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Multiple sequence alignment of family kinases
Conserved residues:
Group Kinase
AGC PRKCE 203
TK ABL1 261
AGC AKT1 150
Other AURKA 133
TK BLK 241
Other CAMKK2 165
CMGC CDC2 4
CMGC CDK2 4
CMGC CDK4 6
CMGC CDK6 13
CMGC CDK7 2.7.11.23
CMGC CDK9 2.7.11.23
CAMK CHEK1 9
CMGC CLK1 161
CMGC CLK2 163
CMGC CLK4 159
CMGC DYRK1A 150
CMGC DYRK1B 111
CMGC DYRK2 222
TK EPHA1 624
TK EPHB1 619
TK FGR 263
TK FYN 271
CMGC GSK3B 56
TK ITK 363
TK JAK3 822
TK LCK 245
STE MAP2K1 68
TKL MAP3K7 36
CMGC MAPK10 64
TK MET 1078
TK MUSK 575
TK NTRK2 538
TK NTRK3 538
AGC PDPK1 82
CAMK PHKG1 20
CAMK PHKG2 24
AGC PKN1 615
Other PLK1 53
AGC PRKCA 339
AGC PRKCD 349
AGC PRKCQ 380
AGC PRKCZ 252
TK PTK2 422
TK PTK6 191
TK SRC 270
CAMK STK17A 61
TK TNK2 150
TK YES1 277
TK ZAP70 338
---F-NFIKVLGKGSFGKVMLAELK-----G-K-DE-VYAVKVLKKD--V-ILQ---DD--DV-DCTM------------------------TEKRILALARK------HPY-----LTQLYCCFQ--T--------KDRLF--FVMEYVNGG--DLMFQIQ----RSR--------------------------KF---DEPRSRFYAAEVTSALMFLHQ--HG---VIYRDLKLDNILLD--AEG-HC-------------------KLADFGMCKEG-------ILNGVTT--------------TT---FCGTPDYIAPEILQ------ELE--YGPSVDWWALGVLMYEMMA-GQPP-------------FEAD-------NEDDLF-ESILHDDVLYPVWLS-------------------------------------------------------------KEAVS-ILKAFMTKNPHKRLGCVASQNGED-AIKQHP--FF------------
----ITMKHKLGGGQYGEVYEGVWK-----K-Y-SL-TVAVKTLK-E--D-TM----EV--EE-FL-K-------------------------EAAVMKEI-K------HPN-----LVQLLGVCT--R--------EPPFY--IITEFMTYG--NLLDYLR-----EC----------------------NR-QEV---NAVVLLYMATQISSAMEYLEK--KN---FIHRDLAARNCLVG--ENH-LV-------------------KVADFGLSRLM-------T--GDTY--------------TAHAGAKFPIKWTAPESLA------YNK--FSIKSDVWAFGVLLWEIATYGMSP-------------YPGI----DLSQVYELL-EKDYRMERPEGCP---------------------------------------------------------------EKVYE-LMRACWQWNPSDRPS-------FA-EIHQA--F--------------
---F-EYLKLLGKGTFGKVILVKEK-----A-T-GR-YYAMKILKKE--V-IVA---KD--EV-AHTL------------------------TENRVLQNS-R------HPF-----LTALKYSFQ--T--------HDRLC--FVMEYANGG--ELFFHLS----RER--------------------------VF---SEDRARFYGAEIVSALDYLHS-EKN---VVYRDLKLENLMLD--KDG-HI-------------------KITDFGLCKEG-------IKDGATM--------------KT---FCGTPEYLAPEVLE------DND--YGRAVDWWGLGVVMYEMMC-GRLP-------------FYNQ-------DHEKLF-ELILMEEIRFPRTLG-------------------------------------------------------------PEAKS-LLSGLLKKDPKQRLGGG--SEDAK-EIMQHRFF--------------
----FEIGRPLGKGKFGNVYLAREK-----Q-S-KF-ILALKVLFKA--QLEKA---GV--EH-QLRR-------------------------EVEIQSHL-R------HPN-----ILRLYGYFH--D--------ATRVY--LILEYAPLG--TVYRELQ----KLS--------------------------KF---DEQRTATYITELANALSYCHS--KR---VIHRDIKPENLLLG--SAG-EL-------------------KIADFGWSV---------HAPSSRR--------------TT---LCGTLDYLPPEMIE------GRM--HDEKVDLWSLGVLCYEFLV-GKPP-------------FEAN-------TYQETY-KRISRVEFTFPDFVT-------------------------------------------------------------EGARD-LISRLLKHNPSQRPM-------LR-EVLEHPWI--------------
---L-RLVRKLGSGQFGEVWMGYYK-------N-NM-KVAIKTLK-E--G-TM----SP--EA-FL-G-------------------------EANVMKAL-Q------HER-----LVRLYAVVT-----------KEPIY--IVTEYMARG--CLLDFLK-----TD----------------------EG-SRL---SLPRLIDMSAQIAEGMAYIER--MN---SIHRDLRAANILVS--EAL-CC-------------------KIADFGLARII----------DSEY--------------TAQEGAKFPIKWTAPEAIH------FGV--FTIKADVWSFGVLLMEVVTYGRVP-------------YPGM----SNPEVIRNL-ERGYRMPRPDTCP---------------------------------------------------------------PELYRGVIAECWRSRPEERPT-------FE-FLQSV--L--------------
----YTLKDEIGKGSYGVVKLAYNE-----N-D-NT-YYAMKVLSKK--K-LIR---QA--GF-PR-RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKL-D------HPN-----VVKLVEVLD--DP------NEDHLY--MVFELVNQG--PVMEVPT-----LK--------------------------PL---SEDQARFYFQDLIKGIEYLHY--QK---IIHRDIKPSNLLVG--EDG-HI-------------------KIADFGVSNEF-------KGSDALL--------------SN---TVGTPAFMAPESLS-----ETRKIFSGKALDVWAMGVTLYCFVF-GQCP-------------FMDE-------RIMCLH-SKIKSQALEFPDQPDIA-----------------------------------------------------------EDLKD-LITRMLDKNPESRIV-------VP-EIKLHPWV--------------
----YTKIEKIGEGTYGVVYKGRHK-----T-T-GQ-VVAMKKIRLE--S-EEE---GV--PS-TAIR-------------------------EISLLKEL-R------HPN-----IVSLQDVLM--Q--------DSRLY--LIFEFLSM---DLKKYLDS-IPPGQ--------------------------YM---DSSLVKSYLYQILQGIVFCHS--RR---VLHRDLKPQNLLID--DKG-TI-------------------KLADFGLARAF-------GIPIRVY--------------TH---EVVTLWYRSPEVLL-----GSAR--YSTPVDIWSIGTIFAELAT-KKPL-------------FHGD----SEIDQLFRI-FRALGTPNNEVWPEVESLQDYKNTFPKWKP-----------------------------------GSLASHVKNLDENGLD-LLSKMLIYDPAKRIS-------GK-MALNHPYF--------------
----FQKVEKIGEGTYGVVYKARNK-----L-T-GE-VVALKKIRLD--T-ETE---GV--PS-TAIR-------------------------EISLLKEL-N------HPN-----IVKLLDVIH--T--------ENKLY--LVFEFLHQ---DLKKFMDA--SALT--------------------------GI---PLPLIKSYLFQLLQGLAFCHS--HR---VLHRDLKPQNLLIN--TEG-AI-------------------KLADFGLARAF-------GVPVRTY--------------TH---EVVTLWYRAPEILL-----GCKY--YSTAVDIWSLGCIFAEMVT-RRAL-------------FPGD----SEIDQLFRI-FRTLGTPDEVVWPGVTSMPDYKPSFPKWAR-----------------------------------QDFSKVVPPLDEDGRS-LLSQMLHYDPNKRIS-------AK-AALAHPFF--------------
---Y-EPVAEIGVGAYGTVYKARDP-----H-S-GH-FVALKSVRVP--N-GGGGGGGL--PI-STVR-------------------------EVALLRRL-EA---FEHPN-----VVRLMDVCA--TSR---TDREIKVT--LVFEHVDQ---DLRTYLDK--APPP--------------------------GL---PAETIKDLMRQFLRGLDFLHA--NC---IVHRDLKPENILVT--SGG-TV-------------------KLADFGLARI--------YSYQMAL--------------TP---VVVTLWYRAPEVLL------QST--YATPVDMWSVGCIFAEMFR-RKPL-------------FCGN----SEADQLGKI-FDLIGLPPEDDWPRDVSLPRGAFPPRGPR-------------------------------------PVQSVVPEMEESGAQ-LLLEMLTFNPHKRIS-------AF-RALQHSYL--------------
----YECVAEIGEGAYGKVFKARDL-----K-N-GGRFVALKRVRVQ--T-GEE---GM--PL-STIR-------------------------EVAVLRHL-ET---FEHPN-----VVRLFDVCT--VSR---TDRETKLT--LVFEHVDQ---DLTTYLDK--VPEP--------------------------GV---PTETIKDMMFQLLRGLDFLHS--HR---VVHRDLKPQNILVT--SSG-QI-------------------KLADFGLARI--------YSFQMAL--------------TS---VVVTLWYRAPEVLL------QSS--YATPVDLWSVGCIFAEMFR-RKPL-------------FRGS----SDVDQLGKI-LDVIGLPGEEDWPRDVALPRQAFHSKSAQ-------------------------------------PIEKFVTDIDELGKD-LLLKCLTFNPAKRIS-------AY-SALSHPYF--------------
----YEKLDFLGEGQFATVYKARDK-----N-T-NQ-IVAIKKIKLG--H-RSE---AK--DG-INRTA----------------------LREIKLLQEL-S------HPN-----IIGLLDAFG--H--------KSNIS--LVFDFMET---DLEVIIK---DNSL--------------------------VL---TPSHIKAYMLMTLQGLEYLHQ--HW---ILHRDLKPNNLLLD--ENG-VL-------------------KLADFGLAKSF-------GSPNRAY--------------TH---QVVTRWYRAPELLF-----GARM--YGVGVDMWAVGCILAELLL-RVPF-------------LPGD----SDLDQLTRI-FETLGTPTEEQWPDMCSLPDYVTFKSFPG------------------------------------IPLHHIFSAAGDDLLD-LIQGLFLFNPCARIT-------AT-QALKMKYF--------------
----YEKLAKIGQGTFGEVFKARHR-----K-T-GQ-KVALKKVLME--N-EKE---GF--PI-TALR-------------------------EIKILQLL-K------HEN-----VVNLIEICR--TKASPYNRCKGSIY--LVFDFCEH---DLAGLLS---NVLV--------------------------KF---TLSEIKRVMQMLLNGLYYIHR--NK---ILHRDMKAANVLIT--RDG-VL-------------------KLADFGLARAFSL---AKNSQPNRY--------------TN---RVVTLWYRPPELLL-----GERD--YGPPIDLWGAGCIMAEMWT-RSPI-------------MQGN----TEQHQLALI-SQLCGSITPEVWPNVDNYELYEKLELVKGQK--------------------------------RKVKDRLKAYVRDPYALD-LIDKLLVLDPAQRID-------SD-DALNHDFF--------------
---W-DLVQTLGEGAYGEVQLAVNR-----V-T-EE-AVAVKIVDMK--R-AVD---CP--EN-I-KK-------------------------EICINKML-N------HEN-----VVKFYGHRR--E--------GNIQY--LFLEYCSGG--ELFDRIE----PDI--------------------------GM---PEPDAQRFFHQLMAGVVYLHG--IG---ITHRDIKPENLLLD--ERD-NL-------------------KISDFGLATVFR-----YNNRERLL--------------NK---MCGTLPYVAPELLK-----RREF--HAEPVDVWSCGIVLTAMLA-GELP-------------WDQP------SDSCQEY-SDWKEKKTYLNPWKKI--D---------------------------------------------------------SAPLA-LLHKILVENPSARIT-------IP-DIKKDRW-Y-------------
----YEIVDTLGEGAFGKVVECIDH-----K-AGGR-HVAVKIVKNV--D-RYC---EA--AR-S----------------------------EIQVLEHL-NT----TDPNST-FRCVQMLEWFE--H--------HGHIC--IVFELLGL---STYDFIK----ENG--------------------------FLP-FRLDHIRKMAYQICKSVNFLHS--NK---LTHTDLKPENILFV--QSD-YTEAYNPKIKRDERTLINPDIKVVDFGSA----------TYDDEHH--------------ST---LVSTRHYRAPEVIL------ALG--WSQPCDVWSIGCILIEYYL-GFTV-------------FPTH----DSKEHLAMM-ERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRY--------------------VSRRCKPLKEFMLSQDVEHERLFD-LIQKMLEYDPAKRIT-------LR-EALKHPFF--------------
----YEIVSTLGEGTFGRVVQCVDH-----R-R-GGARVALKIIKNV--E-KYK---EA--AR----L-------------------------EINVLEKI-NEK-DPDNKN----LCVQMFDWFD--Y--------HGHMC--ISFELLGL---STFDFLK----DNN--------------------------YLP-YPIHQVRHMAFQLCQAVKFLHD--NK---LTHTDLKPENILFV--NSD-YELTYNLEKKRDERSVKSTAVRVVDFGSAT----------FDHEHH--------------ST---IVSTRHYRAPEVIL------ELG--WSQPCDVWSIGCIIFEYYV-GFTL-------------FQTH----DNREHLAMM-ERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRY--------------------VRENCKPLRRYLTSEAEEHHQLFD-LIESMLEYEPAKRLT-------LG-EALQHPFF--------------
----YEIVDTLGEGAFGKVVECIDH-----GMD-GM-HVAVKIVKNV--G-RYR---EA--AR-S----------------------------EIQVLEHL-NS----TDPNSV-FRCVQMLEWFD--H--------HGHVC--IVFELLGL---STYDFIK----ENS--------------------------FLP-FQIDHIRQMAYQICQSINFLHH--NK---LTHTDLKPENILFV--KSD-YVVKYNSKMKRDERTLKNTDIKVVDFGSA----------TYDDEHH--------------ST---LVSTRHYRAPEVIL------ALG--WSQPCDVWSIGCILIEYYL-GFTV-------------FQTH----DSKEHLAMM-ERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRY--------------------VRRRCKPLKEFMLCHDEEHEKLFD-LVRRMLEYDPTQRIT-------LD-EALQHPFF--------------
----YEIDSLIGKGSFGQVVKAYDR-----V-E-QE-WVAIKIIKNK--K-AFL---NQ--AQ-I----------------------------EVRLLELMNK------HDTEMKYYIVHLKRHFM--F--------RNHLC--LVFEMLSY---NLYDLLR-----NT--------------------------NFRGVSLNLTRKFAQQMCTALLFLATPELS---IIHCDLKPENILLCNPKRS-AI-------------------KIVDFGSSCQ----------LGQRI--------------YQ---YIQSRFYRSPEVLL------GMP--YDLAIDMWSLGCILVEMHT-GEPL-------------FSGA----NEVDQMNKI-VEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKD-LILRMLDYDPKTRIQ-------PY-YALQHSFF--------------
----YEIDSLIGKGSFGQVVKAYDH-----Q-T-QE-LVAIKIIKNK--K-AFL---NQ--AQ-I----------------------------ELRLLELMNQ------HDTEMKYYIVHLKRHFM--F--------RNHLC--LVFELLSY---NLYDLLR-----NT--------------------------HFRGVSLNLTRKLAQQLCTALLFLATPELS---IIHCDLKPENILLCNPKRS-AI-------------------KIVDFGSSCQ----------LGQRI--------------YQ---YIQSRFYRSPEVLL------GTP--YDLAIDMWSLGCILVEMHT-GEPL-------------FSGS----NEVDQMNRI-VEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQD-LVLRMLEYEPAARIS-------PL-GALQHGFF--------------
----YEVLKVIGKGSFGQVVKAYDH-----K-V-HQ-HVALKMVRNE--K-RFH---RQ--AA-E----------------------------EIRILEHL-RKQDKDNTMN-----VIHMLENFT--F--------RNHIC--MTFELLSM---NLYELIKK--NKFQ--------------------------GF---SLPLVRKFAHSILQCLDALHK--NR---IIHCDLKPENILLK--QQG-RSG-----------------IKVIDFGSSC----------YEHQRV--------------YT---YIQSRFYRAPEVIL------GAR--YGMPIDMWSLGCILAELLT-GYPL-------------LPGE----DEGDQLACM-IELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNG-----GRSRRGKLRGPPESREWGNALKGCDDPLFLD-FLKQCLEWDPAVRMT-------PG-QALRHPWL--------------
--LM--VDTVIGEGEFGEVYRGTLR--LPSQ-D-CK-TVAIKTLK-D--T-SP----GGQWWN-FL-R-------------------------EATIMGQF-S------HPH-----ILHLEGVVT--K--------RKPIM--IITEFMENG--ALDAFLR-----ER-----------------------E-DQL---VPGQLVAMLQGIASGMNYLSN--HN---YVHRDLAARNILVN--QNL-CC-------------------KVSDFGLTRLL----D--D--FDGT--------------YETQGGKIPIRWTAPEAIA------HRI--FTTASDVWSFGIVMWEVLSFGDKP-------------YGEM----SNQEVMKSI-EDGYRLPPPVDCP---------------------------------------------------------------APLYE-LMKNCWAYDRARRPH-------FQ-KLQAHL----------------
---V-KIEEVIGAGEFGEVYKGRLK--LPGK-R-EI-YVAIKTLK-A--G-YS----EKQRRD-FL-S-------------------------EASIMGQF-D------HPN-----IIRLEGVVT--K--------SRPVM--IITEFMENG--ALDSFLR-----QN-----------------------D-GQF---TVIQLVGMLRGIAAGMKYLAE--MN---YVHRDLAARNILVN--SNL-VC-------------------KVSDFGLSRYLQ-DDT--S--DPTY--------------TSSLGGKIPVRWTAPEAIA------YRK--FTSASDVWSYGIVMWEVMSFGERP-------------YWDM----SNQDVINAI-EQDYRLPPPMDCP---------------------------------------------------------------AALHQ-LMLDCWQKDRNSRPR-------FA-EIVNTL----------------
----ITLERRLGTGCFGDVWLGTWN-------G-ST-KVAVKTLK-P--G-TM----SP--KA-FL-E-------------------------EAQVMKLL-R------HDK-----LVQLYAVVS-----------EEPIY--IVTEFMCHG--SLLDFLK-----NP----------------------EG-QDL---RLPQLVDMAAQVAEGMAYMER--MN---YIHRDLRAANILVG--ERL-AC-------------------KIADFGLARLI-------K--DDEY--------------NPCQGSKFPIKWTAPEAAL------FGR--FTIKSDVWSFGILLTELITKGRIP-------------YPGM----NKREVLEQV-EQGYHMPCPPGCP---------------------------------------------------------------ASLYE-AMEQTWRLDPEERPT-------FE-YLQSFL----------------
----LQLIKRLGNGQFGEVWMGTWN-------G-NT-KVAIKTLK-P--G-TM----SP--ES-FL-E-------------------------EAQIMKKL-K------HDK-----LVQLYAVVS-----------EEPIY--IVTEYMNKG--SLLDFLK-----DG----------------------EG-RAL---KLPNLVDMAAQVAAGMAYIER--MN---YIHRDLRSANILVG--NGL-IC-------------------KIADFGLARLI-------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR--FTIKSDVWSFGILLTELVTKGRVP-------------YPGM----NNREVLEQV-ERGYRMPCPQDCP---------------------------------------------------------------ISLHE-LMIHCWKKDPEERPT-------FE-YLQSFL----------------
----YTDTKVIGNGSFGVVYQAKLC-----D-S-GE-LVAIKKVLQD--K-RFK---NR----------------------------------ELQIMRKL-D------HCN-----IVRLRYFFY--SSG----EKKDEVYLNLVLDYVPETVYRVA---RHYSRAKQ--------------------------TL---PVIYVKLYMYQLFRSLAYIHS--FG---ICHRDIKPQNLLLD-PDTA-VL-------------------KLCDFGSAKQ--------LVRGEPN--------------VS---YICSRYYRAPELIF-----GATD--YTSSIDVWSAGCVLAELLL-GQPI-------------FPGD----SGVDQLVEI-IKVLGTPTREQIREMNPNYTEFKFPQIKAH-----------------------------------PWTKVFRPRTPPEAIA-LCSRLLEYTPTARLT-------PL-EACAHSFF--------------
----LTFVQEIGSGQFGLVHLGYWL-------N-KD-KVAIKTIR-E--G-AM----SE--ED-FI-E-------------------------EAEVMMKL-S------HPK-----LVQLYGVCL--E--------QAPIC--LVFEFMEHG--CLSDYLR-----TQ-----------------------R-GLF---AAETLLGMCLDVCEGMAYLEE--AC---VIHRDLAARNCLVG--ENQ-VI-------------------KVSDFGMTRFV-------L--DDQY--------------TSSTGTKFPVKWASPEVFS------FSR--YSSKSDVWSFGVLMWEVFSEGKIP-------------YENR----SNSEVVEDI-STGFRLYKPRLAS---------------------------------------------------------------THVYQ-IMNHCWKERPEDRPA-------FS-RLLRQL----------------
---L-KYISQLGKGNFGSVELCRYDP-LGDN-T-GA-LVAVKQLQ-H--S-GP----DQ-QRD-FQ-R-------------------------EIQILKAL-H------SDF-----IVKYRGVSYGPG--------RQSLR--LVMEYLPSG--CLRDFLQ-----RH-----------------------R-ARL---DASRLLLYSSQICKGMEYLGS--RR---CVHRDLAARNILVE--SEA-HV-------------------KIADFGLAKLL---PL--D--KDYY--------------VVREPGQSPIFWYAPESLS------DNI--FSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDV-P--ALCRLLELL-EEGQRLPAPPACP---------------------------------------------------------------AEVHE-LMKLCWAPSPQDRPS-------FS-ALGP---QL-------------
----LKLVERLGAGQFGEVWMGYYN-------G-HT-KVAVKSLK-Q--G-SM----SP--DA-FL-A-------------------------EANLMKQL-Q------HQR-----LVRLYAVVT-----------QEPIY--IITEYMENG--SLVDFLK-----TP----------------------SG-IKL---TINKLLDMAAQIAEGMAFIEE--RN---YIHRDLRAANILVS--DTL-SC-------------------KIADFGLARLI-------E--DNEY--------------TAREGAKFPIKWTAPEAIN------YGT--FTIKSDVWSFGILLTEIVTHGRIP-------------YPGM----TNPEVIQNL-ERGYRMVRPDNCP---------------------------------------------------------------EELYQ-LMRLCWKERPEDRPT-------FD-YLRSV--L--------------
----FEKISELGAGNGGVVFKVSHK-----P-S-GL--VMARKLIHL--E-IKP---AI--RN-QIIR-------------------------ELQVLHEC-N------SPY-----IVGFYGAFY--S--------DGEIS--ICMEHMDGG--SLDQVLK----KAG--------------------------RI---PEQILGKVSIAVIKGLTYLRE-KHK---IMHRDVKPSNILVN--SRG-EI-------------------KLCDFGVSG---------QLIDSMA--------------NS---FVGTRSYMSPERLQ------GTH--YSVQSDIWSMGLSLVEMAV-GRYP-------------IPPP----DAKELELMF-GCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFE--------------------LLDYIVNEPPPKLPSGVFSLEFQD-FVNKCLIKNPAERAD-------LK-QLMVHAFI--------------
----IEVEEVVGRGAFGVVCKAKWR---------AK-DVAIKQIE-------S----ESERKA-FI-V-------------------------ELRQLSRV-N------HPN-----IVKLYGACL------------NPVC--LVMEYAEGG--SLYNVLH-----GA----------------------EPLPYY---TAAHAMSWCLQCSQGVAYLHS--MQPKALIHRDLKPPNLLLV--AGGTVL-------------------KICDFGTACDI-------------Q--------------THMTNNKGSAAWMAPEVFE------GSN--YSEKCDVFSWGIILWEVITR-RKP-------------FDEIGG--PAFRIMWAV-HNGTRPPLIKNLP---------------------------------------------------------------KPIES-LMTRCWSKDPSQRPS-------ME-EIVKI--M--------------
----YQNLKPIGSGAQGIVCAAYDA-----V-L-DR-NVAIKKLSRP--F-QNQ---TH--AK-RAYR-------------------------ELVLMKCV-N------HKN-----IISLLNVFT--PQKT--LEEFQDVY--LVMELMDA---NLCQVIQ------M--------------------------EL---DHERMSYLLYQMLCGIKHLHS--AG---IIHRDLKPSNIVVK--SDC-TL-------------------KILDFGLART--------AGTSFMM--------------TP---YVVTRYYRAPEVIL------GMG--YKENVDIWSVGCIMGEMVR-HKIL-------------FPGR----DYIDQWNKV-IEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPK----------------------LFPDSLFPADSEHNKLKASQARD-LLSKMLVIDPAKRIS-------VD-DALQHPYI--------------
----VHFNEVIGRGHFGCVYHGTLL--DNDG-K-KI-HCAVKSLN-R--I-TD----IGEVSQ-FL-T-------------------------EGIIMKDF-S------HPN-----VLSLLGICL-RS--------EGSPL--VVLPYMKHG--DLRNFIR-----NE-----------------------T-HNP---TVKDLIGFGLQVAKGMKYLAS--KK---FVHRDLAARNCMLD--EKF-TV-------------------KVADFGLARDM----Y--D--KEYYS------------VHNKTGAKLPVKWMALESLQ------TQK--FTTKSDVWSFGVLLWELMTRGAPP-------------YPDV----NTFDITVYL-LQGRRLLQPEYCP---------------------------------------------------------------DPLYE-VMLKCWHPKAEMRPS-------FS-ELVSR--I--------------
---I-EYVRDIGEGAFGRVFQARAPGLLPYE-P-FT-MVAVKMLK-E--E-AS----ADMQAD-FQ-R-------------------------EAALMAEF-D------NPN-----IVKLLGVCA--V--------GKPMC--LLFEYMAYG--DLNEFLR-----SMSPHTVCSLSHSDLSMRAQVSSPGP-PPL---SCAEQLCIARQVAAGMAYLSE--RK---FVHRDLATRNCLVG--ENM-VV-------------------KIADFGLSRNI----Y--S--ADYY--------------KANENDAIPIRWMPPESIF------YNR--YTTESDVWAYGVVLWEIFSYGLQP-------------YYGM----AHEEVIYYV-RDGNILSCPENCP---------------------------------------------------------------VELYN-LMRLCWSKLPADRPS-------FT-SIHRIL----------------
---I-VLKRELGEGAFGKVFLAECYNLCPEQ-D-KI-LVAVKTLK-D--A-SD----NA-RKD-FH-R-------------------------EAELLTNL-Q------HEH-----IVKFYGVCV--E--------GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAV-----------LMAEGNPP-TEL---TQSQMLHIAQQIAAGMVYLAS--QH---FVHRDLATRNCLVG--ENL-LV-------------------KIGDFGMSRDV----Y--S--TDYY--------------RVGGHTMLPIRWMPPESIM------YRK--FTTESDVWSLGVVLWEIFTYGKQP-------------WYQL----SNNEVIECI-TQGRVLQRPRTCP---------------------------------------------------------------QEVYE-LMLGCWQREPHMRKN-------IK-GIHTL--L--------------
---I-VLKRELGEGAFGKVFLAECYNLSPTK-D-KM-LVAVKALK-D--P-TL----AA-RKD-FQ-R-------------------------EAELLTNL-Q------HEH-----IVKFYGVCG--D--------GDPLI--MVFEYMKHG--DLNKFLR-----AHGPDAMIL--------VDGQPRQAK-GEL---GLSQMLHIASQIASGMVYLAS--QH---FVHRDLATRNCLVG--ANL-LV-------------------KIGDFGMSRDV----Y--S--TDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIM------YRK--FTTESDVWSFGVILWEIFTYGKQP-------------WFQL----SNTEVIECI-TQGRVLERPRVCP---------------------------------------------------------------KEVYD-VMLGCWQREPQQRLN-------IK-EIYKIL----------------
---F-KFGKILGEGSFSTVVLAREL-----A-T-SR-EYAIKILEKR--H-IIK---EN--KVPYVTR-------------------------ERDVMSRL-D------HPF-----FVKLYFTFQ--D--------DEKLY--FGLSYAKNG--ELLKYIR----KIG--------------------------SF---DETCTRFYTAEIVSALEYLHG--KG---IIHRDLKPENILLN--EDM-HI-------------------QITDFGTAKVLS-----PESKQARA--------------NS---FVGTAQYVSPELLT------EKS--ACKSSDLWALGCIIYQLVA-GLPP-------------FRAG-------NEYLIF-QKIIKLEYDFPEKFF-------------------------------------------------------------PKARD-LVEKLLVLDATKRLG-------CE-EM------EGYGPLKAHPF---
----YEPKEILGRGVSSVVRRCIHK-----P-T-SQ-EYAVKVIDVT--G-GGS---FS--PE-EVRELRE------------------ATLKEVDILRKVSG------HPN-----IIQLKDTYE--T--------NTFFF--LVFDLMKRG--ELFDYLT----EKV--------------------------TL---SEKETRKIMRALLEVICTLHK--LN---IVHRDLKPENILLD--DNM-NI-------------------KLTDFGFSCQ--------LEPGERL--------------RE---VCGTPSYLAPEIIECSMNEDHPG--YGKEVDMWSTGVIMYTLLA-GSPP-------------FWHR-------KQMLML-RMIMSGNYQFGSPEWDDYS---------------------------------------------------------DTVKD-LVSRFLVVQPQNRYT-------AE-EALAHPFF--------------
-YDP---KDVIGRGVSSVVRRCVHR-----A-T-GH-EFAVKIMEVT--A-ERL---SP--EQ-LEEVREA-------------------TRRETHILRQVAG------HPH-----IITLIDSYE--S--------SSFMF--LVFDLMRKG--ELFDYLT----EKV--------------------------AL---SEKETRSIMRSLLEAVSFLHA--NN---IVHRDLKPENILLD--DNM-QI-------------------RLSDFGFSCH--------LEPGEKL--------------RE---LCGTPGYLAPEILKCSMDETHPG--YGKEVDLWACGVILFTLLA-GSPP-------------FWHR-------RQILML-RMIMEGQYQFSSPEWDDRS---------------------------------------------------------STVKD-LISRLLQVDPEARLT-------AE-QALQHPFF--------------
---F-KFLAVLGRGHFGKVLLSEFR-----P-S-GE-LFAIKALKKG--D-IVA---RD--EV-ESLM------------------------CEKRILAAV-TS---AGHPF-----LVNLFGCFQ--T--------PEHVC--FVMEYSAGG--DLMLHIH-----SD--------------------------VF---SEPRAIFYSACVVLGLQFLHE--HK---IVYRDLKLDNLLLD--TEG-YV-------------------KIADFGLCKEG-------MGYGDRT--------------ST---FCGTPEFLAPEVLT------DTS--YTRAVDWWGLGVLLYEMLV-GESP-------------FPGD-------DEEEVF-DSIVNDEVRYPRFLS-------------------------------------------------------------AEAIG-IMRRLLRRNPERRLGSS--ERDAE-DVKKQPFF--------------
--YV--RGRFLGKGGFAKCFEISDA-----D-T-KE-VFAGKIVPKS--L-LLK---PH--QR-EKMS------------------------MEISIHRSL-A------HQH-----VVGFHGFFE--D--------NDFVF--VVLELCRRR--SLLELHK----RRK--------------------------AL---TEPEARYYLRQIVLGCQYLHR--NR---VIHRDLKLGNLFLN--EDL-EV-------------------KIGDFGLATKV-------EYDGERK--------------KT---LCGTPNYIAPEVLS------KKG--HSFEVDVWSIGCIMYTLLV-GKPP-------------FETS-------CLKETY-LRIKKNEYSIPKHIN-------------------------------------------------------------PVAAS-LIQKMLQTDPTARPT-------IN-ELLNDEFF--------------
---F-NFLMVLGKGSFGKVMLADRK-----G-T-EE-LYAIKILKKD--V-VIQ---DD--DV-ECTM------------------------VEKRVLALLDK------PPF-----LTQLHSCFQ--T--------VDRLY--FVMEYVNGG--DLMYHIQ----QVG--------------------------KF---KEPQAVFYAAEISIGLFFLHK--RG---IIYRDLKLDNVMLD--SEG-HI-------------------KIADFGMCKEH-------MMDGVTT--------------RT---FCGTPDYIAPEIIA------YQP--YGKSVDWWAYGVLLYEMLA-GQPP-------------FDGE-------DEDELF-QSIMEHNVSYPKSLS-------------------------------------------------------------KEAVS-VCKGLMTKHPAKRLG-------C----------GPEGERDVREHAFF
--FI--FHKVLGKGSFGKVLLGELK-----G-R-GE-YFAIKALKKD--V-VLI---DD--DV-ECTM------------------------VEKRVLTLAAE------NPF-----LTHLICTFQ--T--------KDHLF--FVMEFLNGG--DLMYHIQ----DKG--------------------------RF---ELYRATFYAAEIMCGLQFLHS--KG---IIYRDLKLDNVLLD--RDG-HI-------------------KIADFGMCKEN-------IFGESRA--------------ST---FCGTPDYIAPEILQ------GLK--YTFSVDWWSFGVLLYEMLI-GQSP-------------FHGD-------DEDELF-ESIRVDTPHYPRWIT-------------------------------------------------------------KESKD-ILEKLFEREPTKRLG------VTG-NIKIHPFF--------------
--FI--LHKMLGKGSFGKVFLAEFK-----K-T-NQ-FFAIKALKKD--V-VLM---DD--DV-ECTM------------------------VEKRVLSLAWE------HPF-----LTHMFCTFQ--T--------KENLF--FVMEYLNGG--DLMYHIQ----SCH--------------------------KF---DLSRATFYAAEIILGLQFLHS--KG---IVYRDLKLDNILLD--KDG-HI-------------------KIADFGMCKEN-------MLGDAKT--------------NT---FCGTPDYIAPEILL------GQK--YNHSVDWWSFGVLLYEMLI-GQSP-------------FHGQ-------DEEELF-HSIRMDNPFYPRWLE-------------------------------------------------------------KEAKD-LLVKLFVREPEKRLG-------VRGDIRQHPLF--------------
---F-DLIRVIGRGSYAKVLLVRLK-----K-N-DQ-IYAMKVVKKE--L-VHD---DE--DI-DWVQ------------------------TEKHVFEQASS------NPF-----LVGLHSCFQ--T--------TSRLF--LVIEYVNGG--DLMFHMQ----RQR--------------------------KL---PEEHARFYAAEICIALNFLHE--RG---IIYRDLKLDNVLLD--ADG-HI-------------------KLTDYGMCKEG-------LGPGDTT--------------ST---FCGTPNYIAPEILR------GEE--YGFSVDWWALGVLMFEMMA-GRSP-------------FDIITDNPDMNTEDYLF-QVILEKPIRIPRFLS-------------------------------------------------------------VKASH-VLKGFLNKDPKERLGCRP-QTGF----------SDIKSHAFF-----
----IELGRCIGEGQFGDVHQGIYM--SPEN-P-AL-AVAIKTCK-N--C-TS----DSVREK-FL-Q-------------------------EALTMRQF-D------HPH-----IVKLIGVIT-----------ENPVW--IIMELCTLG--ELRSFLQ-----VR-----------------------K-YSL---DLASLILYAYQLSTALAYLES--KR---FVHRDIAARNVLVS--SND-CV-------------------KLGDFGLSRYM-------E--DSTY--------------YKASKGKLPIKWMAPESIN------FRR--FTSASDVWMFGVCMWEILMHGVKP-------------FQGV----KNNDVIGRI-ENGERLPMPPNCP---------------------------------------------------------------PTLYS-LMTKCWAYDPSRRPR-------FT-ELKAQL----------------
---F-TLCRKLGSGYFGEVFEGLWK-------D-RV-QVAIKVIS-R--D-NL----LH-QQM-LQ-S-------------------------EIQAMKKL-R------HKH-----ILALYAVVS--V--------GDPVY--IITELMAKG--SLLELLR-----DS----------------------DE-KVL---PVSELLDIAWQVAEGMCYLES--QN---YIHRDLAARNILVG--ENT-LC-------------------KVGDFGLARLI----------KEDV--------------YLSHDHNIPYKWTAPEALS------RGH--YSTKSDVWSFGILLHEMFSRGQVP-------------YPGM----SNHEAFLRV-DAGYRMPCPLECP---------------------------------------------------------------PSVHK-LMLTCWCRDPEQRPC-------FK-ALRERL----------------
---L-RLEVKLGQGCFGEVWMGTWN-------G-TT-RVAIKTLK-P--G-TM----SP--EA-FL-Q-------------------------EAQVMKKL-R------HEK-----LVQLYAVVS-----------EEPIY--IVTEYMSKG--SLLDFLK-----GE----------------------TG-KYL---RLPQLVDMAAQIASGMAYVER--MN---YVHRDLRAANILVG--ENL-VC-------------------KVADFGLARLI-------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR--FTIKSDVWSFGILLTELTTKGRVP-------------YPGM----VNREVLDQV-ERGYRMPCPPECP---------------------------------------------------------------ESLHD-LMCQCWRKEPEERPT-------FE-YLQAF--L--------------
-LCP---GRELGRGKFAVVRKCIKK-----D-S-GK-EFAAKFMRKR--R-KGQ---DC--RM-EIIH-------------------------EIAVLELAQD------NPW-----VINLHEVYE--T--------ASEMI--LVLEYAAGG--EIFDQCVA--DREE--------------------------AF---KEKDVQRLMRQILEGVHFLHT--RD---VVHLDLKPQNILLT--SES-PLG----------------DIKIVDFGLSRI--------LKNSEEL--------------RE---IMGTPEYVAPEILS------YDP--ISMATDMWSIGVLTYVMLT-GISP-------------FLGN-------DKQETF-LNISQMNLSYSEEEFDVLS---------------------------------------------------------ESAVD-FIRTLLVKKPEDRAT-------AE-ECLKHPWL--------------
---L-RLLEKLGDGSFGVVRRGEWD--APSG-K-TV-SVAVKCLK-PDVL-SQ----PEAMDD-FI-R-------------------------EVNAMHSL-D------HRN-----LIRLYGVVL-----------TPPMK--MVTELAPLG--SLLDRLR-----KH-----------------------Q-GHF---LLGTLSRYAVQVAEGMGYLES--KR---FIHRDLAARNLLLA--TRD-LV-------------------KIGDFGLMRAL---PQ--N--DDHY--------------VMQEHRKVPFAWCAPESLK------TRT--FSHASDTWMFGVTLWEMFTYGQEP-------------WIGL----NGSQILHKIDKEGERLPRPEDCP---------------------------------------------------------------QDIYN-VMVQCWAHKPEDRPT-------FV-ALRDF--L--------------
---L-RLEVKLGQGCFGEVWMGTWN-------G-TT-KVAIKTLK-P--G-TM----MP--EA-FL-Q-------------------------EAQIMKKL-R------HDK-----LVPLYAVVS-----------EEPIY--IVTEFMSKG--SLLDFLK-----EG----------------------DG-KYL---KLPQLVDMAAQIADGMAYIER--MN---YIHRDLRAANILVG--ENL-VC-------------------KIADFGLARLI-------E--DNEY--------------TARQGAKFPIKWTAPEAAL------YGR--FTIKSDVWSFGILQTELVTKGRVP-------------YPGM----VNREVLEQV-ERGYRMPCPQGCP---------------------------------------------------------------ESLHE-LMNLCWKKDPDERPT-------FE-YIQSFL----------------
LIAD----IELGCGNFGSVRQGVYR---MRK-K-QI-DVAIKVLK-Q--G-TE----KADTEE-MM-R-------------------------EAQIMHQL-D------NPY-----IVRLIGVCQ-----------AEALM--LVMEMAGGG--PLHKFLV-----GK-----------------------R-EEI---PVSNVAELLHQVSMGMKYLEE--KN---FVHRDLAARNVLLV--NRH-YA-------------------KISDFGLSKAL---GA--D--DSYY--------------TARSAGKWPLKWYAPECIN------FRK--FSSRSDVWSYGVTMWEALSYGQKP-------------YKKM----KGPEVMAFI-EQGKRMECPPECP---------------------------------------------------------------PELYA-LMSDCWIYKWEDRPD-------FL-TVEQR--M--------------
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