQLR-----REIEIQAHLHHPNILRLYNYFYD-----------------------------RRRIY--LILEYAPRG--ELYKELQ----KSC----TFDEQRTATIMEELADALMYCHGK--K---VIHRDIKPENLLLG-LKG-EL---------KIADFGWSV----------HAPSLRRKT---MCGTLDYLPPEMIE-----GRMHNEKVDLWCIGVLCYELLV-GN-PPFESA-----SHNETYRRIVKVDLKFPASVP---------------------------------------MGAQDLISKLLRHNPSE--RLP-----LAQVSAHPWV-----------
-----FEIGRPLGKGKFGNVYLARLKESHF-IVALKVLFKSQ-IEKEG--LE-HQLR-----REIEIQAHLQHPNILRLYNYFHD-----------------------------ARRVY--LILEYAPRG--ELYKELQ----KSE----KLDEQRTATIIEELADALTYCHDK--K---VIHRDIKPENLLLG-FRG-EV---------KIADFGWSV----------HTPSLRRKT---MCGTLDYLPPEMIE-----GRTYDEKVDLWCIGVLCYELLV-GY-PPFESA-----SHSETYRRILKVDVRFPLSMP---------------------------------------LGARDLISRLLRYQPLE--RLP-----LAQILKHPWV-----------
-----YRLEKTLGKGQTGLVKLGVHCITGQ-KVAIKIVNREK-LSESV--LM-KVER------EIAILKLIEHPHVLKLHDVYEN-----------------------------KKYLY--LVLEHVSGG--ELFDYLV----KKG----RLTPKEARKFFRQIVSALDFCHSY--S---ICHRDLKPENLLLD-EKN-NI---------RIADFGMASL---------QVGDSLLET---SCGSPHYACPEVIK----GEKYDGRRADMWSCGVILFALLV-GA-LPFDDD-----NLRQLLEKVKRGVFHMPHFIP---------------------------------------PDCQSLLRGMIEVEPEK--RLS-----LEQIQKHPW-Y----------
-----YRLEKTLGKGQTGLVKLGVHCVTCQ-KVAIKIVNREK-LSESV--LM-KVER------EIAILKLIEHPHVLKLHDVYEN-----------------------------KKYLY--LVLEHVSGG--ELFDYLV----KKG----RLTPKEARKFFRQIISALDFCHSH--S---ICHRDLKPENLLLD-EKN-NI---------RIADFGMASL---------QVGDSLLET---SCGSPHYACPEVIR----GEKYDGRKADVWSCGVILFALLV-GA-LPFDDD-----NLRQLLEKVKRGVFHMPHFIP---------------------------------------PDCQSLLRGMIEVDAAR--RLT-----LEHIQKHIW-Y----------
-----YQLFEELGKGAFSVVRRCVKVLAGQ-EYAAKIINTKK-LSARD--HQ-KLER------EARICRLLKHPNIVRLHDSISE-----------------------------EGHHY--LIFDLVTGG--ELFEDIV----ARE----YYSEADASHCIQQILEAVLHCHQM--G---VVHRDLKPENLLLA-SKL-KGA------AVKLADFGLAIEV--------EGEQQAWFG---FAGTPGYLSPEVLR-----KDPYGKPVDLWACGVILYILLV-GY-PPFWDE-----DQHRLYQQIKAGAYDFPSPEWDTVT-----------------------------------PEAKDLINKMLTINPSK--RIT-----AAEALKHPWI-----------
-----YQLYEDIGKGAFSVVRRCVKLCTGH-EYAAKIINTKK-LSARD--HQ-KLER------EARICRLLKHSNIVRLHDSISE-----------------------------EGFHY--LVFDLVTGG--ELFEDIV----ARE----YYSEADASHCIQQILEAVLHCHQM--G---VVHRDLKPENLLLA-SKC-KGA------AVKLADFGLAIEV--------QGDQQAWFG---FAGTPGYLSPEVLR-----KEAYGKPVDIWACGVILYILLV-GY-PPFWDE-----DQHKLYQQIKAGAYDFPSPEWDTVT-----------------------------------PEAKNLINQMLTINPAK--RIT-----AHEALKHPWV-----------
-----YTKIEKIGEGTYGVVYKGRHKTTGQ-VVAMKKIRLES-EEEGV--PS-TAIR------EISLLKELRHPNIVSLQDVLMQ-----------------------------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ----YMDSSLVKSYLYQILQGIVFCHSR--R---VLHRDLKPQNLLID-DKG-TI---------KLADFGLARAF--------GIPIRVYTH---EVVTLWYRSPEVLL----GSARYSTPVDIWSIGTIFAELAT-KK-PLFHGD--SEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKP-------------GSLASHVKNLDENGLDLLSKMLIYDPAK--RIS-----GKMALNHPYF-----------
-----FQKVEKIGEGTYGVVYKARNKLTGE-VVALKKIRLDT-ETEGV--PS-TAIR------EISLLKELNHPNIVKLLDVIHT-----------------------------ENKLY--LVFEFLHQ---DLKKFMDA--SALT----GIPLPLIKSYLFQLLQGLAFCHSH--R---VLHRDLKPQNLLIN-TEG-AI---------KLADFGLARAF--------GVPVRTYTH---EVVTLWYRAPEILL----GCKYYSTAVDIWSLGCIFAEMVT-RR-ALFPGD--SEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-------------QDFSKVVPPLDEDGRSLLSQMLHYDPNK--RIS-----AKAALAHPFF-----------
-----FQKVEKIGEGTYGVVYKAKNRETGQ-LVALKKIRLDL-EMEGV--PS-TAIR------EISLLKELKHPNIVRLLDVVHN-----------------------------ERKLY--LVFEFLSQ---DLKKYMDS--TPGS----ELPLHLIKSYLFQLLQGVSFCHSH--R---VIHRDLKPQNLLIN-ELG-AI---------KLADFGLARAF--------GVPLRTYTH---EVVTLWYRAPEILL----GSKFYTTAVDIWSIGCIFAEMVT-RK-ALFPGD--SEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTR-------------KGLEEIVPNLEPEGRDLLMQLLQYDPSQ--RIT-----AKTALAHPYF-----------
---YI--MSKTLGSGACGEVKLAFERKTCK-KVAIKIISKRK-FAIGS--AR-EADPALNVETEIEILKKLNHPCIIKIKNFF-D-----------------------------AEDYY--IVLELMEGG--ELFDKVV----GNK----RLKEATCKLYFYQMLLAVQYLHEN--G---IIHRDLKPENVLLS-SQE-EDC------LIKITDFGHSKI---------LGETSLMRT---LCGTPTYLAPEVLVS--VGTAGYNRAVDCWSLGVILFICLS-GY-PPFSEH----RTQVSLKDQITSGKYNFIPEVWAEVS-----------------------------------EKALDLVKKLLVVDPKA--RFT-----TEEALRHPWL-----------
----F-KEIELIGSGGFGQVFKAKHRIDGK-TYVIKRVKYNN-EKAER---------------EVKALAKLDHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLF--IQMEFCDKG--TLEQWIEK--RRGE----KLDKVLALELFEQITKGVDYIHSK--K---LIHRDLKPSNIFLV-DTK-QV---------KIGDFGLVTS---------LKNDGKRTR---SKGTLRYMSPEQIS-----SQDYGKEVDLYALGLILAELLH-VCDTAFET---------SKFFTDLRDGIISDIFDK----------------------------------------KEKTLLQKLLSKKPED--RPN-----TSEILR----TLT--------
---VI--LGELLGKGNFGEVYKGTLK-DKT-SVAVKTCK-ED-LP-QELKIK-FL-Q------EAKILKQYDHPNIVKLIGVCTQ-----------------------------RQPVY--IIMELVSGG--DFLTFLR-----RK-K-DELKLKQLVKFSLDAAAGMLYLESK--N---CIHRDLAARNCLVG-ENN-VL---------KISDFGMSRQE--------D--GGVYSSSGLKQIPIKWTAPEALN-----YGRYSSESDVWSFGILLWETFSLGV-CPYPGM--TNQQAREQVERGYRMSAPQHCP-----------------------------------------EDISKIMMKCWDYKPEN--RPK-----FSELQKEL-------------
----L-VLGEQIGRGNFGEVFSGRLRADNT-LVAVKSCR-ET-LP-PDLKAK-FL-Q------EARILKQYSHPNIVRLIGVCTQ-----------------------------KQPIY--IVMELVQGG--DFLTFLR-----TE-G-ARLRVKTLLQMVGDAAAGMEYLESK--C---CIHRDLAARNCLVT-EKN-VL---------KISDFGMSREE---A----D--GVYAASGGLRQVPVKWTAPEALN-----YGRYSSESDVWSFGILLWETFSLGA-SPYPNL--SNQQTREFVEKGGRLPCPELCP-----------------------------------------DAVFRLMEQCWAYEPGQ--RPS-----FSTIYQEL-------------
-----YTDIKVIGNGSFGVVYQARLAETRE-LVAIKKVLQDK-RFKNR---------------ELQIMRKLDHCNIVRLRYFFYSSG-------------------------EKKDELYLNLVLEYVPETVYRVARHFT---KAKL----TIPILYVKVYMYQLFRSLAYIHSQ--G---VCHRDIKPQNLLVDPDTA-VL---------KLCDFGSAKQ---------LVRGEPNVS---YICSRYYRAPELIF----GATDYTSSIDVWSAGCVLAELLL-GQ-PIFPGD--SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFKSRTPPEAIALCSSLLEYTPSS--RLS-----PLEACAHSFF-----------
-----YTDTKVIGNGSFGVVYQAKLCDSGE-LVAIKKVLQDK-RFKNR---------------ELQIMRKLDHCNIVRLRYFFYSSG-------------------------EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ----TLPVIYVKLYMYQLFRSLAYIHSF--G---ICHRDIKPQNLLLDPDTA-VL---------KLCDFGSAKQ---------LVRGEPNVS---YICSRYYRAPELIF----GATDYTSSIDVWSAGCVLAELLL-GQ-PIFPGD--SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAH-------------PWTKVFRPRTPPEAIALCSRLLEYTPTA--RLT-----PLEACAHSFF-----------
-----IEVEEVVGRGAFGVVCKAKWR--AK-DVAIKQIE-----S-ESERKA-FI-V------ELRQLSRVNHPNIVKLYGACL-------------------------------NPVC--LVMEYAEGG--SLYNVLH-----GAEPLPYYTAAHAMSWCLQCSQGVAYLHSM--QPKALIHRDLKPPNLLLV-AGGTVL---------KICDFGTACDI--------------QTHMTNNKGSAAWMAPEVFE-----GSNYSEKCDVFSWGIILWEVITR-R-KPFDEIGGPAFRIMWAVHNGTRPPLIKNLP-----------------------------------------KPIESLMTRCWSKDPSQ--RPS-----MEEIVKI--M-----------
-----YQNLKPIGSGAQGIVCAAYDAVLDR-NVAIKKLSRPF-QNQTH--AK-RAYR------ELVLMKCVNHKNIISLLNVFTPQKT-----------------------LEEFQDVY--LVMELMDA---NLCQVIQ------M----ELDHERMSYLLYQMLCGIKHLHSA--G---IIHRDLKPSNIVVK-SDC-TL---------KILDFGLART---------AGTSFMMTP---YVVTRYYRAPEVIL-----GMGYKENVDIWSVGCIMGEMVR-HK-ILFPGR--DYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAK--RIS-----VDDALQHPYI-----------
-----YRLLKTIGKGNFAKVKLARHILTGK-EVAVKIIDKTQ-LNSSS--LQ-KLFR------EVRIMKVLNHPNIVKLFEVIET-----------------------------EKTLY--LVMEYASGG--EVFDYLV----AHG----RMKEKEARAKFRQIVSAVQYCHQK--F---IVHRDLKAENLLLD-ADM-NI---------KIADFGFSNE---------FTFGNKLDT---FCGSPPYAAPELFQ----GKKYDGPEVDVWSLGVILYTLVS-GS-LPFDGQ-----NLKELRERVLRGKYRIPFYMS---------------------------------------TDCENLLKKFLILNPSK--RGT-----LEQIMKDRWM-----------
-----YRLLRTIGKGNFAKVKLARHILTGR-EVAIKIIDKTQ-LNPSS--LQ-KLFR------EVRIMKGLNHPNIVKLFEVIET-----------------------------EKTLY--LVMEYASAG--EVFDYLV----SHG----RMKEKEARAKFRQIVSAVHYCHQK--N---IVHRDLKAENLLLD-AEA-NI---------KIADFGFSNE---------FTLGSKLDT---FCGSPPYAAPELFQ----GKKYDGPEVDIWSLGVILYTLVS-GS-LPFDGH-----NLKELRERVLRGKYRVPFYMS---------------------------------------TDCESILRRFLVLNPAK--RCT-----LEQIMKDKWI-----------
----Y-VRLQKIGEGSFGKAILVKSTEDGR-QYVIKEINISR-MSSKE--RE-ESRR------EVAVLANMKHPNIVQYRESFEE-----------------------------NGSLY--IVMDYCEGG--DLFKRINA--QKGV----LFQEDQILDWFVQICLALKHVHDR--K---ILHRDIKSQNIFLT-KDG-TV---------QLGDFGIARVL--------NSTVELART---CIGTPYYLSPEICE-----NKPYNNKSDIWALGCVLYELCT-LK-HAFEAG-----SMKNLVLKIISGSFPPVSLHYS--------------------------------------YDLRSLVSQLFKRNPRD--RPS-----VNSILEKGF-I----------
----Y-MVLRMIGEGSFGRALLVQHESSNQ-MFAMKEIRLPK-SFSNT--QN--SRK------EAVLLAKMKHPNIVAFKESFEA-----------------------------EGHLY--IVMEYCDGG--DLMQKIKQ--QKGK----LFPEDMILNWFTQMCLGVNHIHKK--R---VLHRDIKSKNIFLT-QNG-KV---------KLGDFGSARLL--------SNPMAFACT---YVGTPYYVPPEIWE-----NLPYNNKSDIWSLGCILYELCT-LK-HPFQAN--SWKNLILKVCQGCISPLPSHYS-----------------------------------------YELQFLVKQMFKRNPSH--RPS-----ATTLLS----RGIV-------
-----YERIRVVGRGAFGIVHLCLRKADQK-LVIIKQIPVEQ-MTKEE--RQ-AAQN------ECQVLKLLNHPNVIEYYENFLE-----------------------------DKALM--IAMEYAPGG--TLAEFIQK--RCNS----LLEEETILHFFVQILLALHHVHTH--L---ILHRDLKTQNILLDKHRM-VV---------KIGDFGISKI---------LSSKSKAYT---VVGTPCYISPELCE-----GKPYNQKSDIWALGCVLYELAS-LK-RAFEAA-----NLPALVLKIMSGTFAPISDRY---S-----------------------------------PELRQLVLSLLSLEPAQ--RPP-----LSHIMAQP--LC---------
-----YELQETLGKGTYGKVKRATERFSGR-VVAIKSIRKDK-IKDEQ--DM-VHIR-----REIEIMSSLNHPHIISIYEVFEN-----------------------------KDKIV--IIMEYASKG--ELYDYIS----ERR----RLSERETRHFFRQIVSAVHYCHKN--G---VVHRDLKLENILLD-DNC-NI---------KIADFGLSNL---------YQKDKFLQT---FCGSPLYASPEIVN----GRPYRGPEVDSWALGVLLYTLVY-GT-MPFDGF-----DHKNLIRQISSGEYREPTQP----------------------------------------SDARGLIRWMLMVNPDR--RAT-----IEDIANHWW-V----------
-----YEFLETLGKGTYGKVKKARESSGR--LVAIKSIRKDK-IKDEQ--DL-MHIR-----REIEIMSSLNHPHIIAIHEVFEN-----------------------------SSKIV--IVMEYASRG--DLYDYIS----ERQ----QLSEREARHFFRQIVSAVHYCHQN--R---VVHRDLKLENILLD-ANG-NI---------KIADFGLSNL---------YHQGKFLQT---FCGSPLYASPEIVN----GKPYTGPEVDSWSLGVLLYILVH-GT-MPFDGH-----DHKILVKQISNGAYREPPK-----P-----------------------------------SDACGLIRWLLMVNPTR--RAT-----LEDVASHWW-V----------
-ANFI-----KIGEGSTGIVCIATEKHTGK-QVAVKKMDLRK-QQRRE--L---LFN------EVVIMRDYHHDNVVDMYSSYLV-----------------------------GDELW--VVMEFLEGG--ALTDIVT-----HT----RMNEEQIATVCLSVLRALSYLHNQ--G---VIHRDIKSDSILLT-SDG-RI---------KLSDFGFCAQV--------SKEVPKRKS---LVGTPYWMAPEVIS-----RLPYGTEVDIWSLGIMVIEMID-GE-PPYFNE--PPLQAMRRIRDSLPPRVKDLHK----VS-----------------------------------SVLRGFLDLMLVREPSQ--RAT-----AQELLGHPFL-----------
----F-KFGKILGEGSFSTVVLARELATSR-EYAIKILEKRH-IIKEN--KVPYVTR------ERDVMSRLDHPFFVKLYFTFQD-----------------------------DEKLY--FGLSYAKNG--ELLKYIR----KIG----SFDETCTRFYTAEIVSALEYLHGK--G---IIHRDLKPENILLN-EDM-HI---------QITDFGTAKVLS------PESKQARANS---FVGTAQYVSPELLT-----EKSACKSSDLWALGCIIYQLVA-GL-PPFRAG-----NEYLIFQKIIKLEYDFPEKFF---------------------------------------PKARDLVEKLLVLDATK--RLG-----CEEM------EGYGPLKAHPF
---YV--RGRFLGKGGFAKCFEISDADTKE-VFAGKIVPKSL-LLKPH--QR-EKMS-----MEISIHRSLAHQHVVGFHGFFED-----------------------------NDFVF--VVLELCRRR--SLLELHK----RRK----ALTEPEARYYLRQIVLGCQYLHRN--R---VIHRDLKLGNLFLN-EDL-EV---------KIGDFGLATKV--------EYDGERKKT---LCGTPNYIAPEVLS-----KKGHSFEVDVWSIGCIMYTLLV-GK-PPFETS-----CLKETYLRIKKNEYSIPKHIN---------------------------------------PVAASLIQKMLQTDPTA--RPT-----INELLNDEFF-----------
---YL--KGRLLGKGGFARCYEATDTETGS-AYAVKVIPQSR-VAKPH--QR-EKIL-----NEIELHRDLQHRHIVRFSHHFED-----------------------------ADNIY--IFLELCSRK--SLAHIWK----ARH----TLLEPEVRYYLRQILSGLKYLHQR--G---ILHRDLKLGNFFIT-ENM-EL---------KVGDFGLAARL--------EPPEQRKKT---ICGTPNYVAPEVLL-----RQGHGPEADVWSLGCVMYTLLC-GS-PPFETA-----DLKETYRCIKQVHYTLPASLS---------------------------------------LPARQLLAAILRASPRD--RPS-----IDQILRHDFF-----------
----F-KVGNLLGKGSFAGVYRAESIHTGL-EVAIKMIDKKA-MYKAG--MV-QRVQ-----NEVKIHCQLKHPSILELYNYFED-----------------------------SNYVY--LVLEMCHNG--EMNRYLK---NRVK----PFSENEARHFMHQIITGMLYLHSH--G---ILHRDLTLSNLLLT-RNM-NI---------KIADFGLATQL--------KMPHEKHYT---LCGTPNYISPEIAT-----RSAHGLESDVWSLGCMFYTLLI-GR-PPFDTD-----TVKNTLNKVVLADYEMPSFLS---------------------------------------IEAKDLIHQLLRRNPAD--RLS-----LSSVLDHPFM-----------
---PD----EVLGSGQFGIVYGGKHRKTGR-DVAIKIIDKLR-FPTKQ--ES-QLRN------EVAILQNLHHPGVVNLECMFET-----------------------------PERVF--VVMEKLHGD--MLEMILS---SEKG----RLPEHITKFLITQILVALRHLHFK--N---IVHCDLKPENVLLA-SAD-PFP------QVKLCDFGFARI---------IGEKSFRRS---VVGTPAYLAPEVLR-----NKGYNRSLDMWSVGVIIYVSLS-GT-FPFNED-------EDIHDQIQNAAFMYPPNPWKEIS-----------------------------------HEAIDLINNLLQVKMRK--RYS-----VDKTLSHPWL-----------
---PD----EVLGSGQFGVVYGGKHRKTGR-DVAVKVIDKLR-FPTKQ--ES-QLRN------EVAILQSLRHPGIVNLECMFET-----------------------------PEKVF--VVMEKLHGD--MLEMILS---SEKG----RLPERLTKFLITQILVALRHLHFK--N---IVHCDLKPENVLLA-SAD-PFP------QVKLCDFGFARI---------IGEKSFRRS---VVGTPAYLAPEVLL-----NQGYNRSLDMWSVGVIMYVSLS-GT-FPFNED-------EDINDQIQNAAFMYPASPWSHIS-----------------------------------AGAIDLINNLLQVKMRK--RYS-----VDKSLSHPWL-----------
--FAD----EVLGSGQFGIVYGGKHRKTGR-DVAIKVIDKMR-FPTKQ--ES-QLRN------EVAILQNLHHPGIVNLECMFET-----------------------------PERVF--VVMEKLHGD--MLEMILS---SEKS----RLPERITKFMVTQILVALRNLHFK--N---IVHCDLKPENVLLA-SAE-PFP------QVKLCDFGFARI---------IGEKSFRRS---VVGTPAYLAPEVLR-----SKGYNRSLDMWSVGVIIYVSLS-GT-FPFNED-------EDINDQIQNAAFMYPPNPWREIS-----------------------------------GEAIDLINNLLQVKMRK--RYS-----VDKSLSHPWL-----------
-----YEVVKVIGRGAFGEVQLVRHKSTRK-VYAMKLLSKFE-MIKRS--DS-AFFW-----EERDIMAFANSPWVVQLFYAFQD-----------------------------DRYLY--MVMEYMPGG--DLVNLMS-----NY----DVPEKWARFYTAEVVLALDAIHSM--G---FIHRDVKPDNMLLD-KSG-HL---------KLADFGTCMKM-------NKEGMVRCDT---AVGTPDYISPEVLKS-QGGDGYYGRECDWWSVGVFLYEMLV-GD-TPFYAD-----SLVGTYSKIMNHKNSLTFPDDNDIS-----------------------------------KEAKNLICAFLTDREVRLGRNG-----VEEIKRHLFF-----------
-----YDVVKVIGRGAFGEVQLVRHKASQK-VYAMKLLSKFE-MIKRS--DS-AFFW-----EERDIMAFANSPWVVQLFYAFQD-----------------------------DRYLY--MVMEYMPGG--DLVNLMS-----NY----DVPEKWAKFYTAEVVLALDAIHSM--G---LIHRDVKPDNMLLD-KHG-HL---------KLADFGTCMKM-------DETGMVHCDT---AVGTPDYISPEVLKS-QGGDGFYGRECDWWSVGVFLYEMLV-GD-TPFYAD-----SLVGTYSKIMDHKNSLCFPEDAEIS-----------------------------------KHAKNLICAFLTDREVRLGRNG-----VEEIRQHPFF-----------
-----YDIERTLGKGNFAVVKLARHRVTKT-QVAIKIIDKTR-LDSSN--LE-KIYR------EVQLMKLLNHPHIIKLYQVMET-----------------------------KDMLY--IVTEFAKNG--EMFDYLT----SNG----HLSENEARKKFWQILSAVEYCHDH--H---IVHRDLKTENLLLD-GNM-DI---------KLADFGFGNF---------YKSGEPLST---WCGSPPYAAPEVFE----GKEYEGPQLDIWSLGVVLYVLVC-GS-LPFDGP-----NLPTLRQRVLEGRFRIPFFMS---------------------------------------QDCESLIRRMLVVDPAR--RIT-----IAQIRQHRWM-----------
-----YDIEGTLGKGNFAVVKLGRHRITKT-EVAIKIIDKSQ-LDAVN--LE-KIYR------EVQIMKMLDHPHIIKLYQVMET-----------------------------KSMLY--LVTEYAKNG--EIFDYLA----NHG----RLNESEARRKFWQILSAVDYCHGR--K---IVHRDLKAENLLLD-NNM-NI---------KIADFGFGNF---------FKSGELLAT---WCGSPPYAAPEVFE----GQQYEGPQLDIWSMGVVLYVLVC-GA-LPFDGP-----TLPILRQRVLEGRFRIPYFMS---------------------------------------EDCEHLIRRMLVLDPSK--RLT-----IAQIKEHKWM-----------
-----WEIIGELGDGAFGKVYKAQNKETSV-LAAAKVIDTKS-EEELE--DY-M--V------EIDILASCDHPNIVKLLDAFYY-----------------------------ENNLW--ILIEFCAGG--AVDAVML---ELER----PLTESQIQVVCKQTLDALNYLHDN--K---IIHRDLKAGNILFT-LDG-DI---------KLADFGVSAKN--------TRTIQRRDS---FIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMAE-IE-PPHHEL--NPMRVLLKIAKSEPPTLAQPSRWS---------------------------------------SNFKDFLKKCLEKNVDA--RWT-----TSQLLQHPFV-----------
-----WEIVGELGDGAFGKVYKAKNKETGA-LAAAKVIETKS-EEELE--DY-I--V------EIEILATCDHPYIVKLLGAYYH-----------------------------DGKLW--IMIEFCPGG--AVDAIML---ELDR----GLTEPQIQVVCRQMLEALNFLHSK--R---IIHRDLKAGNVLMT-LEG-DI---------RLADFGVSAKN--------LKTLQKRDS---FIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQ-IE-PPHHEL--NPMRVLLKIAKSDPPTLLTPSKWS---------------------------------------VEFRDFLKIALDKNPET--RPS-----AAQLLEHPFV-----------
---YL--LLHLLGRGGFSEVYKAFDLYEQR-YAAVKIHQLNK-SWRDE--KK-ENYHKH-ACREYRIHKELDHPRIVKLYDYFSL----------------------------DTDTFC--TVLEYCEGN--DLDFYLK----QHK----LMSEKEARSIVMQIVNALRYLNEIKPP---IIHYDLKPGNILLV-DGT-ACG------EIKITDFGLSKIMDDD--SYGVDGMDLTSQ---GAGTYWYLPPECFVV-GKEPPKISNKVDVWSVGVIFFQCLY-GR-KPFGHN---QSQQDILQENTILKATEVQFPVKPVVS-----------------------------------SEAKAFIRRCLAYRKED--RFD-----VHQLANDPYL-----------
---YL--LLHLLGRGGFSEVYKAFDLTEQR-YVAVKIHQLNK-NWRDE--KK-ENYHKH-ACREYRIHKELDHPRIVKLYDYFSL----------------------------DTDSFC--TVLEYCEGN--DLDFYLK----QHK----LMSEKEARSIIMQIVNALKYLNEIKPP---IIHYDLKPGNILLV-NGT-ACG------EIKITDFGLSKIMDDD-SYNSVDGMELTSQ---GAGTYWYLPPECFVV-GKEPPKISNKVDVWSVGVIFYQCLY-GR-KPFGHN---QSQQDILQENTILKATEVQFPPKPVVT-----------------------------------PEAKAFIRRCLAYRKED--RID-----VQQLACDPYL-----------
YLLGI-----NLGEGSYAKVKSAYSERLKF-NVAIKIIDRKK-APADF--LE-KFLP-----REIEILAMLNHCSIIKTYEIFET----------------------------SHGKVY--IVMELAVQG--DLLELIK----TRG----ALHEDEARKKFHQLSLAIKYCHDL--D---VVHRDLKCDNLLLD-KDF-NI---------KLSDFSFSKRCLR----DDSGRMALSKT---FCGSPAYAAPEVLQ----GIPYQPKVYDIWSLGVILYIMVC-GS-MPYDDS-----NIKKMLRIQKEHRVNFPRSKHLT-------------------------------------GECKDLIYHMLQPDVNR--RLH-----IDEILSHCWM-----------
---FS--RKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKN-LAKSQ--T--LLGK------EIKILKELKHENIVALYDFQEM-----------------------------ANSVY--LVMEYCNGG--DLADYLH----AMR----TLSEDTIRLFLQQIAGAMRLLHSK--G---IIHRDLKPQNILLS-NPA-GRRANPNSIRVKIADFGFARY---------LQSNMMAAT---LCGSPMYMAPEVIM-----SQHYDGKADLWSIGTIVYQCLT-GK-APFQAS--SPQDLRLFYEKNKTLVPTIPRETS---------------------------------------APLRQLLLALLQRNHKD--RMD-----FDEFFHHPFL-----------
----Y-SKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKN-LSKSQ---I-LLGK------EIKILKELQHENIVALYDVQEL-----------------------------PNSVF--LVMEYCNGG--DLADYLQ----AKG----TLSEDTIRVFLHQIAAAMRILHSK--G---IIHRDLKPQNILLS-YAN-RRKSSVSGIRIKIADFGFARY---------LHSNMMAAT---LCGSPMYMAPEVIM-----SQHYDAKADLWSIGTVIYQCLV-GK-PPFQAN--SPQDLRMFYEKNRS--LMPSIPRETS-------------------------------------PYLANLLLGLLQRNQKD--RMD-----FEAFFSHPFL-----------
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